To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Scientific result | Chemistry | Health ＆ life sciences
A Research Team of the SCBM (Frédéric Joliot Institute), in collaboration with the SIMOPRO (Frédéric Joliot Institute), Strasbourg University and the start-up Syndivia, has just discovered a new chemical reaction allowing both to bind and to cleave molecules in biological media ("click and release" reaction).
We report the discovery of a new bioorthogonal click-and-release reaction involving iminosydnones and strained alkynes. This transformation leads to two products resulting from the ligation and fragmentation of iminosydnones under physiological conditions. Optimized iminosydnones were successfully used to design innovative cleavable linkers for protein modification, thus opening up new areas in the fields of drug release and target-fishing applications. This click-and-release technology offers the possibility of exchanging tags on proteins for functionalized cyclooctynes under mild and bioorthogonal conditions.Read the French version.
S Bernard, D Audisio, M Riomet, S Bregant, A Sallustrau, L Plougastel, E Decuypere, S Gabillet, RA Kumar, J Elyian, MN Trinh, O Koniev, A Wagner, S Kolodych, F Taran (2017) Discovery of New Click and Release Reactions by Screening of Mesoionics and Cycloalkynes Combinations. Angew. Chem. Int. Ed. http://dx.doi.org/10.1002/anie.201708790
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.