Frédéric Joliot Institute for Life Sciences - On the same theme https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2022/Autophagy-senescence.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.frhttps://www-cea-fr.admsite.extra.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot.png Frédéric Joliot Institute for Life Sciences - On the same theme https://joliot.cea.fr/drf/joliot/en Autophagy, a cellular self-defense mechanism, is involved in protecting cells against ricin https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Autophagy-involved-protecting-cells-against-ricin.aspx A team from SIMoS and SCBM, in collaboration with researchers from I2BC, has shown that autophagic degradation is at work when mammalian cells are poisoned by ricin. Stimulating this process could provide additional protection against this deadly toxin. CBRN-E threats ; Cellular mechanisms SCBM Scientific result ; Article Thu, 28 Sep 2023 10:00:00 GMT PET imaging monitoring of an antibody targeting endothelin receptors expressed by glioblastoma tumors https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/PET-imaging-antibody-endothelin-receptors-glioblastoma-tumors.aspx Researchers at BioMaps (SHFJ) and SPI (DMTS) have studied the pharmacokinetics of a novel immuno-radioligand targeting the endothelin A receptor (ETA), overexpressed in many cancers, particularly glioblastoma. The immunoPET imaging approach used in this study in a preclinical model confirms the theranostic potential of this antibody. Positron Emission Tomography ; Cancer ; Medical imaging Neurospin Scientific result Thu, 07 Sep 2023 10:00:00 GMT Identification of metabolomic signatures of high-grade breast tumors https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Metabolomic-signatures-high-grade-breast-tumors.aspx The TIRO laboratory of the SHFJ (Nice) identifies for the first time discriminating biomarkers of high-grade invasive breast tumors, using a non-targeted metabolomics approach performed on surgical specimens and cytoponctions from patients at different stages of malignancy. Metabolomics ; Cancer ; Biomarkers SHFJ Scientific result Fri, 04 Aug 2023 10:00:00 GMT Radiomarquage du crizotinib au fluor-18 : un nouvel outil pour suivre par TEP la biodistribution de ce médicament https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Radiomarquage-crizotinib-fluor-18-nouvel-outil-TEP.aspx Des chercheurs du SHFJ ont mis au point la radiosynthèse au fluor-18 du crizotinib, un médicament qui ne pénètre pas dans le cerveau. Ce nouvel outil pour l’imagerie TEP permettra d’explorer de futures stratégies visant à faire passer la barrière hémato-encéphalique à ce médicament pour traiter certaines métastases cérébrales. Positron Emission Tomography ; Cancer ; Diagnosis and innovative treatment Researchers SHFJ Scientific result ; Article Thu, 27 Apr 2023 10:00:00 GMT A mathematical model applicable to nuclear processes at the genome scale, and at very high spatial resolution https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Mathematical-model-repair-genome.aspx The protocols applied for in vivo mapping of nuclear processes, at the genome scale and at very high spatial resolution, do not allow for high temporal resolution. A team from the I2BC has therefore demonstrated that such an understanding could be wrong by using a mathematical model. This model can be applied to any process that can be modeled by a transition between two states. DNA ; Cellular mechanisms Researchers IBITECS Scientific result XR-seq;réparation de l’ADN;NER; Tue, 13 Dec 2022 11:00:00 GMT The insertion of iron initiating the biosynthesis of Fe-S centers is a conserved process https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Iron-insertion-initiating-biosynthesis-Fe-S-centers.aspx A team from SBIGeM (I2BC) shows, by several spectroscopic approaches, that the assembly of a Fe-S cluster, the catalytic center of many essential proteins, is a highly conserved process, initiated by the insertion of ferrous iron at the cysteine-rich assembly site of the scaffold protein ISCU (Iron-sulfur cluster assembly enzyme). Health & life sciences ; Fundamental Research ; Cellular mechanisms SBIGEM Scientific result Fri, 09 Dec 2022 11:00:00 GMT The Mediator of transcription at the heart of gene expression regulation and DNA repair https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Mediator-transcription-gene-expression-regulation-DNA-repair.aspx An I2BC team has analyzed, at the genome scale of the yeast S.cerevisiae, the functional interactions between the Mediator of gene transcription and DNA repair proteins, reinforcing the idea that these two fundamental cellular processes are closely linked. Molecular mechanisms ; Cellular mechanisms ; DNA SBIGEM Scientific result Mon, 26 Sep 2022 10:00:00 GMT Food allergies: the sensitization route influences the immune response https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Food-allergies-sensitization-route-influences-immune-response.aspx Researchers at the LIAA (SPI/DMTS) show that the initial route of sensitization to a food allergen (oral, respiratory, cutaneous) directly influences the nature of immune responses at multiple sites in the body. Allergies ; Cellular mechanisms Researchers SPI Scientific result cellular immune responses;food allergy;BABL/c mice; Mon, 25 Apr 2022 10:00:00 GMT New radioligands for anti-PD-1/PD-L1 immunoPET https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Radioligands-immunoPET-PD-1-PD-L1.aspx Researchers from the SHFJ and the DMTS have developed optimized radioligands for immunoPET imaging. The objective is to better predict the effectiveness of anti-PD1/anti-PDL1 immunotherapy used to fight certain cancers. Positron Emission Tomography ; Cancer Researchers SIMOPRO Scientific result programmed cell death-ligand 1; Tue, 12 Apr 2022 10:00:00 GMT Inhibiting autophagy: a new line to fight cellular senescence? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Autophagy-senescence.aspx Researchers from the Frédéric Joliot Institute have identified ouabain and chloroquine as two selective senolytic molecules that are effective in eliminating certain senescent cells. The study has been published in the journal Aging Cell. Cancer ; Cellular mechanisms Researchers SCBM Scientific result Tue, 15 Mar 2022 11:00:00 GMT Multiparametric PET-MRI imaging: toward a biological characterization of tumors at the supervoxel level https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PET-MRI-imaging-tumors-supervoxel-level.aspx A collaborative study led by BioMaps researchers (SHFJ) demonstrates that fully integrated quantitative multiparametric analysis of non-small cell lung cancer in hybrid 18F-FDG PET/MRI 3T imaging is clinically feasible and could enable biological characterization of tumors at the supervoxel scale. Medical imaging ; Positron Emission Tomography ; MRI ; Cancer Scientific result Wed, 10 Nov 2021 11:00:00 GMT Accelerating mutation accumulation studies with microfluidics https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/accumulation-mutations-microfluidique.aspx Teams from CEA-Iramis and CEA-Joliot (team "Genome transcriptional regulation /I2BC) have joined forces to develop and validate an innovative microfluidic-based system that automatizes cell culture over many generations. It enables with considerable time savings large-scale experiments to be carried out, which are essential for understanding the cellular mechanisms involved in DNA mutation events. DNA ; Cellular mechanisms Researchers Iramis Scientific result Fri, 11 Jun 2021 10:00:00 GMT Anti-cancer therapeutic strategy: a chimera to inhibit ASF1 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Foldamer-inhibitor-ASF1.aspx I2BC researchers, in collaboration with the European Institute of Chemistry and Biology (University of Bordeaux, CNRS), have developed a chimeric peptide/foldamer molecule that is resistant to proteolysis and inhibits ASF1, a potential target for anticancer treatment. The resolution of the structure of this chimera in interaction with its target, the first of its kind, reveals an unsuspected plasticity of the urea-based backbone that hugs the surface of ASF1. Structural biology ; Molecular mechanisms ; Epigenetics ; Cancer Researchers SB2SM Scientific result NMR;radiocristallography; Fri, 19 Mar 2021 11:00:00 GMT A micellar probe for fluorine magnetic resonance tumor imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Micellar-probe-fluorine-MRI-tumor.aspx A SCBM (DMTS) team, in collaboration with researchers at NeuroSpin and I2BC, is describing micellar nanometric vectors targeting tumors that have been imaged by fluorine magnetic resonance imaging (MRI). The observed 19F signal made it possible to precisely delimit the volume of the tumor zone in a mouse model and to quantify the probe accumulated in the target tissue. Chemistry ; Nanomedicine ; Cancer ; MRI Scientific result Thu, 04 Mar 2021 11:00:00 GMT Mambaquaretin: therapeutic and diagnostic interest? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mambaquaretin-theranostic.aspx In pursuing their work on mambaquaretin, SIMoS researchers conducted a collaborative study confirming the therapeutic potential of the toxin and paving the way for its use as a diagnostic tool. Diagnosis and innovative treatment ; Molecular mechanisms ; Cellular mechanisms SIMOPRO Scientific result PET Scan;PK/PD; Tue, 10 Nov 2020 11:00:00 GMT Permeabilizing the blood-brain barrier to deliver therapeutic antibodies into the brain? ImmunoPET imaging provides answers https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/ImmunoPET-BBB-Ab.aspx Researchers from SHFJ, NeuroSpin and DMTS have demonstrated, by immunoPET imaging, the impact of transient BBB permeabilization on brain exposure to an anti-EGFR antibody. Promising prospects for targeted immunotherapy of glioblastoma. Cancer ; Medical imaging ; Positron Emission Tomography SIMOPRO Scientific result radiomarquage;zirconium;IRM; Tue, 06 Oct 2020 10:00:00 GMT BRCA2 and breast cancer: a new mechanism revealed? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/BRCA2-breast-cancer.aspx ​In a study conducted by a team from the Institut Curie, I2BC researchers have used their NMR know-how to study the phosphorylation of BRCA2 and have thus contributed to revealing a mechanism potentially at the origin of chromosomal aberrations observed in breast BRCA2-mutated tumors. Molecular mechanisms ; Cancer SB2SM Scientific result homologous recombination;Rad51;kinase; Mon, 27 Apr 2020 10:00:00 GMT From bacteria to Humans: characterization of a new player in tolerance to thermal and oxidative stress https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Characterization-new-player-tolerance-thermal-oxidative-stress.aspx Researchers from SB2SM (I2BC@Saclay) have shown for the first time in vivo in the model cyanobacterium Synechocystis that a cellular detoxification enzyme, the membrane glutathione-S-transferase (GST), maintained in part by evolution, plays a major role in resistance to thermal and oxidative stress, making this cellular model a valuable tool for the study of GSTs conserved from bacteria to plants, down to Humans. Photosynthesis ; Stress response Scientific result Tue, 18 Feb 2020 11:00:00 GMT Innovative approach to radiolabel peptides with fluorine-18 for PET imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Innovative-approach-radiolabel-peptides-fluorine-18-PET-imaging.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated a new fluor-18 radiolabelling method for peptides used to characterize specific pathological molecular signatures and thus target treatments. Peptides were conjugated to a specific tag, then radiolabeled in a single step under mild conditions, making this approach an innovative solution for PET imaging of peptides labeled with fluorine-18. Chemistry ; Positron Emission Tomography ; Cancer Scientific result Mon, 17 Feb 2020 11:00:00 GMT Glucocorticoids: a better evaluation of their effects in specific cancers? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Glucocorticoids-better-evaluation-effect-cancers.aspx Senescence specialists (SBIGEM), in collaboration with the SCBM and the CNRGH (Jacob Institute), show that glucocorticoids can delay or even short-circuit it and disrupt its function as a tumor suppressor. Cellular mechanisms ; Molecular mechanisms ; Cancer Fontenay-aux-Roses Scientific result MEK/ERK;oncogenesis;Senescence; Mon, 09 Sep 2019 10:00:00 GMT A new biomarker to predict tumor progression from whole body PET images. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-prediction-biomarker-tumor-progression-PET-images.aspx The SHFJ/IMIV laboratory (Inserm 1023/CNRS/CEA/UP-Sud), in collaboration with hospital-university teams, has shown that, in patients with advanced-stage large cell lymphoma (B type), automatic quantitative measurements of tumor dissemination detected by whole-body PET imaging have a predictive value of progression-free survival (tumor stabilization) and overall survival. Medical imaging ; Positron Emission Tomography ; Cancer Scientific result Tue, 16 Jul 2019 10:00:00 GMT How a “self” protein can be immunogenic? The example of relaxin, a human hormone https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Relaxin-immunogenic.aspx A collaboration between teams from SIMOPRO and Sanofi sheds new light on the origin of the immune responses developed by patients with scleroderma when treated by injection of relaxin, a therapeutic protein. The study was published in The Journal of Immunology. Autoimmune diseases ; Cellular mechanisms Saclay Tue, 18 Jun 2019 10:00:00 GMT « Click and Release » chemistry for the targeted delivery of drugs in vivo https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Click-Release-chemistry-targeted-delivery-drug-invivo.aspx A team from the SCBM, in collaboration with the SPI, the IC2MP and the University Hospital of Poitiers, has developed a bioorthogonal chemistry strategy that allows, in vivo, the controlled release of active ingredients contained in micelles-targeting cancerous tumors. These results pave the way for new strategies for targeted drug delivery. Chemistry ; Cancer ; Nanomedicine Scientific result Fri, 15 Mar 2019 11:00:00 GMT Towards a better detection of glioblastoma infiltration https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Towards-better-detection-glioblastoma-infiltration.aspx Glioblastoma is a very aggressive cancer of the central nervous system, mainly because of its ability to infiltrate the surrounding areas. A collaboration led by a team of SHFJ and involving NeuroSpin demonstrates the interest of two imaging techniques for the early detection of tumor infiltration. Cancer ; Medical imaging ; Positron Emission Tomography Scientific result PET imaging;glioblastoma; Tue, 26 Feb 2019 11:00:00 GMT Physicists and pharmacologists join forces to better understand the biology of the blood-brain barrier. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/Physicist-pharmacologists-to-better-understand-BBB.aspx Thanks to complementary imaging techniques, researchers from the SHFJ and NeuroSpin have shown that the physical blood-brain barrier (BBB) disruption is not necessarly enough to deliver some drugs into the brain, especially when there are recognized and supported by efflux transporters. Medical imaging ; MRI ; Positron Emission Tomography ; Cellular mechanisms SHFJ News Thu, 20 Dec 2018 11:00:00 GMT New function discovered for the protein Rad52, a serious therapeutic target in breast cancer https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/New-function-discovered-protein-Rad52-serious-therapeutic-target-breast-cancer.aspx Rad52 has garnered great attention lately as a promising target in the battle against certain types of breast cancer. A team from IRCM, in partnership with researchers from the Frédéric-Joliot and Gustave Roussy Institutes, has shed new light on this protein. Stress response ; Molecular mechanisms Jacob Scientific result Rad51 filament;budding yeast;Srs2; Fri, 12 Oct 2018 10:00:00 GMT Cerebral lymphoma: a new indication for [18F]Fludarabine? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/TEP-18FFludarabine-lymphome-cerebral.aspx A SHFJ research team (LDM-TEP, GIP Cyceron, Caen) has previously developed and produced a radiopharmaceutical, the [18F]-Fludarabine, to detect lymphomas using PET scan. The team has recently conducted a preclinical study that shows the molecule can help in diagnosis of cerebral lymphoma by differentiate it from glioblastoma, the main brain tumor. A clinical study should be launched before the end of the year. Brain ; Medical imaging ; Cancer ; Diagnosis Joliot Scientific result FDG;lymphoma;glioblastoma; Mon, 08 Oct 2018 10:00:00 GMT What is the relationship between variants of the BRCA1 gene and susceptibility to cancer? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/relationship-variants-BRCA1-cancer.aspx Research Teams from the Curie Institute, the Gustave Roussy Institute, as well as the biophysics teams from the Institute of Chemistry of Natural Substances and SB2SM (I2BC@Saclay) met to systematically identify structural defects and BRCA1 proteins encoded by variants of the BRCA1 gene, a gene predisposing to breast and ovarian cancer. Their results make it possible to propose a classification of these variants (neutral versus causal). Cancer ; Structural biology ; DNA Scientific result Fri, 28 Sep 2018 10:00:00 GMT Functionalized micellar nanovectors for targeted tumor therapy https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/functionalized-micellar-nanovectors.aspx ​As part of a collaboration with MIRCen (Institute of Biology François Jacob) and SBIGeM, SCBM researchers have developed functional micellar nanovectors capable of targeting a population of cancer cells. Chemistry ; Cancer Scientific result Thu, 12 Apr 2018 10:00:00 GMT [18F] Fludarabine, a hope for lymphoma imaging https://www.cea.fr/drf/joliot/en/Pages/news/News/Science_news/2017/fludarabine_hope.aspx A Research Team of the SHFJ (LDM-TEP) has just developed an innovative radiopharmaceutical for lymphoproliferative diseases, [18F] Fludarabine. Cancer ; Medical imaging Scientific result Mon, 29 May 2017 10:00:00 GMT Pierre Fabre and H-Immune: a strategic research partnership for the development of immunotherapies in the field of cancer. https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2017/Pierre_fabre_h_immune.aspx ​After its creation by Michel Léonetti, a researcher at SPI / LERI, and Luc Boblet, external holder at the CEA, backed by the IDEX Paris-Saclay funding among other things, the H-Immune start-up recently signed a partnership agreement with the Pierre Fabre Innovation Fund to develop cancer immunotherapy treatments. Cancer ; Institutional News Wed, 03 May 2017 10:00:00 GMT MeioC, discreet but essential orchestra conductor of meiosis. https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2016/MeioC_orchestra_conductor_meiosis.aspx This study, in which a team of SPI/LI2D, specialized in proteogenomics, has contributed reveals the crucial role of the Meioc protein as a meiosis regulator. This protein stabilizes the mRNAs essential to the chronological procedure of the very complex phenomenon of sexual reproduction.​​ Cell division News Wed, 12 Apr 2017 13:23:25 GMT Monitoring hadrontherapy to improve patient safety https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/Monitoring_hadrontherapy_to_improve_patient_safety.aspx Evaluating the biological impact of hadrontherapy in healthy tissue upstream of a tumor is essential to assess the risk of radiation-induced sequelae. In the treatment of bone tumors, healthy articular cartilages are present in the path of the carbon ion beams. The development of 3D models has enabled IRCM's LARIA Research Team, in collaboration with IRAMIS and IBITECS (SBIGeM), to have relevant evaluation systems for these tissues. Cancer ; Health & life sciences Scientific result Mon, 13 Mar 2017 11:00:00 GMT Micellar nanovectors for tumor imaging. https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/Micellar_nanovectors_tumor_imaging.aspx In the context of a collaboration with the I²BM institute, researchers from SCBM have designed micellar vectors for targeting and visual delineation of tumors. Nanomedicine ; Cancer News Tue, 15 Dec 2015 11:00:00 GMT Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit. https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/Hug1_and_RNR.aspx ​A study, coordinated by a SBIGeM team in collaboration with a SB2SM team, allowed to describe the role of the Hug1 protein in regulating the activity of the ribonucleotide reductase complex (RNR). The level of active RNR is controlled during cell cycle and in response to DNA damages. DNA ; Stress response ; Cell division News Mon, 04 May 2015 10:00:00 GMT The catalytic mechanism of cyclodipeptide synthases finally elucidated! https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/cyclodipeptide_synthases_elucidated-.aspx Teams of IBITECS and Ecole Polytechnique (Palaiseau) have deciphered the mechanism used by the cyclodipeptide synthases (CDPS) to catalyze the formation of peptide bonds. Structural biology ; Cellular mechanisms News Fri, 01 May 2015 10:00:00 GMT Lynch Syndrome: structural biology in the service of diagnostic support https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2013/Lynch-Syndrome-structural-biology-in-the-service-of-diagnostic-support.aspx Researchers at the CEA, CNRS and Université Paris-Sud have presented the first model of the architecture of the MLH1 protein associated with Lynch syndrome, a genetic predisposition to colorectal cancer. This atomic level “image” of MLH1 will lead to better understanding of the genetic processes that cause the disease. Structural biology ; Cancer IBITECS Scientific result Mon, 25 Feb 2013 11:00:00 GMT