Frédéric Joliot Institute for Life Sciences - On the same theme https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2021/Carbon-labeling_light.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.frhttps://www-cea-fr.admsite.extra.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot.png Frédéric Joliot Institute for Life Sciences - On the same theme https://joliot.cea.fr/drf/joliot/en Nanometric micelles for targeted delivery of a prodrug against atherosclerosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Nanomicelles-targeted-delivery-prodrug-atherosclerosis.aspx Teams from SCBM and SIMoS (DMTS) have developed nano-micelles for the vectorization of an active principle which regulates cholesterol metabolism towards atherosclerotic lesions. Nanomedicine ; Diseases SIMOPRO Scientific result ; Article preclinic;animal models; Thu, 14 Mar 2024 11:00:00 GMT Improved diagnosis of acute hepatic porphyrias using mass spectrometry https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Diagnosis-acute-hepatic-porphyrias-mass-spectrometry.aspx A collaborative study between SPI and a team from Hôpital Louis Mourier demonstrates the contribution of liquid chromatography coupled with mass spectrometry to the day-to-day analytical needs of a clinical laboratory. Application to the rapid quantification of biomarkers in acute hepatic porphyrias. Diagnosis ; Mass spectrometry ; Biomarkers SPI Scientific result ; Article Fri, 23 Feb 2024 11:00:00 GMT Functionalization of the B subunit of Shiga toxin as a vaccine tool https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Functionalization-B-subunit-Shigatoxin-vaccine-tool.aspx Researchers at SIMoS (DMTS) describe the synthesis, engineering and evaluation of the properties of the B subunit of bacterial Shiga toxin (STxB), administered mucosally, as a vaccine tool. Their results confirm the value of using a synthetic STxB in an anti-tumor and anti-infectious vaccination strategy. Biotechnology ; Vaccine SIMOPRO Scientific result préclinique; Fri, 26 Jan 2024 11:00:00 GMT Validation of a new elasticity biomarker for biological tissue diagnosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/elasticity-biomarker-biological-tissue-diagnostics.aspx SHFJ researchers have validated the use of a new biomarker, the nonlinear shear modulus, to measure the elasticity of biological tissues, by comparing results obtained using echography with those obtained using MRI imaging and digital simulation. This biomarker is of particular interest for the diagnosis of certain breast cancers. Medical imaging ; MRI ; Diagnosis SHFJ Scientific result Wed, 24 Jan 2024 11:00:00 GMT Combiner des stratégies in silico et in vitro pour de meilleurs anticorps thérapeutiques : exemple avec des dérivés de l’adalimumab, un anti-TNF. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/meilleurs-anticorps-therapeutiques-exemple-derives-adalimumab.aspx ​Des chercheurs du SIMoS montrent que la combinaison de deux approches in silico et in vitro permet de sélectionner des anticorps thérapeutiques dont la fonctionnalité est préservée tout en diminuant le risque qu’ils induisent une réponse immunitaire indésirable. Diagnosis and innovative treatment Researchers SIMOPRO Scientific result ; Article Thu, 18 Jan 2024 11:00:00 GMT Photocatalytic carbon dioxide reduction for radiolabeled drug synthesis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Photocatalytic-CO2-reduction-for-radiolabeled-drug-synthesis.aspx Researchers from SCBM (DMTS) and SB2SM (I2BC) describe a novel and optimized approach to the total photoreduction of 13C-labelled CO2 to carbon monoxide (CO), and the immediate reuse of the latter for the synthesis of high value-added compounds. A step towards a radiochemistry of carbon isotopes potentially useful in human health. Bio-inspired catalysis ; Chemistry ; Green Chemistry ; Carbon cycle SHFJ Scientific result Wed, 22 Nov 2023 11:00:00 GMT Cardiac transplantation: better graft eligibility criteria thanks to metabolomics? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Cardiac-Transplantation--metabolomics.aspx In a study conducted by a team from the Marie Lannelongue Hospital, SPI researchers have established a difference between the metabolomic profiles of heart grafts harvested from pigs in a state of encephalic death or dead after controlled circulatory arrest. This work contributes to the exploration and validation of the use of hearts taken from people who have died after controlled circulatory arrest as a new source of grafts. Large-scale biology ; Diagnosis and innovative treatment Researchers SPI Scientific result ; Article preclinical studies; Wed, 15 Nov 2023 11:00:00 GMT Click-Chemistry: optimized drug delivery from nanomicelles into tumor cells https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Click-Chemistry-optimized-drug-delivery-nanomicelles.aspx Researchers at SCBM have used a click-and-release chemistry approach to mass-release an anti-cancer drug into cells from cleavable nanomicelles, thanks to a bioorthogonal activation process. A step towards the development of new nanomedicines Chemistry ; Biotechnology SCBM Scientific result Fri, 10 Nov 2023 11:00:00 GMT Chimie : passer par le radical anion du CO2 pour le radiomarquage de médicament est possible https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Radical-anion-CO2-radiomarquage.aspx Des chercheurs de l'institut montrent qu’une stratégie fondée sur la formation du radical anion CO2●- marqué au carbone 14 ou carbone 11 s’avère payante pour radiomarquer en conditions douces des médicaments. Chemistry ; Diagnosis and innovative treatment Researchers SHFJ Scientific result ; Article préclinique; Tue, 24 Oct 2023 10:00:00 GMT Impact of metabolic variations on PET imaging of neuroinflammation in humans https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Impact-metabolism-PET-imaging-neuroinflammation.aspx Researchers at BioMaps evaluated the effect of several factors on the distribution of [18F]DPA-714 in 201 subjects who participated in SHFJ PET imaging protocols to better understand the role of neuroinflammation in various neurological diseases. They conclude that measures of individual metabolism are important in image interpretation. Positron Emission Tomography ; Medical imaging ; Pharmacology SHFJ Scientific result Thu, 12 Oct 2023 10:00:00 GMT Un composé radiosensible pour combiner radiothérapie et chimiothérapie ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Composé-radiosensible-combiner-radiotherapie-et-chimiotherapie.aspx Des chercheurs du SCBM et de l’Iramis publient une étude preuve-de-concept d’un composé radiosensible qui pourrait servir à « libérer » in vivo des médicaments anti-tumoraux, et ainsi de combiner les effets d’une radiothérapie et d’une chimiothérapie. Chemistry ; Radiotherapy Researchers SCBM Scientific result ; Article Tue, 05 Sep 2023 10:00:00 GMT After ISOTOPICS, ISOBIOTICS, the renewal of isotope labeling to strengthen european therapeutic innovation https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2023/ISOBIOTICS-renewal-isotope-labeling-biodrugs.aspx The SCBM was awarded funding from the Horizon Europe program for the ISOBIOTICS project, coordinated by Christophe Dugave. This project will enable the theoretical and practical training of 11 PhD students, including two at SCBM and one at SHFJ, on the development of innovative methods for the isotopic labeling of biodrugs Chemistry SCBM News ; Article ; Europe ; European & international partnerships Wed, 09 Aug 2023 10:00:00 GMT Identification of metabolomic signatures of high-grade breast tumors https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Metabolomic-signatures-high-grade-breast-tumors.aspx The TIRO laboratory of the SHFJ (Nice) identifies for the first time discriminating biomarkers of high-grade invasive breast tumors, using a non-targeted metabolomics approach performed on surgical specimens and cytoponctions from patients at different stages of malignancy. Metabolomics ; Cancer ; Biomarkers SHFJ Scientific result Fri, 04 Aug 2023 10:00:00 GMT Creatine transporter deficiency: use of two original models to characterize this rare genetic disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Proteins-involved-pathogenesis-creatine-transporter-deficiency.aspx Researchers at SPI (DMTS) have identified by mass spectrometry and bioinformatics analysis several biomarkers linked to the creatine transporter deficiency disorder (CTD) using two original models : mice with the clinical characteristics of CTD subjects and brain organoids derived from CTD patient cells. Mass spectrometry ; Genetic diseases ; Biomarkers ; Proteomics SPI Scientific result Thu, 22 Jun 2023 10:00:00 GMT Radiomarquage du crizotinib au fluor-18 : un nouvel outil pour suivre par TEP la biodistribution de ce médicament https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Radiomarquage-crizotinib-fluor-18-nouvel-outil-TEP.aspx Des chercheurs du SHFJ ont mis au point la radiosynthèse au fluor-18 du crizotinib, un médicament qui ne pénètre pas dans le cerveau. Ce nouvel outil pour l’imagerie TEP permettra d’explorer de futures stratégies visant à faire passer la barrière hémato-encéphalique à ce médicament pour traiter certaines métastases cérébrales. Positron Emission Tomography ; Cancer ; Diagnosis and innovative treatment Researchers SHFJ Scientific result ; Article Thu, 27 Apr 2023 10:00:00 GMT Combining neuroanatomical markers to strengthen the diagnosis of fetal alcohol spectrum disorder https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Structuring-neuroanatomical-criteria-fetal-alcohol-spectrum-disorder.aspx By analyzing brain imaging data, researchers from InDEV (NeuroSpin / UMR NeuroDiderot) have identified recurrent abnormalities in subjects with fetal alcohol syndrome, the combination of which could have a particularly interesting diagnostic value for non-syndromic forms of fetal alcohol spectrum disorders. MRI ; Diagnosis and innovative treatment Researchers Scientific result Mon, 13 Mar 2023 11:00:00 GMT Platinum nanoparticles to improve radiotherapy ? PET imaging provides answers https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Nanoparticles-to-improve-radiotherapy.aspx Researchers from the SHFJ laboratory at ISMO have demonstrated the value of platinum nanoparticles as potential radiosensitizing agents for radiation therapy. Diagnosis and innovative treatment ; Positron Emission Tomography Researchers SHFJ Scientific result Radiotherapy;biodistribution;platinum nanoparticles; Tue, 21 Feb 2023 11:00:00 GMT Development of a new radiolabeling strategy in immunoPET for precision imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/New-radiolabeling-strategy-immunoTEP.aspx Researchers from the BioMaps laboratory (SHFJ) and the Molecular Engineering for Health Service (SIMoS, DMTS) developed an enzymatic approach for radiofluorination of an anti-PD-L1 Fab and compared its in vivo properties to the same Fab stochastically labeled by two conventional methods. Diagnosis and innovative treatment ; Positron Emission Tomography Researchers SHFJ Scientific result PD-L1;radiomarquage;lipoate-protéine ligase;radiofluoration; Tue, 21 Feb 2023 11:00:00 GMT Glioblastoma: Does focused ultrasound increase the therapeutic efficacy of cetuximab? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Glioblastoma-FUS-cetuximab.aspx Researchers from the SHFJ, in collaboration with NeuroSpin, show that the use of focused ultrasound does not increase the therapeutic effects of cetuximab on glioblastoma although the opening of the blood-brain barrier is transiently effective. Positron Emission Tomography ; Diagnosis and innovative treatment Researchers Neurospin Scientific result Wed, 15 Feb 2023 11:00:00 GMT From a marine toxin to a melanocortin receptor antagonist, a therapeutic target for energy metabolism disorders https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Cone-marine-toxin-melanocortin-receptor-antagonist.aspx A SIMoS team discovered a toxin in the venom of a marine cone that it engineers into a high affinity antagonistic peptide for the melanocortin receptor, a major regulator of energy homeostasis. A step towards the development of innovative treatments for certain eating disorders Pharmacology ; High-throughput screening ; Proteomics ; Transcriptomics SIMOPRO Scientific result Thu, 09 Feb 2023 11:00:00 GMT Click chemistry: new "electrophilic" iminosydnones https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/click-electrophilic-iminosydnones.aspx Researchers at the Joliot Institute have developed two new families of iminosydnones that allow the bio-orthogonal release of electrophilic species. These molecules constitute "building blocks" of click-and-release chemistry, useful for reactions with nucleophilic compounds contained in cells. Chemistry Researchers SCBM Scientific result Thu, 02 Feb 2023 11:00:00 GMT Detection of monkeypox: Mass spectrometry proves once again its effectiveness https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Detection-monkeypox-massspectrometry.aspx A Li2D team has released the peptidomic profile of the virus that causes monkeypox, which they established using tandem mass spectrometry. These data should help to better understand the evolution of the epidemic and allow the creation of targeted tests to potentially detect the threat more quickly and prevent a new epidemic. Diagnosis ; Infectious diseases Researchers SPI Scientific result Mon, 28 Nov 2022 11:00:00 GMT Dual labeling and digital imaging for the evaluation of protein-drug conjugates in preclinical models https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/In-vivo-evaluation-antibody-drug-conjugate.aspx A team from SIMoS, in collaboration with the SCBM (DMTS), has developed an original bioanalytical approach based on the double 14C-3H isotopic labeling of an antibody-drug conjugate, allowing the simultaneous in vivo monitoring of the two components in mouse models as well as their precise quantification in the organs. Pharmacology ; Cell and molecular imaging SIMOPRO Scientific result Mon, 22 Aug 2022 10:00:00 GMT Fight against antibiotic resistance: two additional rapid lateral flow immuno-assays https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/antibioresistance-2-nouveaux-tests.aspx Researchers at the LERI together with the AP-HP have developed 2 rapid and inexpensive immunological tests to detect antibiotic resistance. The novelty: the tests detect the activity of bacterial enzymes that hydrolyze extended-spectrum cephalosporins. Antibiotics ; Diagnosis Researchers SPI Scientific result penicillin;carbapenemase;CTX-M; Tue, 02 Aug 2022 10:00:00 GMT A novel fluorine-18 thiol carrier for labeling biomolecules used in PET imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/fluorine-18-thiol-labeking-biomolecules-TEP.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated the synthesis of an 18F-fluoropyridine containing a thiol function (-SH), allowing its conjugation to model biomolecules within 45 minutes. A step towards rapid radiolabeling of complex biological molecules for PET imaging. Radioactivity ; Chemistry ; Positron Emission Tomography SHFJ Scientific result Tue, 28 Jun 2022 10:00:00 GMT New perspectives for CO2 photoreduction by iron porphyrins https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Photoreduction-of-CO2-by-iron-porphyrins.aspx ​Researchers from ICMMO* and ISMO**, in collaboration with a team from I2BC, show that the urea-decorated iron porphyrin catalysts they developed previously for the electro-catalysis of CO2, can be successfully employed in a photo-catalytic approach. Chemistry ; Bio-inspired catalysis ; Photosynthesis SB2SM Scientific result Thu, 16 Jun 2022 10:00:00 GMT A possible link between changes in gut microbiota and fecal SARS-CoV-2 load ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Link-intestinal-microbiota-Covid-19.aspx A team from SPI used mass spectrometry to analyze the degree of alteration of the intestinal microbiota of Covid-19 patients and to look for signatures of intestinal infection by the SARS-CoV-2 virus. The level of the observed gut dysbiosis would be an indicator of the stage and extent of the infection. Mass spectrometry ; Proteomics ; Biomarkers ; Infectious diseases SPI Scientific result ; Article Thu, 12 May 2022 10:00:00 GMT ptairMS software: real-time study of biomarkers in exhaled breath https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/ptairMS-COVs-biomarkers.aspx The ptairMS software, developed in the framework of a collaboration led by the CEA-Joliot, allows the processing and analysis of proton transfer mass spectrometry data, an ideal method for the real-time study of volatile organic compounds (VOCs) present in exhaled breath. Bioinformatic ; Biomarkers Researchers List Scientific result Tue, 26 Apr 2022 10:00:00 GMT Facilitating access to deuterated and tritiated molecules: towards more diversity! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Deuterated-tritiated-molecules-more-dversity.aspx Researchers from the SCBM describe a hydrogen isotope labeling process that is easy to implement and whose starting point is a "simple" mixture, in a solvent, of the product to be labeled with a pre-catalyst. Explanations of this process which finds applications in many fields including drug development or medical imaging. Chemistry ; Diagnosis and innovative treatment ; Medical imaging Researchers SCBM Scientific result marquage isotopique;biomolécule;activation C-H;ADME-DMPK; Wed, 06 Apr 2022 10:00:00 GMT Buprenorphine/benzodiazepine interaction: why is it more dangerous? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Interaction-buprenorphine-benzodiazepine.aspx ​A collaboration between the SHFJ and the UMR-S 1144 (University of Paris) shows that the deleterious effect of the buprenorphine/benzodiazepine combination would result from the combined action of each drug on its target. Diagnosis and innovative treatment ; Pharmacology Researchers SHFJ Scientific result ; Article pharmacodynamics;opioids; Fri, 25 Mar 2022 11:00:00 GMT Biochemical analysis and mass spectrometry for the diagnosis of congenital disorders of glycosylation https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Diagnosis-MS-congenital-disorders-glycosylation.aspx A collaboration initiated in 2017 between AP-HP (Bichat Hospital), Paris-Saclay University (Inserm 1193) and the Laboratoire d’Études du Métabolisme des Médicaments (LEMM/SPI/DMTS), leading to 4 publications in 2021, is advancing knowledge on the origin of certain congenital disorders of glycosylation, through the identification of specific biochemical biomarkers. Mass spectrometry ; Biomarkers ; Genetic diseases SPI Scientific result Tue, 04 Jan 2022 11:00:00 GMT Lipid biomarkers to identify the different stages of liver cirrhosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/biomarkers-lipids-cirrhosis.aspx European research teams, including one from the CEA's Joliot Institute, have analyzed the blood lipidome of patients with cirrhosis. They highlight specific biomarkers of the different stages of the disease. Methodologies for life sciences ; Biomarkers ; Diseases Researchers SPI Scientific result Mon, 06 Dec 2021 11:00:00 GMT Deeptope: accelerating the development of therapeutic antibodies via high-throughput functional tests https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/Deeptope-start-up-Simos.aspx Deeptope, founded in February 2021 from a technology developed at the DMTS Laboratory of Cellular Immunology and Biotechnology (LICB), is a company of therapeutic antibody engineering that provides antibody optimization and characterization services to biotech or pharmaceutical firms with the goal of increasing the quality of antibodies in a very short timeframe. Biotechnology ; Pharmacology News ; Article Mon, 29 Nov 2021 11:00:00 GMT Diffusion MRI characterizes radiation-induced neurological impairments https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress. Brain ; Impacts on living (organisms) ; MRI ; Biomarkers ; Radiobiology Researchers ; Journalists ; general public DRF Scientific result ; Highlight ionizing radiations;Brain;neurodevelopmental disorder;neurogenesis;MRI;structural MRI;diffusion MRI; Thu, 24 Jun 2021 10:00:00 GMT Characteristics of the initial symptoms of Alzheimer's disease in young patients https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Initial-symptoms-Alzheimer-disease-in-young.aspx Researchers from BioMaps (SHFJ) and the Department of Memory and Language Neurology (Ste Anne's Hospital) studied the early clinical signs of Alzheimer's disease (AD) reported by young patients (< 62 years old) compared to those reported in classic AD of the elderly (> 65 years old). They show that these signs are misleading and often appear in the professional context. Alzheimer's disease ; Diagnosis ; Brain Scientific result Thu, 10 Jun 2021 10:00:00 GMT Evaluation of the immunogenicity of peptide-drugs containing non-natural modifications https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Immunogenicity-therapeutic-peptides.aspx A team from SIMoS (DMTS) in collaboration with Sanofi shows that the introduction of non-natural sequences into an immunogenic peptide attenuates the immune response against this peptide, an approach that could guide the design of less immunogenic, and therefore more effective, therapeutic peptides. Health & life sciences ; Pharmacology Scientific result Tue, 01 Jun 2021 10:00:00 GMT Société Chimique de France: two prizes for two researchers from the Institute https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/SCF-2-prizé-2-researchers-SCBM.aspx The members of the Organic Chemistry Division (DCO) of the French Chemical Society met on Monday 10 May to award the DCO 2021 prizes. Sophie Feuillastre and Davide Audisio, both researchers at the SCBM (CEA-Joliot Department of Medicines and Technology for Health) are among the lucky winners. Chemistry Researchers SCBM Article radiolabeling; Thu, 27 May 2021 10:00:00 GMT PET imaging reveals the neuropharmacology of buprenorphine https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PETimaging-neuropharmacology-buprenorphine.aspx Researchers at BioMaps (SHFJ) have succeeded in determining the interaction dynamics of buprenorphine, an opioid drug with a particularly complex pharmacology, with its brain receptors in vivo. To do so, they developed an original PET imaging approach based on the use of the radiolabeled molecule (11C-buprenorphine). Brain ; Positron Emission Tomography ; Pharmacology Scientific result Wed, 05 May 2021 10:00:00 GMT Carbon labeling by isotopic exchange of nitriles https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Nitrile-carbon-isotope-labeling.aspx Researchers at the CEA-Joliot Institute (Carbon-14 labeling Laboratory), in collaboration with teams from AstraZeneca, Sanofi and Nimbe (CEA-Iramis), have developed a labeling method, based on nitrile exchange using nickel catalysis. This method is currently under study at Sanofi for the labeling of a drug candidate. Chemistry Scientific result ; Europe Fri, 30 Apr 2021 10:00:00 GMT How works Mambalgin-1, an analgesic peptide from black mamba venom https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/How-works-Mambalgin-1.aspx Teams from IPMC and SIMoS (DMTS) defined the molecular determinants of the interaction between Mambalgin-1, an analgesic peptide isolated from black mamba venom, and its target, ASIC1 (Acid-Sensing Ion Channels), to model, using molecular dynamics, this complex. The resulting model provides clues to develop blockers of ASIC1, interesting targets for clinical pain relief applications. Pharmacology Scientific result Thu, 08 Apr 2021 10:00:00 GMT Salmonellosis and shigellosis: a monoclonal antibody induces cross-protection https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Salmonellosis-shigellosis-monoclonal-Ab-cross-protection.aspx Researchers at CEA-Joliot (SPI unit in collaboration with SIMoS unit) have developed a monoclonal antibody directed against a common region of two proteins of the bacteria Shigella and Salmonella and capable of inducing cross-protection against infections caused by these bacteria. Bacteria ; Vaccine Researchers SIMOPRO Scientific result Antibody;IpaD-318;host cell;injectiosome; Thu, 25 Mar 2021 11:00:00 GMT Première étape vers un test quantitatif par spectrométrie de masse pour le diagnostic spécifique de la COVID-19 ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Vers-test-quantitatif-MS-diagnostic-specifique-COVID-19.aspx Le LEMM, en collaboration avec le LI2D et l’AP-HP, développe un test de diagnostic spécifique de la Covid-19 par spectrométrie de masse qui permettrait aussi la quantification de la charge virale du patient. Objectif à terme : adapter la méthode pour la rendre plus sensible et compatible avec les équipements d’analyse des hôpitaux. Diagnosis ; Mass spectrometry ; Virus Researchers SPI Scientific result SARS-CoV-2; Tue, 09 Mar 2021 11:00:00 GMT A micellar probe for fluorine magnetic resonance tumor imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Micellar-probe-fluorine-MRI-tumor.aspx A SCBM (DMTS) team, in collaboration with researchers at NeuroSpin and I2BC, is describing micellar nanometric vectors targeting tumors that have been imaged by fluorine magnetic resonance imaging (MRI). The observed 19F signal made it possible to precisely delimit the volume of the tumor zone in a mouse model and to quantify the probe accumulated in the target tissue. Chemistry ; Nanomedicine ; Cancer ; MRI Scientific result Thu, 04 Mar 2021 11:00:00 GMT Carbon labeling with light https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Carbon-labeling_light.aspx Researchers from the LMC (DMTS), in collaboration with a team from AstraZeneca, have developed a labeling method, based on the exchange of carbon dioxide, simply using visible blue light and a photocatalyst. Chemistry ; Biomarkers ; Diagnosis and innovative treatment Researchers SCBM Scientific result ; Europe radiolabeling; Wed, 24 Feb 2021 11:00:00 GMT Decompensated cirrhosis: involvement of amino acid metabolism in systemic inflammation https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Decompensated-cirrhosis-aa-metabolism.aspx A European study involving CEA-Joliot provides the first overview of the amino acids circulating in the blood of patients with decompensated cirrhosis and concludes that there is a strong redistribution of their metabolism in order to provide the fuel necessary for the intense inflammatory response. Diagnosis and innovative treatment Researchers SPI Europe spectrométrie de masse;métabolomique;métabolome;cirrhosis;liver failure; Mon, 14 Dec 2020 11:00:00 GMT Chemical synthesis and characterization of a non-radioactive chiral probe for studying enzymatic reaction mechanisms https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/chiral-probe-study-transferases.aspx Chemists of CEA-Joliot have synthesized the two enantiomers of a molecule containing a deuterated chiral ethyl group and characterized their chiral properties using advanced spectroscopic tools. These two compounds will be useful for probing the reaction mechanism of enzymes, as alkyl transferases. Chemistry Researchers SCBM Scientific result isotopic labeling; Tue, 24 Nov 2020 11:00:00 GMT World Antimicrobial Awareness Week: the Institute continues its actions https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/World_AMR_week_LERI.aspx The recent publication, in the journal Diagnostics, of a collaborative study associating AP-HP, NG-Biotech and a team from the Institute, is an opportunity to recall the Institute's commitment to the development of means of detecting antimicrobial resistance, a global phenomenon in the WHO's sights, as recalled by the World Antimicrobial Awareness Week. Antibiotics Researchers SPI Scientific result ; Article LFIA;bacteria;lateral flow immunoassay;gram negative; Thu, 19 Nov 2020 11:00:00 GMT Mambaquaretin: therapeutic and diagnostic interest? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mambaquaretin-theranostic.aspx In pursuing their work on mambaquaretin, SIMoS researchers conducted a collaborative study confirming the therapeutic potential of the toxin and paving the way for its use as a diagnostic tool. Diagnosis and innovative treatment ; Molecular mechanisms ; Cellular mechanisms SIMOPRO Scientific result PET Scan;PK/PD; Tue, 10 Nov 2020 11:00:00 GMT Seeing tomorrow's OLED display technology emerge https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Seeing-tomorrow-OLED-display-technology-emerge.aspx A team from SCBM, in collaboration with IRAMIS, LETI, ENS Paris-Saclay, the Universities of Rennes and San José (USA), has developed new electroluminescent molecules with properties that improve the energy consumption and light production of organic light-emitting diodes (OLEDs). This is the first study correlating the structure and properties of this type of materials, with a promising future in display technologies. Chemistry ; Technologies Scientific result Thu, 22 Oct 2020 10:00:00 GMT A new molecule to fight against intracellular pathogens https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Retro1-new-molecule-against-intracellular-pathogens.aspx The SCBM and SIMoS collaborated to optimize the activity of Retro-1, a benzodiazepine compound, inhibitor of Shiga toxins and ricin, derived from high-throughput biological screening. They succeeded in obtaining an analog 70 times more protective against the cytotoxicity of Shiga toxins, Retro-1.1. Chemistry ; High-throughput screening ; CBRN-E threats Scientific result Mon, 14 Sep 2020 10:00:00 GMT Development of a general strategy for the isotopic labelling of carbamates by incorporation of CO2 https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/carbamates-CO2-isotope-labeling.aspx In a study published in Chemical Communications, the Joliot Institute Carbon labeling laboratory (LMC), in collaboration with the SHFJ, provides proof of concept of a "click" strategy for carbon isotope marking of pharmaceutical molecules containing carbamates. Chemistry ; Diagnosis and innovative treatment SCBM Scientific result ; Europe Thu, 10 Sep 2020 10:00:00 GMT Hydrogen isotopes in the race for new drugs https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Hydrogen-isotopes-race-new-drugs.aspx ​The Grégory Pieters' team (LMT/SCBM) publishes, in the prestigious Angewandte Chemie, two major advances in the field of carbon-hydrogen bonds activation involving the two isotopes of hydrogen, deuterium and tritium, facilitating in particular access to labeled analogues of complex molecules, a prerequisite for the development of new drugs. Chemistry Scientific result Tue, 01 Sep 2020 10:00:00 GMT SARS-CoV-2 detection: mass spectrometry shows its potential for rapidity. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/SARS-CoV-2-detection-mass-spectrometry-rapidity.aspx A team from SPI in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method. Mass spectrometry ; Virus ; Biodetection ; Diagnosis Scientific result Thu, 06 Aug 2020 10:00:00 GMT Chemistry: releasing two fluorophores into living cells by "click and release". https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Click-and-release-liberation-2-fluorophores-dans-cellule.aspx Researchers from the LMC have developed a new series of iminosydnones that can split in two and release two fluorophores. They are providing a proof of concept that this "click and release" reaction can be triggered in living cells. Chemistry SCBM Scientific result Diels-Alder;cycloaddition;BCN;pyrazole; Mon, 29 Jun 2020 10:00:00 GMT Mapping of Ebola T-cell response: towards a new vaccine ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Mapping-Ebola-T-cell-response.aspx SIMoS researchers, in collaboration with Genopole, Excellgene, Vaxeal holding SA (Switzerland), used a large-scale approach to map and characterize the response of CD4 T-cells from healthy donors, against two proteins from the Ebola-Zaire virus. They observed a strong response to the viral nucleoprotein (NP) and suggest that components of NP may be included in the design of new Ebola vaccines. Virus ; Vaccine Scientific result Wed, 24 Jun 2020 10:00:00 GMT Salmonellosis and shigellosis: first demonstration of cross-protection induced by virulence factors SipD and IpaD https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Salmonella-shigella-cross-protection.aspx SPI researchers show for the first time, in a mouse model, the induction of cross-protection against Salmonella and Shigella infections, two pathogenic bacteria responsible for gastrointestinal diseases (typhoid, dysentery among others), one of the main causes of morbidity and mortality in several regions of Africa and Asia. Vaccine ; Bacteria Scientific result Mon, 22 Jun 2020 10:00:00 GMT How the identification of attenuated forms of the SARS-CoV-2 virus could help to control the current epidemic ? https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Identification-attenuated-covid-virus-variants.aspx An opinion article, published in Environmental Microbiology, and written by an international consortium initiated by three researchers of Joliot Institute, proposes an original way of research on Covid-19 through the identification by sequencing of attenuated variants of the SARS-CoV-2 virus in populations at risk with little or no symptoms. Virus ; Genomics ; Vaccine Tue, 12 May 2020 10:00:00 GMT Clickable bambusurils to access promising multivalent architectures. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Clickable-bambusurils.aspx A team from SCBM, in collaboration with researchers from I2BC, SHFJ and IRAMIS, has synthesized new neutral macrocycles called bambusurils (BUs). These BUs can be functionalized by “click chemistry” to obtain multivalent architectures decorated with 8 to 12 ligands of interest, an alternate topology which gives them remarkable supramolecular properties. Chemistry Scientific result Mon, 04 May 2020 10:00:00 GMT Characterization of a predictive survival biomarker in the event of septic shock https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Characterization-predictive-survival-biomarker-septic-shock.aspx Two recent studies conducted by SPI researchers, in collaboration with Inserm and AP/HP teams, reveal the value of measuring plasma levels of calgranulins as biomarkers for the prediction of mortality risk of patients with septic shock, admitted in intensive care unit. Biomarkers ; Mass spectrometry ; Infectious diseases Scientific result Tue, 24 Mar 2020 11:00:00 GMT Launch of FLIX, a European project for the isotopic labeling of molecules with high added values https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Launch-of-FLIX.aspx In June 2019, the SCBM obtained a European FET-Open funding for the FLIX project (FLow chemistry for Isotopic eXchange), a radically innovative concept of isotopic labeling of molecules with high added values. This 4-year project, coordinated by CEA/SCBM, with an overall budget of 3.5 million euros started on January 1, 2020 and consists of seven European academic or industrial partners in five countries. Chemistry News ; Europe ; Article Wed, 19 Feb 2020 11:00:00 GMT Innovative approach to radiolabel peptides with fluorine-18 for PET imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Innovative-approach-radiolabel-peptides-fluorine-18-PET-imaging.aspx Radiochemists from the BioMaps unit (SHFJ) have developed and automated a new fluor-18 radiolabelling method for peptides used to characterize specific pathological molecular signatures and thus target treatments. Peptides were conjugated to a specific tag, then radiolabeled in a single step under mild conditions, making this approach an innovative solution for PET imaging of peptides labeled with fluorine-18. Chemistry ; Positron Emission Tomography ; Cancer Scientific result Mon, 17 Feb 2020 11:00:00 GMT Davide Audisio (SCBM), winner of a « 2019 Consolidator Grant » from the European Research Council https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2019/Davide-Audisio-winner-Consolidator-Grant-ERC.aspx The European Research Council (ERC) announced, on December 10, 2019, the winners of the 2019 ERC "Consolidator Grants". Three CEA researchers are rewarded for the excellence of their work in astrophysics, particle physics and chemistry. In Joliot, chemistry is honored with the award of the research grant to Davide Audisio, SCBM, for his expertise in labeling molecules of interest with 14Carbone. Chemistry News ; Europe Tue, 10 Dec 2019 11:00:00 GMT Light to release the tension of cycles https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Light-release-tension-of-cycles.aspx A team from SCBM, in collaboration with Mauritian modelers, has shown that carboxylic acids can be easily converted into small rings with four carbon atoms, the cyclobutanes, using blue LEDs and an iridium catalyst. Cyclobutanes are increasingly used in the design of new drugs and the method described here will help to significantly expand the chemical space explored in "drug discovery". Chemistry Scientific result Tue, 03 Dec 2019 11:00:00 GMT Lassa fever: a vaccine soon to be tested. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Lassa-fever-vaccine.aspx Researchers from Pasteur Institute, in collaboration with seven research teams, including SPI (LI2D/Marcoule), developed and evaluated the efficacy of several vaccine candidates against the virus responsible for Lassa haemorrhagic fever, endemic in Western Africa. They identified one of them as being the most effective, likely to quickly enter clinical trials in humans. Results are published in the journal Science Translational Medicine. Vaccine Scientific result Wed, 09 Oct 2019 10:00:00 GMT See a tumor in PET imaging by « click-chemistry » in vivo https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/See-tumor-PET-imaging-click-chemistry-in-vivo.aspx A new PET imaging method by antibody pretargeting was developed at SHFJ, in collaboration with teams of SCBM and SPI. It consists in reacting in vivo a molecule labeled with 18Fluor with an antibody previously fixed on a tumor and this, in an extremely fast and selective manner, thanks to a « click-chemistry » reaction. The very good results obtained allow to consider the use of pre-targeted antibodies in nuclear medicine. Positron Emission Tomography ; Chemistry Scientific result Tue, 03 Sep 2019 10:00:00 GMT A new generation of nanovectors for anticancer therapies. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/New-nanovectors-anticancer-therapies.aspx As part of a collaboration with MIRCen (Jacob Institute), researchers of SCBM have developed functional micellar vectors that can effectively target tumors and whose therapeutic activity is intrinsically carried by the constitutive unit of the micelle. This combination leads to better drug load and avoids premature drug release. Chemistry ; Nanosciences ; Nanomedicine Scientific result Wed, 12 Jun 2019 10:00:00 GMT A promising therapeutic innovation for creatine transporter deficiency. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/therapeutic-innovation-creatine-transporter-deficiency.aspx ​Two teams from JOLIOT (SPI / SCBM), in collaboration with the University of Cincinnati, confirm the interest of a drug candidate to treat the congenital creatine deficiency syndrome, a rare neurological childhood disease, responsible for developmental delays and intellectual disability. The results obtained in an animal model of the disease show that it is possible to administer, nasally, dodecyl creatine ester-loaded microspheres, thus improving the cognitive functions of treated animals. Genetic diseases ; Pharmacology Scientific result Fri, 17 May 2019 10:00:00 GMT IBiSA labeling of the Saclay plateau screening platforms (C@PS) https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2019/IBiSA-screening-saclay-plateau.aspx ​The union of the Saclay Plateau screening platforms under a single banner C @ PS (Criblage sur le Plateau de Saclay) has just obtained the IBiSA label. Jean-Christophe Cintrat (Joliot / SCBM) is in charge of the overall infrastructure. Chemistry ; High-throughput screening News Tue, 26 Mar 2019 11:00:00 GMT « Click and Release » chemistry for the targeted delivery of drugs in vivo https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Click-Release-chemistry-targeted-delivery-drug-invivo.aspx A team from the SCBM, in collaboration with the SPI, the IC2MP and the University Hospital of Poitiers, has developed a bioorthogonal chemistry strategy that allows, in vivo, the controlled release of active ingredients contained in micelles-targeting cancerous tumors. These results pave the way for new strategies for targeted drug delivery. Chemistry ; Cancer ; Nanomedicine Scientific result Fri, 15 Mar 2019 11:00:00 GMT Pain: a promising toxin isolated from a spider venom https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/pain-promising-toxin-spider-venom.aspx A collaboration between SIMOPRO, Sanofi R & D, Smartox Laboratories and the Thorax Institute, has isolated a toxin with antinociceptive properties from a high-throughput electrophysiological screening of a collection of more than 100 venoms. Cyriotoxin-1a has been identified, sequenced, chemically synthesized and functionally characterized - from cell to organism in vivo. Pharmacology ; High-throughput screening SIMOPRO Scientific result antinociception;venoms;sodium channel;Pain; Mon, 11 Mar 2019 11:00:00 GMT Incorporating in a single step hydrogene isotopes into nucleic acid derivatives https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Single-step-incorporation-hydrogen-isotopes-in-nucleobases.aspx Facilitating the deuterium and tritium labeling of molecules containing nucleic bases such as many compounds of pharmacological interest? This is what researchers from SCBM in partnership with teams from SPI and Toulouse managed to achieve. Chemistry SPI Scientific result tritium;deuterium;ruthenium;nucleic base;isotopic labeling; Thu, 28 Feb 2019 11:00:00 GMT The identification of biomarkers by metabolomics should allow a better follow-up of cirrhotic patients https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Biomarkers-metabolomics-follow-up-cirrhotic-patients.aspx Researchers from SPI, in collaboration with teams from an European foundation, EF Clif, carried out global and targeted metabolomic analyzes which made possible to highlight, in cirrhotic patients, an activation of the kynurenine metabolic pathway (tryptophan degradation pathway). The imbalance of this pathway is probably the cause of the symptoms observed during cirrhotic decompensation, when the body can no longer compensate for liver dysfunctions. Metabolomics ; Biomarkers ; Diseases Scientific result Thu, 07 Feb 2019 11:00:00 GMT European funding for better management of liver diseases https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2019/European-Funding-liver-diseases-microb-predict.aspx Europe is committed to better diagnostic and therapeutic management of patients with severe forms of cirrhosis. It finances the MICROB-PREDICT consortium, which aims to better understand the role of the human microbiome in the pathogenesis and evolution of cirrhosis. Final goal is to uture personalized therapeutic strategies and diagnostic tools. The SPI (Joliot Institute) is the main project lead for the CEA. Diagnosis and innovative treatment SPI Europe Europe;foie;consortium;métabolomique;lipidomique;cirrhose;MICROB-PREDICT; Fri, 01 Feb 2019 11:00:00 GMT Helicenes: the familly gets bigger https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Helicenes-familly-gets-bigger.aspx Helicenes are synthetic molecules with attractive properties for physicists expert in materials but also for biologists. A collaboration led by chemists from the SCBM (CEA-Joliot) and involving the NIMBE (CEA-Iramis) allowed the synthesis of a particular class of helicenes. Chemistry SCBM Scientific result helicenes;regioselectivity; Tue, 22 Jan 2019 11:00:00 GMT CO2 and copper to radiolabel pharmaceutical compounds https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/CO2-copper-carbon-label-pharmaceutical-compounds.aspx Researchers from the SCBM and the IRAMIS (CEA/CNRS) have develop a 14C labeling method for therapeutic molecules based on dynamic Misspelled Wordcarbone dioxide exchange. This one step method generates far less radioactive waste. By facilitating some preclinical and clinical steps, it should eventually help to speed up the marketing applications of some new drug discoveries. Chemistry SCBM News échange isotopique;carbone 14;CO2; Fri, 11 Jan 2019 11:00:00 GMT Cerebral lymphoma: a new indication for [18F]Fludarabine? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/TEP-18FFludarabine-lymphome-cerebral.aspx A SHFJ research team (LDM-TEP, GIP Cyceron, Caen) has previously developed and produced a radiopharmaceutical, the [18F]-Fludarabine, to detect lymphomas using PET scan. The team has recently conducted a preclinical study that shows the molecule can help in diagnosis of cerebral lymphoma by differentiate it from glioblastoma, the main brain tumor. A clinical study should be launched before the end of the year. Brain ; Medical imaging ; Cancer ; Diagnosis Joliot Scientific result FDG;lymphoma;glioblastoma; Mon, 08 Oct 2018 10:00:00 GMT A reliable and accessible algorithm based on EEG to diagnose states of consciousness https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/EEG-algorithm-diagnosis-states-consciousness.aspx An international collaboration, led by the Institut du Cerveau et de la Moelle épinière – ICM (Brain & Spine Institute) and involving researchers from NeuroSpin, offers a new electroencephalogram (EEG) tool that helps the diagnosis of disorders of consciousness. Unlike other tools developed so far and dedicated to a few expert centers, “DoC-Forest” would be accessible to most of the hospitals worldwide. Brain ; Medical imaging ; Artificial intelligence ; Diagnosis Neurospin Scientific result EEG;biomarker;disorders of consciousness;machine learning; Fri, 05 Oct 2018 10:00:00 GMT Mass spectrometry for quality control of vaccines https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/spectrometry-quality-control-vaccines.aspx ​A SPI Research Team (LI2D, Marcoule), in collaboration with CIRAD and AU-PANVAC, proposes a new quality control technique for veterinary vaccines, based on very high resolution mass spectrometry. This strategy, based on the use of an ad hoc database to measure the proportion of antigens and contaminants in the vaccine preparation, will improve the quality control of vaccines against contagious caprine pleuropneumonia. Mass spectrometry ; Vaccine Scientific result Thu, 05 Jul 2018 10:00:00 GMT A new method for ultra-rapid isotope labeling of drugs https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/ultra-rapid-isotope-labeling.aspx ​A SCBM Research Team, in collaboration with SHFJ, SIMOPRO and Karolinska Institute, has discovered a method inspired by the "click" chemistry which, from radioactive carbon dioxide, can synthesize in just five minutes radiolabeled molecules containing a cyclic urea moiety. This method has been used for the ultra-rapid isotope labeling of drugs, without modification of their structure and with an unequaled efficiency. Chemistry Scientific result Tue, 19 Jun 2018 10:00:00 GMT A SIMOPRO project supported by SATT Paris-Saclay https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2018/SIMOPRO-project-supported-by-SATT-paris-saclay.aspx ​A SIMOPRO project supported by SATT Paris-Saclay: in vivo validation of the efficacy of the DTR8 molecule, developed and patented at SIMOPRO (Department of Medicines and Technologies for Health) in collaboration with Inserm, as a treatment for glomerulonephritis rapidly progressive. Institutional ; Toxicology ; Diagnosis and innovative treatment News Wed, 30 May 2018 10:00:00 GMT Toxins, vaccines, biobetters: a mission at the Butantan Institute of São Paulo https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2018/Toxins-vaccines-biobetters-butantan.aspx ​​Last April, a delegation of experts from the DRF visited colleagues at the Butantan Institute of São Paulo, a biomedical research center that has had close links with several researchers at the Joliot Institute since 2014. This mission is is concluded by the signing of a framework agreement between the two institutes in the field of therapeutic and vaccine innovation. Institutional ; Toxicology ; Vaccine News Fri, 25 May 2018 10:00:00 GMT Importance of chemical modifications of proteins for their interactions with nanoparticles https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/modifications-proteins-nanoparticules.aspx ​Two Research Teams from I2BC@Saclay and SPI (LI2D, Marcoule), in collaboration with IRAMIS, highlight the very strong affinity of silica nanoparticles for proteins with RGG motifs (family of binding proteins). RNA), especially when these are methylated. These results are important for the development of safe by design approaches. Chemistry Scientific result Thu, 24 May 2018 10:00:00 GMT Metabolomic analysis facilitated by very high resolution mass spectrometry https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/metabolomic-analysis-facilitated-by-mass-spectrometry.aspx In a study published in Analytical Chemistry, the Mass Spectrometry Research Team of the Laboratory Drug Metabolism Research Laboratory (SPI) demonstrated the interest of Orbitrap Fusion, a state-of-the-art mass spectrometer for the identification of relevant metabolites based on their masses and isotopes measured with high accuracy. Chemistry ; Metabolomics ; Mass spectrometry Scientific result Wed, 25 Apr 2018 10:00:00 GMT Functionalized micellar nanovectors for targeted tumor therapy https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/functionalized-micellar-nanovectors.aspx ​As part of a collaboration with MIRCen (Institute of Biology François Jacob) and SBIGeM, SCBM researchers have developed functional micellar nanovectors capable of targeting a population of cancer cells. Chemistry ; Cancer Scientific result Thu, 12 Apr 2018 10:00:00 GMT A rapid isotopic labeling method for complex molecules containing a sulfur atom https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/isotopic-labeling-complex-molecules.aspx ​Researchers from SCBM, in collaboration with Paris-Sud University and INSA Toulouse, developed the first general method for tritium and deuterium labeling of complex molecules with thioether-type motifs (including sulfur atom). This method allows rapid access to tritiated or deuterated molecules used in the pharmaceutical industry for in vivo monitoring or the biological assay of substances of interest. Chemistry Scientific result Thu, 22 Mar 2018 11:00:00 GMT Ultrasound to improve drug delivery to the brain https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/ultrasound-drug-delivery-brain.aspx Researchers from NeuroSpin (Frédéric Joliot Institute/CEA) and MIRCen (François Jacob Institute/CEA Institute of Biology) have just developed an ultrasound device guided by magnetic resonance imaging (MRI) to increase temporarily and locally the vascular permeability in non-human primates, which could be used to effectively deliver drugs to the brain. Brain ; Health & life sciences ; Pharmacology Scientific result Mon, 19 Feb 2018 11:00:00 GMT Transcription regulation by the Mediator: recent progress https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/transcription-regulation-mediator.aspx Julie Soutourina (I2BC@Saclay / SBIGeM) was invited by Nature Reviews Molecular Cell Biology to publish a review on the molecular functioning of the Mediator, a multi-protein complex, conserved from yeast to humans, and essential to the regulation of the expression of genes. Potential therapeutic approaches targeting the Mediator (cancer, fungal infections) are also adressed. Health & life sciences ; Gene and cell therapy Scientific result Wed, 17 Jan 2018 11:00:00 GMT Antibiotic resistance: a Joliot Institute project funded by EIT Health https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/antibiotic-resistance-a-joliot-institute-project-funded-by-eit-health.aspx ​A SPI/LERI Research Team has recently developed new test strips for the detection of some multi-resistant bacteria. A hospitalization project for these high-speed screening tests will be rolled out in 2018 with funding from EIT Health. Health & life sciences ; Antibiotics ; Bacteria Scientific result Wed, 29 Nov 2017 11:00:00 GMT To link and to release selectively molecules in biological media https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/link_and_release_selectively_molecules_in_biological_media.aspx A Research Team of the SCBM (Frédéric Joliot Institute), in collaboration with the SIMOPRO (Frédéric Joliot Institute), Strasbourg University and the start-up Syndivia, has just discovered a new chemical reaction allowing both to bind and to cleave molecules in biological media ("click and release" reaction). Chemistry ; Health & life sciences Scientific result Tue, 24 Oct 2017 10:00:00 GMT A new biomarker of senescence in humans https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/A_new_biomarker_of_senescence_in_humans.aspx In an article published the 10th of May in Nature Communications, some Research Teams of the Frédéric Joliot Institute (SBIGeM, SPI) discovered that a new histone variant called H2A.J accumulates in human fibroblasts in senescence. Health & life sciences ; Genomics ; Biomarkers Scientific result Wed, 14 Jun 2017 10:00:00 GMT New Project Aimed at Reducing Antibiotic Resistance https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2017/new-project-aimed-at-reducing-antibiotic-resistance.aspx ​The CEA Frédéric Joliot Institute is involved in project CARBAMAT to fight against antibiotic resistance. SATT Paris-Saclay, a company promoting technology transfer, supports this project. Institutional ; Antibiotics ; Health & life sciences News Fri, 28 Apr 2017 10:00:00 GMT Micellar nanovectors for tumor imaging. https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/Micellar_nanovectors_tumor_imaging.aspx In the context of a collaboration with the I²BM institute, researchers from SCBM have designed micellar vectors for targeting and visual delineation of tumors. Nanomedicine ; Cancer News Tue, 15 Dec 2015 11:00:00 GMT Modulating cerebral cholesterol: a new avenue of research to treat Alzheimer’s disease? https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/I2BM_anglais/News/Scientific_news/Articles/2015/Modulating-cerebral-cholesterol-new-avenue-research-treat-Alzheimer.aspx Two French research teams have recently shown in a rodent model that overexpression of an enzyme capable of eliminating excess cholesterol in the brain can act in a beneficial way on the tau component of the disease to completely correct it. Alzheimer's disease ; Gene and cell therapy ; Biotechnology MIRcen Scientific result Mon, 14 Sep 2015 10:00:00 GMT How does a mobile DNA sequence find its target? https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/How-does-mobile-DNA-sequence-find-target.aspx Certain mobile DNA sequences shape genomes and are maintained over the course of generations. How is this explained? The interaction between two proteins, which is essential for their integration into a specific area of the yeast genome, has been identified. This finding has interesting implications for gene therapy. DNA ; Gene and cell therapy Saclay Scientific result Fri, 01 May 2015 10:00:00 GMT A nano-drug for protecting neurons https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2015/a-nano-drug-for-protecting-neurons.aspx A nano-drug has been developed for treating certain neurological diseases such as brain ischemia, as well as injuries to bone marrow. It is composed of a therapeutic molecule, adenosine, and the vector squalene, which allows it to circulate in the body and reach the areas to be treated. Brain ; Pharmacology IBITECS Scientific result Thu, 05 Mar 2015 11:00:00 GMT Bio-magnet for targeted medical imaging https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/I2BM_anglais/News/Scientific_news/Articles/2015/Bio-magnet-for-targeted-medical-imaging.aspx The CEA-IBEB has partnered with the CEA-I2BM to develop original MRI contrast agents. Nano-magnets produced by bacteria may reveal targets at the molecular level. Biotechnology ; Cell and molecular imaging ; MRI ; Diagnosis ; Nanomedicine LBC Scientific result Fri, 20 Feb 2015 11:00:00 GMT Performing chemistry within the cell https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2014/Performing-chemistry-within-the-cell.aspx Researchers from the CEA-IBITECS in collaboration with a team from the University of Strasbourg (UDS) have developed new reagents known as “chelating azides”, which can rapidly and selectively couple to any compound equipped with an alkyne group. The reaction can take place in any environment, including within a cell. Chemistry ; Methodologies for life sciences Saclay Scientific result Tue, 06 May 2014 10:00:00 GMT Towards a new generation of antiviruses https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2014/Towards-a-new-generation-of-antiviruses.aspx A team from the CEA-IBITECS participated in the identification of a novel role for an enzyme, the protease MMP-12, in the immune response to viral infection. The researchers developed an inhibitor of MMP-12, which enhances the immune response in a rodent model. This work, opens the way for the development of new antiviral therapies. Diagnosis and innovative treatment ; Immune system Saclay Scientific result Tue, 29 Apr 2014 10:00:00 GMT Parkinson’s disease: a major breakthrough thanks to gene therapy https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/I2BM_anglais/News/Scientific_news/Articles/2014/Parkinsons-disease-a-major-breakthrough-thanks-to-gene-therapy.aspx An Anglo-French team (AP-HP, Inserm, CEA/Mircen, UPEC, Oxford Biomedica, Cambridge University) coordinated by Professor Stéphane Palfi (head of the neurosurgery department at the hôpital Henri-Mondor) conducted a gene therapy trial in 15 patients with an advanced form of Parkinson’s disease. Parkinson's disease ; Gene and cell therapy MIRcen Scientific result Fri, 10 Jan 2014 11:00:00 GMT Quantum dot: a promising new imaging agent https://www.cea.fr/drf/joliot/en/Pages/ARCHIVES/IBITECS_anglais/News/2013/Quantum-dot-a-promising-new-imaging-agent.aspx The drawback to current optical imaging markers is their short life. Researchers are now developing fluorescent nanocrystals (quantum dots) to supplant these markers. A team from the CEA-iBiTec-S, in collaboration with the CEA-I2BM and ESPCI, has developed a new surface chemistry for these particularly effective nanoparticles. Cell and molecular imaging ; Nanomedicine ; Chemistry Fontenay-aux-Roses Scientific result Fri, 22 Mar 2013 11:00:00 GMT