To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
Within the Institute, the "Funding Research and Technology Transfer" team is at your disposal to identify the scientists and the skills you need to set up a joint project, to define the terms of a collaboration contract or study.
Whether you are an academic, a SME or an industrialist, our team informs and advices you about the possibilities of consortium assembly, technology transfer, patent licensing or use of our platforms.
The team is also at the disposal of the researchers of the institute to accompany them in achieving their valorization objectives.
All the news of the Institute of life sciences Frédéric Joliot
An I2BC Research Team, in collaboration with the ICSN and the Ecole Polytechnique, has mapped for the first time, in man and the model plant Arabidopsis thaliana, the myristoylome, namely the whole proteins modified with a fatty acid, myristate. This modification is important because it targets these proteins to the membranes and thus contributes to their subcellular compartmentalization. These data represent an important resource, available to the community of biologists.
A SCBM Research Team, in collaboration with SHFJ, SIMOPRO and Karolinska Institute, has discovered a method inspired by the "click" chemistry which, from radioactive carbon dioxide, can synthesize in just five minutes radiolabeled molecules containing a cyclic urea moiety. This method has been used for the ultra-rapid isotope labeling of drugs, without modification of their structure and with an unequaled efficiency.
Being part of an international consortium, the Neurofunctional Imaging Group (NeuroSpin, Bordeaux) and the Max Planck Institute for Psycholinguinstics have characterized the asymmetries of surface and thickness of the cerebral cortex of 17,141 individuals from MRI. This study published in PNAS, the largest ever done, provides a unique reference for studying the genetic basis of cerebral asymmetries and the alteration of lateralization during cognitive, neurological and psychiatric disorders.
A team from I2BC@Saclay (SB2SM), in collaboration with the RPBS platform, has put online a server for structural prediction of interactions between proteins. This server, designed for biologists, uses the information provided by the coevolution of protein sequences and predicts the structure of protein complexes, essential information for understanding their functional role.
NeuroSpin researchers (UNATI and UNICOG), in collaboration with the Timone Neuroscience Institute, have studied a type of individual anatomical variation in the structure of the human cortex, the transverse gyrus or 'fold crossing', which separates grooves in two parts. They showed that the presence of this structure in the upper temporal groove is heritable. This result is important, given the role of this region of the brain in the production of language.
Two Research Teams from I2BC@Saclay and SPI (LI2D, Marcoule), in collaboration with IRAMIS, highlight the very strong affinity of silica nanoparticles for proteins with RGG motifs (family of binding proteins). RNA), especially when these are methylated. These results are important for the development of safe by design approaches.
The SHFJ LDM-PET team (GIP Cyceron, Caen), in collaboration with the University Hospital of Caen, successfully used, for the first time in the clinic, the radiopharmaceutical drug developed and produced by the researchers of the team. , the [18F] Fludarabine. This drug, which is innovative for lymphoproliferative diseases, has been shown to be more effective in terms of specificity and sensitivity than its current counterpart, [18F] FDG.
Collaborative work between the SBIGeM (I2BC@Saclay) and the Marseille Cancer Research Center, published in Molecular Cell, illuminates the mechanistic basis and genetic control of homologous recombination, a mechanism for repairing DNA breaks responsible for chromosome exchange during meiosis. However, canonical models do not explain the complexity of meiotic recombination profiles and this study, which reconstructs reaction intermediates, constitutes a major advance in the understanding of this mechanism.
In a study published in Analytical Chemistry, the Mass Spectrometry Research Team of the Laboratory Drug Metabolism Research Laboratory (SPI) demonstrated the interest of Orbitrap Fusion, a state-of-the-art mass spectrometer for the identification of relevant metabolites based on their masses and isotopes measured with high accuracy.
As part of a collaboration with MIRCen (Institute of Biology François Jacob) and SBIGeM, SCBM researchers have developed functional micellar nanovectors capable of targeting a population of cancer cells.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.