Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2020/Magnetic-sensors-ultra-sensitive-biochips.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.frhttps://www-cea-fr.admsite.extra.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot.png Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en Functionalization of the B subunit of Shiga toxin as a vaccine tool https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Functionalization-B-subunit-Shigatoxin-vaccine-tool.aspx Researchers at SIMoS (DMTS) describe the synthesis, engineering and evaluation of the properties of the B subunit of bacterial Shiga toxin (STxB), administered mucosally, as a vaccine tool. Their results confirm the value of using a synthetic STxB in an anti-tumor and anti-infectious vaccination strategy. Biotechnology ; Vaccine SIMOPRO Scientific result préclinique; Fri, 26 Jan 2024 11:00:00 GMT Click-Chemistry: optimized drug delivery from nanomicelles into tumor cells https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Click-Chemistry-optimized-drug-delivery-nanomicelles.aspx Researchers at SCBM have used a click-and-release chemistry approach to mass-release an anti-cancer drug into cells from cleavable nanomicelles, thanks to a bioorthogonal activation process. A step towards the development of new nanomedicines Chemistry ; Biotechnology SCBM Scientific result Fri, 10 Nov 2023 11:00:00 GMT Exploring the potential of a model cyanobacterium for the photosynthetic production of high-value terpenes https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Model-cyanobacterium-production-high-value-terpenes.aspx Through two publications, an I2BC team demonstrates the high biotechnological potential of the model cyanobacterium Synechocystis PCC 6803 for the photosynthetic production of high value-added organic compounds, the terpenes. Photosynthesis ; Microalgae ; Biotechnology SB2SM Scientific result Fri, 10 Feb 2023 11:00:00 GMT Discovery of a natural peptide from black mamba venom, with anticholinergic properties https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Discovery-natural-peptide-black-mamba-venom.aspx ​A team from SIMoS (DMTS) identifies and characterizes a toxin isolated from black mamba venom, whose specific anticholinergic properties at the type 2 acetylcholine receptor, a regulator of arterial tone, position it as a potential drug candidate for the treatment of cardiovascular diseases. Health & life sciences ; Biotechnology SIMOPRO Scientific result ; Article Mon, 21 Nov 2022 11:00:00 GMT Molecular engineering of antibodies to accommodate antigenic drift of SARS-CoV-1 and 2 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Engineering-antibodies-accommodate-antigenic-drift-SARS-CoV-1-2.aspx Researchers from SIMoS and SPI (DMTS) demonstrate that molecular engineering of llama antibodies, capable of neutralizing SARS-CoV-1, allows to obtain optimized antibodies with very high affinities for SARS-CoV-2 and its variants, the culprits of the Covid-19 epidemic. Biotechnology ; Virus SPI Scientific result Thu, 22 Sep 2022 10:00:00 GMT How to make biodrugs less immunogenic? Answer with a monoclonal antibody with anti-inflammatory properties https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/How-to-make-biodrugs-less-immunogenic.aspx SIMoS team, in collaboration with Bicêtre Hospital, shows that certolizumab pegol, a pegylated monoclonal antibody fragment for anti-inflammatory use, is less likely to trigger an adverse immune response than the non-pegylated form. Health & life sciences ; Biotechnology SIMOPRO Scientific result Mon, 20 Jun 2022 10:00:00 GMT Signal optimization in very high field functional MRI: a matter of compromise? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/tSNR-optimization-functional-MRI.aspx A NeuroSpin team (BAOBAB) has tested a signal denoising method dedicated to very high field (7T) functional MRI. It is based on the weighted combination of images from each reception channel of the radio frequency coil, a combination that optimizes the stability of the signal over time. MRI ; Physics Neurospin Scientific result ; Article Thu, 27 Jan 2022 11:00:00 GMT Deeptope: accelerating the development of therapeutic antibodies via high-throughput functional tests https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/Deeptope-start-up-Simos.aspx Deeptope, founded in February 2021 from a technology developed at the DMTS Laboratory of Cellular Immunology and Biotechnology (LICB), is a company of therapeutic antibody engineering that provides antibody optimization and characterization services to biotech or pharmaceutical firms with the goal of increasing the quality of antibodies in a very short timeframe. Biotechnology ; Pharmacology News ; Article Mon, 29 Nov 2021 11:00:00 GMT The most powerful MRI scanner in the world delivers its first images! https://www.cea.fr/drf/joliot/en/Pages/news/Press/premieres-images-irm-iseult-2021.aspx September 2021, the 11.7 Tesla MRI of the Iseult project, the most powerful in the world for human imaging, has just unveiled its first images. Health & life sciences ; Brain ; Physics Journalists ; general public ; Researchers ; Partners Neurospin News ; Press release ; Découvertes et avancées Brain;MRI;neuroanatomy;Iseult;supra; Thu, 07 Oct 2021 05:00:00 GMT Quantum physics in flowers: role of carotenoids https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Singlet-Fission-Plants-Carotenoids.aspx Researchers from I2BC (CEA-Joliot/CNRS/UPSay, in collaboration with the JP Bourgin Institute and the University of Vilnius, decipher for the first time the energy dissipation process called "singlet fission" in two natural flower carotenoids, a fundamental mechanism for the design of new and more efficient multi-electron photocatalysts. Solar energy ; Photosynthesis ; Quantum Physics Scientific result Mon, 30 Aug 2021 10:00:00 GMT Bruno Robert (head of SB2SM/I2BC) is awarded Honoris causa Professor at the University of Vilnius https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Bruno-Robert-awarded-Honoris-causa-Professor-Vilnius.aspx This appointment comes after more than 15 years of close scientific collaboration between Bruno Robert's team in CEA Paris-Saclay and the Physics Department of the University of Vilnius. Quantum Physics ; Photosynthesis News ; Article Thu, 19 Nov 2020 11:00:00 GMT A double ceramic probe to optimize magnetic resonance microscopy. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Double-ceramic-probe-magnetic-resonance-microscopy.aspx Researchers from the M-CUBE european consortium, together with a team from NeuroSpin, are demonstrating the possibility of imaging two samples by 17.2 T magnetic resonance microscopy (NeuroSpin imager), at a single acquisition time, using two coupled ceramic resonators (probes) that lead to a better signal-to-noise ratio compared to reference MRI probes. MRI ; Physics Scientific result ; Article Mon, 26 Oct 2020 11:00:00 GMT Synthetic biology: new tools to increase the diversity of the 2,5-diketopiperazines produced in E.coli https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Synthetic-biology-increase-diversity-diketopiperazines.aspx Researchers from I2BC (SBIGeM), in collaboration with teams from Sorbonne University, have characterized cyclodipeptide oxidases in vivo and shown that they are valuable tools for producing dehydrogenated 2,5-diketopiperazines, precursors of bioactive molecules of pharmaceutical interest, in Escherichia coli using synthetic biology approaches. Fundamental Research ; Health & life sciences ; Biotechnology Scientific result Fri, 25 Sep 2020 10:00:00 GMT SARS-CoV-2 detection: mass spectrometry shows its potential for rapidity. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/SARS-CoV-2-detection-mass-spectrometry-rapidity.aspx A team from SPI in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method. Mass spectrometry ; Virus ; Biodetection ; Diagnosis Scientific result Thu, 06 Aug 2020 10:00:00 GMT Towards a new generation of antennas for ultra-high field imaging of the brain https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/M-ONE-project-Antenna.aspx The European Commission once more places its trust on Multiwave company and its partners, Aix-Marseille Université, CEA and Université Catholique de Louvain to revolutionize ultra-high field magnetic resonance imaging of the brain. MRI ; Physics ; Brain News ; Europe ; Article Fri, 03 Apr 2020 10:00:00 GMT Success of the workshop organized under the EurobioTox European program https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Succes-workshop-EuroBioTox.aspx ​​A training seminar "on biological toxins and on site detection" on in situ detection of biological toxins for first responders and validation of forensic procedures was held at CEA Paris-Saclay from 3 to 5 March 2020. Biodetection SPI Event ; Article Tue, 31 Mar 2020 10:00:00 GMT Magnetic sensors for ultra-sensitive biochips https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Magnetic-sensors-ultra-sensitive-biochips.aspx Researchers from IRAMIS collaborated with a team from SPI (LERI) for the development of a microfluidic biochip ("lab-on-chip") based on ultra-sensitive magnetic sensors with giant magnetoresistance (GMR sensors), capable of individually and effectively detect magnetically-labeled biological targets. Biotechnology ; Biodetection ; Physics Scientific result Wed, 08 Jan 2020 11:00:00 GMT A ferredoxin to fuel metabolic pathways of biotechnological interest https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/A-ferredoxin-to-fuel-metabolic-pathways.aspx Researchers at BIAM and I2BC@Saclay, in collaboration with Japanese colleagues from Okayama University and Ehime, have characterized in a cyanobacterium a minor protein that diverts part of the energy from photosynthesis to secondary metabolic pathways. This discovery is promising to exploit these metabolic pathways in a biotechnological process of bioenergy production. Biotechnology ; Bioenergy ; Photosynthesis Scientific result Mon, 14 Oct 2019 10:00:00 GMT Iseult project: the MRI magnet has just reached a magnetic field of 9.51T https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2019/Iseult-Project-MRI-magnet-9,51T.aspx The magnet of the future MRI at 11.7 teslas of the Iseult project at NeuroSpin (CEA Paris-Saclay) reached a magnetic field of 9.51 teslas during tests carried out on Wednesday 22 May. This new level is a record since the magnet has become on this occasion the most powerful MRI magnet in the world for imaging in humans with a stored energy of 221 MJ. This successful outcome is the result of the work of the Iseult project’s team from the CEA. MRI ; Cryogenics ; Tools & research instruments ; Brain ; Physics ; Technologies Researchers ; general public ; Journalists Joliot Scientific result Fri, 24 May 2019 10:00:00 GMT A new ceramic probe for magnetic resonance microscopy. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-ceramic-probe-magnetic-resonance-microscopy.aspx ​The Fresnel Institute, in collaboration with the University of St Petersburg and a team from NeuroSpin, has developed a new ceramic resonator (probe) suitable for 17T magnetic resonance microscopy, i.e. for spatial resolutions below 100 μm3. This probe allows the production of MRI images with a signal-to-noise ratio 2 times greater than those obtained with reference probes, in copper. MRI ; Medical imaging ; Physics Scientific result Thu, 23 May 2019 10:00:00 GMT An original biotechnological approach to create new bioactive molecules https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/biotechnological-approach-new-bioactive-molecules.aspx ​Muriel Gondry's Research Team (I2BC@Saclay / SBIGeM), in collaboration with SIMOPRO and Biomolecules Laboratory of the Sorbonne University's one, produced 200 cyclodipeptides containing non-natural amino acids by luring and diverting the cellular machinery for the synthesis of proteins. This unprecedented approach significantly increases the diversity of these bioactive molecules. Biotechnology ; Structural biology Scientific result Mon, 05 Mar 2018 11:00:00 GMT The team of Laurent Bellanger receives the trophy of societal resilience. https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/societal_resilience_trophy_2015.aspx ​​On September 17, the jury for Societal Resilience Trophies of the French High Committee for Civil Defence (HCFDC) awarded to the team of Laurent Bellanger (CEA-IBITECS) the price of technological innovation​​​ for the development of the diagnostic test for Ebola virus disease, named Ebola eZYSCREEN®​​.​ CBRN-E threats ; Virus ; Biodetection News Thu, 17 Sep 2015 10:00:00 GMT Modulating cerebral cholesterol: a new avenue of research to treat Alzheimer’s disease? https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/I2BM_anglais/News/Scientific_news/Articles/2015/Modulating-cerebral-cholesterol-new-avenue-research-treat-Alzheimer.aspx Two French research teams have recently shown in a rodent model that overexpression of an enzyme capable of eliminating excess cholesterol in the brain can act in a beneficial way on the tau component of the disease to completely correct it. Alzheimer's disease ; Gene and cell therapy ; Biotechnology MIRcen Scientific result Mon, 14 Sep 2015 10:00:00 GMT Bio-magnet for targeted medical imaging https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/I2BM_anglais/News/Scientific_news/Articles/2015/Bio-magnet-for-targeted-medical-imaging.aspx The CEA-IBEB has partnered with the CEA-I2BM to develop original MRI contrast agents. Nano-magnets produced by bacteria may reveal targets at the molecular level. Biotechnology ; Cell and molecular imaging ; MRI ; Diagnosis ; Nanomedicine LBC Scientific result Fri, 20 Feb 2015 11:00:00 GMT