https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2022/Food-allergies-sensitization-route-influences-immune-response.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot-2023.png https://joliot.cea.fr/drf/joliot/en https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Regulation-Fe–S-cluster-biosynthesis-elucidated.aspx A team from I2BC has uncovered the key steps governing the assembly and regulation of iron–sulfur cluster biosynthesis, essential metallic cofactors involved in numerous biological functions. Defects in this process lead to pathologies such as Friedreich’s ataxia. These studies represent major advances toward the development of future therapies. Cellular mechanisms ; Molecular mechanisms ; Diseases SBIGEM Scientific result Fri, 16 Jan 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Sequence-desordonnee-Rad52-assemblage-Rad51.aspx En utilisant Saccharomyces cerevisiae comme modèle, des chercheurs des instituts CEA-Jacob et CEA-Joliot, et de l’Institut Curie, avec leurs partenaires du synchrotron SOLEIL, ont révélé comment la protéine Rad52 agit comme un chaperon pour guider et stabiliser l’assemblage de Rad51, une étape clé de la recombinaison homologue.​ Structural biology ; Cellular mechanisms ; Molecular mechanisms Researchers SB2SM Scientific result Mon, 28 Jul 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/T-lymphocytes-specific-facteur8.aspx A SIMoS team has made a significant breakthrough in understanding the cellular immune response to factor VIII, a protein essential for blood coagulation, by demonstrating for the first time the existence of human FVIII-specific regulatory T cells in the blood of healthy donors. Cellular mechanisms ; Methodologies for life sciences SIMOPRO Scientific result ; Article Fri, 07 Jun 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Food-allergy.aspx Researchers at the LIAA (SPI/DMTS) have shown that pre- and perinatal exposure of mice to titanium dioxide increases the risk of developing a food allergy, particularly in males. Allergies ; Large-scale biology Researchers SPI Scientific result ; Article omics;Animal;animal models;allergen; Wed, 28 Feb 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Autophagy-involved-protecting-cells-against-ricin.aspx A team from SIMoS and SCBM, in collaboration with researchers from I2BC, has shown that autophagic degradation is at work when mammalian cells are poisoned by ricin. Stimulating this process could provide additional protection against this deadly toxin. CBRN-E threats ; Cellular mechanisms SCBM Scientific result ; Article Thu, 28 Sep 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Mathematical-model-repair-genome.aspx The protocols applied for in vivo mapping of nuclear processes, at the genome scale and at very high spatial resolution, do not allow for high temporal resolution. A team from the I2BC has therefore demonstrated that such an understanding could be wrong by using a mathematical model. This model can be applied to any process that can be modeled by a transition between two states. DNA ; Cellular mechanisms Researchers IBITECS Scientific result XR-seq;réparation de l’ADN;NER; Tue, 13 Dec 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Iron-insertion-initiating-biosynthesis-Fe-S-centers.aspx A team from SBIGeM (I2BC) shows, by several spectroscopic approaches, that the assembly of a Fe-S cluster, the catalytic center of many essential proteins, is a highly conserved process, initiated by the insertion of ferrous iron at the cysteine-rich assembly site of the scaffold protein ISCU (Iron-sulfur cluster assembly enzyme). Health ＆ life sciences ; Fundamental Research ; Cellular mechanisms SBIGEM Scientific result Fri, 09 Dec 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Mediator-transcription-gene-expression-regulation-DNA-repair.aspx An I2BC team has analyzed, at the genome scale of the yeast S.cerevisiae, the functional interactions between the Mediator of gene transcription and DNA repair proteins, reinforcing the idea that these two fundamental cellular processes are closely linked. Molecular mechanisms ; Cellular mechanisms ; DNA SBIGEM Scientific result Mon, 26 Sep 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Food-allergies-sensitization-route-influences-immune-response.aspx Researchers at the LIAA (SPI/DMTS) show that the initial route of sensitization to a food allergen (oral, respiratory, cutaneous) directly influences the nature of immune responses at multiple sites in the body. Allergies ; Cellular mechanisms Researchers SPI Scientific result cellular immune responses;food allergy;BABL/c mice; Mon, 25 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Autophagy-senescence.aspx Researchers from the Frédéric Joliot Institute have identified ouabain and chloroquine as two selective senolytic molecules that are effective in eliminating certain senescent cells. The study has been published in the journal Aging Cell. Cancer ; Cellular mechanisms Researchers SCBM Scientific result Tue, 15 Mar 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Immune-signature-severe-asthma-children.aspx Researchers from the Laboratory of Food Immuno-Allergy (SPI/DMTS), in collaboration with the Necker-Enfants Malades Hospital, identify an immune signature of severe asthma (SA) in children, through a non-targeted global analysis of all immune and inflammatory constituents present in blood and bronchoalveolar lavages of children with SA. Allergies ; Diseases Scientific result Mon, 11 Oct 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/accumulation-mutations-microfluidique.aspx Teams from CEA-Iramis and CEA-Joliot (team "Genome transcriptional regulation /I2BC) have joined forces to develop and validate an innovative microfluidic-based system that automatizes cell culture over many generations. It enables with considerable time savings large-scale experiments to be carried out, which are essential for understanding the cellular mechanisms involved in DNA mutation events. DNA ; Cellular mechanisms Researchers Iramis Scientific result Fri, 11 Jun 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mambaquaretin-theranostic.aspx In pursuing their work on mambaquaretin, SIMoS researchers conducted a collaborative study confirming the therapeutic potential of the toxin and paving the way for its use as a diagnostic tool. Diagnosis and innovative treatment ; Molecular mechanisms ; Cellular mechanisms SIMOPRO Scientific result PET Scan;PK/PD; Tue, 10 Nov 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Characterization-new-player-tolerance-thermal-oxidative-stress.aspx Researchers from SB2SM (I2BC@Saclay) have shown for the first time in vivo in the model cyanobacterium Synechocystis that a cellular detoxification enzyme, the membrane glutathione-S-transferase (GST), maintained in part by evolution, plays a major role in resistance to thermal and oxidative stress, making this cellular model a valuable tool for the study of GSTs conserved from bacteria to plants, down to Humans. Photosynthesis ; Stress response Scientific result Tue, 18 Feb 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Glucocorticoids-better-evaluation-effect-cancers.aspx Senescence specialists (SBIGEM), in collaboration with the SCBM and the CNRGH (Jacob Institute), show that glucocorticoids can delay or even short-circuit it and disrupt its function as a tumor suppressor. Cellular mechanisms ; Molecular mechanisms ; Cancer Fontenay-aux-Roses Scientific result MEK/ERK;oncogenesis;Senescence; Mon, 09 Sep 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Relaxin-immunogenic.aspx A collaboration between teams from SIMOPRO and Sanofi sheds new light on the origin of the immune responses developed by patients with scleroderma when treated by injection of relaxin, a therapeutic protein. The study was published in The Journal of Immunology. Autoimmune diseases ; Cellular mechanisms Saclay Tue, 18 Jun 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/Physicist-pharmacologists-to-better-understand-BBB.aspx Thanks to complementary imaging techniques, researchers from the SHFJ and NeuroSpin have shown that the physical blood-brain barrier (BBB) disruption is not necessarly enough to deliver some drugs into the brain, especially when there are recognized and supported by efflux transporters. Medical imaging ; MRI ; Positron Emission Tomography ; Cellular mechanisms SHFJ News Thu, 20 Dec 2018 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/New-function-discovered-protein-Rad52-serious-therapeutic-target-breast-cancer.aspx Rad52 has garnered great attention lately as a promising target in the battle against certain types of breast cancer. A team from IRCM, in partnership with researchers from the Frédéric-Joliot and Gustave Roussy Institutes, has shed new light on this protein. Stress response ; Molecular mechanisms Jacob Scientific result Rad51 filament;budding yeast;Srs2; Fri, 12 Oct 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2016/MeioC_orchestra_conductor_meiosis.aspx This study, in which a team of SPI/LI2D, specialized in proteogenomics, has contributed reveals the crucial role of the Meioc protein as a meiosis regulator. This protein stabilizes the mRNAs essential to the chronological procedure of the very complex phenomenon of sexual reproduction.​​ Cell division News Wed, 12 Apr 2017 13:23:25 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/Hug1_and_RNR.aspx ​A study, coordinated by a SBIGeM team in collaboration with a SB2SM team, allowed to describe the role of the Hug1 protein in regulating the activity of the ribonucleotide reductase complex (RNR). The level of active RNR is controlled during cell cycle and in response to DNA damages. DNA ; Stress response ; Cell division News Mon, 04 May 2015 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/cyclodipeptide_synthases_elucidated-.aspx Teams of IBITECS and Ecole Polytechnique (Palaiseau) have deciphered the mechanism used by the cyclodipeptide synthases (CDPS) to catalyze the formation of peptide bonds. Structural biology ; Cellular mechanisms News Fri, 01 May 2015 10:00:00 GMT