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FLow chemistry for Isotopic eXchange


FLIX is a radically innovative concept of isotope labeling of molecules with high added value (drugs, biological products, smart materials) with stable isotopes (2H, 13C, 15N) using the properties of new generations of catalysts.

H2020 funding: ria (Research and Innovation Actions)

Call H2020-FETOPEN-2018-2019-2020-01

Published on 25 February 2020


The objective of FLIX is to design and build a new flow chemistry system, composed of different modules for rapid, flexible and combinable isotopic labeling of complex molecules and biological products. Each module, composed of one or more catalysts for a specific labeling, will be able to be associated with one or more others to obtain multi-labeled compounds. A particular effort will be made to label molecules in the last step, or even a simple isotopic exchange from the original molecule, a process developed at SCBM for hydrogen and carbon isotopes.

A major economic impact of the project is expected on all sectors using stable isotopes, including:

 1.innovation in the field of drugs: preclinical studies could be accelerated and the development of deuterated drugs promoted; 
 2. the design of new tracers with improved biological properties for PET and MRI diagnostic imaging (hyperpolarized organic tracers) 
 3. the development of new intelligent labelled materials (OLED emitters) with improved properties such as an extended lifetime.

Project duration

4 years

3.5 millions €

​Number of partners


Starting date

January 01, 2020

Coordinator : CEA

Joliot Institute Contact: Sophie Feuillastre (

website :

H2020 agreement id : 862179


FET Open, part of the EIC Pathfinder, supports the early stages of scientific and technological research and innovation around new ideas for radically new future technologies. It also funds coordination and support actions to ensure that this high-risk prospective research flourishes in Europe, as well as FET Innovation Launch actions to turn the results of FET-funded projects into real societal or economic innovations.

The European Innovation Council (EIC) pilot project supports researchers and innovators who develop high-risk breakthrough innovations with the potential to create new markets and stimulate jobs, growth and prosperity in Europe.