To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Whether you are an academic, a SME or an industrialist, our team informs and advices you about the possibilities of consortium assembly, technology transfer, patent licensing or use of our platforms.
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All the news of the Institute of life sciences Frédéric Joliot
As part of a collaboration with MIRCen (Jacob Institute), researchers of SCBM have developed functional micellar vectors that can effectively target tumors and whose therapeutic activity is intrinsically carried by the constitutive unit of the micelle. This combination leads to better drug load and avoids premature drug release.
The Fresnel Institute, in collaboration with the University of St Petersburg and a team from NeuroSpin, has developed a new ceramic resonator (probe) suitable for 17T magnetic resonance microscopy, i.e. for spatial resolutions below 100 μm3. This probe allows the production of MRI images with a signal-to-noise ratio 2 times greater than those obtained with reference probes, in copper.
Two teams from JOLIOT (SPI / SCBM), in collaboration with the University of Cincinnati, confirm the interest of a drug candidate to treat the congenital creatine deficiency syndrome, a rare neurological childhood disease, responsible for developmental delays and intellectual disability. The results obtained in an animal model of the disease show that it is possible to administer, nasally, dodecyl creatine ester-loaded microspheres, thus improving the cognitive functions of treated animals.
A team of NeuroSpin (GIN Bordeaux), within a multidisciplinary consortium, led an exploratory study of whole genome sequencing to search for rare genetic mutations that may be implicated in the atypical inverted right-hemispheric dominance for language (DLAtyp), present in less than 1% of the adult population. A higher rate of mutations affecting the actin cytoskeleton was revealed in DLAtyp individuals identified by functional MRI.
A collaboration involving NeuroSpin sheds new light on the action of lithium in bipolar disorder. The modeling (NODDI) of water diffusion measured by diffusion MRI allowed analysis of cerebral microstructure. Results indicate increased dendritic density in the frontal cortex of lithium-treated patients. This suggests that an improved communication between neurons in this region of the brain may underlie the beneficial effects of lithium in bipolar disorder.
A team from NeuroSpin, in collaboration with Maastricht and Minnesota universities, conducted for the first time an entire functional MRI exam based on 7T parallel transmission technology, as part of the Human Connectome Project. The results show that the problem of radiofrequency field inhomogeneities, a barrier to the full exploitation of very high-field MRI, is thus correctly solved, without any additional cost for the user.
Imaging the brain of a patient at the microscopic scale is as of yet not possible but might turn into a reality thanks to a new tool for creating virtual biopsies. This algorithm has been developed by a team of NeuroSpin (CEA-Joliot) in collaboration with the Institute of NeuroScience and Medicine of Juelich as part of the European Human Brain Project. A first study demontrsating the potentiel of the algorithm ot simulate white matter samples has been published in NeuroImage.
Researchers from Inserm, in collaboration with a team from NeuroSpin, have developed a preparation to observe sequentially the neuronal activity and vascular responses of the same mouse with bi-photonic microscopy, ultrasound imaging and BOLD-fMRI, in response to an olfactory stimulus. This approach made it possible to quantitatively compare the responses to odors observed both at the microscopic and mesoscopic scales. Results, published in Nat. Comm, show that the three techniques similarly measure the concentration of an odor.
Plants, algae, cyanobacteria regulate their photosynthesis so that it is as effective as possible and not deleterious. A sutdy led by a SB2SM team unveils one of the mechanisms of regulation in cyanobacteria and show that it is very different from that equivalent in plants and algae.
A team from the SCBM, in collaboration with the SPI, the IC2MP and the University Hospital of Poitiers, has developed a bioorthogonal chemistry strategy that allows, in vivo, the controlled release of active ingredients contained in micelles-targeting cancerous tumors. These results pave the way for new strategies for targeted drug delivery.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.