To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Project leader: Daniel Gouel
Research and innovation in molecular imaging using PET can currently be performed mostly in laboratories equipped with a cyclotron and a radiochemistry facility on site where new radiotracers and radiopharmaceuticals can be prepared. LOTUS is an integrated solution to produce radionuclides (fluorine-18 and carbon-11) and manufacture innovative radiotracers and radiopharmaceuticals "on demand". This "à la carte" concept will make it possible to evaluate at a large scale new compounds and will facilitate the translation to clinical applications. Started in 2013, this project is a joint collaboration between CEA (DSM/DSV/DRT) and two industrial partners (PMB and SigmaPhi) and is supported by the Banque Publique d'Investissement (BPI France).
The "Molecular Probes", "Experimental Imaging" and "Clinical Applications" teams of IMIV are involved in this transversal project. The "Molecular Probes" team participates to the setup and the validation of the microfluidic devices dedicated to the manufacturing of radiopharmaceuticals. The "Experimental Imaging" and "Clinical Applications" teams will evaluate how to implement this new methodology in preclinical and biomedical research protocols.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.