Frédéric Joliot Institute for Life Sciences - Sur le même thème

Regulation of Fe–S cluster biosynthesis, whose failure causes a rare neurological disease, finally elucidated !

Fri, 16 Jan 2026 11:00:00 GMT

A team from I2BC has uncovered the key steps governing the assembly and regulation of iron–sulfur cluster biosynthesis, essential metallic cofactors involved in numerous biological functions. Defects in this process lead to pathologies such as Friedreich’s ataxia. These studies represent major advances toward the development of future therapies.

Seismic-wave physics for diagnosing brain tumors with passive MRI elastography

Wed, 26 Nov 2025 11:00:00 GMT

Researchers at SHFJ and NeuroSpin applied a passive MRI elastography sequence to patients with brain tumors. This non-invasive approach provided information on tumor stiffness and nature, and could support early detection, surgical planning, and treatment monitoring.

A mechanism protecting telomeres against chromosomal fusions

Mon, 17 Nov 2025 11:00:00 GMT

Researchers from CEA-Jacob and the Genome Integrity team at I2BC, in collaboration with Gustave Roussy and the Institut Pasteur, demonstrate that the Rap1 protein prevents the translocation of the Ku protein— a major factor in double-strand break repair — thereby avoiding deleterious fusions between chromosomes.

Proof of concept for the passage of trastuzumab formulated in nanoparticles through an in vitro-reconstituted nasal epithelium.

Wed, 12 Nov 2025 11:00:00 GMT

Researchers from SPI (DMTS) developed a formulation of PLGA nanoparticles loaded with the anticancer trastuzumab (NP-TZB) and measured their ability to cross a cellular model of the nasal epithelial barrier. This first validated step supports a potential nose-to-brain (N2B) delivery route.

Cyanine 5-huwentoxin-IV : a new imaging agent for non-small cell lung cancer ?

Mon, 10 Nov 2025 11:00:00 GMT

A team from SIMoS (DMTS) has demonstrated the ability of a peptide derived from a spider venom toxin to detect overexpressed sodium channels in a metastatic non-small cell lung cancer (NSCLC) cell line.

Mitosis: condense to better attach

Mon, 08 Sep 2025 10:00:00 GMT

A study led by the I2BC shows that the formation of condensates of the enzyme KIF2C enables the concentration of two other proteins, PLK1 and phosphorylated BRCA2, on kinetochore microtubules during mitosis. This would serve to control chromosome alignment on the spindle and contribute to their stability.

Grâce à de petits motifs dans une séquence désordonnée, Rad52 organise l’assemblage de Rad51

Mon, 28 Jul 2025 10:00:00 GMT

En utilisant Saccharomyces cerevisiae comme modèle, des chercheurs des instituts CEA-Jacob et CEA-Joliot, et de l’Institut Curie, avec leurs partenaires du synchrotron SOLEIL, ont révélé comment la protéine Rad52 agit comme un chaperon pour guider et stabiliser l’assemblage de Rad51, une étape clé de la recombinaison homologue.

Cancer : transformer la mertansine en prodrogue pour une chimiothérapie ciblée et moins toxique grâce à une approche théranostique.

Tue, 01 Jul 2025 10:00:00 GMT

Une équipe du laboratoire BioMaps, en collaboration avec l’Institut Galien Paris-Saclay a mis au point une stratégie innovante associant une prodrogue polymère et l'imagerie par tomographie par émission de positons (TEP) pour améliorer l'efficacité de la mertansine, un agent antitumoral puissant mais toxique.

A promising drug candidate for the treatment of neonatal hypoxic-ischemic encephalopathy

Thu, 26 Jun 2025 10:00:00 GMT

Researchers from the SPI (DMTS) and the Women & Infants Hospital in Providence have laid the molecular basis for the neuroprotection of a purine derivative in a preclinical model of neonatal hypoxic-ischemic encephalopathy (HIE). The promising results support the development of this drug candidate to treat HIE in neonates.

Une méthode d’analyse en IRM de diffusion pour étudier les altérations des faisceaux de substance blanche dans la maladie d’Alzheimer et la pathologie LATE ?

Wed, 11 Jun 2025 10:00:00 GMT

Des chercheurs du SHFJ, de NeuroSpin et du GHU Paris Psychiatrie & Neurosciences mettent en évidence des différences dans les altérations des faisceaux de substance blanche entre des patients diagnostiqués Alzheimer et d’autres vraisemblablement atteints de la pathologie LATE.

Computational modeling reveals the nature of human alpha-synuclein interactions with polyethylene nanoplastics

Tue, 27 May 2025 10:00:00 GMT

A team from I2BC, in collaboration with the NIMBE (CEA-Iramis), is unveiling the nature of the interactions of human alpha-synuclein (hαSn) with polyethylene nanoplastics, using molecular dynamics simulations and experimental methods.

Theranostic antibodies targeting endothelin receptors in preclinical models of glioblastoma and melanoma

Thu, 22 May 2025 10:00:00 GMT

Researchers from SPI (DMTS) propose immunodiagnostic and immunotherapeutic approaches based on the use of innovative antibodies targeting two subtypes of endothelin receptors (ETA and ETB), recognised as relevant therapeutic targets in oncology.

Quand les interfaces protéine-ARN se réinventent : une conservation globale avec une pointe de versatilité !

Tue, 20 May 2025 10:00:00 GMT

Une équipe de l’I2BC a mené une étude prédictive de la structure des interfaces d’interaction dans les complexes protéine - ARN : bien que de nombreux aspects de ces interfaces soient largement conservés au cours de l’évolution, une grande versatilité existe dans les contacts polaires entre les molécules.

Synthesis of an anti-cancer drug in living cells using micelle-based nanoreactors

Fri, 11 Apr 2025 10:00:00 GMT

A team at SCBM (DMTS) has designed nanomicelles that can be activated by a bioorthogonal reaction releasing a first chemical species, which then reacts with a second compound encapsulated in the micelles. Application to the synthesis of an anti-cancer drug, sorafenib, inside living cells.

COVID-PATH: Unveiling the gut’s role in COVID-19 and Long COVID

Thu, 10 Apr 2025 10:00:00 GMT

The COVID-PATH project was officially launched on March 12, 2025, to investigate the gastrointestinal impact of SARS-CoV-2 and its link to Long COVID.

La progression du SARS-Cov-2 observée à l’échelle du corps entier

Wed, 02 Apr 2025 10:00:00 GMT

Le laboratoire BioMaps (SHFJ) a collaboré à une étude dirigée par IDMIT (CEA-Jacob) montrant en imagerie TEP sur le modèle animal primate la progression de SARS –Cov-2 en phase aigüe et trois mois après l’infection, notamment dans les poumons et le cerveau.

A new toxin derived from snake venom to treat kidney diseases

Thu, 20 Mar 2025 11:00:00 GMT

Researchers at SIMoS, SPI (DMTS) and BioMaps (SHFJ) report the development of a new molecule, MQ232, derived from mambaquaretin. As a specific antagonist of the vasopressin V2 receptor, MQ232 is a promising drug candidate for the treatment of renal pathologies.

Universal identification of pathogenic viruses by LC-MS/MS proteotyping

Wed, 29 Jan 2025 11:00:00 GMT

Researchers at Li2D (SPI/DMTS, Marcoule) have proposed an innovative tandem mass spectrometry proteotyping method for the universal identification of pathogenic viruses, requiring no prior knowledge of sample composition. A step towards improved diagnosis of viral infections

Un test bandelette pour détecter les infections à Candida auris

Mon, 20 Jan 2025 11:00:00 GMT

Des chercheurs du LERI (SPI/DMTS), en collaboration avec NG Biotech, ont développé un test-bandelette de détection de Candida auris, un champignon à l’origine d’infections nosocomiales de plus en plus fréquentes. Leurs premiers résultats sur des souches isolées indiquent d’excellentes performances du dispositif.

Immunological profiling of cancer : when click-chemistry meets mass spectrometry

Mon, 13 Jan 2025 11:00:00 GMT

Researchers at DMTS and SHFJ have carried out a multiplexed analysis of tumor cells and tissues, based on the use of cleavable therapeutic antibodies carrying mass tags, for the identification and quantification of cancer biomarkers. A proof-of-concept demonstrating the high potential of this tumor immunoprofiling approach

Immunothérapie anticancéreuse : un modèle structural pour comprendre l’action synergique de deux anticorps thérapeutiques sur la cible HER2

Fri, 08 Nov 2024 11:00:00 GMT

Des chercheurs de l’I2BC, en collaboration avec Sanofi, l’IMPMC et l’Institut Pasteur, ont modélisé la structure du complexe associant le récepteur membranaire HER2 avec deux fragments de liaison (Fab) de deux anticorps thérapeutiques dirigés contre cette cible, le trastuzumab et le pertuzumab.

Micelles : comment améliorer l’efficacité radiothérapeutique lorsque les tumeurs résistent ?

Wed, 23 Oct 2024 10:00:00 GMT

Des équipes du SCBM et du SHFJ, en collaboration avec le CEA-Jacob et l’ISMO ont développé une micelle perfluorée biocompatible pour améliorer l’efficacité des radiothérapies et qui serait particulièrement intéressante dans des environnements tumoraux radiorésistants.

Study of subcortical neuromodulatory systems alteration in Alzheimer's disease and related disorders

Wed, 16 Oct 2024 10:00:00 GMT

A team from GHU Paris and SHFJ has used brain MRI to study the integrity of the locus coeruleus and nucleus basalis of Meynert in patients with early-onset Alzheimer's disease (AD), age-related TDP-43 encephalopathy (LATE) and fronto-temporal dementia (FTD). Both structures are altered in early AD, LATE and probably FTD, making these neuromodulatory areas potential therapeutic targets

Studying functional brain connectivity to understand the different emotional states in bipolar disorder

Mon, 30 Sep 2024 10:00:00 GMT

A study conducted by NeuroSpin researchers reveals abnormalities in functional brain connectivity in the sub-nucleus region of the amygdala (emotion center), in patients with bipolar disorder. These anomalies, which depend on whether the patient is depressed or manic, are potential biomarkers of interest.

L’épigénétique comme biomarqueur d’efficacité thérapeutique contre le déficit en transporteur de la créatine lié à l’X.

Tue, 17 Sep 2024 10:00:00 GMT

Des résultats obtenus par une équipe du SPI, en collaboration avec CERES Brain Therapeutics et l’Université de Sharjah (Emirats arabes unis), indique que le niveau de méthylation de l’ADN pourrait constituer un biomarqueur intéressant de l’efficacité thérapeutique d’un traitement potentiel du déficit en transporteur de la créatine lié à l’X.

The structure of the transmembrane region of the SARS-CoV-2 nsp3 protein confirms its essential role in viral replication

Thu, 08 Aug 2024 10:00:00 GMT

An I2BC team has revealed the structure of the C-terminal transmembrane region of the SARS-CoV-2 protein nsp3, essential for virus replication. This region self-assembles into hexamers that form molecular pores on the surface of double-membrane vesicles, the sites of viral genome replication. Nsp3 therefore appears to be a promising therapeutic target.

DNA recombination: AlphaFold2 breaks a lock

Tue, 25 Jun 2024 10:00:00 GMT

Teams from I2BC, Institut Curie and IRB shed light on how the human nuclease MRN works. Structural predictions obtained with AlphaFold2 and confirmed by in vitro and in vivo experiments show that the phosphorylated Sae2/CtIP protein forms a network of interactions with MRN that favours the removal of its autoinhibition.

Insight into the activation process of MCM8-MCM9 Helicases

Wed, 22 May 2024 10:00:00 GMT

Researchers from the AMIG team (I2BC department), in collaboration with the IRB (Switzerland), have modeled the interaction between HROB and the helicases MCM8-MCM9, some mutations of which predispose individuals to infertility or cancer. They demonstrate that HROB promotes the catalytic activity of the MCM8-MCM9 complex but does not play a role in its recruitment or stability.

Response to intra-tumoral immunotherapy assessed by immunoPET in mice

Fri, 19 Apr 2024 10:00:00 GMT

A team from BioMaps (SHFJ), in partnership with the Gustave Roussy Institute, has used immunoPET imaging to assess the influence of tissue distribution on the efficacy of cancer immunotherapy, administered intra-tumor and intravenously in mice. Intratumoral administration is more effective and reduces overall exposure of organs at risk

A world premiere: the living brain imaged with unrivaled clarity thanks to the world’s most powerful MRI machine

Tue, 02 Apr 2024 10:00:00 GMT

The CEA is revealing a series of in vivo human brain images acquired with the Iseult MRI machine and its unmatched 11.7 teslas magnetic field strength. This success is the fruit of more than 20 years of R&D as part of the Iseult project, with one pillar goal being to design and build the world’s most powerful MRI machine. Its ambition is to study healthy and diseased human brains with an unprecedented resolution, allowing us to discover new details relating to the brain’s anatomy, connections, and activity.

Epigenetics: combining flexible and rigid regions in a single structure to guarantee genome replication and stability

Tue, 26 Mar 2024 11:00:00 GMT

A team from the I2BC, in collaboration with the Institut Curie and Soleil, has shown that the CAF-1 protein combines flexible regions and rigid modules in its spatial organisation to deposit histones on DNA and effectively couple this process to DNA synthesis.

Towards a neurodevelopmental model for the prediction of psychotic transition

Thu, 21 Mar 2024 11:00:00 GMT

A NeuroSpin team has built a predictive model for the onset of psychosis using a combination of supervised learning analyses and a model of neuroanatomical age, based on neuroimaging data from healthy subjects and those at risk of psychotic transition.

Nanometric micelles for targeted delivery of a prodrug against atherosclerosis

Thu, 14 Mar 2024 11:00:00 GMT

Teams from SCBM and SIMoS (DMTS) have developed nano-micelles for the vectorization of an active principle which regulates cholesterol metabolism towards atherosclerotic lesions.

Food allergies: the impact of E171 (titanium dioxide)

Wed, 28 Feb 2024 11:00:00 GMT

Researchers at the LIAA (SPI/DMTS) have shown that pre- and perinatal exposure of mice to titanium dioxide increases the risk of developing a food allergy, particularly in males.

Cryo-EM : A ring-shaped organisation for better control of the local concentration of BRCA2 essential for homologous recombination

Thu, 08 Feb 2024 11:00:00 GMT

A collaboration involving the I2BC has modelled the structure of the complex between HSF2BP and a fragment of BRCA2, which is essential for DNA repair by homologous recombination. The researchers propose a mechanism for regulating the unexpected ring-like assembly of this complex.

Protein-protein interactions: how to push forward the limits of the revolutionary AlphaFold2 programme?

Mon, 29 Jan 2024 11:00:00 GMT

In an article published in Nature Communications, researchers from the I2BC show that applying a fragmentation strategy to the protein partners of assemblies depending on intrinsically disordered regions very significantly improves AlphaFold2's prediction capacity.

Phytic acid: a small molecule that helps repair DNA breaks

Mon, 04 Dec 2023 11:00:00 GMT

In an article published in the journal Nucleic Acids Research, scientists from the I2BC, lPBS and the Institute for Structural and Chemical Biology (University of Leicester, UK) demonstrate how phytic acid, a product of cellular metabolism, stabilises the assembly of a complex enabling the repair of DNA breaks in humans.

Deciphering microbiota: multiplex proteotyping speeds up identification of microbial isolates

Fri, 24 Nov 2023 11:00:00 GMT

Researchers at SPI are proposing an innovative multiplexing method for rapid identification of several microbial isolates in a single mass spectrometry analysis. This approach opens up prospects for the large-scale identification of microorganisms resulting from culturomics programs.

Multiplier les chimères pour mieux comprendre les interactions inhibiteur-cible protéique

Tue, 12 Sep 2023 10:00:00 GMT

En substituant des segments d’hélice alpha par des segments d’oligo-urées dans un peptide inhibiteur d’ASF1, lui conférant ainsi une résistance accrue aux protéases, des chercheurs de l’I2BC en collaboration avec l’IECB explorent les modes de liaison de ces chimères peptide-urée à leur cible.

PET imaging monitoring of an antibody targeting endothelin receptors expressed by glioblastoma tumors

Thu, 07 Sep 2023 10:00:00 GMT

Researchers at BioMaps (SHFJ) and SPI (DMTS) have studied the pharmacokinetics of a novel immuno-radioligand targeting the endothelin A receptor (ETA), overexpressed in many cancers, particularly glioblastoma. The immunoPET imaging approach used in this study in a preclinical model confirms the theranostic potential of this antibody.

Identification of metabolomic signatures of high-grade breast tumors

Fri, 04 Aug 2023 10:00:00 GMT

The TIRO laboratory of the SHFJ (Nice) identifies for the first time discriminating biomarkers of high-grade invasive breast tumors, using a non-targeted metabolomics approach performed on surgical specimens and cytoponctions from patients at different stages of malignancy.

Longitudinal monitoring of tauopathy in PET imaging to better understand the various modalities of clinical evolution of Alzheimer's disease

Wed, 02 Aug 2023 10:00:00 GMT

A joint team from GHU Paris and BioMaps (SHFJ) conducted a 2-year longitudinal study of 27 people with Alzheimer's disease, tracking the progression of tau pathology measured by PET imaging, of cortical atrophy using MRI, and their links with cognitive decline.

Creatine transporter deficiency: use of two original models to characterize this rare genetic disease

Thu, 22 Jun 2023 10:00:00 GMT

Researchers at SPI (DMTS) have identified by mass spectrometry and bioinformatics analysis several biomarkers linked to the creatine transporter deficiency disorder (CTD) using two original models : mice with the clinical characteristics of CTD subjects and brain organoids derived from CTD patient cells.

Hypertension: an animal toxin active on angiotensin II receptors

Fri, 16 Jun 2023 10:00:00 GMT

SIMoS researchers have identified and characterised an animal toxin (A-CTX-Mila) as a ligand for angiotensin II receptors, which are involved in one of the signalling pathways targeted by antihypertensive drugs. A tool of choice for studying the cellular mechanisms controlled by these receptors.

DNA repair machinery more flexible thanks to PAXX?

Tue, 06 Jun 2023 10:00:00 GMT

An international collaboration led by researchers from I2BC/CEA-Joliot and IPBS (Toulouse) has solved the atomic structure of molecular assemblies involved in the repair of DNA double-strand breaks. The diversity of assemblies involving the PAXX protein identified in this study highlights the great flexibility of the repair machinery, which could reflect its ability to adapt to biological conditions. The results were published in Science Advances.

The "rabbit motif" in 18F-DOPA PET imaging for a simplified diagnostic evaluation of parkinsonian syndromes

Tue, 23 May 2023 10:00:00 GMT

BioMaps researchers compared the diagnostic performance of the rabbit visual pattern observed in 18F-DOPA PET imaging with the standard procedure approved by the international nuclear imaging societies for the diagnosis of parkinsonian syndromes in PET/MRI and obtained encouraging results, which may validate the clinical utility of such a model

Radiomarquage du crizotinib au fluor-18 : un nouvel outil pour suivre par TEP la biodistribution de ce médicament

Thu, 27 Apr 2023 10:00:00 GMT

Des chercheurs du SHFJ ont mis au point la radiosynthèse au fluor-18 du crizotinib, un médicament qui ne pénètre pas dans le cerveau. Ce nouvel outil pour l’imagerie TEP permettra d’explorer de futures stratégies visant à faire passer la barrière hémato-encéphalique à ce médicament pour traiter certaines métastases cérébrales.

Hepatitis E virus: AlphaFold to the rescue to better understand how this pathogen multiplies its genome

Wed, 08 Feb 2023 11:00:00 GMT

I2BC researchers unveil an atomic model of the hepatitis E virus replication polyprotein obtained with the AlphaFold artificial intelligence program. The model provides a better understanding of how this RNA virus multiplies its genome in infected cells.

Anatomical atypia in autistic people ? Fine morphological analyses contradict the results of the last decade

Mon, 06 Feb 2023 11:00:00 GMT

By studying the morphology of the cerebellar gray matter, an international consortium coordinated by NeuroSpin researchers concludes that there are no anatomical atypia in the cerebellum of people with autism.

Numerical simulation provides information on the restriction of BAF protein dynamics by phosphorylation

Mon, 16 Jan 2023 11:00:00 GMT

Using molecular dynamics simulation and NMR studies, I2BC researchers detail the restriction mechanisms of BAF protein dynamics due to its phosphorylation.

Detection of monkeypox: Mass spectrometry proves once again its effectiveness

Mon, 28 Nov 2022 11:00:00 GMT

A Li2D team has released the peptidomic profile of the virus that causes monkeypox, which they established using tandem mass spectrometry. These data should help to better understand the evolution of the epidemic and allow the creation of targeted tests to potentially detect the threat more quickly and prevent a new epidemic.

Molecular engineering of antibodies to accommodate antigenic drift of SARS-CoV-1 and 2

Thu, 22 Sep 2022 10:00:00 GMT

Researchers from SIMoS and SPI (DMTS) demonstrate that molecular engineering of llama antibodies, capable of neutralizing SARS-CoV-1, allows to obtain optimized antibodies with very high affinities for SARS-CoV-2 and its variants, the culprits of the Covid-19 epidemic.

Towards understanding the mechanisms responsible for intrahepatic cholestasis: biochemical and structural study of the human ATPase ATP8B1

Thu, 09 Jun 2022 10:00:00 GMT

A collaborative study involving an I2BC team unveils the mechanism of autoinhibition of the human flippase ATP8B1, as well as its regulation by lipids and phosphorylation. The study provides a better understanding of the impact of flippase mutations responsible for intrahepatic cholestasis on its enzymatic activity.

A possible link between changes in gut microbiota and fecal SARS-CoV-2 load ?

Thu, 12 May 2022 10:00:00 GMT

A team from SPI used mass spectrometry to analyze the degree of alteration of the intestinal microbiota of Covid-19 patients and to look for signatures of intestinal infection by the SARS-CoV-2 virus. The level of the observed gut dysbiosis would be an indicator of the stage and extent of the infection.

Food allergies: the sensitization route influences the immune response

Mon, 25 Apr 2022 10:00:00 GMT

Researchers at the LIAA (SPI/DMTS) show that the initial route of sensitization to a food allergen (oral, respiratory, cutaneous) directly influences the nature of immune responses at multiple sites in the body.

New radioligands for anti-PD-1/PD-L1 immunoPET

Tue, 12 Apr 2022 10:00:00 GMT

Researchers from the SHFJ and the DMTS have developed optimized radioligands for immunoPET imaging. The objective is to better predict the effectiveness of anti-PD1/anti-PDL1 immunotherapy used to fight certain cancers.

Alzheimer's: PET imaging of tau protein predicts cognitive decline and progression of brain atrophy

Sun, 03 Apr 2022 10:00:00 GMT

A joint team from GHU Paris and SHFJ shows the predictive value of PET imaging data of the Tau protein in the progression of Alzheimer's disease.

Inhibiting autophagy: a new line to fight cellular senescence?

Tue, 15 Mar 2022 11:00:00 GMT

Researchers from the Frédéric Joliot Institute have identified ouabain and chloroquine as two selective senolytic molecules that are effective in eliminating certain senescent cells. The study has been published in the journal Aging Cell.

7T Sodium MRI confirms early metabolic damage in Alzheimer's disease

Mon, 07 Mar 2022 11:00:00 GMT

7T Sodium MRI may well prove increasingly useful in the study of physiological processes in inflammatory and neurodegenerative diseases and brain tumors. An example is a study on Alzheimer's disease, led by a NeuroSpin team.

Brain development and mental health in adolescents and young adults

Tue, 25 Jan 2022 11:00:00 GMT

A NeuroSpin team has exploited data on mental health and brain developmental disorders of subjects in the Healthy Brain Network cohort. It established a link between certain symptoms, precursors of possible mood disorders, and structural changes in the developing brain in more than 650 young people.

The unveiling of atomic structure of lanreotide nanotubes surprises!

Thu, 20 Jan 2022 11:00:00 GMT

Thanks to recent developments in cryo-electron microscopy, a study led by a team from the I2BC reveals, at the atomic scale, the unsuspected structural complexity of lanreotide nanotubes, a drug used in the treatment of acromegaly and some neuro-endocrine cancers.

In silico modelling unveils mechanisms of coordination between pairing and crossovers during meiosis

Thu, 13 Jan 2022 11:00:00 GMT

In a study conducted by a team from the Institut Curie, researchers from the CEA-Joliot (B3S/I2BC department) have modeled in silico protein-protein interactions and thus contributed to establish at the molecular level the mechanisms that coordinate the pairing and recombination of homologous chromosomes during meiosis.

Biochemical analysis and mass spectrometry for the diagnosis of congenital disorders of glycosylation

Tue, 04 Jan 2022 11:00:00 GMT

A collaboration initiated in 2017 between AP-HP (Bichat Hospital), Paris-Saclay University (Inserm 1193) and the Laboratoire d’Études du Métabolisme des Médicaments (LEMM/SPI/DMTS), leading to 4 publications in 2021, is advancing knowledge on the origin of certain congenital disorders of glycosylation, through the identification of specific biochemical biomarkers.

Lipid biomarkers to identify the different stages of liver cirrhosis

Mon, 06 Dec 2021 11:00:00 GMT

European research teams, including one from the CEA's Joliot Institute, have analyzed the blood lipidome of patients with cirrhosis. They highlight specific biomarkers of the different stages of the disease.

Multiparametric PET-MRI imaging: toward a biological characterization of tumors at the supervoxel level

Wed, 10 Nov 2021 11:00:00 GMT

A collaborative study led by BioMaps researchers (SHFJ) demonstrates that fully integrated quantitative multiparametric analysis of non-small cell lung cancer in hybrid 18F-FDG PET/MRI 3T imaging is clinically feasible and could enable biological characterization of tumors at the supervoxel scale.

PET imaging of tau and amyloid deposits improves the diagnosis of progressive amnesia

Thu, 04 Nov 2021 11:00:00 GMT

Researchers from BioMaps (SHFJ) and the Service de Neurologie de la Mémoire et du Langage (Hôpital Ste-Anne) show, through amyloid and tau molecular imaging in patients followed for 2 years, that the diagnosis of progressive amnesia in the elderly is not necessarily Alzheimer's disease and may be caused by other mechanisms clearly distinguishable from it.

Identification of an immune signature of severe asthma in children

Mon, 11 Oct 2021 10:00:00 GMT

Researchers from the Laboratory of Food Immuno-Allergy (SPI/DMTS), in collaboration with the Necker-Enfants Malades Hospital, identify an immune signature of severe asthma (SA) in children, through a non-targeted global analysis of all immune and inflammatory constituents present in blood and bronchoalveolar lavages of children with SA.

Metaproteomics and data science for an eco-health diagnosis of soil microbiota

Thu, 07 Oct 2021 10:00:00 GMT

Researchers from Li2D (SPI/DMTS, Marcoule) and LSCE have developed an innovative methodology for analyzing soil microbiota based on an optimal computational interpretation of metaproteomic databases, which should lead to a better understanding of the impact of pollutants on soil quality and to the prediction of their restoration potential.

The european PPI4HPC project echoes high-performance computing at CEA for the modelisation of complex molecular assemblages

Tue, 14 Sep 2021 10:00:00 GMT

A project at the interface between quantum chemistry and molecular dynamics for the study of complex molecular assemblies, led by Michel Masella (Joliot) and Luigi Genovese (IRIG), makes it possible, for applications in biology/health, to take full advantage of the new supercomputers of the Public Procurement of Innovations for High-Performance Computing (PPI4HPC, H2020) project hosted at the Très Grand Centre de Calcul (TGCC) of the CEA-Bruyères-le-Châtel.

Structure of the BRCA2-HFS2BP complex: the interaction is not required for Rad51 recruitment to DNA in meiosis

Mon, 13 Sep 2021 10:00:00 GMT

By solving the three-dimensional structure of a fragment of the BRCA2-HSF2BP complex, a collaboration involving teams from I2BC and ERASMUS MC identifies the precise BRCA2 motif that causes the very high affinity between the two partners and shows that, in vivo, this complex has no function in the recruitment of Rad51 to meiotic sites of homologous recombination.

3rd version of the InterEvDock server: better exploiting protein sequence evolution data to improving the prediction of interface structures

Mon, 21 Jun 2021 10:00:00 GMT

Researchers at I2BC/CEA-Joliot, in collaboration with the RPBS platform, have developed the third version of their InterEvDock server for structural modelling of protein-protein interactions. The server integrates new algorithms for exploiting sequence evolution information.

Characteristics of the initial symptoms of Alzheimer's disease in young patients

Thu, 10 Jun 2021 10:00:00 GMT

Researchers from BioMaps (SHFJ) and the Department of Memory and Language Neurology (Ste Anne's Hospital) studied the early clinical signs of Alzheimer's disease (AD) reported by young patients (< 62 years old) compared to those reported in classic AD of the elderly (> 65 years old). They show that these signs are misleading and often appear in the professional context.

Molecular basis of the “scissors” mechanism involved in meiotic recombination and DNA repair

Mon, 07 Jun 2021 10:00:00 GMT

Researchers from I2BC/CEA-Joliot in collaboration with teams from Institut Curie and IRCM/CEA-Jacob, lay the molecular basis to explain the dual role of the Mlh1-Mlh3 complex in DNA mismatch repair and, quite uniquely, in one of the key steps of genetic mixing during meiosis.

Phosphorylation of BAF alters its dynamics and interaction with DNA but not its contacts with the nuclear envelope

Mon, 29 Mar 2021 10:00:00 GMT

A study by researchers from I2BC department shows in vitro the effect of mitotic phosphorylation of the BAF protein on its structure and its interactions with DNA and lamina and unveils consequences on genome organization and on mechanisms responsible for progeroid syndromes.

Aloïse Mabondzo receives exceptional funding from NIH !

Mon, 29 Mar 2021 10:00:00 GMT

Aloïse Mabondzo, research director, head of the Neurovascular Pharmacology Group of the SPI (DMTS), co-founder and scientific director (CSO) of CERES BRAIN THERAPEUTICS, has just obtained funding of nearly one million US dollars from the prestigious National Institute of Health for his project « Neuroprotective Strategy: Novel Purine Derivatives for Neonatal Hypoxia-ischemia ».

Salmonellosis and shigellosis: a monoclonal antibody induces cross-protection

Thu, 25 Mar 2021 11:00:00 GMT

Researchers at CEA-Joliot (SPI unit in collaboration with SIMoS unit) have developed a monoclonal antibody directed against a common region of two proteins of the bacteria Shigella and Salmonella and capable of inducing cross-protection against infections caused by these bacteria.

Anti-cancer therapeutic strategy: a chimera to inhibit ASF1

Fri, 19 Mar 2021 11:00:00 GMT

I2BC researchers, in collaboration with the European Institute of Chemistry and Biology (University of Bordeaux, CNRS), have developed a chimeric peptide/foldamer molecule that is resistant to proteolysis and inhibits ASF1, a potential target for anticancer treatment. The resolution of the structure of this chimera in interaction with its target, the first of its kind, reveals an unsuspected plasticity of the urea-based backbone that hugs the surface of ASF1.

First functional characterization of ATP2, an essential Plasmodium flippase and potential antimalarial target

Wed, 17 Mar 2021 11:00:00 GMT

I2BC researchers, in collaboration with the Autonomous University of Barcelona, have provided the first studies of the function and structural organization of a flippase encoded by a parasite responsible for malaria, a first step towards understanding the essential physiological function of this transporter and its potential use as an antimalarial target.

Première étape vers un test quantitatif par spectrométrie de masse pour le diagnostic spécifique de la COVID-19 ?

Tue, 09 Mar 2021 11:00:00 GMT

Le LEMM, en collaboration avec le LI2D et l’AP-HP, développe un test de diagnostic spécifique de la Covid-19 par spectrométrie de masse qui permettrait aussi la quantification de la charge virale du patient. Objectif à terme : adapter la méthode pour la rendre plus sensible et compatible avec les équipements d’analyse des hôpitaux.

A micellar probe for fluorine magnetic resonance tumor imaging

Thu, 04 Mar 2021 11:00:00 GMT

A SCBM (DMTS) team, in collaboration with researchers at NeuroSpin and I2BC, is describing micellar nanometric vectors targeting tumors that have been imaged by fluorine magnetic resonance imaging (MRI). The observed 19F signal made it possible to precisely delimit the volume of the tumor zone in a mouse model and to quantify the probe accumulated in the target tissue.

Metabolomics for the clinician and the development of a neuroprotective strategy in acute stroke

Thu, 04 Feb 2021 11:00:00 GMT

The TIRO team (SHFJ), in collaboration with the neurovascular clinicians of the Nice and Marseille University Hospitals, carried out analyses of the metabolome of cerebral clots at the origin of the occlusion of a cerebral artery responsible for a cerebral vascular accident (stroke). A pilot study that improved the understanding of the complex relationship between blood glucose levels and patients' functional prognosis.

SPI is committed to precision medicine for autoimmune and inflammatory diseases

Thu, 14 Jan 2021 11:00:00 GMT

Coordinated by the Imagine Institute for Genetic Diseases, the ATRACTion program is based on a consortium of 11 academic and industrial partners, including SPI (DMTS), and aims to develop a precision medicine for patients with autoimmune and inflammatory diseases associated with primary immune deficiencies.

Amazing discovery: Variovorax, a bacterium that lives in the heart of a working nuclear reactor!

Thu, 17 Dec 2020 11:00:00 GMT

Researchers from I2BC and SPI (DMTS, Marcoule), in collaboration with CEA Grenoble and the Belgian nuclear research center, discovered, by using two meta-omic approaches, living bacteria in the core pool of the CEA Paris-Saclay research reactor, Osiris, in operation, thus opening up perspectives for the discovery of new radioresistant species.

Flexizymes help undestanding the functioning of cyclodipeptide synthases

Thu, 05 Nov 2020 11:00:00 GMT

A team from I2BC (SBIGeM), in collaboration with DMTS, took advantage of flexizymes technology to elucidate the functioning of the synthases of cyclodipeptides, enzymes implicated in the synthesis of 2,5-diketopiperazines, compounds that represent an unequaled source of bioactive molecules for the pharmacopoeia.

Permeabilizing the blood-brain barrier to deliver therapeutic antibodies into the brain? ImmunoPET imaging provides answers

Tue, 06 Oct 2020 10:00:00 GMT

Researchers from SHFJ, NeuroSpin and DMTS have demonstrated, by immunoPET imaging, the impact of transient BBB permeabilization on brain exposure to an anti-EGFR antibody. Promising prospects for targeted immunotherapy of glioblastoma.

The peripheral nervous system is also altered in multiple sclerosis

Mon, 28 Sep 2020 10:00:00 GMT

A SIMoS team, in collaboration with the SHFJ, NeuroSpin and the Butantan Institute, is highlighting, in an experimental model of multiple sclerosis, alterations of the peripheral nervous system, hitherto little documented.

Composition of the microbiota of animals in natura: a challenge met by mass spectrometry

Mon, 24 Aug 2020 10:00:00 GMT

A team from SPI in Marcoule, in collaboration with INRAE, characterized the intestinal microbiota of a small crustacean, Gammarus fossarum, used as a sentinel of water quality in France, by combining proteogenomics and metaproteomics approaches, thus opening up interesting perspectives for the analysis of host/microbiota interactions in other animal models.

Lamins and Progeria: What Does Structural Biology Tell Us?

Mon, 24 Aug 2020 10:00:00 GMT

A team from the I2BC publishes in FEBS Journal an exhaustive review of the various mutations affecting the structure of type A lamins, proteins that make up the envelope of the cell nucleus (nuclear lamina), which lead to premature aging in people with the disease (Progeria).

SARS-CoV-2 detection: mass spectrometry shows its potential for rapidity.

Thu, 06 Aug 2020 10:00:00 GMT

A team from SPI in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method.

Mapping of normal brain aging: unprecedented results from the SENIOR cohort

Tue, 04 Aug 2020 10:00:00 GMT

The SENIOR study, conducted by several NeuroSpin teams, consists in monitoring, since March 2012, a cohort of 100 subjects aged 50 to 70 years by annual MRI imaging over a period of 10 years, to establish a normal aging brain imaging biomarkers mapping. This publication in Alzheimer's Research & Therapy describes the baseline experimental protocol and presents first promising results.

Bacteria and archaea: a new taxonomy to better describe the unknowns?

Mon, 20 Jul 2020 10:00:00 GMT

The discovery of myriads of new species of bacteria and archaea, linked to the explosion of metagenomics, is leading microbiologists to consider rethinking how to map certain branches of life. Tools, such as the phylopeptidomics developed at Li2D, could help them do so.

Proteomic analysis of SARS-CoV-2 infected cells

Mon, 06 Jul 2020 10:00:00 GMT

In order to optimize the amplification of quality inactivated virus, for the manufacture of a vaccine, a team from SPI (CEA Marcoule) used mass spectrometry to analyze the dynamics of the proteome of SARS-CoV-2 infected cells, at two multiplicities of infection. With more than 3,220 identified host proteins, researchers are also starting to decipher the processes and cellular networks impacted by this virus.

Mapping of Ebola T-cell response: towards a new vaccine ?

Wed, 24 Jun 2020 10:00:00 GMT

SIMoS researchers, in collaboration with Genopole, Excellgene, Vaxeal holding SA (Switzerland), used a large-scale approach to map and characterize the response of CD4 T-cells from healthy donors, against two proteins from the Ebola-Zaire virus. They observed a strong response to the viral nucleoprotein (NP) and suggest that components of NP may be included in the design of new Ebola vaccines.

Salmonellosis and shigellosis: first demonstration of cross-protection induced by virulence factors SipD and IpaD

Mon, 22 Jun 2020 10:00:00 GMT

SPI researchers show for the first time, in a mouse model, the induction of cross-protection against Salmonella and Shigella infections, two pathogenic bacteria responsible for gastrointestinal diseases (typhoid, dysentery among others), one of the main causes of morbidity and mortality in several regions of Africa and Asia.

Tracking down SARS-CoV-2 signature peptides is launched !

Fri, 05 Jun 2020 10:00:00 GMT

SPI researchers (Marcoule) used proteomics to identify signature peptides of the SARS-CoV-2 virus expressed in vitro. A "short list" of 14 identified and characterized peptides allows to consider developments in targeted mass spectrometry, making this direct and rapid large-scale approach, implantable in hospitals, a potential tool of choice in the detection of the virus responsible for Covid-19.

How the identification of attenuated forms of the SARS-CoV-2 virus could help to control the current epidemic ?

Tue, 12 May 2020 10:00:00 GMT

An opinion article, published in Environmental Microbiology, and written by an international consortium initiated by three researchers of Joliot Institute, proposes an original way of research on Covid-19 through the identification by sequencing of attenuated variants of the SARS-CoV-2 virus in populations at risk with little or no symptoms.

BRCA2 and breast cancer: a new mechanism revealed?

Mon, 27 Apr 2020 10:00:00 GMT

In a study conducted by a team from the Institut Curie, I2BC researchers have used their NMR know-how to study the phosphorylation of BRCA2 and have thus contributed to revealing a mechanism potentially at the origin of chromosomal aberrations observed in breast BRCA2-mutated tumors.

Characterization of a predictive survival biomarker in the event of septic shock

Tue, 24 Mar 2020 11:00:00 GMT

Two recent studies conducted by SPI researchers, in collaboration with Inserm and AP/HP teams, reveal the value of measuring plasma levels of calgranulins as biomarkers for the prediction of mortality risk of patients with septic shock, admitted in intensive care unit.

The way is now open for the development of a broad-spectrum drug candidate for several pathogenic viruses, bacteria and toxins

Fri, 21 Feb 2020 11:00:00 GMT

Innovative approach to radiolabel peptides with fluorine-18 for PET imaging

Mon, 17 Feb 2020 11:00:00 GMT

Radiochemists from the BioMaps unit (SHFJ) have developed and automated a new fluor-18 radiolabelling method for peptides used to characterize specific pathological molecular signatures and thus target treatments. Peptides were conjugated to a specific tag, then radiolabeled in a single step under mild conditions, making this approach an innovative solution for PET imaging of peptides labeled with fluorine-18.