To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Laboratory | Medical imaging
Clinical MRI methodological team
Team Leader: Alexandre Vignaud
Taking advantage of innovative clinical and
neuroscientific projects, the team focuses on improving image quality using
only the single channel transmission chain and coils optimizing compatible
imaging protocols. This implies to set up “product” sequences or to implement
news approaches compatibles with 7T challenges: Endogenous biomarker mapping, MR
imaging compatible with classic brain segmentation pipelines (Figure 1), or
more specific compartments (e.g.: hippocampus sub-segmentation). Such data
extraction can be important for pathology assessment or to identify therapeutic
targets. Another team’s stated objective is to develop functional MRI at high
spatial and temporal resolution as well as a very high in vivo spatial
resolution close to 100µm isotropic.
Of course, radiofrequency inhomogeneity
management is a very important topic. First, it can be tackled by using high
dielectric permittivity materials in standard system to modify its behavior
(Figure 2). Later, we will see that the problem can also be solved more
elegantly using parallel transmission.
Volunteer and staff security is also major consideration for METRIC team. Passive and active solutions to RF inhomogeneities are carefully studied for Specific Absorption Ratio (SAR) perspective. Volunteer acoustic noise protection and staff magnetic field longitudinal exposition is also a research topic for the team and its collaborators.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.