To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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NeuroSpin clinical platform
Leader: Alexis Amadon(contact : firstname.lastname@example.org)
At NeuroSpin, we have a Magnetom Prisma Fit imager from Siemens Healthcare (Figure 1). This system is equipped with a whole-body gradient tunnel going up to 80 mT/m, a whole-body transmit RF coil, and head/neck phased-array coils going up to 64 receive elements distributed around the subject (Figure 2). By default, we suggest using the 64-channel coil for an optimal signal-to-noise ratio, but for difficult subjects (children, elderly, large heads), the use of a more spacious coil with 20 channels is recommended.
The current user interface of our Prisma Fit is Syngo MR, in its VE-11 version. Besides the vendor’s traditional acquisition sequences, other sequences are available for spectroscopy, perfusion MRI (ASL sequence), static and RF field mapping (particularly for quantitative MRI and relaxometry), or simultaneous-multi-slice Echo-Planar imaging. The image reconstruction from the latter sequence is performed on a dedicated GPU-based server to avoid dead time between exams. The details of available sequences is given on NeuroSpin’s wiki.
Methodology protocols (on healthy volunteers): they aim at improving imaging techniques and data processing to obtain richer information on the human brain. For instance, one project compares the sensitivity to detect cerebral activations with ASL (perfusion measurement) and BOLD (blood oxygen level) sequences during motor tasks. Other projects analyze the potential of diffusion MRI for fMRI or for iron quantification in the brain.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.