https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2025/Tolerance-opioid-PET.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot-2023.png https://joliot.cea.fr/drf/joliot/en https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/proteins-nanoplastics.aspx Peptides and proteins adsorb onto plastic nanoparticles, forming a corona. Researchers from I2BC and CEA-Iramis, using molecular modeling, reveal distinct adsorption behaviors depending on their amino acid sequences. They thus establish a mechanical basis for predicting peptide-plastic interactions, a crucial element for assessing the risks these interactions pose to health and ecosystems. Molecular mechanisms ; Simulation ＆ modelling Researchers SB2SM Scientific result ; Article Mon, 16 Mar 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Photosynthese-carence-de-manganese-mutants-transporteur-mn-Arabidopsis.aspx Researchers from the I2BC show that two Arabidopsis thaliana mutants deficient in manganese transport do not regulate photosynthetic electron transport in the same way, with different consequences for photosynthesis. Molecular mechanisms ; Photosynthesis Researchers SB2SM Scientific result ; Article induction de fluorescence;fluorescence de la chlorophylle;quenching non photochimique;transitions d’état; Thu, 12 Mar 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Regulation-Fe–S-cluster-biosynthesis-elucidated.aspx A team from I2BC has uncovered the key steps governing the assembly and regulation of iron–sulfur cluster biosynthesis, essential metallic cofactors involved in numerous biological functions. Defects in this process lead to pathologies such as Friedreich’s ataxia. These studies represent major advances toward the development of future therapies. Cellular mechanisms ; Molecular mechanisms ; Diseases SBIGEM Scientific result Fri, 16 Jan 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Ketamine-TEP-synaptogenesis.aspx Researchers from BioMaps (SHFJ) and MOODS have validated an innovative molecular neuroimaging approach that allows non-invasive monitoring of ketamine’s effects on synaptic density in a preclinical model of depression. Positron Emission Tomography ; Diagnosis and innovative treatment Researchers SHFJ Scientific result préclinique;modèle animal; Mon, 22 Dec 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Reconstruction-TEP-regularisation-Plug-and-Play-convergente.aspx A team of researchers from BioMaps (SHFJ) is proposing a new reconstruction method for PET imaging that combines optimization algorithms with deep neural networks. Their “plug-and-play” regularization approach ensures improved image quality thanks to PET-specific reconstruction learning, while guaranteeing stability and robustness—two critical aspects in the use of AI-based medical techniques. Positron Emission Tomography ; Artificial intelligence Researchers SHFJ Scientific result Tue, 16 Dec 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/PET-imaging-OATP-function-impacts-sex-age.aspx Researchers from BioMaps (SHFJ) investigated the hepatic activity of organic anion-transporting polypeptides (OATPs), key players in the elimination of certain drugs, using a PET imaging approach with 11C-glyburide, which revealed differences in tracer pharmacokinetics between men and women. Pharmacology ; Positron Emission Tomography ; Medical imaging SHFJ Scientific result Wed, 15 Oct 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Radioligands-TEP-neuroinflammation.aspx Des chercheurs du SHFJ, en collaboration avec le CEA-Jacob, le CRN à Lyon et le PharmaCenter à Bonn ont imaginé, synthétisé et caractérisé deux radiotraceurs TEP ciblant P2Y12, une protéine impliquée dans l’activation de la microglie durant la neuroinflammation.​ Positron Emission Tomography ; Pharmacology Researchers MIRcen Scientific result préclinique;modèle animal; Fri, 03 Oct 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Effet-qualite-lumiere-sur-photosynthese.aspx Une étude menée par une équipe de l'I2BC montre que la surexcitation du photosystème II est responsable de la faible valeur de qL, un paramètre de fluorescence, chez des mutants d’Arabidopsis thaliana incapables de réaliser des « transitions d’état ». Photosynthesis ; Molecular mechanisms ; Cell and molecular imaging Researchers SB2SM Scientific result ; Article Fri, 26 Sep 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Mitose-KIF2C.aspx A study led by the I2BC shows that the formation of condensates of the enzyme KIF2C enables the concentration of two other proteins, PLK1 and phosphorylated BRCA2, on kinetochore microtubules during mitosis. This would serve to control chromosome alignment on the spindle and contribute to their stability. DNA ; Structural biology ; Cancer Researchers SB2SM Scientific result Mon, 08 Sep 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Tolerance-opioid-PET.aspx A study combining PET imaging and pharmacology, conducted by researchers at BioMaps (SHFJ), suggests that decreased availability of opioid receptors and altered neuronal energy metabolism constitute molecular signatures of opioid tolerance. These observations, made in an animal model, could help improve understanding and treatment of opioid dependence. Positron Emission Tomography ; Molecular mechanisms Researchers SHFJ Scientific result ; Article opiate;preclinical model; Wed, 06 Aug 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Sequence-desordonnee-Rad52-assemblage-Rad51.aspx En utilisant Saccharomyces cerevisiae comme modèle, des chercheurs des instituts CEA-Jacob et CEA-Joliot, et de l’Institut Curie, avec leurs partenaires du synchrotron SOLEIL, ont révélé comment la protéine Rad52 agit comme un chaperon pour guider et stabiliser l’assemblage de Rad51, une étape clé de la recombinaison homologue.​ Structural biology ; Cellular mechanisms ; Molecular mechanisms Researchers SB2SM Scientific result Mon, 28 Jul 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Correlation-neuroinflammation-epileptogenic-zone-TSPO-PET.aspx A study by SHFJ researchers has established a strong correlation between biomarkers of neuroinflammation, revealed by original PET imaging, and intracranial electroencephalographic recordings of epileptogenic activity. This offers hope for drug-resistant patients who are candidates for surgery. Positron Emission Tomography ; Medical imaging ; Brain SHFJ Scientific result ; Article Tue, 15 Jul 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Drug-candidate-for-treatment-neonatal-encephalopathy.aspx Researchers from the SPI (DMTS) and the Women & Infants Hospital in Providence have laid the molecular basis for the neuroprotection of a purine derivative in a preclinical model of neonatal hypoxic-ischemic encephalopathy (HIE). The promising results support the development of this drug candidate to treat HIE in neonates. Pharmacology ; Brain ; Molecular mechanisms ; Diseases SPI Scientific result animal models;preclinic; Thu, 26 Jun 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Theranostic-antibodies-endothelin-receptors-models-glioblastoma-melanoma.aspx Researchers from SPI (DMTS) propose immunodiagnostic and immunotherapeutic approaches based on the use of innovative antibodies targeting two subtypes of endothelin receptors (ETA and ETB), recognised as relevant therapeutic targets in oncology. Health ＆ life sciences ; Cancer ; Medical imaging ; Positron Emission Tomography Neurospin Scientific result preclinical research;animal models; Thu, 22 May 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Next-generation-sequencing-chess-game.aspx A team from I2BC has proposed a thought experiment -the Next Generation Sequencing chess problem-, which treats sequencing data as a superimposed image of several independent chess games. A more realistic approach to the dynamics of cellular processes within each cell, revealing the limits of NGS approaches to temporal analysis. Bioinformatic ; DNA ; Molecular mechanisms ; Simulation ＆ modelling SBIGEM Scientific result Mon, 17 Feb 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/neuromodulatory-nuclei-Alzheimer-and-related-disorders.aspx A team from GHU Paris and SHFJ has used brain MRI to study the integrity of the locus coeruleus and nucleus basalis of Meynert in patients with early-onset Alzheimer's disease (AD), age-related TDP-43 encephalopathy (LATE) and fronto-temporal dementia (FTD). Both structures are altered in early AD, LATE and probably FTD, making these neuromodulatory areas potential therapeutic targets Diseases ; Brain ; Cognition ; MRI ; Positron Emission Tomography ; Alzheimer's disease Neurospin Scientific result Wed, 16 Oct 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/PET-image-reconstruction-deep-learning-clearmind-detector.aspx Three DES and DRF laboratories have developed an innovative Machine Learning algorithm to improve the reconstruction of PET images acquired as part of the ClearMind project, a technology based on the detection of gamma photons by a monolithic lead tungstate crystal detector. A step towards more accurate PET imaging Positron Emission Tomography ; Methodologies for life sciences ; Artificial intelligence Irfu Scientific result Mon, 07 Oct 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/PET-monitoring-central-effects-innovative-smoking-cessation-therapy.aspx A BioMaps team has used PET imaging to monitor glucose metabolism as a marker of the cerebral impact of smoking cessation, as well as the effects of a promising drug-candidate for the treatment of such cessation. By revealing the restoration of normal activity in the brain area associated with craving, these results offer hope for smoking cessation in humans Positron Emission Tomography ; Medical imaging ; Pharmacology ; Brain SHFJ Scientific result Preclinical;animal models;murine model; Thu, 29 Aug 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Nucleosome-positioning-yeast-genome.aspx A team from I2BC has studied the positioning of nucleosomes in the yeast S cerevisiae genome, using an original mathematical method to analyze next-generation sequencing data. This mapping highlights the role of chromatin remodeling complexes in nucleosome organization. DNA ; Large-scale biology SBIGEM Scientific result Fri, 28 Jun 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/DNA-recombination-lock.aspx Teams from I2BC, Institut Curie and IRB shed light on how the human nuclease MRN works. Structural predictions obtained with AlphaFold2 and confirmed by in vitro and in vivo experiments show that the phosphorylated Sae2/CtIP protein forms a network of interactions with MRN that favours the removal of its autoinhibition. Structural biology ; DNA ; Molecular mechanisms ; Artificial intelligence Researchers SB2SM Scientific result Tue, 25 Jun 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/HROB-MCM8-MCM9.aspx Researchers from the AMIG team (I2BC department), in collaboration with the IRB (Switzerland), have modeled the interaction between HROB and the helicases MCM8-MCM9, some mutations of which predispose individuals to infertility or cancer. They demonstrate that HROB promotes the catalytic activity of the MCM8-MCM9 complex but does not play a role in its recruitment or stability. Structural biology ; Molecular mechanisms Researchers SB2SM Scientific result ; Article AlphaFold;AlphaFold2; Wed, 22 May 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Response-intra-tumoral-immunotherapy-by-immunoPET.aspx A team from BioMaps (SHFJ), in partnership with the Gustave Roussy Institute, has used immunoPET imaging to assess the influence of tissue distribution on the efficacy of cancer immunotherapy, administered intra-tumor and intravenously in mice. Intratumoral administration is more effective and reduces overall exposure of organs at risk Medical imaging ; Positron Emission Tomography ; Cancer SHFJ Scientific result preclinical research;animal models; Fri, 19 Apr 2024 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Epigenetics-CAF-1.aspx A team from the I2BC, in collaboration with the Institut Curie and Soleil, has shown that the CAF-1 protein combines flexible regions and rigid modules in its spatial organisation to deposit histones on DNA and effectively couple this process to DNA synthesis. Epigenetics ; Structural biology Researchers SB2SM Scientific result ; Article Tue, 26 Mar 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Rapid-genome-replication-role-of-Rif1-protein.aspx I2BC researchers show that the Rif1 protein restrains the replication program and the recruitment of replication initiation factors during early embryonic divisions in X laevis. A step towards elucidating the molecular mechanisms involved in diseases resulting from Rif1 mutations in humans Molecular mechanisms ; DNA SBIGEM Scientific result ; Article Thu, 21 Dec 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/phytic-acid-DNA-repair.aspx In an article published in the journal Nucleic Acids Research, scientists from the I2BC, lPBS and the Institute for Structural and Chemical Biology (University of Leicester, UK) demonstrate how phytic acid, a product of cellular metabolism, stabilises the assembly of a complex enabling the repair of DNA breaks in humans. DNA ; Structural biology Researchers SB2SM Scientific result ; Article Mon, 04 Dec 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Impact-metabolism-PET-imaging-neuroinflammation.aspx Researchers at BioMaps evaluated the effect of several factors on the distribution of [18F]DPA-714 in 201 subjects who participated in SHFJ PET imaging protocols to better understand the role of neuroinflammation in various neurological diseases. They conclude that measures of individual metabolism are important in image interpretation. Positron Emission Tomography ; Medical imaging ; Pharmacology SHFJ Scientific result Thu, 12 Oct 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Multiplier-chimeres-mieux-comprendre-interactions-inhibiteur-cible-proteique.aspx En substituant des segments d’hélice alpha​ par des segments d’oligo-urées dans un peptide inhibiteur d’ASF1, lui conférant ainsi une résistance accrue aux protéases, des chercheurs de l’I2BC en collaboration avec l’IECB explorent les modes de liaison de ces chimères peptide-urée à leur cible. Molecular mechanisms ; Structural biology Researchers SB2SM Scientific result ; Article Tue, 12 Sep 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/PET-imaging-antibody-endothelin-receptors-glioblastoma-tumors.aspx Researchers at BioMaps (SHFJ) and SPI (DMTS) have studied the pharmacokinetics of a novel immuno-radioligand targeting the endothelin A receptor (ETA), overexpressed in many cancers, particularly glioblastoma. The immunoPET imaging approach used in this study in a preclinical model confirms the theranostic potential of this antibody. Positron Emission Tomography ; Cancer ; Medical imaging Neurospin Scientific result Thu, 07 Sep 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Longitudinal-monitoring-tauopathy-PET-imaging.aspx A joint team from GHU Paris and BioMaps (SHFJ) conducted a 2-year longitudinal study of 27 people with Alzheimer's disease, tracking the progression of tau pathology measured by PET imaging, of cortical atrophy using MRI, and their links with cognitive decline. Alzheimer's disease ; Medical imaging ; MRI ; Positron Emission Tomography SHFJ Scientific result ; Article Wed, 02 Aug 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/New-role-Mediator-transcription-chromatin-organization.aspx A team from I2BC has shown that the Mediator of transcription from the yeast S.cerevisiae physically interacts with the chromatin remodeling complex, and that by co-localizing with this complex on DNA promoter regions, it contributes to chromatin organization favorable to transcription initiation. Health ＆ life sciences ; DNA ; Molecular mechanisms SBIGEM Scientific result Mon, 24 Jul 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/proteines-dispersion-microplastiques-dans-eau.aspx Des chercheurs de l’I2BC ont contribué à une étude menée par l’Iramis qui dévoile le rôle des protéines dans la dispersion des microplastiques dans l’eau. Leurs résultats permettent d’imaginer de nouvelles stratégies low tech pour débarrasser l’eau de cette pollution. Impacts on living (organisms) ; Molecular mechanisms ; Remediation Researchers SB2SM Scientific result surfactant;polypropylène;polyéthylène; Wed, 12 Jul 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/HTA-toxine-animale-recepteur-angiotensine-II.aspx SIMoS researchers have identified and characterised an animal toxin (A-CTX-Mila) as a ligand for angiotensin II receptors, which are involved in one of the signalling pathways targeted by antihypertensive drugs. A tool of choice for studying the cellular mechanisms controlled by these receptors. Molecular mechanisms ; Diseases Researchers SIMOPRO Scientific result Fri, 16 Jun 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Reparation-ADN-PAXX.aspx An international collaboration led by researchers from I2BC/CEA-Joliot and IPBS (Toulouse) has solved the atomic structure of molecular assemblies involved in the repair of DNA double-strand breaks. The diversity of assemblies involving the PAXX protein identified in this study highlights the great flexibility of the repair machinery, which could reflect its ability to adapt to biological conditions. The results were published in Science Advances. Structural biology ; Molecular mechanisms Researchers SB2SM Scientific result cryoEM;radiocristallographie; Tue, 06 Jun 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/rabbit-motif-PET-imaging-diagnostic-evaluation-parkinsonian-syndromes.aspx BioMaps researchers compared the diagnostic performance of the rabbit visual pattern observed in 18F-DOPA PET imaging with the standard procedure approved by the international nuclear imaging societies for the diagnosis of parkinsonian syndromes in PET/MRI and obtained encouraging results, which may validate the clinical utility of such a model Positron Emission Tomography ; Medical imaging ; Parkinson's disease ; Brain SHFJ Scientific result Tue, 23 May 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Radiomarquage-crizotinib-fluor-18-nouvel-outil-TEP.aspx Des chercheurs du SHFJ ont mis au point la radiosynthèse au fluor-18 du crizotinib, un médicament qui ne pénètre pas dans le cerveau. Ce nouvel outil pour l’imagerie TEP permettra d’explorer de futures stratégies visant à faire passer la barrière hémato-encéphalique à ce médicament pour traiter certaines métastases cérébrales. Positron Emission Tomography ; Cancer ; Diagnosis and innovative treatment Researchers SHFJ Scientific result ; Article Thu, 27 Apr 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/New-radiolabeling-strategy-immunoTEP.aspx Researchers from the BioMaps laboratory (SHFJ) and the Molecular Engineering for Health Service (SIMoS, DMTS) developed an enzymatic approach for radiofluorination of an anti-PD-L1 Fab and compared its in vivo properties to the same Fab stochastically labeled by two conventional methods. Diagnosis and innovative treatment ; Positron Emission Tomography Researchers SHFJ Scientific result PD-L1;radiomarquage;lipoate-protéine ligase;radiofluoration; Tue, 21 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Nanoparticles-to-improve-radiotherapy.aspx Researchers from the SHFJ laboratory at ISMO have demonstrated the value of platinum nanoparticles as potential radiosensitizing agents for radiation therapy. Diagnosis and innovative treatment ; Positron Emission Tomography Researchers SHFJ Scientific result Radiotherapy;biodistribution;platinum nanoparticles; Tue, 21 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Glioblastoma-FUS-cetuximab.aspx Researchers from the SHFJ, in collaboration with NeuroSpin, show that the use of focused ultrasound does not increase the therapeutic effects of cetuximab on glioblastoma although the opening of the blood-brain barrier is transiently effective. Positron Emission Tomography ; Diagnosis and innovative treatment Researchers Neurospin Scientific result Wed, 15 Feb 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/BAF-numerical-simulation-phosphorylation.aspx Using molecular dynamics simulation and NMR studies, I2BC researchers detail the restriction mechanisms of BAF protein dynamics due to its phosphorylation. Molecular mechanisms ; Structural biology ; Simulation ＆ modelling Researchers SB2SM Scientific result Mon, 16 Jan 2023 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Mathematical-model-repair-genome.aspx The protocols applied for in vivo mapping of nuclear processes, at the genome scale and at very high spatial resolution, do not allow for high temporal resolution. A team from the I2BC has therefore demonstrated that such an understanding could be wrong by using a mathematical model. This model can be applied to any process that can be modeled by a transition between two states. DNA ; Cellular mechanisms Researchers IBITECS Scientific result XR-seq;réparation de l’ADN;NER; Tue, 13 Dec 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Mediator-transcription-gene-expression-regulation-DNA-repair.aspx An I2BC team has analyzed, at the genome scale of the yeast S.cerevisiae, the functional interactions between the Mediator of gene transcription and DNA repair proteins, reinforcing the idea that these two fundamental cellular processes are closely linked. Molecular mechanisms ; Cellular mechanisms ; DNA SBIGEM Scientific result Mon, 26 Sep 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/fluorine-18-thiol-labeking-biomolecules-TEP.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated the synthesis of an 18F-fluoropyridine containing a thiol function (-SH), allowing its conjugation to model biomolecules within 45 minutes. A step towards rapid radiolabeling of complex biological molecules for PET imaging. Radioactivity ; Chemistry ; Positron Emission Tomography SHFJ Scientific result Tue, 28 Jun 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Intrahepatic-cholestasis-biochemistry-structure-ATP8B1.aspx A collaborative study involving an I2BC team unveils the mechanism of autoinhibition of the human flippase ATP8B1, as well as its regulation by lipids and phosphorylation. The study provides a better understanding of the impact of flippase mutations responsible for intrahepatic cholestasis on its enzymatic activity. Molecular mechanisms ; Structural biology Researchers SB2SM Scientific result ATP;hydrolyse;protéine membranaire;modifications post-traductionnelles;expression hétérologue;membranes;cryo-EM; Thu, 09 Jun 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Radioligands-immunoPET-PD-1-PD-L1.aspx Researchers from the SHFJ and the DMTS have developed optimized radioligands for immunoPET imaging. The objective is to better predict the effectiveness of anti-PD1/anti-PDL1 immunotherapy used to fight certain cancers. Positron Emission Tomography ; Cancer Researchers SIMOPRO Scientific result programmed cell death-ligand 1; Tue, 12 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/PET-MRI-imaging-epilepsy-detection.aspx A team from BioMaps (SHFJ), in collaboration with several hospital groups, shows that hybrid PET/MRI imaging significantly improves the detection of epileptogenic foci and, consequently, the outcome of surgical treatment of epilepsy. Medical imaging ; Positron Emission Tomography ; MRI SHFJ Scientific result Tue, 05 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Alzheimer-Tau-PET-imaging.aspx A joint team from GHU Paris and SHFJ shows the predictive value of PET imaging data of the Tau protein in the progression of Alzheimer's disease. Alzheimer's disease ; Positron Emission Tomography Researchers SHFJ Scientific result ; Press release radiotracer; Sun, 03 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Modeling-pairing-crossover-meiosis.aspx In a study conducted by a team from the Institut Curie, researchers from the CEA-Joliot (B3S/I2BC department) have modeled in silico protein-protein interactions and thus contributed to establish at the molecular level the mechanisms that coordinate the pairing and recombination of homologous chromosomes during meiosis. Simulation ＆ modelling ; Structural biology ; Molecular mechanisms Researchers SB2SM Article ; Scientific result recombinaison homologue;AlphaFold;crossing-over;InterEvDock3; Thu, 13 Jan 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/senescence_biomarkers_chromatin.aspx Researchers from the DMTS and I2BC depatments of the Joliot Institute's " identify three potential new biomarkers of senescent cells containing persistent DNA damage. Molecular mechanisms Researchers SBIGEM Scientific result Wed, 17 Nov 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PET-MRI-imaging-tumors-supervoxel-level.aspx A collaborative study led by BioMaps researchers (SHFJ) demonstrates that fully integrated quantitative multiparametric analysis of non-small cell lung cancer in hybrid 18F-FDG PET/MRI 3T imaging is clinically feasible and could enable biological characterization of tumors at the supervoxel scale. Medical imaging ; Positron Emission Tomography ; MRI ; Cancer Scientific result Wed, 10 Nov 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Amyloid-tau-imaging-diagnosis-progressive-amnesia.aspx Researchers from BioMaps (SHFJ) and the Service de Neurologie de la Mémoire et du Langage (Hôpital Ste-Anne) show, through amyloid and tau molecular imaging in patients followed for 2 years, that the diagnosis of progressive amnesia in the elderly is not necessarily Alzheimer's disease and may be caused by other mechanisms clearly distinguishable from it. Positron Emission Tomography ; Medical imaging ; Alzheimer's disease Scientific result Thu, 04 Nov 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Plants-dissipation-exces-energy.aspx In a study published in JBC, a team from I2BC/CEA-Joliot, in collaboration with the Beijing Botanical Institute (China), describes for the first time an intermediate state of the light-harvesting antenna of higher plants that provides a better understanding of the changes that take place at the molecular level during the activation of a plant's photoprotection mechanism. Photosynthesis ; Molecular mechanisms Researchers SB2SM Scientific result Raman analyzer; Mon, 05 Jul 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Small-RNA-regulates-photoprotection-cyanobacteria.aspx A team of the I2BC (LMB/SB2SM), in collaboration with the Institute of Biology (Freiburg University), discovered a posttranscriptional regulatory mechanism linking the expression of the cyanobacterial Orange Carotenoid Protein, related to photoprotection, directly and in an inverse fashion, to the synthesis of the light collector complexes (phycobilisomes), via a 3’ end-derived small RNA. Photosynthesis ; Microalgae ; Molecular mechanisms Scientific result Wed, 23 Jun 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/accumulation-mutations-microfluidique.aspx Teams from CEA-Iramis and CEA-Joliot (team "Genome transcriptional regulation /I2BC) have joined forces to develop and validate an innovative microfluidic-based system that automatizes cell culture over many generations. It enables with considerable time savings large-scale experiments to be carried out, which are essential for understanding the cellular mechanisms involved in DNA mutation events. DNA ; Cellular mechanisms Researchers Iramis Scientific result Fri, 11 Jun 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PETimaging-neuropharmacology-buprenorphine.aspx Researchers at BioMaps (SHFJ) have succeeded in determining the interaction dynamics of buprenorphine, an opioid drug with a particularly complex pharmacology, with its brain receptors in vivo. To do so, they developed an original PET imaging approach based on the use of the radiolabeled molecule (11C-buprenorphine). Brain ; Positron Emission Tomography ; Pharmacology Scientific result Wed, 05 May 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/phosphorylation-BAF-interaction.aspx ​A study by researchers from I2BC department shows in vitro the effect of mitotic phosphorylation of the BAF protein on its structure and its interactions with DNA and lamina and unveils consequences on genome organization and on mechanisms responsible for progeroid syndromes. Molecular mechanisms ; DNA ; Structural biology Researchers SB2SM Scientific result NMR;radiocristallography; Mon, 29 Mar 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Foldamer-inhibitor-ASF1.aspx I2BC researchers, in collaboration with the European Institute of Chemistry and Biology (University of Bordeaux, CNRS), have developed a chimeric peptide/foldamer molecule that is resistant to proteolysis and inhibits ASF1, a potential target for anticancer treatment. The resolution of the structure of this chimera in interaction with its target, the first of its kind, reveals an unsuspected plasticity of the urea-based backbone that hugs the surface of ASF1. Structural biology ; Molecular mechanisms ; Epigenetics ; Cancer Researchers SB2SM Scientific result NMR;radiocristallography; Fri, 19 Mar 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Sarcolipin.aspx By combining molecular dynamics and in vitro experiments, researchers at the LPSM (I2BC) have revealed the mode of action of sarcolipin in regulating the activity of SERCA1a, responsible for muscle relaxation. Molecular mechanisms ; Fundamental Research Researchers Saclay Scientific result Fri, 05 Mar 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/E340-SERCA-communication.aspx A study led by Oxford University researchers and involving researchers from the Institut Joliot (I2BC) and the University of Århus reveals the crucial role of the E340 residue in the inter-domain communication of the calcium transporter SERCA. Molecular mechanisms Researchers SB2SM Scientific result fluorescence;mutagenesis;tryptophan; Fri, 15 Jan 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Depression-gut-microbiota.aspx A study led by the Institut Pasteur and involving CEA-Joliot has shown, in a mouse model, that a modification of the intestinal microbiota caused by chronic stress is accompanied by modifications of the metabolome which induce a defect in the signaling pathway for endogenous cannabinoids in the hippocampus, which may explain the mood disorders observed. Metabolomics ; Molecular mechanisms Researchers SPI Scientific result Microbiology;neural circuits; Tue, 15 Dec 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mambaquaretin-theranostic.aspx In pursuing their work on mambaquaretin, SIMoS researchers conducted a collaborative study confirming the therapeutic potential of the toxin and paving the way for its use as a diagnostic tool. Diagnosis and innovative treatment ; Molecular mechanisms ; Cellular mechanisms SIMOPRO Scientific result PET Scan;PK/PD; Tue, 10 Nov 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/ImmunoPET-BBB-Ab.aspx Researchers from SHFJ, NeuroSpin and DMTS have demonstrated, by immunoPET imaging, the impact of transient BBB permeabilization on brain exposure to an anti-EGFR antibody. Promising prospects for targeted immunotherapy of glioblastoma. Cancer ; Medical imaging ; Positron Emission Tomography SIMOPRO Scientific result radiomarquage;zirconium;IRM; Tue, 06 Oct 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/DUB-virale-ubiquitin.aspx A study led by a team from the Institut Joliot (I2BC/B3S) reveals an unusual mode of interaction between a viral deubiquitinase and a ubiquitin, which appears to be optimized to finely control virus replication. Molecular mechanisms SB2SM Scientific result crystal structure;deubiquitinilation;viral protease; Tue, 08 Sep 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/SENIOR-cohort-cerebral-aging.aspx The SENIOR study, conducted by several NeuroSpin teams, consists in monitoring, since March 2012, a cohort of 100 subjects aged 50 to 70 years by annual MRI imaging over a period of 10 years, to establish a normal aging brain imaging biomarkers mapping. This publication in Alzheimer's Research & Therapy describes the baseline experimental protocol and presents first promising results. Neurodegenerative diseases ; Brain ; MRI ; Positron Emission Tomography Scientific result Tue, 04 Aug 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Dynamics-PTOX-thylakoides.aspx A collaboration led by I2BC researchers presents, in the Journal of Experimental Botany, a body of evidence for a dynamic association of the PTOX protein with thylakoid membranes, dependent on proton motive force. Bioenergy ; Molecular mechanisms SB2SM Scientific result photosystem;ATP; Sat, 02 May 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/BRCA2-breast-cancer.aspx ​In a study conducted by a team from the Institut Curie, I2BC researchers have used their NMR know-how to study the phosphorylation of BRCA2 and have thus contributed to revealing a mechanism potentially at the origin of chromosomal aberrations observed in breast BRCA2-mutated tumors. Molecular mechanisms ; Cancer SB2SM Scientific result homologous recombination;Rad51;kinase; Mon, 27 Apr 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mobile-laboratory-study-genetic-material-extinct-species.aspx A collaboration between researchers from I2BC@Saclay, the french Muséum National d'Histoire Naturelle and owners of prehistoric sites shows the possibility of using a mobile laboratory to quickly identify DNA of archaeological specimens. Evolution ; DNA Scientific result Wed, 08 Apr 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Innovative-approach-radiolabel-peptides-fluorine-18-PET-imaging.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated a new fluor-18 radiolabelling method for peptides used to characterize specific pathological molecular signatures and thus target treatments. Peptides were conjugated to a specific tag, then radiolabeled in a single step under mild conditions, making this approach an innovative solution for PET imaging of peptides labeled with fluorine-18. Chemistry ; Positron Emission Tomography ; Cancer Scientific result Mon, 17 Feb 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Lanreotide-nanoscrolls.aspx By studying the self-assembly of a hormone-derived peptide in the presence of lipid membranes, a team of the SB2SM (Joliot Institute / I2BC) in collaboration with the University of Rennes 1 and Ipsen biopharmaceutical group, shows how the interactions electrostatic type modify the structures of the assemblies formed by each of these molecules alone in solution. Molecular mechanisms ; Cell and molecular imaging SB2SM Scientific result Mon, 23 Sep 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Glucocorticoids-better-evaluation-effect-cancers.aspx Senescence specialists (SBIGEM), in collaboration with the SCBM and the CNRGH (Jacob Institute), show that glucocorticoids can delay or even short-circuit it and disrupt its function as a tumor suppressor. Cellular mechanisms ; Molecular mechanisms ; Cancer Fontenay-aux-Roses Scientific result MEK/ERK;oncogenesis;Senescence; Mon, 09 Sep 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Friedreich-Ataxia-reliable-in-vitro-model-function-frataxin.aspx By improving the in vitro reconstitution of the iron-sulfur clusters biosynthesis machinery, a team from SBIGEM (CEA-Joliot / I2BC), with its French, German and Spanish collaborators, clarifies the function of frataxin, a protein involved in Friedreich’s ataxia. Molecular mechanisms SBIGEM Scientific result Frataxin;Mössbauer;circular dichroism; Fri, 06 Sep 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/See-tumor-PET-imaging-click-chemistry-in-vivo.aspx A new PET imaging method by antibody pretargeting was developed at SHFJ, in collaboration with teams of SCBM and SPI. It consists in reacting in vivo a molecule labeled with 18Fluor with an antibody previously fixed on a tumor and this, in an extremely fast and selective manner, thanks to a « click-chemistry » reaction. The very good results obtained allow to consider the use of pre-targeted antibodies in nuclear medicine. Positron Emission Tomography ; Chemistry Scientific result Tue, 03 Sep 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Transcription-and-DNA-repair.aspx Recent work by SBIGeM (I2BC@Saclay) highlights how two essential components of DNA transcription into RNA coordinate to recruit the Rad2/XPG DNA repair protein, thus linking these two fundamental cellular processes. Molecular mechanisms ; DNA Scientific result Thu, 22 Aug 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-prediction-biomarker-tumor-progression-PET-images.aspx The SHFJ/IMIV laboratory (Inserm 1023/CNRS/CEA/UP-Sud), in collaboration with hospital-university teams, has shown that, in patients with advanced-stage large cell lymphoma (B type), automatic quantitative measurements of tumor dissemination detected by whole-body PET imaging have a predictive value of progression-free survival (tumor stabilization) and overall survival. Medical imaging ; Positron Emission Tomography ; Cancer Scientific result Tue, 16 Jul 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Drs2-Cdc50-CryoEM-Structure-Nature.aspx Researchers from I2BC@Saclay, the University of Aarhus and the Max Planck Institute of Biophysics in Frankfurt reveals the first cryo-EM high-resolution structures of one of the P4-ATPases. Study has been published in Nature. It give a better insight towards the understanding of the transport mechanisms of membrane lipids. A lipid pathway through the protein membrane domain is suggested. Structural biology ; Molecular mechanisms Saclay Press release ; Scientific result lipid asymetry;P4-ATPase;membrane lipid translocation; Thu, 27 Jun 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Towards-better-detection-glioblastoma-infiltration.aspx Glioblastoma is a very aggressive cancer of the central nervous system, mainly because of its ability to infiltrate the surrounding areas. A collaboration led by a team of SHFJ and involving NeuroSpin demonstrates the interest of two imaging techniques for the early detection of tumor infiltration. Cancer ; Medical imaging ; Positron Emission Tomography Scientific result PET imaging;glioblastoma; Tue, 26 Feb 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Alzheimer-disease-role-neuroimmune-reaction.aspx A collaboration involving the Sainte-Anne Hospital, the SHFJ, the Saint-Antoine research center and the ICM identified, through a PET brain imaging study in patients with Alzheimer's disease, two distinct kinetic profiles of the cerebral neuroimmune response, that impact the disease progression differently. Researchers propose an original model of neuroinflammation, likely to open new therapeutic avenues. Brain ; Alzheimer's disease ; Positron Emission Tomography Scientific result Thu, 10 Jan 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/Physicist-pharmacologists-to-better-understand-BBB.aspx Thanks to complementary imaging techniques, researchers from the SHFJ and NeuroSpin have shown that the physical blood-brain barrier (BBB) disruption is not necessarly enough to deliver some drugs into the brain, especially when there are recognized and supported by efflux transporters. Medical imaging ; MRI ; Positron Emission Tomography ; Cellular mechanisms SHFJ News Thu, 20 Dec 2018 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/New-function-discovered-protein-Rad52-serious-therapeutic-target-breast-cancer.aspx Rad52 has garnered great attention lately as a promising target in the battle against certain types of breast cancer. A team from IRCM, in partnership with researchers from the Frédéric-Joliot and Gustave Roussy Institutes, has shed new light on this protein. Stress response ; Molecular mechanisms Jacob Scientific result Rad51 filament;budding yeast;Srs2; Fri, 12 Oct 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/DNA-repair-zoom-first-steps.aspx A research team from the SB2SM (I2BC@Saclay), in collaboration with the CNRS, SOLEIL , Universities of Paris-Sud, Aix-Marseille and Paul Sabatier - Toulouse III and Gustave Roussy, has resolved structures of two complexes involved in radiation-induced DNA damages. These results were published in Nature Structural & Molecular Biology on October, the 5th. DNA ; Structural biology ; Molecular mechanisms SB2SM Press release Mon, 08 Oct 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/relationship-variants-BRCA1-cancer.aspx Research Teams from the Curie Institute, the Gustave Roussy Institute, as well as the biophysics teams from the Institute of Chemistry of Natural Substances and SB2SM (I2BC@Saclay) met to systematically identify structural defects and BRCA1 proteins encoded by variants of the BRCA1 gene, a gene predisposing to breast and ovarian cancer. Their results make it possible to propose a classification of these variants (neutral versus causal). Cancer ; Structural biology ; DNA Scientific result Fri, 28 Sep 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/LIFEx-popular.aspx ​IMIV unit (SHFJ), in collaboration with the Gustave Roussy Institute, has developed the free software platform LIFEx that allows to characterize the tumor heterogeneity from any type of medical images: PET, MRI, scanner, ultrasound. With nearly 900 members, this platform has an international success because it facilitates the realization of radiomic studies, conducted in the context of personalized medicine. Positron Emission Tomography ; MRI ; Medical imaging Scientific result Thu, 05 Jul 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/fludarabine-lymphoma-imaging.aspx ​The SHFJ LDM-PET team (GIP Cyceron, Caen), in collaboration with the University Hospital of Caen, successfully used, for the first time in the clinic, the radiopharmaceutical drug developed and produced by the researchers of the team. , the [18F] Fludarabine. This drug, which is innovative for lymphoproliferative diseases, has been shown to be more effective in terms of specificity and sensitivity than its current counterpart, [18F] FDG. Positron Emission Tomography ; Medical imaging Scientific result Wed, 23 May 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/advance-exchanges-recombination.aspx Collaborative work between the SBIGeM (I2BC@Saclay) and the Marseille Cancer Research Center, published in Molecular Cell, illuminates the mechanistic basis and genetic control of homologous recombination, a mechanism for repairing DNA breaks responsible for chromosome exchange during meiosis. However, canonical models do not explain the complexity of meiotic recombination profiles and this study, which reconstructs reaction intermediates, constitutes a major advance in the understanding of this mechanism. DNA ; Genomics News Tue, 15 May 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/pharmacokinetic-model-neuroinflammation.aspx ​Research Teams from SHFJ, MIRCen and NeuroSpin tested a pharmacokinetic analysis model of Positron-emission tomography (PET) data at 18F-DPA-714, taking into account endothelial cell activity not specifically associated with an inflammatory state. This model allows a more precise interpretation of PET images of neuroinflammation present in most neurodegenerative pathologies. Positron Emission Tomography ; Brain ; Health ＆ life sciences Scientific result Thu, 22 Feb 2018 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/pet_brain_damage_alcohol.aspx A Research Team from the SHFJ (IMIV) highlights, through a preclinical model of exposure to alcohol, an immediate and persistent neuro-immune response, several months after the initial exposure of alcohol. These results confirm the occurrence of brain damage that may play a key role in the neurological deficits reported in teenagers who like "binge-drinking", that is to say an excessive consumption of alcohol over a very short time. Brain ; Positron Emission Tomography Scientific result Tue, 07 Nov 2017 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/New_method_for_quantifying_images_in_PET_MRI.aspx Deriving from a collaboration between the SHFJ and MIRCen, this work presents a new and original method of quantification of positron emission tomography (PET) images adapted to hybrid PET / MRI cameras, developed by combining the expertise of MIRCen in MRI preclinical and SHFJ expertise in preclinical PET. Health ＆ life sciences ; Positron Emission Tomography ; MRI ; Medical imaging Scientific result Fri, 30 Jun 2017 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2017/It_happened_at_the_SHFJ.aspx The "First international course on PET in Epilepsy", organized by the SHFJ in early June, brought together about thirty international specialists in the field. The challenge was to disseminate know-how widely developed at SHFJ: the pre-surgical localization of epileptic foci by PET in patients with focal drug-resistant epilepsies, candidates for resection neurosurgery. Institutional ; Brain ; Positron Emission Tomography News Tue, 27 Jun 2017 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/A_new_vision_of_the_in_vivo_function_of_the_transcription_mediator.aspx An in vivo, in vitro and in silico study of the Mediator of Transcriptional Regulation has shown how the function of this multiprotein complex is coordinated with another essential component of the transcription machinery, the TFIIB factor, and the architecture of the promoter. This study, led by SBIGeM, was conducted in collaboration with several other Research Teams (CNRS, CEA, INRA). DNA ; Health ＆ life sciences Scientific result Tue, 31 Jan 2017 11:00:00 GMT