To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
Within the Institute, the "Funding Research and Technology Transfer" team is at your disposal to identify the scientists and the skills you need to set up a joint project, to define the terms of a collaboration contract or study.
Whether you are an academic, a SME or an industrialist, our team informs and advices you about the possibilities of consortium assembly, technology transfer, patent licensing or use of our platforms.
The team is also at the disposal of the researchers of the institute to accompany them in achieving their valorization objectives.
All the news of the Institute of life sciences Frédéric Joliot
A SHFJ research team (LDM-TEP, GIP Cyceron, Caen) has previously developed and produced a radiopharmaceutical, the [18F]-Fludarabine, to detect lymphomas using PET scan. The team has recently conducted a preclinical study that shows the molecule can help in diagnosis of cerebral lymphoma by differentiate it from glioblastoma, the main brain tumor. A clinical study should be launched before the end of the year.
An international collaboration, led by the Institut du Cerveau et de la Moelle épinière – ICM (Brain & Spine Institute) and involving researchers from NeuroSpin, offers a new electroencephalogram (EEG) tool that helps the diagnosis of disorders of consciousness. Unlike other tools developed so far and dedicated to a few expert centers, “DoC-Forest” would be accessible to most of the hospitals worldwide.
Research Teams from the Curie Institute, the Gustave Roussy Institute, as well as the biophysics teams from the Institute of Chemistry of Natural Substances and SB2SM (I2BC@Saclay) met to systematically identify structural defects and BRCA1 proteins encoded by variants of the BRCA1 gene, a gene predisposing to breast and ovarian cancer. Their results make it possible to propose a classification of these variants (neutral versus causal).
A SB2SM Research Team (I2BC@Saclay) solved by crystallography the structure of a ternary protein complex at the interface between the nuclear envelope (emerin and lamin A / C) and the genome (BAF). In collaboration with Teams from Paris-Sud and Paris-Diderot Universities, the structure analysis, as well as in vitro interaction and proximity experiments in cellulo, suggests that a lack of interaction between the lamina A / C (nucleoskeleton) and chromatin-associated protein (BAF) may be one of the mechanisms responsible for premature aging syndromes.
SHFJ Researchers (IMIV), in collaboration with Vienna University, studied the brain transport of a drug, called metoclopramide. Radiolabelling of carbon-11 metoclopramide and PET imaging showed that a transporter of the blood-brain barrier, P-glycoprotein, blocked not only the entry of the drug into the brain but also facilitated the elimination to the blood. This result demonstrates for the first time in vivo and non-invasively a detoxification system able to eliminate certain compounds of the brain.
In studies published in ChemPhotoChem, I2BC@Saclay, SCBM and ICMMO researchers have developed a gentle method for photo-CO2 reduction by molecular catalysts, followed by a carbonylation reaction that immediately reuse the CO produced. This device can be used for the introduction of radioactive carbon atoms into molecules of therapeutic interest.
By studying the cerebral dynamics of monkeys under general anesthesia using functional MRI (fMRI) and electroencephalography (EEG), NeuroSpin researchers, in collaboration with several hospital-university Teams, have identified a universal brain signature of the induced loss of consciousness by general anesthesia. This signature corresponds to a "stiffening" of the information flow within the brain.
Funded by the Human Brain Project, Individual Brain Charting is a collaborative project involving NeuroSpin that involves acquiring a set of high-resolution functional MRI maps of the human brain while performing behavioral tasks. The data, in open access, will be used to develop a macroscopic functional atlas including a cognitive mapping. This is the first version of the IBC project dataset.
IMIV unit (SHFJ), in collaboration with the Gustave Roussy Institute, has developed the free software platform LIFEx that allows to characterize the tumor heterogeneity from any type of medical images: PET, MRI, scanner, ultrasound. With nearly 900 members, this platform has an international success because it facilitates the realization of radiomic studies, conducted in the context of personalized medicine.
A SPI Research Team (LI2D, Marcoule), in collaboration with CIRAD and AU-PANVAC, proposes a new quality control technique for veterinary vaccines, based on very high resolution mass spectrometry. This strategy, based on the use of an ad hoc database to measure the proportion of antigens and contaminants in the vaccine preparation, will improve the quality control of vaccines against contagious caprine pleuropneumonia.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.