Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Lamines-Progeria-Structural-Biology.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.frhttps://www-cea-fr.admsite.extra.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot.png Frédéric Joliot Institute for Life Sciences - Sur le même thème https://joliot.cea.fr/drf/joliot/en Towards a neurodevelopmental model for the prediction of psychotic transition https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Neurodevelopmental-model-prediction-psychotic-transition.aspx A NeuroSpin team has built a predictive model for the onset of psychosis using a combination of supervised learning analyses and a model of neuroanatomical age, based on neuroimaging data from healthy subjects and those at risk of psychotic transition. MRI ; Diseases ; Artificial intelligence ; Brain Neurospin Scientific result Thu, 21 Mar 2024 11:00:00 GMT Nanometric micelles for targeted delivery of a prodrug against atherosclerosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Nanomicelles-targeted-delivery-prodrug-atherosclerosis.aspx Teams from SCBM and SIMoS (DMTS) have developed nano-micelles for the vectorization of an active principle which regulates cholesterol metabolism towards atherosclerotic lesions. Nanomedicine ; Diseases SIMOPRO Scientific result ; Article preclinic;animal models; Thu, 14 Mar 2024 11:00:00 GMT Protein-protein interactions: how to push forward the limits of the revolutionary AlphaFold2 programme? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/proteins-proteins-interactions-AlphaFold2.aspx In an article published in Nature Communications, researchers from the I2BC show that applying a fragmentation strategy to the protein partners of assemblies depending on intrinsically disordered regions very significantly improves AlphaFold2's prediction capacity. Structural biology ; Artificial intelligence Researchers SB2SM Scientific result Mon, 29 Jan 2024 11:00:00 GMT Phytic acid: a small molecule that helps repair DNA breaks https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/phytic-acid-DNA-repair.aspx In an article published in the journal Nucleic Acids Research, scientists from the I2BC, lPBS and the Institute for Structural and Chemical Biology (University of Leicester, UK) demonstrate how phytic acid, a product of cellular metabolism, stabilises the assembly of a complex enabling the repair of DNA breaks in humans. DNA ; Structural biology Researchers SB2SM Scientific result ; Article Mon, 04 Dec 2023 11:00:00 GMT Deciphering microbiota: multiplex proteotyping speeds up identification of microbial isolates https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Multiplex-proteotyping-for-identification-microbial-isolates.aspx Researchers at SPI are proposing an innovative multiplexing method for rapid identification of several microbial isolates in a single mass spectrometry analysis. This approach opens up prospects for the large-scale identification of microorganisms resulting from culturomics programs. High-throughput screening ; Methodologies for life sciences ; Proteomics ; Bacteria SPI Scientific result Fri, 24 Nov 2023 11:00:00 GMT Multiplier les chimères pour mieux comprendre les interactions inhibiteur-cible protéique https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Multiplier-chimeres-mieux-comprendre-interactions-inhibiteur-cible-proteique.aspx En substituant des segments d’hélice alpha​ par des segments d’oligo-urées dans un peptide inhibiteur d’ASF1, lui conférant ainsi une résistance accrue aux protéases, des chercheurs de l’I2BC en collaboration avec l’IECB explorent les modes de liaison de ces chimères peptide-urée à leur cible. Molecular mechanisms ; Structural biology Researchers SB2SM Scientific result ; Article Tue, 12 Sep 2023 10:00:00 GMT PET imaging monitoring of an antibody targeting endothelin receptors expressed by glioblastoma tumors https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/PET-imaging-antibody-endothelin-receptors-glioblastoma-tumors.aspx Researchers at BioMaps (SHFJ) and SPI (DMTS) have studied the pharmacokinetics of a novel immuno-radioligand targeting the endothelin A receptor (ETA), overexpressed in many cancers, particularly glioblastoma. The immunoPET imaging approach used in this study in a preclinical model confirms the theranostic potential of this antibody. Positron Emission Tomography ; Cancer ; Medical imaging Neurospin Scientific result Thu, 07 Sep 2023 10:00:00 GMT Identification of metabolomic signatures of high-grade breast tumors https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Metabolomic-signatures-high-grade-breast-tumors.aspx The TIRO laboratory of the SHFJ (Nice) identifies for the first time discriminating biomarkers of high-grade invasive breast tumors, using a non-targeted metabolomics approach performed on surgical specimens and cytoponctions from patients at different stages of malignancy. Metabolomics ; Cancer ; Biomarkers SHFJ Scientific result Fri, 04 Aug 2023 10:00:00 GMT Longitudinal monitoring of tauopathy in PET imaging to better understand the various modalities of clinical evolution of Alzheimer's disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Longitudinal-monitoring-tauopathy-PET-imaging.aspx A joint team from GHU Paris and BioMaps (SHFJ) conducted a 2-year longitudinal study of 27 people with Alzheimer's disease, tracking the progression of tau pathology measured by PET imaging, of cortical atrophy using MRI, and their links with cognitive decline. Alzheimer's disease ; Medical imaging ; MRI ; Positron Emission Tomography SHFJ Scientific result ; Article Wed, 02 Aug 2023 10:00:00 GMT Creatine transporter deficiency: use of two original models to characterize this rare genetic disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Proteins-involved-pathogenesis-creatine-transporter-deficiency.aspx Researchers at SPI (DMTS) have identified by mass spectrometry and bioinformatics analysis several biomarkers linked to the creatine transporter deficiency disorder (CTD) using two original models : mice with the clinical characteristics of CTD subjects and brain organoids derived from CTD patient cells. Mass spectrometry ; Genetic diseases ; Biomarkers ; Proteomics SPI Scientific result Thu, 22 Jun 2023 10:00:00 GMT Hypertension: an animal toxin active on angiotensin II receptors https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/HTA-toxine-animale-recepteur-angiotensine-II.aspx SIMoS researchers have identified and characterised an animal toxin (A-CTX-Mila) as a ligand for angiotensin II receptors, which are involved in one of the signalling pathways targeted by antihypertensive drugs. A tool of choice for studying the cellular mechanisms controlled by these receptors. Molecular mechanisms ; Diseases Researchers SIMOPRO Scientific result Fri, 16 Jun 2023 10:00:00 GMT DNA repair machinery more flexible thanks to PAXX? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Reparation-ADN-PAXX.aspx An international collaboration led by researchers from I2BC/CEA-Joliot and IPBS (Toulouse) has solved the atomic structure of molecular assemblies involved in the repair of DNA double-strand breaks. The diversity of assemblies involving the PAXX protein identified in this study highlights the great flexibility of the repair machinery, which could reflect its ability to adapt to biological conditions. The results were published in Science Advances. Structural biology ; Molecular mechanisms Researchers SB2SM Scientific result cryoEM;radiocristallographie; Tue, 06 Jun 2023 10:00:00 GMT The "rabbit motif" in 18F-DOPA PET imaging for a simplified diagnostic evaluation of parkinsonian syndromes https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/rabbit-motif-PET-imaging-diagnostic-evaluation-parkinsonian-syndromes.aspx BioMaps researchers compared the diagnostic performance of the rabbit visual pattern observed in 18F-DOPA PET imaging with the standard procedure approved by the international nuclear imaging societies for the diagnosis of parkinsonian syndromes in PET/MRI and obtained encouraging results, which may validate the clinical utility of such a model Positron Emission Tomography ; Medical imaging ; Parkinson's disease ; Brain SHFJ Scientific result Tue, 23 May 2023 10:00:00 GMT Radiomarquage du crizotinib au fluor-18 : un nouvel outil pour suivre par TEP la biodistribution de ce médicament https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Radiomarquage-crizotinib-fluor-18-nouvel-outil-TEP.aspx Des chercheurs du SHFJ ont mis au point la radiosynthèse au fluor-18 du crizotinib, un médicament qui ne pénètre pas dans le cerveau. Ce nouvel outil pour l’imagerie TEP permettra d’explorer de futures stratégies visant à faire passer la barrière hémato-encéphalique à ce médicament pour traiter certaines métastases cérébrales. Positron Emission Tomography ; Cancer ; Diagnosis and innovative treatment Researchers SHFJ Scientific result ; Article Thu, 27 Apr 2023 10:00:00 GMT Hepatitis E virus: AlphaFold to the rescue to better understand how this pathogen multiplies its genome https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Virus-hepatite-E-AlphaFold.aspx I2BC researchers unveil an atomic model of the hepatitis E virus replication polyprotein obtained with the AlphaFold artificial intelligence program. The model provides a better understanding of how this RNA virus multiplies its genome in infected cells. Structural biology ; Simulation & modelling ; Artificial intelligence Researchers SB2SM Scientific result AlphaFold2;RNA virus;in vitro translation; Wed, 08 Feb 2023 11:00:00 GMT Anatomical atypia in autistic people ? Fine morphological analyses contradict the results of the last decade https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Anatomical-atypia-cerebellum-autistic-people.aspx By studying the morphology of the cerebellar gray matter, an international consortium coordinated by NeuroSpin researchers concludes that there are no anatomical atypia in the cerebellum of people with autism. Diseases ; Brain ; Medical imaging Researchers Saclay Scientific result IRM 3T;TDAH; Mon, 06 Feb 2023 11:00:00 GMT Numerical simulation provides information on the restriction of BAF protein dynamics by phosphorylation https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/BAF-numerical-simulation-phosphorylation.aspx Using molecular dynamics simulation and NMR studies, I2BC researchers detail the restriction mechanisms of BAF protein dynamics due to its phosphorylation. Molecular mechanisms ; Structural biology ; Simulation & modelling Researchers SB2SM Scientific result Mon, 16 Jan 2023 11:00:00 GMT Detection of monkeypox: Mass spectrometry proves once again its effectiveness https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Detection-monkeypox-massspectrometry.aspx A Li2D team has released the peptidomic profile of the virus that causes monkeypox, which they established using tandem mass spectrometry. These data should help to better understand the evolution of the epidemic and allow the creation of targeted tests to potentially detect the threat more quickly and prevent a new epidemic. Diagnosis ; Infectious diseases Researchers SPI Scientific result Mon, 28 Nov 2022 11:00:00 GMT Molecular engineering of antibodies to accommodate antigenic drift of SARS-CoV-1 and 2 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Engineering-antibodies-accommodate-antigenic-drift-SARS-CoV-1-2.aspx Researchers from SIMoS and SPI (DMTS) demonstrate that molecular engineering of llama antibodies, capable of neutralizing SARS-CoV-1, allows to obtain optimized antibodies with very high affinities for SARS-CoV-2 and its variants, the culprits of the Covid-19 epidemic. Biotechnology ; Virus SPI Scientific result Thu, 22 Sep 2022 10:00:00 GMT Towards understanding the mechanisms responsible for intrahepatic cholestasis: biochemical and structural study of the human ATPase ATP8B1 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Intrahepatic-cholestasis-biochemistry-structure-ATP8B1.aspx A collaborative study involving an I2BC team unveils the mechanism of autoinhibition of the human flippase ATP8B1, as well as its regulation by lipids and phosphorylation. The study provides a better understanding of the impact of flippase mutations responsible for intrahepatic cholestasis on its enzymatic activity. Molecular mechanisms ; Structural biology Researchers SB2SM Scientific result ATP;hydrolyse;protéine membranaire;modifications post-traductionnelles;expression hétérologue;membranes;cryo-EM; Thu, 09 Jun 2022 10:00:00 GMT A possible link between changes in gut microbiota and fecal SARS-CoV-2 load ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Link-intestinal-microbiota-Covid-19.aspx A team from SPI used mass spectrometry to analyze the degree of alteration of the intestinal microbiota of Covid-19 patients and to look for signatures of intestinal infection by the SARS-CoV-2 virus. The level of the observed gut dysbiosis would be an indicator of the stage and extent of the infection. Mass spectrometry ; Proteomics ; Biomarkers ; Infectious diseases SPI Scientific result ; Article Thu, 12 May 2022 10:00:00 GMT Food allergies: the sensitization route influences the immune response https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Food-allergies-sensitization-route-influences-immune-response.aspx Researchers at the LIAA (SPI/DMTS) show that the initial route of sensitization to a food allergen (oral, respiratory, cutaneous) directly influences the nature of immune responses at multiple sites in the body. Allergies ; Cellular mechanisms Researchers SPI Scientific result cellular immune responses;food allergy;BABL/c mice; Mon, 25 Apr 2022 10:00:00 GMT New radioligands for anti-PD-1/PD-L1 immunoPET https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Radioligands-immunoPET-PD-1-PD-L1.aspx Researchers from the SHFJ and the DMTS have developed optimized radioligands for immunoPET imaging. The objective is to better predict the effectiveness of anti-PD1/anti-PDL1 immunotherapy used to fight certain cancers. Positron Emission Tomography ; Cancer Researchers SIMOPRO Scientific result programmed cell death-ligand 1; Tue, 12 Apr 2022 10:00:00 GMT Alzheimer's: PET imaging of tau protein predicts cognitive decline and progression of brain atrophy https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Alzheimer-Tau-PET-imaging.aspx A joint team from GHU Paris and SHFJ shows the predictive value of PET imaging data of the Tau protein in the progression of Alzheimer's disease. Alzheimer's disease ; Positron Emission Tomography Researchers SHFJ Scientific result ; Press release radiotracer; Sun, 03 Apr 2022 10:00:00 GMT Inhibiting autophagy: a new line to fight cellular senescence? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Autophagy-senescence.aspx Researchers from the Frédéric Joliot Institute have identified ouabain and chloroquine as two selective senolytic molecules that are effective in eliminating certain senescent cells. The study has been published in the journal Aging Cell. Cancer ; Cellular mechanisms Researchers SCBM Scientific result Tue, 15 Mar 2022 11:00:00 GMT 7T Sodium MRI confirms early metabolic damage in Alzheimer's disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/7T-sodium-MRI-Alzheimer.aspx ​7T Sodium MRI may well prove increasingly useful in the study of physiological processes in inflammatory and neurodegenerative diseases and brain tumors. An example is a study on Alzheimer's disease, led by a NeuroSpin team. Brain ; Alzheimer's disease Researchers SHFJ Scientific result Mon, 07 Mar 2022 11:00:00 GMT Brain development and mental health in adolescents and young adults https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Brain-development-mental-health.aspx A NeuroSpin team has exploited data on mental health and brain developmental disorders of subjects in the Healthy Brain Network cohort. It established a link between certain symptoms, precursors of possible mood disorders, and structural changes in the developing brain in more than 650 young people. Brain ; Diseases Neurospin Scientific result Tue, 25 Jan 2022 11:00:00 GMT The unveiling of atomic structure of lanreotide nanotubes surprises! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/structure-nanotubes-lanreotide.aspx ​Thanks to recent developments in cryo-electron microscopy, a study led by a team from the I2BC reveals, at the atomic scale, the unsuspected structural complexity of lanreotide nanotubes, a drug used in the treatment of acromegaly and some neuro-endocrine cancers. Structural biology Researchers SB2SM Scientific result Thu, 20 Jan 2022 11:00:00 GMT In silico modelling unveils mechanisms of coordination between pairing and crossovers during meiosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Modeling-pairing-crossover-meiosis.aspx In a study conducted by a team from the Institut Curie, researchers from the CEA-Joliot (B3S/I2BC department) have modeled in silico protein-protein interactions and thus contributed to establish at the molecular level the mechanisms that coordinate the pairing and recombination of homologous chromosomes during meiosis. Simulation & modelling ; Structural biology ; Molecular mechanisms Researchers SB2SM Article ; Scientific result recombinaison homologue;AlphaFold;crossing-over;InterEvDock3; Thu, 13 Jan 2022 11:00:00 GMT Biochemical analysis and mass spectrometry for the diagnosis of congenital disorders of glycosylation https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Diagnosis-MS-congenital-disorders-glycosylation.aspx A collaboration initiated in 2017 between AP-HP (Bichat Hospital), Paris-Saclay University (Inserm 1193) and the Laboratoire d’Études du Métabolisme des Médicaments (LEMM/SPI/DMTS), leading to 4 publications in 2021, is advancing knowledge on the origin of certain congenital disorders of glycosylation, through the identification of specific biochemical biomarkers. Mass spectrometry ; Biomarkers ; Genetic diseases SPI Scientific result Tue, 04 Jan 2022 11:00:00 GMT Lipid biomarkers to identify the different stages of liver cirrhosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/biomarkers-lipids-cirrhosis.aspx European research teams, including one from the CEA's Joliot Institute, have analyzed the blood lipidome of patients with cirrhosis. They highlight specific biomarkers of the different stages of the disease. Methodologies for life sciences ; Biomarkers ; Diseases Researchers SPI Scientific result Mon, 06 Dec 2021 11:00:00 GMT Multiparametric PET-MRI imaging: toward a biological characterization of tumors at the supervoxel level https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PET-MRI-imaging-tumors-supervoxel-level.aspx A collaborative study led by BioMaps researchers (SHFJ) demonstrates that fully integrated quantitative multiparametric analysis of non-small cell lung cancer in hybrid 18F-FDG PET/MRI 3T imaging is clinically feasible and could enable biological characterization of tumors at the supervoxel scale. Medical imaging ; Positron Emission Tomography ; MRI ; Cancer Scientific result Wed, 10 Nov 2021 11:00:00 GMT PET imaging of tau and amyloid deposits improves the diagnosis of progressive amnesia https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Amyloid-tau-imaging-diagnosis-progressive-amnesia.aspx Researchers from BioMaps (SHFJ) and the Service de Neurologie de la Mémoire et du Langage (Hôpital Ste-Anne) show, through amyloid and tau molecular imaging in patients followed for 2 years, that the diagnosis of progressive amnesia in the elderly is not necessarily Alzheimer's disease and may be caused by other mechanisms clearly distinguishable from it. Positron Emission Tomography ; Medical imaging ; Alzheimer's disease Scientific result Thu, 04 Nov 2021 11:00:00 GMT Identification of an immune signature of severe asthma in children https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Immune-signature-severe-asthma-children.aspx Researchers from the Laboratory of Food Immuno-Allergy (SPI/DMTS), in collaboration with the Necker-Enfants Malades Hospital, identify an immune signature of severe asthma (SA) in children, through a non-targeted global analysis of all immune and inflammatory constituents present in blood and bronchoalveolar lavages of children with SA. Allergies ; Diseases Scientific result Mon, 11 Oct 2021 10:00:00 GMT Metaproteomics and data science for an eco-health diagnosis of soil microbiota https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Metaproteomics-data-science-soil-microbiota.aspx Researchers from Li2D (SPI/DMTS, Marcoule) and LSCE have developed an innovative methodology for analyzing soil microbiota based on an optimal computational interpretation of metaproteomic databases, which should lead to a better understanding of the impact of pollutants on soil quality and to the prediction of their restoration potential. Environment ; Proteomics ; Mass spectrometry ; Bacteria Scientific result Thu, 07 Oct 2021 10:00:00 GMT The european PPI4HPC project echoes high-performance computing at CEA for the modelisation of complex molecular assemblages https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/High-performance-computing-molecular-modelisation.aspx A project at the interface between quantum chemistry and molecular dynamics for the study of complex molecular assemblies, led by Michel Masella (Joliot) and Luigi Genovese (IRIG), makes it possible, for applications in biology/health, to take full advantage of the new supercomputers of the Public Procurement of Innovations for High-Performance Computing (PPI4HPC, H2020) project hosted at the Très Grand Centre de Calcul (TGCC) of the CEA-Bruyères-le-Châtel. Computing ; Simulation & modelling ; Supercomputers ; Structural biology News ; Article Tue, 14 Sep 2021 10:00:00 GMT Structure of the BRCA2-HFS2BP complex: the interaction is not required for Rad51 recruitment to DNA in meiosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/BRCA2-HFS2BP-meiosis.aspx By solving the three-dimensional structure of a fragment of the BRCA2-HSF2BP complex, a collaboration involving teams from I2BC and ERASMUS MC identifies the precise BRCA2 motif that causes the very high affinity between the two partners and shows that, in vivo, this complex has no function in the recruitment of Rad51 to meiotic sites of homologous recombination. Structural biology Researchers SB2SM Article ; Scientific result RMN;radiocristallographie; Mon, 13 Sep 2021 10:00:00 GMT 3rd version of the InterEvDock server: better exploiting protein sequence evolution data to improving the prediction of interface structures https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/InterEvDock3.aspx Researchers at I2BC/CEA-Joliot, in collaboration with the RPBS platform, have developed the third version of their InterEvDock server for structural modelling of protein-protein interactions. The server integrates new algorithms for exploiting sequence evolution information. Structural biology Researchers SB2SM Scientific result HADDOCK;FRODOCK;coMSAs;CAPRI; Mon, 21 Jun 2021 10:00:00 GMT Characteristics of the initial symptoms of Alzheimer's disease in young patients https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Initial-symptoms-Alzheimer-disease-in-young.aspx Researchers from BioMaps (SHFJ) and the Department of Memory and Language Neurology (Ste Anne's Hospital) studied the early clinical signs of Alzheimer's disease (AD) reported by young patients (< 62 years old) compared to those reported in classic AD of the elderly (> 65 years old). They show that these signs are misleading and often appear in the professional context. Alzheimer's disease ; Diagnosis ; Brain Scientific result Thu, 10 Jun 2021 10:00:00 GMT Molecular basis of the “scissors” mechanism involved in meiotic recombination and DNA repair https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Mlh1-Mlh3.aspx Researchers from I2BC/CEA-Joliot in collaboration with teams from Institut Curie and IRCM/CEA-Jacob, lay the molecular basis to explain the dual role of the Mlh1-Mlh3 complex in DNA mismatch repair and, quite uniquely, in one of the key steps of genetic mixing during meiosis. Structural biology Researchers SB2SM Scientific result cristallography;repair;recombination; Mon, 07 Jun 2021 10:00:00 GMT Phosphorylation of BAF alters its dynamics and interaction with DNA but not its contacts with the nuclear envelope https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/phosphorylation-BAF-interaction.aspx ​A study by researchers from I2BC department shows in vitro the effect of mitotic phosphorylation of the BAF protein on its structure and its interactions with DNA and lamina and unveils consequences on genome organization and on mechanisms responsible for progeroid syndromes. Molecular mechanisms ; DNA ; Structural biology Researchers SB2SM Scientific result NMR;radiocristallography; Mon, 29 Mar 2021 10:00:00 GMT Aloïse Mabondzo receives exceptional funding from NIH ! https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/A-Mabondzo-funding-from-NIH.aspx Aloïse Mabondzo, research director, head of the Neurovascular Pharmacology Group of the SPI (DMTS), co-founder and scientific director (CSO) of CERES BRAIN THERAPEUTICS, has just obtained funding of nearly one million US dollars from the prestigious National Institute of Health for his project « Neuroprotective Strategy: Novel Purine Derivatives for Neonatal Hypoxia-ischemia ». Brain ; Diseases News ; Article Mon, 29 Mar 2021 10:00:00 GMT Salmonellosis and shigellosis: a monoclonal antibody induces cross-protection https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Salmonellosis-shigellosis-monoclonal-Ab-cross-protection.aspx Researchers at CEA-Joliot (SPI unit in collaboration with SIMoS unit) have developed a monoclonal antibody directed against a common region of two proteins of the bacteria Shigella and Salmonella and capable of inducing cross-protection against infections caused by these bacteria. Bacteria ; Vaccine Researchers SIMOPRO Scientific result Antibody;IpaD-318;host cell;injectiosome; Thu, 25 Mar 2021 11:00:00 GMT Anti-cancer therapeutic strategy: a chimera to inhibit ASF1 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Foldamer-inhibitor-ASF1.aspx I2BC researchers, in collaboration with the European Institute of Chemistry and Biology (University of Bordeaux, CNRS), have developed a chimeric peptide/foldamer molecule that is resistant to proteolysis and inhibits ASF1, a potential target for anticancer treatment. The resolution of the structure of this chimera in interaction with its target, the first of its kind, reveals an unsuspected plasticity of the urea-based backbone that hugs the surface of ASF1. Structural biology ; Molecular mechanisms ; Epigenetics ; Cancer Researchers SB2SM Scientific result NMR;radiocristallography; Fri, 19 Mar 2021 11:00:00 GMT First functional characterization of ATP2, an essential Plasmodium flippase and potential antimalarial target https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Functional-characterization-PcATP2-essential-Plasmodium-flippase.aspx I2BC researchers, in collaboration with the Autonomous University of Barcelona, have provided the first studies of the function and structural organization of a flippase encoded by a parasite responsible for malaria, a first step towards understanding the essential physiological function of this transporter and its potential use as an antimalarial target. Structural biology ; Infectious diseases Scientific result Wed, 17 Mar 2021 11:00:00 GMT Première étape vers un test quantitatif par spectrométrie de masse pour le diagnostic spécifique de la COVID-19 ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Vers-test-quantitatif-MS-diagnostic-specifique-COVID-19.aspx Le LEMM, en collaboration avec le LI2D et l’AP-HP, développe un test de diagnostic spécifique de la Covid-19 par spectrométrie de masse qui permettrait aussi la quantification de la charge virale du patient. Objectif à terme : adapter la méthode pour la rendre plus sensible et compatible avec les équipements d’analyse des hôpitaux. Diagnosis ; Mass spectrometry ; Virus Researchers SPI Scientific result SARS-CoV-2; Tue, 09 Mar 2021 11:00:00 GMT A micellar probe for fluorine magnetic resonance tumor imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Micellar-probe-fluorine-MRI-tumor.aspx A SCBM (DMTS) team, in collaboration with researchers at NeuroSpin and I2BC, is describing micellar nanometric vectors targeting tumors that have been imaged by fluorine magnetic resonance imaging (MRI). The observed 19F signal made it possible to precisely delimit the volume of the tumor zone in a mouse model and to quantify the probe accumulated in the target tissue. Chemistry ; Nanomedicine ; Cancer ; MRI Scientific result Thu, 04 Mar 2021 11:00:00 GMT Metabolomics for the clinician and the development of a neuroprotective strategy in acute stroke https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Metabolomics-clinician-neuroprotective-strategy-stroke.aspx The TIRO team (SHFJ), in collaboration with the neurovascular clinicians of the Nice and Marseille University Hospitals, carried out analyses of the metabolome of cerebral clots at the origin of the occlusion of a cerebral artery responsible for a cerebral vascular accident (stroke). A pilot study that improved the understanding of the complex relationship between blood glucose levels and patients' functional prognosis. Metabolomics ; Brain ; Diseases Scientific result Thu, 04 Feb 2021 11:00:00 GMT SPI is committed to precision medicine for autoimmune and inflammatory diseases https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/SPI-ATRACTion-consortium.aspx Coordinated by the Imagine Institute for Genetic Diseases, the ATRACTion program is based on a consortium of 11 academic and industrial partners, including SPI (DMTS), and aims to develop a precision medicine for patients with autoimmune and inflammatory diseases associated with primary immune deficiencies. Metabolomics ; Mass spectrometry ; Autoimmune diseases News Thu, 14 Jan 2021 11:00:00 GMT Amazing discovery: Variovorax, a bacterium that lives in the heart of a working nuclear reactor! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Variovorax-bacteria-living-heart-working-nuclear-reactor.aspx Researchers from I2BC and SPI (DMTS, Marcoule), in collaboration with CEA Grenoble and the Belgian nuclear research center, discovered, by using two meta-omic approaches, living bacteria in the core pool of the CEA Paris-Saclay research reactor, Osiris, in operation, thus opening up perspectives for the discovery of new radioresistant species. Bacteria ; Nuclear Toxicology Scientific result Thu, 17 Dec 2020 11:00:00 GMT Flexizymes help undestanding the functioning of cyclodipeptide synthases https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Flexizymes-undestanding-functioning-cyclodipeptide-synthases.aspx A team from I2BC (SBIGeM), in collaboration with DMTS, took advantage of flexizymes technology to elucidate the functioning of the synthases of cyclodipeptides, enzymes implicated in the synthesis of 2,5-diketopiperazines, compounds that represent an unequaled source of bioactive molecules for the pharmacopoeia. Health & life sciences ; Bacteria Scientific result Thu, 05 Nov 2020 11:00:00 GMT Permeabilizing the blood-brain barrier to deliver therapeutic antibodies into the brain? ImmunoPET imaging provides answers https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/ImmunoPET-BBB-Ab.aspx Researchers from SHFJ, NeuroSpin and DMTS have demonstrated, by immunoPET imaging, the impact of transient BBB permeabilization on brain exposure to an anti-EGFR antibody. Promising prospects for targeted immunotherapy of glioblastoma. Cancer ; Medical imaging ; Positron Emission Tomography SIMOPRO Scientific result radiomarquage;zirconium;IRM; Tue, 06 Oct 2020 10:00:00 GMT The peripheral nervous system is also altered in multiple sclerosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Alteration-SNP-multiple-sclerosis.aspx A SIMoS team, in collaboration with the SHFJ, NeuroSpin and the Butantan Institute, is highlighting, in an experimental model of multiple sclerosis, alterations of the peripheral nervous system, hitherto little documented. Autoimmune diseases SIMOPRO Scientific result Mon, 28 Sep 2020 10:00:00 GMT Composition of the microbiota of animals in natura: a challenge met by mass spectrometry https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Composition-microbiota-animals-in-natura-mass-spectro.aspx A team from SPI in Marcoule, in collaboration with INRAE, characterized the intestinal microbiota of a small crustacean, Gammarus fossarum, used as a sentinel of water quality in France, by combining proteogenomics and metaproteomics approaches, thus opening up interesting perspectives for the analysis of host/microbiota interactions in other animal models. Mass spectrometry ; Bacteria ; Metagenomics ; Proteomics Scientific result Mon, 24 Aug 2020 10:00:00 GMT Lamins and Progeria: What Does Structural Biology Tell Us? https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Lamines-Progeria-Structural-Biology.aspx A team from the I2BC publishes in FEBS Journal an exhaustive review of the various mutations affecting the structure of type A lamins, proteins that make up the envelope of the cell nucleus (nuclear lamina), which lead to premature aging in people with the disease (Progeria). Structural biology ; Diseases Mon, 24 Aug 2020 10:00:00 GMT SARS-CoV-2 detection: mass spectrometry shows its potential for rapidity. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/SARS-CoV-2-detection-mass-spectrometry-rapidity.aspx A team from SPI in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method. Mass spectrometry ; Virus ; Biodetection ; Diagnosis Scientific result Thu, 06 Aug 2020 10:00:00 GMT Mapping of normal brain aging: unprecedented results from the SENIOR cohort https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/SENIOR-cohort-cerebral-aging.aspx The SENIOR study, conducted by several NeuroSpin teams, consists in monitoring, since March 2012, a cohort of 100 subjects aged 50 to 70 years by annual MRI imaging over a period of 10 years, to establish a normal aging brain imaging biomarkers mapping. This publication in Alzheimer's Research & Therapy describes the baseline experimental protocol and presents first promising results. Neurodegenerative diseases ; Brain ; MRI ; Positron Emission Tomography Scientific result Tue, 04 Aug 2020 10:00:00 GMT Bacteria and archaea: a new taxonomy to better describe the unknowns? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/New-taxonomy-bacteria-archea.aspx The discovery of myriads of new species of bacteria and archaea, linked to the explosion of metagenomics, is leading microbiologists to consider rethinking how to map certain branches of life. Tools, such as the phylopeptidomics developed at Li2D, could help them do so. Mass spectrometry ; Bacteria ; Proteomics Researchers SPI Mon, 20 Jul 2020 10:00:00 GMT Proteomic analysis of SARS-CoV-2 infected cells https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Proteomic-analysis-SARS-CoV-2-infected-cells.aspx In order to optimize the amplification of quality inactivated virus, for the manufacture of a vaccine, a team from SPI (CEA Marcoule) used mass spectrometry to analyze the dynamics of the proteome of SARS-CoV-2 infected cells, at two multiplicities of infection. With more than 3,220 identified host proteins, researchers are also starting to decipher the processes and cellular networks impacted by this virus. Virus ; Mass spectrometry ; Proteomics News Mon, 06 Jul 2020 10:00:00 GMT Mapping of Ebola T-cell response: towards a new vaccine ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mapping-Ebola-T-cell-response.aspx SIMoS researchers, in collaboration with Genopole, Excellgene, Vaxeal holding SA (Switzerland), used a large-scale approach to map and characterize the response of CD4 T-cells from healthy donors, against two proteins from the Ebola-Zaire virus. They observed a strong response to the viral nucleoprotein (NP) and suggest that components of NP may be included in the design of new Ebola vaccines. Virus ; Vaccine Scientific result Wed, 24 Jun 2020 10:00:00 GMT Salmonellosis and shigellosis: first demonstration of cross-protection induced by virulence factors SipD and IpaD https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Salmonella-shigella-cross-protection.aspx SPI researchers show for the first time, in a mouse model, the induction of cross-protection against Salmonella and Shigella infections, two pathogenic bacteria responsible for gastrointestinal diseases (typhoid, dysentery among others), one of the main causes of morbidity and mortality in several regions of Africa and Asia. Vaccine ; Bacteria Scientific result Mon, 22 Jun 2020 10:00:00 GMT Tracking down SARS-CoV-2 signature peptides is launched ! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Proteomics-SARS-CoV-2-signature-peptides.aspx SPI researchers (Marcoule) used proteomics to identify signature peptides of the SARS-CoV-2 virus expressed in vitro. A "short list" of 14 identified and characterized peptides allows to consider developments in targeted mass spectrometry, making this direct and rapid large-scale approach, implantable in hospitals, a potential tool of choice in the detection of the virus responsible for Covid-19. Proteomics ; Virus Scientific result Fri, 05 Jun 2020 10:00:00 GMT How the identification of attenuated forms of the SARS-CoV-2 virus could help to control the current epidemic ? https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Identification-attenuated-covid-virus-variants.aspx An opinion article, published in Environmental Microbiology, and written by an international consortium initiated by three researchers of Joliot Institute, proposes an original way of research on Covid-19 through the identification by sequencing of attenuated variants of the SARS-CoV-2 virus in populations at risk with little or no symptoms. Virus ; Genomics ; Vaccine Tue, 12 May 2020 10:00:00 GMT BRCA2 and breast cancer: a new mechanism revealed? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/BRCA2-breast-cancer.aspx ​In a study conducted by a team from the Institut Curie, I2BC researchers have used their NMR know-how to study the phosphorylation of BRCA2 and have thus contributed to revealing a mechanism potentially at the origin of chromosomal aberrations observed in breast BRCA2-mutated tumors. Molecular mechanisms ; Cancer SB2SM Scientific result homologous recombination;Rad51;kinase; Mon, 27 Apr 2020 10:00:00 GMT Characterization of a predictive survival biomarker in the event of septic shock https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Characterization-predictive-survival-biomarker-septic-shock.aspx Two recent studies conducted by SPI researchers, in collaboration with Inserm and AP/HP teams, reveal the value of measuring plasma levels of calgranulins as biomarkers for the prediction of mortality risk of patients with septic shock, admitted in intensive care unit. Biomarkers ; Mass spectrometry ; Infectious diseases Scientific result Tue, 24 Mar 2020 11:00:00 GMT The way is now open for the development of a broad-spectrum drug candidate for several pathogenic viruses, bacteria and toxins https://www.cea.fr/drf/joliot/en/Pages/news/Press/The-way-is-now-open-for-the-development-of-a-broad-spectrum-drug-candidate-for-several-pathogenic-viruses,-bacteria-and-tox.aspx Health & life sciences ; Toxicology ; Virus News ; Press release Fri, 21 Feb 2020 11:00:00 GMT Innovative approach to radiolabel peptides with fluorine-18 for PET imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Innovative-approach-radiolabel-peptides-fluorine-18-PET-imaging.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated a new fluor-18 radiolabelling method for peptides used to characterize specific pathological molecular signatures and thus target treatments. Peptides were conjugated to a specific tag, then radiolabeled in a single step under mild conditions, making this approach an innovative solution for PET imaging of peptides labeled with fluorine-18. Chemistry ; Positron Emission Tomography ; Cancer Scientific result Mon, 17 Feb 2020 11:00:00 GMT Alzheimer's or Lewy bodies dementia? The answer with high-resolution mass spectrometry https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Alzheimer-or-Lewy-bodies-dementia-MS-answer.aspx A team from SPI, in collaboration with the metabolic biochemistry service and the Institute of Memory and Alzheimer's Disease (IM²A) of the university hospitals Pitié-Salpêtrière, has developed a method for the simultaneous quantification of tau and α-synuclein proteins in human cerebrospinal fluid by high-resolution mass spectrometry. A promising new approach for the differential diagnosis of Lewy bodies dementia and Alzheimer's disease. Neurodegenerative diseases ; Mass spectrometry Scientific result Thu, 07 Nov 2019 11:00:00 GMT Alzheimer's: a more effective method to diagnose the disease? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Sulcal-morphology-to-diagnose-Alzheimer.aspx A study conducted by Maxime Bertoux (Unit 1171 Inserm / Lille University / CHU Lille) in collaboration with researchers from the Centre Hospitalier Saint Anne, the SHFJ (CEA-Joliot), NeuroSpin (CEA-Joliot) and the ICM shows that the morphological analysis of the cortical sulci would make it possible to recognize Alzheimer's disease in 91% of the cases, against 80% now by anatomical analysis of the cortex. Alzheimer's disease ; MRI Researchers SHFJ Scientific result Fri, 20 Sep 2019 10:00:00 GMT NeuroSpin and ENIGMA identify a potential biomarker of bipolar disorder https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/NeuroSpin-ENIGMA-potential-biomarker-bipolar-disorder.aspx NeuroSpin's psychiatric researchers and the Inserm U955 unit (CHU Mondor) coordinated, in collaboration with the ENIGMA consortium (an international group of researchers sharing brain imaging data), the first mega-analysis of diffusion MRI data including 3033 subjects with or without bipolar disorders. They identified extensive abnormalities in the cerebral white matter microstructure in sick people. Abnormalities that could represent a robust biomarker of bipolar disorder. Brain ; MRI ; Diseases Scientific result Tue, 10 Sep 2019 10:00:00 GMT Glucocorticoids: a better evaluation of their effects in specific cancers? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Glucocorticoids-better-evaluation-effect-cancers.aspx Senescence specialists (SBIGEM), in collaboration with the SCBM and the CNRGH (Jacob Institute), show that glucocorticoids can delay or even short-circuit it and disrupt its function as a tumor suppressor. Cellular mechanisms ; Molecular mechanisms ; Cancer Fontenay-aux-Roses Scientific result MEK/ERK;oncogenesis;Senescence; Mon, 09 Sep 2019 10:00:00 GMT 11.7 teslas: The World-Record Magnetic Field Generated by a Human MRI Magnet https://www.cea.fr/drf/joliot/en/Pages/news/Press/Iseult-MRI-Magnet-Record.aspx The Iseult project magnet being installed at Neurospin (CEA Paris-Saclay) reached a nominal magnetic field of 11.7 teslas (T) on July 18, 2019. This is a world record for a whole-body magnetic resonance imager (MRI) magnet, the culmination of years of R&D, at the forefront of innovation in the field of superconducting magnets. Fundamental Research ; Health & life sciences ; Brain ; Neurodegenerative diseases ; Diseases ; Tools & research instruments Journalists ; general public ; Institutions ; Companies ; Partners ; Researchers Neurospin Press release ; News ; En direct ; Focus Joliot;NeuroSpin;RFU;GE HealthCare;IRM;Iseult;magnet;Brain;MRI; Thu, 18 Jul 2019 11:49:45 GMT A new biomarker to predict tumor progression from whole body PET images. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-prediction-biomarker-tumor-progression-PET-images.aspx The SHFJ/IMIV laboratory (Inserm 1023/CNRS/CEA/UP-Sud), in collaboration with hospital-university teams, has shown that, in patients with advanced-stage large cell lymphoma (B type), automatic quantitative measurements of tumor dissemination detected by whole-body PET imaging have a predictive value of progression-free survival (tumor stabilization) and overall survival. Medical imaging ; Positron Emission Tomography ; Cancer Scientific result Tue, 16 Jul 2019 10:00:00 GMT Lipid transmembrane transport: very first structures are revealed! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Drs2-Cdc50-CryoEM-Structure-Nature.aspx Researchers from I2BC@Saclay, the University of Aarhus and the Max Planck Institute of Biophysics in Frankfurt reveals the first cryo-EM high-resolution structures of one of the P4-ATPases. Study has been published in Nature. It give a better insight towards the understanding of the transport mechanisms of membrane lipids. A lipid pathway through the protein membrane domain is suggested. Structural biology ; Molecular mechanisms Saclay Press release ; Scientific result lipid asymetry;P4-ATPase;membrane lipid translocation; Thu, 27 Jun 2019 10:00:00 GMT How a “self” protein can be immunogenic? The example of relaxin, a human hormone https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Relaxin-immunogenic.aspx A collaboration between teams from SIMOPRO and Sanofi sheds new light on the origin of the immune responses developed by patients with scleroderma when treated by injection of relaxin, a therapeutic protein. The study was published in The Journal of Immunology. Autoimmune diseases ; Cellular mechanisms Saclay Tue, 18 Jun 2019 10:00:00 GMT A promising therapeutic innovation for creatine transporter deficiency. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/therapeutic-innovation-creatine-transporter-deficiency.aspx ​Two teams from JOLIOT (SPI / SCBM), in collaboration with the University of Cincinnati, confirm the interest of a drug candidate to treat the congenital creatine deficiency syndrome, a rare neurological childhood disease, responsible for developmental delays and intellectual disability. The results obtained in an animal model of the disease show that it is possible to administer, nasally, dodecyl creatine ester-loaded microspheres, thus improving the cognitive functions of treated animals. Genetic diseases ; Pharmacology Scientific result Fri, 17 May 2019 10:00:00 GMT FRISBI: the structural biology platform of Genopole joins the National Infrastructure https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2019/Genopole-structural-biology-platforms-joins-FRISBI.aspx The French National Infrastructure of Integrated Structural Biology (FRISBI) is now integratinf Genopole's structural biology platform into its Paris-Sud node. Structural biology Researchers Saclay Academic partnerships i;microscope à force atomique;plateforme; Fri, 10 May 2019 10:00:00 GMT « Click and Release » chemistry for the targeted delivery of drugs in vivo https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Click-Release-chemistry-targeted-delivery-drug-invivo.aspx A team from the SCBM, in collaboration with the SPI, the IC2MP and the University Hospital of Poitiers, has developed a bioorthogonal chemistry strategy that allows, in vivo, the controlled release of active ingredients contained in micelles-targeting cancerous tumors. These results pave the way for new strategies for targeted drug delivery. Chemistry ; Cancer ; Nanomedicine Scientific result Fri, 15 Mar 2019 11:00:00 GMT Towards a better detection of glioblastoma infiltration https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Towards-better-detection-glioblastoma-infiltration.aspx Glioblastoma is a very aggressive cancer of the central nervous system, mainly because of its ability to infiltrate the surrounding areas. A collaboration led by a team of SHFJ and involving NeuroSpin demonstrates the interest of two imaging techniques for the early detection of tumor infiltration. Cancer ; Medical imaging ; Positron Emission Tomography Scientific result PET imaging;glioblastoma; Tue, 26 Feb 2019 11:00:00 GMT The identification of biomarkers by metabolomics should allow a better follow-up of cirrhotic patients https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Biomarkers-metabolomics-follow-up-cirrhotic-patients.aspx Researchers from SPI, in collaboration with teams from an European foundation, EF Clif, carried out global and targeted metabolomic analyzes which made possible to highlight, in cirrhotic patients, an activation of the kynurenine metabolic pathway (tryptophan degradation pathway). The imbalance of this pathway is probably the cause of the symptoms observed during cirrhotic decompensation, when the body can no longer compensate for liver dysfunctions. Metabolomics ; Biomarkers ; Diseases Scientific result Thu, 07 Feb 2019 11:00:00 GMT "Mini-brains" for research on Alzheimer's disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/mini-brains-research-Alzheimer-disease.aspx A partnership between the François Jacob Institute of Biology/CEA, The Frédéric Joliot Institute for Life Sciences/CEA and CellTechs (a Sup'Biotech lab) has led to a new approach for modeling Alzheimer's disease in vitro. Health & life sciences ; Brain ; Alzheimer's disease MIRcen Scientific result Brain;Alzheimer; Mon, 14 Jan 2019 11:00:00 GMT Evolution of Alzheimer's disease : a dual role of the neuroimmune reaction https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Alzheimer-disease-role-neuroimmune-reaction.aspx A collaboration involving the Sainte-Anne Hospital, the SHFJ, the Saint-Antoine research center and the ICM identified, through a PET brain imaging study in patients with Alzheimer's disease, two distinct kinetic profiles of the cerebral neuroimmune response, that impact the disease progression differently. Researchers propose an original model of neuroinflammation, likely to open new therapeutic avenues. Brain ; Alzheimer's disease ; Positron Emission Tomography Scientific result Thu, 10 Jan 2019 11:00:00 GMT Autism spectrum disorders : a new brain imaging study appears to challenge the dominant theoretical model. https://www.cea.fr/drf/joliot/en/Pages/news/Press/AUTISM-SPECTRUM-DISORDERS-a-new-brain-imaging-study-appears-to-challenge-the-dominant-theoretical-model.aspx Brain ; Diseases ; Medical imaging Press release ; Scientific result Wed, 14 Nov 2018 11:00:00 GMT Understanding autism: novel brain imaging study challenges the dominant explanation https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/autism-novel-brain-imaging-study-challenges-dominant-explanation.aspx As part of the InFoR-Autism scientific program involving NeuroSpin, a new neuroimaging study has revealed a correlation between decreased local anatomical connectivity and social cognitive deficits in people with autism spectrum disorders (ASD). Published in the renowned journal Brain, the results challenge the dominant theoretical model explaining ASD and could pave the way for the exploration of new therapeutic approaches. Cognition ; MRI ; Diseases Neurospin Scientific result IRM de diffusion;autisme; Tue, 13 Nov 2018 11:00:00 GMT Cerebral lymphoma: a new indication for [18F]Fludarabine? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/TEP-18FFludarabine-lymphome-cerebral.aspx A SHFJ research team (LDM-TEP, GIP Cyceron, Caen) has previously developed and produced a radiopharmaceutical, the [18F]-Fludarabine, to detect lymphomas using PET scan. The team has recently conducted a preclinical study that shows the molecule can help in diagnosis of cerebral lymphoma by differentiate it from glioblastoma, the main brain tumor. A clinical study should be launched before the end of the year. Brain ; Medical imaging ; Cancer ; Diagnosis Joliot Scientific result FDG;lymphoma;glioblastoma; Mon, 08 Oct 2018 10:00:00 GMT DNA repair: in-depth look at the initial stages https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/DNA-repair-zoom-first-steps.aspx A research team from the SB2SM (I2BC@Saclay), in collaboration with the CNRS, SOLEIL , Universities of Paris-Sud, Aix-Marseille and Paul Sabatier - Toulouse III and Gustave Roussy, has resolved structures of two complexes involved in radiation-induced DNA damages. These results were published in Nature Structural & Molecular Biology on October, the 5th. DNA ; Structural biology ; Molecular mechanisms SB2SM Press release Mon, 08 Oct 2018 10:00:00 GMT What is the relationship between variants of the BRCA1 gene and susceptibility to cancer? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/relationship-variants-BRCA1-cancer.aspx Research Teams from the Curie Institute, the Gustave Roussy Institute, as well as the biophysics teams from the Institute of Chemistry of Natural Substances and SB2SM (I2BC@Saclay) met to systematically identify structural defects and BRCA1 proteins encoded by variants of the BRCA1 gene, a gene predisposing to breast and ovarian cancer. Their results make it possible to propose a classification of these variants (neutral versus causal). Cancer ; Structural biology ; DNA Scientific result Fri, 28 Sep 2018 10:00:00 GMT Protein modification: myristoylation finally decoded https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/myristoylation-decoded.aspx An I2BC Research Team, in collaboration with the ICSN and the Ecole Polytechnique, has mapped for the first time, in man and the model plant Arabidopsis thaliana, the myristoylome, namely the whole proteins modified with a fatty acid, myristate. This modification is important because it targets these proteins to the membranes and thus contributes to their subcellular compartmentalization. These data represent an important resource, available to the community of biologists. Structural biology News Tue, 26 Jun 2018 10:00:00 GMT Functionalized micellar nanovectors for targeted tumor therapy https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/functionalized-micellar-nanovectors.aspx ​As part of a collaboration with MIRCen (Institute of Biology François Jacob) and SBIGeM, SCBM researchers have developed functional micellar nanovectors capable of targeting a population of cancer cells. Chemistry ; Cancer Scientific result Thu, 12 Apr 2018 10:00:00 GMT The ghosts of fluorescence https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/ghosts-of-fluorescence.aspx Cell biology uses fluorescent labeling, an essential technique to follow the life of the cell. But fluorescent proteins have their limits, which researchers from IBS and I2BC @ Saclay (SB2SM) are trying to repel. Structural biology ; Proteomics Scientific result Wed, 28 Mar 2018 10:00:00 GMT The Retro-2 antiviral spectrum is widening https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/retro-2-is-widening.aspx ​Two Research Teams from SIMOPRO and SCBM, in collaboration with Texas Biomedical Research Institute and Jilin University, showed that anti-ricin compounds Retro-2, discovered at CEA during researches against bioterrorism, inhibit two families of viruses important for public health (Ebola and Marburg filovirus and enterovirus EV71). These results broaden the antiviral spectrum of Retro-2 type compounds. Virus ; Infectious diseases Scientific result Fri, 16 Mar 2018 11:00:00 GMT An original biotechnological approach to create new bioactive molecules https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/biotechnological-approach-new-bioactive-molecules.aspx ​Muriel Gondry's Research Team (I2BC@Saclay / SBIGeM), in collaboration with SIMOPRO and Biomolecules Laboratory of the Sorbonne University's one, produced 200 cyclodipeptides containing non-natural amino acids by luring and diverting the cellular machinery for the synthesis of proteins. This unprecedented approach significantly increases the diversity of these bioactive molecules. Biotechnology ; Structural biology Scientific result Mon, 05 Mar 2018 11:00:00 GMT A trick of nature: a water cluster makes the activation of a DNA photolyase more efficient https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/water-cluster-photolyase.aspx In collaboration with a German Research Team from Marburg University, Pavel Müller and Klaus Brettel (I2BC @ Saclay / SB2SM) have studied the first steps of photoactivation of a Class II photolyase of the Methanosarcina mazei archaeobacteria by resolute optical spectroscopy time and discovered a peculiarity of this class of photolyases: photoinduced separation of charges is stabilized by a water cluster, a structural element also preserved in class II photolyases of plants and animals. Bacteria ; Health & life sciences Scientific result Wed, 14 Feb 2018 11:00:00 GMT A disruptor of late endosomes with anti-infectious properties https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/disruptor-late-endosomes.aspx A SIMOPRO Research Team, in collaboration with a SCBM Team, has identified, by screening a library of small chemical molecules, a compound capable of reducing the sensitivity of cells to a plant toxin, that is ricin. By collaborating with seven Teams of microbiologists, researchers have shown that this compound, called ABMA, protects cells by blocking an intracellular transport pathway borrowed by many other bacterial and intracellular pathogenic toxins. ABMA defines a new family of broad-spectrum anti-infective agents.​ Health & life sciences ; High-throughput screening ; Bacteria Scientific result Tue, 16 Jan 2018 11:00:00 GMT Antibiotic resistance: a Joliot Institute project funded by EIT Health https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/antibiotic-resistance-a-joliot-institute-project-funded-by-eit-health.aspx ​A SPI/LERI Research Team has recently developed new test strips for the detection of some multi-resistant bacteria. A hospitalization project for these high-speed screening tests will be rolled out in 2018 with funding from EIT Health. Health & life sciences ; Antibiotics ; Bacteria Scientific result Wed, 29 Nov 2017 11:00:00 GMT An brand new animal model to accelerate the fight against Alzheimer's disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/alzheimer_unpublished_animal_model.aspx ​For the first time, an animal model expresses the two biological characteristics of Alzheimer's disease. Researchers from MIRCen (François Jacob Institute), SPI (LEMM), Inserm, Universities Paris-Sud and Paris-Descartes and CNRS have developed an animal model that reproduces the progression of the human disease. Neurodegenerative diseases ; Brain ; Health & life sciences Scientific result Mon, 23 Oct 2017 10:00:00 GMT Identification of a common molecular mechanism for schizophrenia and bipolar disorder https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/Identification_common_molecular_mechanism_schizophrenia_bipolar_disorder.aspx ​A Research Team in psychiatry at CEA-NeuroSpin, in collaboration with the Mondor Institute for Biomedical Research (INSERM) and Henri-Mondor University Hospitals, AP-HP, has shown that a genetic variant associated with multiple psychiatric disorders alters a network. prefronto-limbic, which would increase the risk of developing schizophrenia or bipolar disorder. The results of this study are published online October 2, 2017 in the Journal of Neuroscience. Health & life sciences ; Brain ; Diseases Scientific result Wed, 11 Oct 2017 10:00:00 GMT CEA and Inserm about understanding and managing DYS disorders https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2017/CEA_Inserm_understanding-_management_DYS_disorders.aspx On the occasion of the national day of "dys", discover the work carried out by the teams of the NeuroSpin research infrastructure, on the CEA Paris-Saclay center. Institutional ; Brain ; Diseases News Mon, 09 Oct 2017 10:00:00 GMT New MOOC on biological crystallography https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2017/New_MOOC_on_biological_crystallography.aspx Paris-Saclay University is pleased to present the MOOC "Journey to the heart of life with X-rays: crystallography", result of a close collaboration between the Department I2BC @ Saclay (pedagogical director: Marie-Hélène Le Du ), the Sun Synchrotron, the Ecole Polytechnique, the CNRS, and the University Paris Sud. Institutional ; Health & life sciences ; Structural biology News Mon, 18 Sep 2017 10:00:00 GMT [18F] Fludarabine, a hope for lymphoma imaging https://www.cea.fr/drf/joliot/en/Pages/news/News/Science_news/2017/fludarabine_hope.aspx A Research Team of the SHFJ (LDM-TEP) has just developed an innovative radiopharmaceutical for lymphoproliferative diseases, [18F] Fludarabine. Cancer ; Medical imaging Scientific result Mon, 29 May 2017 10:00:00 GMT