To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Laboratory | Epigenetics | Brain | Alzheimer's disease | Cognition | Genomics
Accurate control of genome expression is crucial for proper cell functioning. Our team is investigating how the epigenetic regulation of gene expression is altered in the brain during aging and Alzheimer’s disease, with the aim of identifying novel strategies for the treatment of cognitive impairment.
Our team is expert in the study of the
mechanisms that regulate gene expression and access of the transcription machinery to the genome in its physiological chromatin environment (e.g. Houlard et al., 2006, PMID: 17083276; Chantalat et al., 2011, PMID: 21803857; Carrière et al., 2012, PMID: 21911356; Montellier et al., 2013, PMID: 23884607). The basic unit of chromatin, the nucleosome, is composed of 147 base pairs of DNA tightly wrapped around a core of eight histone proteins. Nucleosomal organization represents a strong physical barrier that prevents binding of most transcription factors to DNA. ATP-dependent chromatin remodeling factors (also called remodelers) are enzymes that control the density and positioning of nucleosomes on the genome. A major predicted function of these enzymes is to regulate access of the transcription machinery to the genome by generating (or suppressing) open chromatin regions at specific locations.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.