FROM MOLECULE...TO HUMAN
To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Team Leader: Dr Lucie Hertz-Pannier and Jessica Dubois
The Neuropediatrics Team InDEv was created in 2013 at NeuroSpin, as a team of UNIACT (Research Unit in Clinical and Translational Application Neuroimaging).The InDEv team is under the co-supervision of CEA and UMR1129 unit (INSERM - Paris Descartes University - CEA) "Child Epilepsy and Cerebral Plasticity", headed by Professor Catherine Chiron. This is the "Imaging" team of the UMR1129(site).
InDEv research themes concern the study of brain development in typical children or carriers of early brain diseases (epilepsies, microencephaly, brain tumors, neonatal stroke, ...) using structural and functional MRI. In sick children, we are particularly interested in the brain plasticity of the immature brain, which allows learning and surprising functional efficiency with regard to brain damage.Our multidisciplinary team (neuropediatricians, neuroscientists, neuropsychologists, engineers) show the interest of an interface between fundamental research and clinical research.
These pediatric studies, in collaboration with other groups of NeuroSpin or Ile de France region, include:
1. On the anatomical point of view: changes that occur during development related to gyrification; the development of the internal temporal lobe by measurement of regions of interest such as the hippocampus, amygdala, parahippocampal gyrus, under study of the white matter by means of diffusion MRI and the diffusion tensor, which provides information on myelination, anatomical connectivity ...2. On the functional side: the establishment and organization of the neuronal networks that underlie the development of cognitive functions, more specifically language and memory and the plasticity of these networks in a healthy brain and pathological. To meet these goals, fMRI paradigms are adapted for different developmental ages (from child to adolescent), to controls and to patients. We study concomitant brain activities of tasks. We are also interested in the functional activity of rest (functional connectivity) to better understand the development of neural networks.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.