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Laboratory | Epigenetics | Brain | Alzheimer's disease | Cognition | Genomics


LEM

Mammalian Epigenomics Laboratory

Accurate control of genome expression is crucial for proper cell functioning. Our team is investigating how the epigenetic regulation of gene expression is altered in the brain during aging and Alzheimer’s disease, with the aim of identifying novel strategies for the treatment of cognitive impairment.

 

​​FRENCH

 

Published on 2 November 2019

Team Leader
Matthieu GERARD
+33 1 69 08 94 29
Matthieu.Gerard@Cea.Fr

Mammalian Epigenomics (Matthieu GERARD)

 

Our team is expert in the study of the mechanisms that regulate gene expression and access of the transcription machinery to the genome in its physiological chromatin environment (e.g. Houlard et al., 2006, PMID: 17083276; Chantalat et al., 2011, PMID: 21803857; Carrière et al., 2012, PMID: 21911356; Montellier et al., 2013, PMID: 23884607). The basic unit of chromatin, the nucleosome, is composed of 147 base pairs of DNA tightly wrapped around a core of eight histone proteins. Nucleosomal organization represents a strong physical barrier that prevents binding of most transcription factors to DNA. ATP-dependent chromatin remodeling factors (also called remodelers) are enzymes that control the density and positioning of nucleosomes on the genome. A major predicted function of these enzymes is to regulate access of the transcription machinery to the genome by generating (or suppressing) open chromatin regions at specific locations. 

Human resources
Matthieu GERARD, Researcher
Emilie DROUINEAU, Research Engineer
Hélène PICAUD, Technician
Anida MESIHOVIC, Post doctoral fellow
Marina NOCENTE, PhD Student

RNA interference platform (PARi) is part of the lab
Scientific management
Matthieu GERARD (Researcher, CEA)
Operational management
Guillaume PINNA (Researcher, CEA)
Gueorgui KRATASSIOUK (Research Ingeneer, CNRS)
Marie VANDAMME (Technician, CEA)
Bioinformatic
Nadya MOROZOVA (Research Ingeneer, CNRS)
Gene targeting and animal facility

Patrick HERY, Technician, Platform manager
+33 1 69 08 94 32
patrick.hery@cea.fr

Anne-Sophie CHAPLAULT, Technician
+33 1 69 08 80 18
anne-sophie.chaplaut@cea.fr

Sylvain THESSIER, Technician
+33 1 69 08 80 18
sylvain.thessier@cea.fr

Jean-Charles ROBILLARD, Technician
+33 1 69 08 54 78
jean-charles.robillard@cea.fr