The group is interested in molecular mechanisms of eukaryotic transcriptional regulation in vivo on the genomic scale. The Mediator complex, essential for regulation of transcription by RNA polymerase II, is central for our projects. We use the budding yeast Saccharomyces cerevisiae and human cells as our biological models and apply integrative approaches to understand how the transcriptional regulation works and how transcription is coordinated with others nuclear processes like DNA repair.
This team is part of I2BC
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