To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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This project is about developing new tracers for
targeting neuroinflammation (Molecular Probes group), characterizing their
properties in animal models (Experimental Imaging group), designing specific
quantification methods (Biomedical Physics group), and investigating the
clinical relevance (Clinical Applications group).
Project leader: Alexandra Winkeler
The « neuroinflammation » project is focusing on the molecular imaging of neuroinflammation, in particular activated microglia, in order to follow neuroinflammation in different pathologies in space and time.
Neuroinflammation is investigated within the context of neurodegenerative diseases (Alzheimer, Parkinson, Multiple Sclerosis), but also in glioma, addiction and drug exposure. Common efforts within IMIV will lead to the development and characterization of new or improved PET radioligands for neuroinflammation. We will further investigate and develop most appropriate quantification methods for image analysis of these radiotracers.
Improved knowledge concerning the role of neuroinflammation in glioma, neurodegenerative diseases, addiction and drug exposure are expected.
A large part of this project is funded by the European FP7 INMiND (2012-2017) project.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.