The research projects of the Integrative Biology and Molecular Genetics Unit (SBIGeM) aim at understanding the fundamental mechanisms used by eukaryotic and prokaryotic cells to adapt to their natural environment or to a variety of stresses.
The teams of the Unit try to unravel the mechanisms that control
DNA damage and
cellular proliferation, those that regulate
gene expression, the implication of
chromatin structure in
epigenetic mechanisms, and the nature of the
stress responses induced by
oxidants,
heavy metals,
nanoparticules or ionizing radiations.
Various
biological model systems chosen for their biological and experimental relevance
are studied (bacteria, yeast
Saccharomyces cerevisae, the mouse or mammalian cell cultures). The research teams use a large number of experimental
approaches that are
either targeted (biochemistry, genetics, molecular and cellular biology…)
or global (transcriptomics, proteomics, metabolomics, bio-informatics, model building…) to understand the mechanisms under study in an integrated fashion at the
molecular, cellular or tissular level.
The Unit is organized in four laboratories