Frédéric Joliot Institute for Life Sciences - On the same theme https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2022/Deuterated-tritiated-molecules-more-dversity.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.frhttps://www-cea-fr.admsite.extra.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot.png Frédéric Joliot Institute for Life Sciences - On the same theme https://joliot.cea.fr/drf/joliot/en Towards a neurodevelopmental model for the prediction of psychotic transition https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Neurodevelopmental-model-prediction-psychotic-transition.aspx A NeuroSpin team has built a predictive model for the onset of psychosis using a combination of supervised learning analyses and a model of neuroanatomical age, based on neuroimaging data from healthy subjects and those at risk of psychotic transition. MRI ; Diseases ; Artificial intelligence ; Brain Neurospin Scientific result Thu, 21 Mar 2024 11:00:00 GMT Nanometric micelles for targeted delivery of a prodrug against atherosclerosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Nanomicelles-targeted-delivery-prodrug-atherosclerosis.aspx Teams from SCBM and SIMoS (DMTS) have developed nano-micelles for the vectorization of an active principle which regulates cholesterol metabolism towards atherosclerotic lesions. Nanomedicine ; Diseases SIMOPRO Scientific result ; Article preclinic;animal models; Thu, 14 Mar 2024 11:00:00 GMT Improved diagnosis of acute hepatic porphyrias using mass spectrometry https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Diagnosis-acute-hepatic-porphyrias-mass-spectrometry.aspx A collaborative study between SPI and a team from Hôpital Louis Mourier demonstrates the contribution of liquid chromatography coupled with mass spectrometry to the day-to-day analytical needs of a clinical laboratory. Application to the rapid quantification of biomarkers in acute hepatic porphyrias. Diagnosis ; Mass spectrometry ; Biomarkers SPI Scientific result ; Article Fri, 23 Feb 2024 11:00:00 GMT Innovative methodological developments for the emergence of ultra-high field MRI in clinical research https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Methodological-developments-emergence-ultra-high-field-MRI.aspx Researchers at NeuroSpin have recently published 3 articles in Magnetic Resonance in Medicine on their technological and methodological developments that will help meet the challenges of ultra-high field MRI for tomorrow's medical brain imaging. MRI ; Technologies Neurospin Scientific result Mon, 19 Feb 2024 11:00:00 GMT First complete atlas of chimpanzee brain connectivity https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/First-complete-atlas-chimpanzee-brain-connectivity.aspx NeuroSpin researchers map chimpanzee brain structural connectivity for the first time using diffusion MRI data. New image processing enabled them to create two atlases of deep and superficial white matter connectivity. A step towards a better understanding of the evolution of the hominid brain. Brain ; MRI ; Computing Neurospin Scientific result préclinique; Mon, 12 Feb 2024 11:00:00 GMT Functionalization of the B subunit of Shiga toxin as a vaccine tool https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Functionalization-B-subunit-Shigatoxin-vaccine-tool.aspx Researchers at SIMoS (DMTS) describe the synthesis, engineering and evaluation of the properties of the B subunit of bacterial Shiga toxin (STxB), administered mucosally, as a vaccine tool. Their results confirm the value of using a synthetic STxB in an anti-tumor and anti-infectious vaccination strategy. Biotechnology ; Vaccine SIMOPRO Scientific result préclinique; Fri, 26 Jan 2024 11:00:00 GMT Validation of a new elasticity biomarker for biological tissue diagnosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/elasticity-biomarker-biological-tissue-diagnostics.aspx SHFJ researchers have validated the use of a new biomarker, the nonlinear shear modulus, to measure the elasticity of biological tissues, by comparing results obtained using echography with those obtained using MRI imaging and digital simulation. This biomarker is of particular interest for the diagnosis of certain breast cancers. Medical imaging ; MRI ; Diagnosis SHFJ Scientific result Wed, 24 Jan 2024 11:00:00 GMT Combiner des stratégies in silico et in vitro pour de meilleurs anticorps thérapeutiques : exemple avec des dérivés de l’adalimumab, un anti-TNF. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/meilleurs-anticorps-therapeutiques-exemple-derives-adalimumab.aspx ​Des chercheurs du SIMoS montrent que la combinaison de deux approches in silico et in vitro permet de sélectionner des anticorps thérapeutiques dont la fonctionnalité est préservée tout en diminuant le risque qu’ils induisent une réponse immunitaire indésirable. Diagnosis and innovative treatment Researchers SIMOPRO Scientific result ; Article Thu, 18 Jan 2024 11:00:00 GMT Photocatalytic carbon dioxide reduction for radiolabeled drug synthesis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Photocatalytic-CO2-reduction-for-radiolabeled-drug-synthesis.aspx Researchers from SCBM (DMTS) and SB2SM (I2BC) describe a novel and optimized approach to the total photoreduction of 13C-labelled CO2 to carbon monoxide (CO), and the immediate reuse of the latter for the synthesis of high value-added compounds. A step towards a radiochemistry of carbon isotopes potentially useful in human health. Bio-inspired catalysis ; Chemistry ; Green Chemistry ; Carbon cycle SHFJ Scientific result Wed, 22 Nov 2023 11:00:00 GMT Cardiac transplantation: better graft eligibility criteria thanks to metabolomics? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Cardiac-Transplantation--metabolomics.aspx In a study conducted by a team from the Marie Lannelongue Hospital, SPI researchers have established a difference between the metabolomic profiles of heart grafts harvested from pigs in a state of encephalic death or dead after controlled circulatory arrest. This work contributes to the exploration and validation of the use of hearts taken from people who have died after controlled circulatory arrest as a new source of grafts. Large-scale biology ; Diagnosis and innovative treatment Researchers SPI Scientific result ; Article preclinical studies; Wed, 15 Nov 2023 11:00:00 GMT Click-Chemistry: optimized drug delivery from nanomicelles into tumor cells https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Click-Chemistry-optimized-drug-delivery-nanomicelles.aspx Researchers at SCBM have used a click-and-release chemistry approach to mass-release an anti-cancer drug into cells from cleavable nanomicelles, thanks to a bioorthogonal activation process. A step towards the development of new nanomedicines Chemistry ; Biotechnology SCBM Scientific result Fri, 10 Nov 2023 11:00:00 GMT Chimie : passer par le radical anion du CO2 pour le radiomarquage de médicament est possible https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Radical-anion-CO2-radiomarquage.aspx Des chercheurs de l'institut montrent qu’une stratégie fondée sur la formation du radical anion CO2●- marqué au carbone 14 ou carbone 11 s’avère payante pour radiomarquer en conditions douces des médicaments. Chemistry ; Diagnosis and innovative treatment Researchers SHFJ Scientific result ; Article préclinique; Tue, 24 Oct 2023 10:00:00 GMT Impact of metabolic variations on PET imaging of neuroinflammation in humans https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Impact-metabolism-PET-imaging-neuroinflammation.aspx Researchers at BioMaps evaluated the effect of several factors on the distribution of [18F]DPA-714 in 201 subjects who participated in SHFJ PET imaging protocols to better understand the role of neuroinflammation in various neurological diseases. They conclude that measures of individual metabolism are important in image interpretation. Positron Emission Tomography ; Medical imaging ; Pharmacology SHFJ Scientific result Thu, 12 Oct 2023 10:00:00 GMT IRM : effets transitoires des ultra hauts champs sur le système vestibulaire https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/IRM-effets-transitoires-UHF-systeme-vestibulaire.aspx Des chercheurs de NeuroSpin, en collaboration avec NeuroPSI montrent que l’effet des ultra hauts champs magnétiques sur l’appareil vestibulaire de souris est transitoire. MRI Researchers Neurospin Scientific result ; Article cochlée; Fri, 06 Oct 2023 10:00:00 GMT Understanding the relationship between cerebellar structure and social abilities in young subjects with autism-related symptoms https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Relationship-cerebellar-structure-social-abilities-young-autistic.aspx A collaborative study by NeuroSpin researchers, using anatomical MRI data and a dimensional approach in 850 subjects from the Healthy Brain Network cohort, shows how the social skills of these children and adolescents are linked to the structure of their cerebellum Brain ; Cognition ; MRI Neurospin Scientific result Tue, 12 Sep 2023 10:00:00 GMT Rentrée « en mode kick-off » pour l’équipe MIND https://www.cea.fr/drf/joliot/en/Pages/news/Events/2023/Kick-off-meeting-MIND.aspx ​​​Le 07 septembre, l'équipe MIND organisait son kick-off meeting, symbolisant la volonté commune de sestutell es, CEA et Inria, de consolider et de créer des synergies en intelligence artificielle et machine learning pour les neurosciences. MRI ; Artificial intelligence ; Brain Researchers ; Institutions Neurospin Inauguration ; Colloquium deep learning;Deep Neural Network;réseaux de neurones; Mon, 11 Sep 2023 10:00:00 GMT kick-off meeting for the MIND team https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2023/Kick-off-meeting-MIND.aspx On 07 September, the young MIND team organised its kick-off meeting, symbolising the shared desire of its two supervisory administrations, the CEA and Inria, to consolidate and create synergies in artificial intelligence and machine learning for neuroscience. MRI ; Artificial intelligence ; Brain Researchers ; Institutions Neurospin Inauguration ; Colloquium deep learning;Deep Neural Network; Mon, 11 Sep 2023 10:00:00 GMT PET imaging monitoring of an antibody targeting endothelin receptors expressed by glioblastoma tumors https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/PET-imaging-antibody-endothelin-receptors-glioblastoma-tumors.aspx Researchers at BioMaps (SHFJ) and SPI (DMTS) have studied the pharmacokinetics of a novel immuno-radioligand targeting the endothelin A receptor (ETA), overexpressed in many cancers, particularly glioblastoma. The immunoPET imaging approach used in this study in a preclinical model confirms the theranostic potential of this antibody. Positron Emission Tomography ; Cancer ; Medical imaging Neurospin Scientific result Thu, 07 Sep 2023 10:00:00 GMT Un composé radiosensible pour combiner radiothérapie et chimiothérapie ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Composé-radiosensible-combiner-radiotherapie-et-chimiotherapie.aspx Des chercheurs du SCBM et de l’Iramis publient une étude preuve-de-concept d’un composé radiosensible qui pourrait servir à « libérer » in vivo des médicaments anti-tumoraux, et ainsi de combiner les effets d’une radiothérapie et d’une chimiothérapie. Chemistry ; Radiotherapy Researchers SCBM Scientific result ; Article Tue, 05 Sep 2023 10:00:00 GMT L’IA pour l’IRM à haut champ : les multiples pistes développées par l’équipe MIND pour ne plus choisir entre temps et qualité de l’image https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/IA-IRM-haut-champ-multiples-pistes-equipe-MIND.aspx Brain ; MRI ; Artificial intelligence Researchers Neurospin Scientific result ; Patent Wed, 30 Aug 2023 10:00:00 GMT After ISOTOPICS, ISOBIOTICS, the renewal of isotope labeling to strengthen european therapeutic innovation https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2023/ISOBIOTICS-renewal-isotope-labeling-biodrugs.aspx The SCBM was awarded funding from the Horizon Europe program for the ISOBIOTICS project, coordinated by Christophe Dugave. This project will enable the theoretical and practical training of 11 PhD students, including two at SCBM and one at SHFJ, on the development of innovative methods for the isotopic labeling of biodrugs Chemistry SCBM News ; Article ; Europe ; European & international partnerships Wed, 09 Aug 2023 10:00:00 GMT Longitudinal monitoring of tauopathy in PET imaging to better understand the various modalities of clinical evolution of Alzheimer's disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Longitudinal-monitoring-tauopathy-PET-imaging.aspx A joint team from GHU Paris and BioMaps (SHFJ) conducted a 2-year longitudinal study of 27 people with Alzheimer's disease, tracking the progression of tau pathology measured by PET imaging, of cortical atrophy using MRI, and their links with cognitive decline. Alzheimer's disease ; Medical imaging ; MRI ; Positron Emission Tomography SHFJ Scientific result ; Article Wed, 02 Aug 2023 10:00:00 GMT The "rabbit motif" in 18F-DOPA PET imaging for a simplified diagnostic evaluation of parkinsonian syndromes https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/rabbit-motif-PET-imaging-diagnostic-evaluation-parkinsonian-syndromes.aspx BioMaps researchers compared the diagnostic performance of the rabbit visual pattern observed in 18F-DOPA PET imaging with the standard procedure approved by the international nuclear imaging societies for the diagnosis of parkinsonian syndromes in PET/MRI and obtained encouraging results, which may validate the clinical utility of such a model Positron Emission Tomography ; Medical imaging ; Parkinson's disease ; Brain SHFJ Scientific result Tue, 23 May 2023 10:00:00 GMT Mise en exploitation de l’IRM 11.7 T Iseult : revue de détails https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Mise-en-exploitation-IRM-11-7-T-Iseult.aspx La mise en exploitation de l’IRM 11.7 T Iseult en 2021 a couronné près de 20 ans de recherche et développement du CEA. Dans un article publié dans le journal Magnetic Resonance Materials in Physics, Biology and Medecine, Nicolas Boulant et Lionel Quettier, chefs du projet Iseult pour les instituts Joliot et Irfu du CEA, passent en revue les détails de cette mise en service. MRI ; Brain Article Fri, 28 Apr 2023 10:00:00 GMT Radiomarquage du crizotinib au fluor-18 : un nouvel outil pour suivre par TEP la biodistribution de ce médicament https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Radiomarquage-crizotinib-fluor-18-nouvel-outil-TEP.aspx Des chercheurs du SHFJ ont mis au point la radiosynthèse au fluor-18 du crizotinib, un médicament qui ne pénètre pas dans le cerveau. Ce nouvel outil pour l’imagerie TEP permettra d’explorer de futures stratégies visant à faire passer la barrière hémato-encéphalique à ce médicament pour traiter certaines métastases cérébrales. Positron Emission Tomography ; Cancer ; Diagnosis and innovative treatment Researchers SHFJ Scientific result ; Article Thu, 27 Apr 2023 10:00:00 GMT Combining neuroanatomical markers to strengthen the diagnosis of fetal alcohol spectrum disorder https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Structuring-neuroanatomical-criteria-fetal-alcohol-spectrum-disorder.aspx By analyzing brain imaging data, researchers from InDEV (NeuroSpin / UMR NeuroDiderot) have identified recurrent abnormalities in subjects with fetal alcohol syndrome, the combination of which could have a particularly interesting diagnostic value for non-syndromic forms of fetal alcohol spectrum disorders. MRI ; Diagnosis and innovative treatment Researchers Scientific result Mon, 13 Mar 2023 11:00:00 GMT Genetic variations in evolutionarily acquired DNA regulatory regions affect the morphology of certain sulci in the human cerebral cortex https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Genetic-variations-regulatory-regions-morphology-brain-sulci.aspx Using UK Biobank imaging-genetics data, a collaborative study led by NeuroSpin found that variation in genomic regions, known as enhancers, could affect the morphology of cortical sulci and be associated with the evolution of locomotion in primates and bipedalism in our hominin ancestors. MRI ; Genomics ; Brain Neurospin Scientific result Mon, 27 Feb 2023 11:00:00 GMT Platinum nanoparticles to improve radiotherapy ? PET imaging provides answers https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Nanoparticles-to-improve-radiotherapy.aspx Researchers from the SHFJ laboratory at ISMO have demonstrated the value of platinum nanoparticles as potential radiosensitizing agents for radiation therapy. Diagnosis and innovative treatment ; Positron Emission Tomography Researchers SHFJ Scientific result Radiotherapy;biodistribution;platinum nanoparticles; Tue, 21 Feb 2023 11:00:00 GMT Development of a new radiolabeling strategy in immunoPET for precision imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/New-radiolabeling-strategy-immunoTEP.aspx Researchers from the BioMaps laboratory (SHFJ) and the Molecular Engineering for Health Service (SIMoS, DMTS) developed an enzymatic approach for radiofluorination of an anti-PD-L1 Fab and compared its in vivo properties to the same Fab stochastically labeled by two conventional methods. Diagnosis and innovative treatment ; Positron Emission Tomography Researchers SHFJ Scientific result PD-L1;radiomarquage;lipoate-protéine ligase;radiofluoration; Tue, 21 Feb 2023 11:00:00 GMT Glioblastoma: Does focused ultrasound increase the therapeutic efficacy of cetuximab? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Glioblastoma-FUS-cetuximab.aspx Researchers from the SHFJ, in collaboration with NeuroSpin, show that the use of focused ultrasound does not increase the therapeutic effects of cetuximab on glioblastoma although the opening of the blood-brain barrier is transiently effective. Positron Emission Tomography ; Diagnosis and innovative treatment Researchers Neurospin Scientific result Wed, 15 Feb 2023 11:00:00 GMT From a marine toxin to a melanocortin receptor antagonist, a therapeutic target for energy metabolism disorders https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Cone-marine-toxin-melanocortin-receptor-antagonist.aspx A SIMoS team discovered a toxin in the venom of a marine cone that it engineers into a high affinity antagonistic peptide for the melanocortin receptor, a major regulator of energy homeostasis. A step towards the development of innovative treatments for certain eating disorders Pharmacology ; High-throughput screening ; Proteomics ; Transcriptomics SIMOPRO Scientific result Thu, 09 Feb 2023 11:00:00 GMT Anatomical atypia in autistic people ? Fine morphological analyses contradict the results of the last decade https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Anatomical-atypia-cerebellum-autistic-people.aspx By studying the morphology of the cerebellar gray matter, an international consortium coordinated by NeuroSpin researchers concludes that there are no anatomical atypia in the cerebellum of people with autism. Diseases ; Brain ; Medical imaging Researchers Saclay Scientific result IRM 3T;TDAH; Mon, 06 Feb 2023 11:00:00 GMT Click chemistry: new "electrophilic" iminosydnones https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/click-electrophilic-iminosydnones.aspx Researchers at the Joliot Institute have developed two new families of iminosydnones that allow the bio-orthogonal release of electrophilic species. These molecules constitute "building blocks" of click-and-release chemistry, useful for reactions with nucleophilic compounds contained in cells. Chemistry Researchers SCBM Scientific result Thu, 02 Feb 2023 11:00:00 GMT Detection of monkeypox: Mass spectrometry proves once again its effectiveness https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Detection-monkeypox-massspectrometry.aspx A Li2D team has released the peptidomic profile of the virus that causes monkeypox, which they established using tandem mass spectrometry. These data should help to better understand the evolution of the epidemic and allow the creation of targeted tests to potentially detect the threat more quickly and prevent a new epidemic. Diagnosis ; Infectious diseases Researchers SPI Scientific result Mon, 28 Nov 2022 11:00:00 GMT MRI: signal-to-noise ratio at high field strengh, when experiment validates theory https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/SNR-high-field-MRI.aspx ​A collaboration led by a METRIC team (BAOBAB/NeuroSpin) has undertaken to measure the signal-to-noise ratio (SNR) in MRI at the centre of a spherical phantom at different magnetic field strengths (B0). Their data confirm the theories that SNR increases with approximately the square of B0. MRI Researchers Neurospin Scientific result ; Article Thu, 17 Nov 2022 11:00:00 GMT Studying low-concentration metabolites in the brain with CEST-linescan https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/CEST-linescan-Etudier-des-metabolites-peu-concentres-dans-cerveau.aspx NeuroSpin researchers, in collaboration with Iramis and the Università Statale di Milano, have developed a CEST magnetic resonance spectroscopy sequence that allows them to detect and confirm the presence of three dipeptides in the brain and skeletal muscle of adult rats and thus to consider future studies of their physiological role. MRI ; Cell and molecular imaging Researchers Neurospin Scientific result Tue, 15 Nov 2022 11:00:00 GMT Specificity of reading and face recognition cerebral circuits during reading acquisition https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Specificity-of-reading-and-face-recognition-cerebral-circuits.aspx By measuring fMRI responses to written words, faces, houses and checkerboards in three groups of children, pre-readers and beginning readers aged 6 and advanced readers aged 9, a team from UNICOG (NeuroSpin) shows that reading acquisition recycles and specializes a pre-existing but plastic visual circuit connected to language areas. Brain ; MRI ; Learning Neurospin Scientific result Mon, 12 Sep 2022 10:00:00 GMT Dual labeling and digital imaging for the evaluation of protein-drug conjugates in preclinical models https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/In-vivo-evaluation-antibody-drug-conjugate.aspx A team from SIMoS, in collaboration with the SCBM (DMTS), has developed an original bioanalytical approach based on the double 14C-3H isotopic labeling of an antibody-drug conjugate, allowing the simultaneous in vivo monitoring of the two components in mouse models as well as their precise quantification in the organs. Pharmacology ; Cell and molecular imaging SIMOPRO Scientific result Mon, 22 Aug 2022 10:00:00 GMT Fight against antibiotic resistance: two additional rapid lateral flow immuno-assays https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/antibioresistance-2-nouveaux-tests.aspx Researchers at the LERI together with the AP-HP have developed 2 rapid and inexpensive immunological tests to detect antibiotic resistance. The novelty: the tests detect the activity of bacterial enzymes that hydrolyze extended-spectrum cephalosporins. Antibiotics ; Diagnosis Researchers SPI Scientific result penicillin;carbapenemase;CTX-M; Tue, 02 Aug 2022 10:00:00 GMT Predicting all cognitive activities from images of the functionning brain, it's possible https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Predicting-cognitives-activities-fMRI-maps.aspx A NeuroSpin team succeeded in decoding a large set of human mental processes by training neural networks to predict cognitive labels from a cognitive atlas and by leveraging the data set of NeuroVault, a web-based database for collecting and sharing statistical maps of the human brain. Brain ; Cognition ; MRI ; Artificial intelligence Neurospin Scientific result Thu, 30 Jun 2022 10:00:00 GMT A novel fluorine-18 thiol carrier for labeling biomolecules used in PET imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/fluorine-18-thiol-labeking-biomolecules-TEP.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated the synthesis of an 18F-fluoropyridine containing a thiol function (-SH), allowing its conjugation to model biomolecules within 45 minutes. A step towards rapid radiolabeling of complex biological molecules for PET imaging. Radioactivity ; Chemistry ; Positron Emission Tomography SHFJ Scientific result Tue, 28 Jun 2022 10:00:00 GMT New perspectives for CO2 photoreduction by iron porphyrins https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Photoreduction-of-CO2-by-iron-porphyrins.aspx ​Researchers from ICMMO* and ISMO**, in collaboration with a team from I2BC, show that the urea-decorated iron porphyrin catalysts they developed previously for the electro-catalysis of CO2, can be successfully employed in a photo-catalytic approach. Chemistry ; Bio-inspired catalysis ; Photosynthesis SB2SM Scientific result Thu, 16 Jun 2022 10:00:00 GMT New generation of dielectric pads for ultra high field MRI imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Pads-dielectriques-IRM-tres-haut-champ.aspx To address the problem of ultre high field MRI signal loss in certain regions of the human body, a collaboration involving the CEA-Joliot, the CEA-Iramis, the Fresnel Institute and Multiwave Imaging has led to the development of a new generation of simple and inexpensive silicon carbide-based pads. The new composition makes the pads invisible to MRI and prolongs their performance when compared to existing solutions. MRI Researchers ; Partners Iramis Scientific result ; Article specific absorption rate;radiofrequency passive shimming;shims; Tue, 07 Jun 2022 10:00:00 GMT First atlas of anatomical brain connectivities in quail! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/First-atlas-anatomical-brain-connectivities-quail.aspx The expertise of NeuroSpin in diffusion MRI has allowed to establish the first atlas of the anatomical connectivities of the Japanese quail brain at a resolution of 150 m in three dimensions. MRI ; Brain Researchers Neurospin Scientific result ; Article Tue, 31 May 2022 10:00:00 GMT What if the shape of the early brain sulci could predict certain pathologies? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Shape-early-brain-sulcus-predict-pathologies.aspx Neurospin researchers conducted a longitudinal brain imaging study in very premature infants to analyze the variability of the shape of the central sulcus early in its development and its functional implications. Brain ; MRI Researchers Neurospin Scientific result brain fold;gyrification;prematurity;hemispheric asymmetry; Fri, 20 May 2022 10:00:00 GMT Object detection facilitates segmentation of rare brain tumors in MR imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Segmentation-rare-brain-tumors.aspx A study led by NeuroSpin researchers proposes an optimized delineation of rare brain tumors, based on a combined approach of object detection and deep learning segmentation in tumor images, a key step in the characterization of cancers. Brain ; Medical imaging ; MRI Neurospin Scientific result ; Article Thu, 05 May 2022 10:00:00 GMT MRI: the SPARKLING algorithm, even more sparkling! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/MRI-3D-sparkling.aspx NeuroSpin researchers propose a new version of their compressed MRI acquisition algorithm, SPARKLING, extended to 3D imaging. Their method reduces acquisition time by a factor of 20 for T2*-weighted scans without compromising image quality. Simulation & modelling ; MRI Researchers Neurospin Scientific result ; Europe Thu, 28 Apr 2022 10:00:00 GMT New radioligands for anti-PD-1/PD-L1 immunoPET https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Radioligands-immunoPET-PD-1-PD-L1.aspx Researchers from the SHFJ and the DMTS have developed optimized radioligands for immunoPET imaging. The objective is to better predict the effectiveness of anti-PD1/anti-PDL1 immunotherapy used to fight certain cancers. Positron Emission Tomography ; Cancer Researchers SIMOPRO Scientific result programmed cell death-ligand 1; Tue, 12 Apr 2022 10:00:00 GMT Facilitating access to deuterated and tritiated molecules: towards more diversity! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Deuterated-tritiated-molecules-more-dversity.aspx Researchers from the SCBM describe a hydrogen isotope labeling process that is easy to implement and whose starting point is a "simple" mixture, in a solvent, of the product to be labeled with a pre-catalyst. Explanations of this process which finds applications in many fields including drug development or medical imaging. Chemistry ; Diagnosis and innovative treatment ; Medical imaging Researchers SCBM Scientific result marquage isotopique;biomolécule;activation C-H;ADME-DMPK; Wed, 06 Apr 2022 10:00:00 GMT Hybrid PET/MRI imaging, a unique examination to improve the detection of epileptogenic lesions https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/PET-MRI-imaging-epilepsy-detection.aspx A team from BioMaps (SHFJ), in collaboration with several hospital groups, shows that hybrid PET/MRI imaging significantly improves the detection of epileptogenic foci and, consequently, the outcome of surgical treatment of epilepsy. Medical imaging ; Positron Emission Tomography ; MRI SHFJ Scientific result Tue, 05 Apr 2022 10:00:00 GMT Alzheimer's: PET imaging of tau protein predicts cognitive decline and progression of brain atrophy https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Alzheimer-Tau-PET-imaging.aspx A joint team from GHU Paris and SHFJ shows the predictive value of PET imaging data of the Tau protein in the progression of Alzheimer's disease. Alzheimer's disease ; Positron Emission Tomography Researchers SHFJ Scientific result ; Press release radiotracer; Sun, 03 Apr 2022 10:00:00 GMT Deep brain stimulation of the thalamus restores signatures of consciousness https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/thalamus-DBS-signatures-conscience.aspx Using fMRI and EEG, NeuroSpin and ICM researchers show that deep brain stimulation of the central part of the thalamus restores the richness of brain activity specific to consciousness, which is "switched off" in an anesthetized non-human primate. This work paves the way for clinical studies in patients with consciousness disorders. Cognition ; MRI Researchers Neurospin Scientific result Sat, 26 Mar 2022 11:00:00 GMT Buprenorphine/benzodiazepine interaction: why is it more dangerous? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Interaction-buprenorphine-benzodiazepine.aspx ​A collaboration between the SHFJ and the UMR-S 1144 (University of Paris) shows that the deleterious effect of the buprenorphine/benzodiazepine combination would result from the combined action of each drug on its target. Diagnosis and innovative treatment ; Pharmacology Researchers SHFJ Scientific result ; Article pharmacodynamics;opioids; Fri, 25 Mar 2022 11:00:00 GMT Brain aging: European funding to evaluate an early biomarker https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2022/QSM4SENIOR.aspx The QSM4SENIOR project, led by NeuroSpin and the company VENTIO, aims at developing an original early biomarker of aging by using data from the SENIOR study of NeuroSpin. QSM4SENIOR has just been funded by the EOSC-Life. Brain ; MRI Researchers ; Institutions Neurospin Europe ; Industrial partnerships Wed, 02 Mar 2022 11:00:00 GMT The genetic architecture of language functional connectivity revealed https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Genetic-architecture-language-functional-connectivity.aspx Using data from the UK Biobank, the world's largest general population imaging-genetics cohort, a collaboration led by a team at BAOBAB (NeuroSpin) has identified genes involved in the genetic architecture of language functional connectivity. These genes could be a priority for studying natural language. Brain ; MRI ; Cognition ; Genomics Neurospin Scientific result Mon, 14 Feb 2022 11:00:00 GMT Signal optimization in very high field functional MRI: a matter of compromise? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/tSNR-optimization-functional-MRI.aspx A NeuroSpin team (BAOBAB) has tested a signal denoising method dedicated to very high field (7T) functional MRI. It is based on the weighted combination of images from each reception channel of the radio frequency coil, a combination that optimizes the stability of the signal over time. MRI ; Physics Neurospin Scientific result ; Article Thu, 27 Jan 2022 11:00:00 GMT Deeptope: accelerating the development of therapeutic antibodies via high-throughput functional tests https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/Deeptope-start-up-Simos.aspx Deeptope, founded in February 2021 from a technology developed at the DMTS Laboratory of Cellular Immunology and Biotechnology (LICB), is a company of therapeutic antibody engineering that provides antibody optimization and characterization services to biotech or pharmaceutical firms with the goal of increasing the quality of antibodies in a very short timeframe. Biotechnology ; Pharmacology News ; Article Mon, 29 Nov 2021 11:00:00 GMT Multiparametric PET-MRI imaging: toward a biological characterization of tumors at the supervoxel level https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PET-MRI-imaging-tumors-supervoxel-level.aspx A collaborative study led by BioMaps researchers (SHFJ) demonstrates that fully integrated quantitative multiparametric analysis of non-small cell lung cancer in hybrid 18F-FDG PET/MRI 3T imaging is clinically feasible and could enable biological characterization of tumors at the supervoxel scale. Medical imaging ; Positron Emission Tomography ; MRI ; Cancer Scientific result Wed, 10 Nov 2021 11:00:00 GMT PET imaging of tau and amyloid deposits improves the diagnosis of progressive amnesia https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Amyloid-tau-imaging-diagnosis-progressive-amnesia.aspx Researchers from BioMaps (SHFJ) and the Service de Neurologie de la Mémoire et du Langage (Hôpital Ste-Anne) show, through amyloid and tau molecular imaging in patients followed for 2 years, that the diagnosis of progressive amnesia in the elderly is not necessarily Alzheimer's disease and may be caused by other mechanisms clearly distinguishable from it. Positron Emission Tomography ; Medical imaging ; Alzheimer's disease Scientific result Thu, 04 Nov 2021 11:00:00 GMT Disentangle the neuronal and vascular components of the BOLD signal for an improved visualization of brain activity https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Disentangle-neuro-vasc-BOLD.aspx Researchers at NeuroSpin have developed a deconvolution method to estimate from BOLD fMRI data the coupling between neuronal activity and blood flow, the characteristic signals of neuronal activity and the associated brain areas. The work was published in NeuroImage. MRI ; Simulation & modelling Researchers SHFJ Scientific result BOLD signal;multivariate modeling;sparsity;dictionary learning; Tue, 14 Sep 2021 10:00:00 GMT Diffusion MRI characterizes radiation-induced neurological impairments https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress. Brain ; Impacts on living (organisms) ; MRI ; Biomarkers ; Radiobiology Researchers ; Journalists ; general public DRF Scientific result ; Highlight ionizing radiations;Brain;neurodevelopmental disorder;neurogenesis;MRI;structural MRI;diffusion MRI; Thu, 24 Jun 2021 10:00:00 GMT Characteristics of the initial symptoms of Alzheimer's disease in young patients https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Initial-symptoms-Alzheimer-disease-in-young.aspx Researchers from BioMaps (SHFJ) and the Department of Memory and Language Neurology (Ste Anne's Hospital) studied the early clinical signs of Alzheimer's disease (AD) reported by young patients (< 62 years old) compared to those reported in classic AD of the elderly (> 65 years old). They show that these signs are misleading and often appear in the professional context. Alzheimer's disease ; Diagnosis ; Brain Scientific result Thu, 10 Jun 2021 10:00:00 GMT Evaluation of the immunogenicity of peptide-drugs containing non-natural modifications https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Immunogenicity-therapeutic-peptides.aspx A team from SIMoS (DMTS) in collaboration with Sanofi shows that the introduction of non-natural sequences into an immunogenic peptide attenuates the immune response against this peptide, an approach that could guide the design of less immunogenic, and therefore more effective, therapeutic peptides. Health & life sciences ; Pharmacology Scientific result Tue, 01 Jun 2021 10:00:00 GMT Société Chimique de France: two prizes for two researchers from the Institute https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/SCF-2-prizé-2-researchers-SCBM.aspx The members of the Organic Chemistry Division (DCO) of the French Chemical Society met on Monday 10 May to award the DCO 2021 prizes. Sophie Feuillastre and Davide Audisio, both researchers at the SCBM (CEA-Joliot Department of Medicines and Technology for Health) are among the lucky winners. Chemistry Researchers SCBM Article radiolabeling; Thu, 27 May 2021 10:00:00 GMT PET imaging reveals the neuropharmacology of buprenorphine https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PETimaging-neuropharmacology-buprenorphine.aspx Researchers at BioMaps (SHFJ) have succeeded in determining the interaction dynamics of buprenorphine, an opioid drug with a particularly complex pharmacology, with its brain receptors in vivo. To do so, they developed an original PET imaging approach based on the use of the radiolabeled molecule (11C-buprenorphine). Brain ; Positron Emission Tomography ; Pharmacology Scientific result Wed, 05 May 2021 10:00:00 GMT Carbon labeling by isotopic exchange of nitriles https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Nitrile-carbon-isotope-labeling.aspx Researchers at the CEA-Joliot Institute (Carbon-14 labeling Laboratory), in collaboration with teams from AstraZeneca, Sanofi and Nimbe (CEA-Iramis), have developed a labeling method, based on nitrile exchange using nickel catalysis. This method is currently under study at Sanofi for the labeling of a drug candidate. Chemistry Scientific result ; Europe Fri, 30 Apr 2021 10:00:00 GMT WIKIBrainStem: a new ex vivo anatomical atlas of the human brainstem from ultra-high field MRI (11.7 T) https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/WIKIBrainStem.aspx The Ginkgo team (BAOBAB / NeuroSpin), in collaboration with the Inserm iBRAIN U1253 unit (Tours), published in NeuroImage the first anatomical atlas of the human brainstem with at mesoscopic scaleresolution from extreme ultra-high field MRI. Freely available as a wiki, this atlas will be used in particular by neuroanatomists and neurosurgeons. MRI Researchers Neurospin Scientific result ; Europe brainstem;Anatomy; Wed, 28 Apr 2021 10:00:00 GMT Brain sulci imaging and genetics: the UK Biobank cohort has spoken. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Brain-sulci-imaging-and-genetics.aspx Researchers from NeuroSpin and CNRGH (Jacob Institute) have studied, on a genome-wide scale, the potential associations of haplotypes (set of variants located side by side on a chromosome) with the opening value of imaged brain sulci, indicator of brain aging, from the UK Biobank neuroimaging-genetics cohort. MRI ; Genomics ; Brain Scientific result Mon, 19 Apr 2021 10:00:00 GMT How works Mambalgin-1, an analgesic peptide from black mamba venom https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/How-works-Mambalgin-1.aspx Teams from IPMC and SIMoS (DMTS) defined the molecular determinants of the interaction between Mambalgin-1, an analgesic peptide isolated from black mamba venom, and its target, ASIC1 (Acid-Sensing Ion Channels), to model, using molecular dynamics, this complex. The resulting model provides clues to develop blockers of ASIC1, interesting targets for clinical pain relief applications. Pharmacology Scientific result Thu, 08 Apr 2021 10:00:00 GMT Salmonellosis and shigellosis: a monoclonal antibody induces cross-protection https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Salmonellosis-shigellosis-monoclonal-Ab-cross-protection.aspx Researchers at CEA-Joliot (SPI unit in collaboration with SIMoS unit) have developed a monoclonal antibody directed against a common region of two proteins of the bacteria Shigella and Salmonella and capable of inducing cross-protection against infections caused by these bacteria. Bacteria ; Vaccine Researchers SIMOPRO Scientific result Antibody;IpaD-318;host cell;injectiosome; Thu, 25 Mar 2021 11:00:00 GMT Première étape vers un test quantitatif par spectrométrie de masse pour le diagnostic spécifique de la COVID-19 ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Vers-test-quantitatif-MS-diagnostic-specifique-COVID-19.aspx Le LEMM, en collaboration avec le LI2D et l’AP-HP, développe un test de diagnostic spécifique de la Covid-19 par spectrométrie de masse qui permettrait aussi la quantification de la charge virale du patient. Objectif à terme : adapter la méthode pour la rendre plus sensible et compatible avec les équipements d’analyse des hôpitaux. Diagnosis ; Mass spectrometry ; Virus Researchers SPI Scientific result SARS-CoV-2; Tue, 09 Mar 2021 11:00:00 GMT A micellar probe for fluorine magnetic resonance tumor imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Micellar-probe-fluorine-MRI-tumor.aspx A SCBM (DMTS) team, in collaboration with researchers at NeuroSpin and I2BC, is describing micellar nanometric vectors targeting tumors that have been imaged by fluorine magnetic resonance imaging (MRI). The observed 19F signal made it possible to precisely delimit the volume of the tumor zone in a mouse model and to quantify the probe accumulated in the target tissue. Chemistry ; Nanomedicine ; Cancer ; MRI Scientific result Thu, 04 Mar 2021 11:00:00 GMT Carbon labeling with light https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Carbon-labeling_light.aspx Researchers from the LMC (DMTS), in collaboration with a team from AstraZeneca, have developed a labeling method, based on the exchange of carbon dioxide, simply using visible blue light and a photocatalyst. Chemistry ; Biomarkers ; Diagnosis and innovative treatment Researchers SCBM Scientific result ; Europe radiolabeling; Wed, 24 Feb 2021 11:00:00 GMT Towards a transcranial echography https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/Towards-transcranial-echography.aspx Jean-Luc Gennisson (BioMaps/SHFJ) coordinated, in partnership with the CEA-List (Sylvain Chatillon), the EchoBrain project (ATTRACT/H2020) aimed at adapting the digital tools developed by the List (CIVA platform) to significantly increase the quality of brain echography images, simple alternative compared to the methods (MRI, X-ray scanner) currently used for the diagnosis of strokes. Brain ; Medical imaging ; Simulation & modelling News ; Article Tue, 19 Jan 2021 11:00:00 GMT Launch of AROMA, a european project to exploit the full potential of NeuroSpin's future 11.7 T scanner. https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/Launch-of-AROMA.aspx AROMA, a FET-Open H2020 project, aims to develop the methodology necessary for the optimal operation of the future 11.7 T MRI being installed at NeuroSpin. This 5-year project, coordinated by Nicolas Boulant (NeuroSpin), with an overall budget of 3.6 million euros, involving six partners from five countries representing academia and industry, started on January 1, 2021. Methodologies for life sciences ; Brain ; MRI News Wed, 06 Jan 2021 11:00:00 GMT Decompensated cirrhosis: involvement of amino acid metabolism in systemic inflammation https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Decompensated-cirrhosis-aa-metabolism.aspx A European study involving CEA-Joliot provides the first overview of the amino acids circulating in the blood of patients with decompensated cirrhosis and concludes that there is a strong redistribution of their metabolism in order to provide the fuel necessary for the intense inflammatory response. Diagnosis and innovative treatment Researchers SPI Europe spectrométrie de masse;métabolomique;métabolome;cirrhosis;liver failure; Mon, 14 Dec 2020 11:00:00 GMT Facebook challenge in AI: CEA researchers ranked 2nd https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Facebook-challenge-IA-CEA-researchers-2d.aspx In the field of artificial intelligence, international competition is tough. So when researchers from CEA-Joliot and Irfu challenge start-ups and other companies specializing in AI, we cheer them on. Here’s a success story from the field of MRI reconstruction. MRI ; Artificial intelligence Researchers Neurospin Success Fri, 11 Dec 2020 11:00:00 GMT An atypical cerebral organization for language https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Atypical-cerebral-organization-for-language.aspx Researchers from the Neurofunctional Imaging Group (GIN, NeuroSpin, Bordeaux) studied by functional MRI, the organization of the brain network of sentence processing in individuals "atypical" for language, i.e. with a major role of the right hemisphere. Brain ; MRI Scientific result Wed, 09 Dec 2020 11:00:00 GMT Psychotic symptoms are linked with poor diffusion of information in the brain https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Psychotic-symptoms-poor-information-diffusion-in-brain.aspx A collaborative study by NeuroSpin suggests that psychosis and impaired conscious access may be closely related phenomena. MRI Researchers Neurospin psychiatry;diffusion MRI;dMRI; Tue, 08 Dec 2020 11:00:00 GMT Chemical synthesis and characterization of a non-radioactive chiral probe for studying enzymatic reaction mechanisms https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/chiral-probe-study-transferases.aspx Chemists of CEA-Joliot have synthesized the two enantiomers of a molecule containing a deuterated chiral ethyl group and characterized their chiral properties using advanced spectroscopic tools. These two compounds will be useful for probing the reaction mechanism of enzymes, as alkyl transferases. Chemistry Researchers SCBM Scientific result isotopic labeling; Tue, 24 Nov 2020 11:00:00 GMT World Antimicrobial Awareness Week: the Institute continues its actions https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/World_AMR_week_LERI.aspx The recent publication, in the journal Diagnostics, of a collaborative study associating AP-HP, NG-Biotech and a team from the Institute, is an opportunity to recall the Institute's commitment to the development of means of detecting antimicrobial resistance, a global phenomenon in the WHO's sights, as recalled by the World Antimicrobial Awareness Week. Antibiotics Researchers SPI Scientific result ; Article LFIA;bacteria;lateral flow immunoassay;gram negative; Thu, 19 Nov 2020 11:00:00 GMT Towards greater accuracy in the measurement of temperature variations induced by MRI examinations https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/thermometry-MRI.aspx Researchers at NeuroSpin are proposing a new magnetic resonance thermometry method to increase the accuracy in the measurement of small temperature variations induced by MRI. MRI ; Methodologies for life sciences Researchers Neurospin Scientific result MR thermometry;ultra high field; Wed, 18 Nov 2020 11:00:00 GMT Mambaquaretin: therapeutic and diagnostic interest? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mambaquaretin-theranostic.aspx In pursuing their work on mambaquaretin, SIMoS researchers conducted a collaborative study confirming the therapeutic potential of the toxin and paving the way for its use as a diagnostic tool. Diagnosis and innovative treatment ; Molecular mechanisms ; Cellular mechanisms SIMOPRO Scientific result PET Scan;PK/PD; Tue, 10 Nov 2020 11:00:00 GMT A double ceramic probe to optimize magnetic resonance microscopy. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Double-ceramic-probe-magnetic-resonance-microscopy.aspx Researchers from the M-CUBE european consortium, together with a team from NeuroSpin, are demonstrating the possibility of imaging two samples by 17.2 T magnetic resonance microscopy (NeuroSpin imager), at a single acquisition time, using two coupled ceramic resonators (probes) that lead to a better signal-to-noise ratio compared to reference MRI probes. MRI ; Physics Scientific result ; Article Mon, 26 Oct 2020 11:00:00 GMT Seeing tomorrow's OLED display technology emerge https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Seeing-tomorrow-OLED-display-technology-emerge.aspx A team from SCBM, in collaboration with IRAMIS, LETI, ENS Paris-Saclay, the Universities of Rennes and San José (USA), has developed new electroluminescent molecules with properties that improve the energy consumption and light production of organic light-emitting diodes (OLEDs). This is the first study correlating the structure and properties of this type of materials, with a promising future in display technologies. Chemistry ; Technologies Scientific result Thu, 22 Oct 2020 10:00:00 GMT Analysis of multitask functional MRI data for the establishment of a neurocognitive atlas of the human brain https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Analysis-multitask-functional-MRI-data-IBC.aspx In this study, NeuroSpin researchers leveraged the Individual Brain Charting (IBC) dataset, acquired by high-resolution functional MRI during the performance of behavioural tasks, to investigate the feasibility of individual mapping of the cognitive components underlying the tasks. They thus individualized six regions of interest in the language network and established their cognitive profile. MRI ; Cognition Scientific result Thu, 08 Oct 2020 10:00:00 GMT Permeabilizing the blood-brain barrier to deliver therapeutic antibodies into the brain? ImmunoPET imaging provides answers https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/ImmunoPET-BBB-Ab.aspx Researchers from SHFJ, NeuroSpin and DMTS have demonstrated, by immunoPET imaging, the impact of transient BBB permeabilization on brain exposure to an anti-EGFR antibody. Promising prospects for targeted immunotherapy of glioblastoma. Cancer ; Medical imaging ; Positron Emission Tomography SIMOPRO Scientific result radiomarquage;zirconium;IRM; Tue, 06 Oct 2020 10:00:00 GMT Functional neuroanatomy of number processing at high-resolution https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Functional-neuroanatomy-number-processing.aspx NeuroSpin researchers used ultra-high field (7 Tesla) functional magnetic resonance imaging (fMRI) to better localize the processing and manipulation of numbers in the human brain. The results, which enrich our understanding of the functional organization of the intra-parietal sulcus, the cerebral center of digitization, are published in NeuroImage. Brain ; MRI ; Cognition ; Mathematics Scientific result Wed, 23 Sep 2020 10:00:00 GMT Towards a new generation of antennas for ultra-high field imaging of the brain https://www.cea.fr/drf/joliot/en/Pages/news/Press/mri-antenna-brain.aspx The European Commission once more places its trust on Multiwave company and its partners, Aix-Marseille Université , CEA and Université Catholique de Louvain to revolutionize ultra-high field magnetic resonance imaging of the brain. Health & life sciences ; Brain ; Methodologies for life sciences ; Medical imaging ; MRI Journalists ; Institutions ; Companies Neurospin News ; Focus NeuroSpin;DRF;Europe;MRI;Brain;project;Joliot;antenna;imagery; Tue, 22 Sep 2020 08:06:13 GMT A new molecule to fight against intracellular pathogens https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Retro1-new-molecule-against-intracellular-pathogens.aspx The SCBM and SIMoS collaborated to optimize the activity of Retro-1, a benzodiazepine compound, inhibitor of Shiga toxins and ricin, derived from high-throughput biological screening. They succeeded in obtaining an analog 70 times more protective against the cytotoxicity of Shiga toxins, Retro-1.1. Chemistry ; High-throughput screening ; CBRN-E threats Scientific result Mon, 14 Sep 2020 10:00:00 GMT Development of a general strategy for the isotopic labelling of carbamates by incorporation of CO2 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/carbamates-CO2-isotope-labeling.aspx In a study published in Chemical Communications, the Joliot Institute Carbon labeling laboratory (LMC), in collaboration with the SHFJ, provides proof of concept of a "click" strategy for carbon isotope marking of pharmaceutical molecules containing carbamates. Chemistry ; Diagnosis and innovative treatment SCBM Scientific result ; Europe Thu, 10 Sep 2020 10:00:00 GMT Florent Meyniel, laureate of the prestigious "ERC Starting grant" call https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Florent-Meyniel-ERC-SG.aspx On September 3, the European Research Council announced the names of the 436 winners of the ERC Starting Grant 2020 call. Florent Meyniel, CEA researcher at the NeuroSpin department of the Joliot Institute, is among them. MRI Neurospin Prizes and awards ; Europe ; Article H2020;Bayes; Thu, 03 Sep 2020 10:05:00 GMT Hydrogen isotopes in the race for new drugs https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Hydrogen-isotopes-race-new-drugs.aspx ​The Grégory Pieters' team (LMT/SCBM) publishes, in the prestigious Angewandte Chemie, two major advances in the field of carbon-hydrogen bonds activation involving the two isotopes of hydrogen, deuterium and tritium, facilitating in particular access to labeled analogues of complex molecules, a prerequisite for the development of new drugs. Chemistry Scientific result Tue, 01 Sep 2020 10:00:00 GMT SARS-CoV-2 detection: mass spectrometry shows its potential for rapidity. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/SARS-CoV-2-detection-mass-spectrometry-rapidity.aspx A team from SPI in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method. Mass spectrometry ; Virus ; Biodetection ; Diagnosis Scientific result Thu, 06 Aug 2020 10:00:00 GMT Mapping of normal brain aging: unprecedented results from the SENIOR cohort https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/SENIOR-cohort-cerebral-aging.aspx The SENIOR study, conducted by several NeuroSpin teams, consists in monitoring, since March 2012, a cohort of 100 subjects aged 50 to 70 years by annual MRI imaging over a period of 10 years, to establish a normal aging brain imaging biomarkers mapping. This publication in Alzheimer's Research & Therapy describes the baseline experimental protocol and presents first promising results. Neurodegenerative diseases ; Brain ; MRI ; Positron Emission Tomography Scientific result Tue, 04 Aug 2020 10:00:00 GMT Multimodal imaging to quantify biliary drug excretion https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Multimodal-imaging-quantify-biliary-drug-excretion.aspx Researchers from the BioMaps unit based at the SHFJ have developed an imaging protocol to study in vivo the hepatobiliary transport capacity responsible for the elimination of many drugs and to better understand the hepatotoxicity of certain drugs. Medical imaging Researchers SHFJ Scientific result technetium-99m;liver;scintigraphy; Thu, 02 Jul 2020 10:00:00 GMT Chemistry: releasing two fluorophores into living cells by "click and release". https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Click-and-release-liberation-2-fluorophores-dans-cellule.aspx Researchers from the LMC have developed a new series of iminosydnones that can split in two and release two fluorophores. They are providing a proof of concept that this "click and release" reaction can be triggered in living cells. Chemistry SCBM Scientific result Diels-Alder;cycloaddition;BCN;pyrazole; Mon, 29 Jun 2020 10:00:00 GMT Mapping of Ebola T-cell response: towards a new vaccine ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mapping-Ebola-T-cell-response.aspx SIMoS researchers, in collaboration with Genopole, Excellgene, Vaxeal holding SA (Switzerland), used a large-scale approach to map and characterize the response of CD4 T-cells from healthy donors, against two proteins from the Ebola-Zaire virus. They observed a strong response to the viral nucleoprotein (NP) and suggest that components of NP may be included in the design of new Ebola vaccines. Virus ; Vaccine Scientific result Wed, 24 Jun 2020 10:00:00 GMT Salmonellosis and shigellosis: first demonstration of cross-protection induced by virulence factors SipD and IpaD https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Salmonella-shigella-cross-protection.aspx SPI researchers show for the first time, in a mouse model, the induction of cross-protection against Salmonella and Shigella infections, two pathogenic bacteria responsible for gastrointestinal diseases (typhoid, dysentery among others), one of the main causes of morbidity and mortality in several regions of Africa and Asia. Vaccine ; Bacteria Scientific result Mon, 22 Jun 2020 10:00:00 GMT Diffusion MRI to monitor astrocyte activity? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/diffusionMRI-astrocyte-activity.aspx In two articles published in PLoS ONE, researchers at NeuroSpin show that diffusion MRI can monitor astrocyte activity in the brain in a non-invasive way, allowing a better understanding of its involvement in the glymphatic system and in functional MRI. MRI ; Brain Neurospin Scientific result BOLD MRI;functional MRI;aquaporins;diffusion MRI; Thu, 11 Jun 2020 10:00:00 GMT