https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2021/Food-poisoning-SE-targeted-mass-spectrometry.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot-2023.png https://joliot.cea.fr/drf/joliot/en https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/spectrometrie-masse-exposomes.aspx Researchers from the DMTS have developed a method for exploring the chemical exposome in large, complex mass spectrometry datasets. They applied it to the analysis of meconium samples from a cohort. Mass spectrometry Researchers SPI Scientific result Thu, 26 Feb 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Analysis-global-metabolism-carbon-13-isotopic-labeling.aspx A collaborative study between the BIAM and Joliot (SPI/DMTS) institutes demonstrates the feasibility of near-complete whole-body carbon-13 isotopic labeling in mice and lays the foundation for a global, quantitative, and unbiased metabolomics approach. This unprecedented strategy could also enable the investigation of certain metabolic troubles. Mass spectrometry ; Metabolomics BIAM Scientific result Mon, 09 Feb 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2026/Identification-new-anti-ricin-monoclonal-antibodies.aspx DMTS teams have characterised 17 monoclonal antibody-candidates targeting ricin using two original biophysical approaches. The identification of ricin residues involved in functional antibody recognition paves the way for the development of powerful monoclonal therapeutic antibodies against this natural toxin, which is a bioterrorism agent. Biodetection ; CBRN-E threats SIMOPRO Scientific result Wed, 21 Jan 2026 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/mineMS2.aspx A LI-MS team presents an innovative strategy and software for structural elucidation in metabolomics using tandem mass spectrometry. Mass spectrometry ; Metabolomics Researchers SPI Article ; Scientific result Fri, 07 Nov 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/GMR-sensor-biochip-for-point-of-care-diagnostics.aspx Researchers from IRAMIS and SPI (DMTS) evaluated their GMR-sensor biochip prototype for its ability to detect cancer cells in a complex medium. This approach, which combines sensor physics with medical biology, aims to develop simpler and portable diagnostic tools that meet the WHO criteria for point-of-care testing. Physics ; Biodetection SPI Scientific result ; Article Tue, 30 Sep 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Ultrasound-counter-exposure-neurotoxic-agent.aspx Researchers from BioMaps (SHFJ), NeuroSpin, and the french IRBA developed an innovative approach using focused ultrasound to improve brain delivery of an antidote, oxime, following exposure to an organophosphorus neurotoxic agent in a murine model. Pharmacology ; Toxicology ; Brain ; CBRN-E threats Neurospin Scientific result preclinic;animal models; Thu, 28 Aug 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Interactions-of-alpha-synuclein-with-polyethylene-nanoplastics.aspx A team from I2BC, in collaboration with the NIMBE (CEA-Iramis), is unveiling the nature of the interactions of human alpha-synuclein (hαSn) with polyethylene nanoplastics, using molecular dynamics simulations and experimental methods. Nanotoxicology ; Simulation ＆ modelling ; Structural biology Iramis Scientific result Tue, 27 May 2025 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Ricin-passive-immunotherapy-Antibodies.aspx ​The LERI (SPI/DMTS) has developed a new generation of anti-ricin antibodies with a high affinity for the D and E isoforms of the protein, providing effective protection for model mice intoxicated with ricin. CBRN-E threats Researchers SPI Scientific result ; Article toxin;Preclinical;animal models; Fri, 28 Mar 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/detection-ricine.aspx Une équipe du LI-MS (SPI/DMTS) a mis au point une méthode de détection de la ricine combinant l’enrichissement des échantillons grâce à l’affinité de la ricine pour une glycoprotéine et la spectrométrie de masse à haute résolution. CBRN-E threats Researchers SPI Scientific result ; Article Wed, 19 Feb 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Universal-identification-pathogenic-viruses-proteotyping.aspx Researchers at Li2D (SPI/DMTS, Marcoule) have proposed an innovative tandem mass spectrometry proteotyping method for the universal identification of pathogenic viruses, requiring no prior knowledge of sample composition. A step towards improved diagnosis of viral infections Virus ; Mass spectrometry ; Biodetection ; CBRN-E threats SPI Scientific result ; Article Wed, 29 Jan 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2025/Cancer-immunoprofiling-click-chemistry-mass-spectrometry.aspx Researchers at DMTS and SHFJ have carried out a multiplexed analysis of tumor cells and tissues, based on the use of cleavable therapeutic antibodies carrying mass tags, for the identification and quantification of cancer biomarkers. A proof-of-concept demonstrating the high potential of this tumor immunoprofiling approach Cancer ; Chemistry ; Mass spectrometry ; Diagnosis SIMOPRO Scientific result preclinical research;animal models; Mon, 13 Jan 2025 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Diagnosis-acute-hepatic-porphyrias-mass-spectrometry.aspx A collaborative study between SPI and a team from Hôpital Louis Mourier demonstrates the contribution of liquid chromatography coupled with mass spectrometry to the day-to-day analytical needs of a clinical laboratory. Application to the rapid quantification of biomarkers in acute hepatic porphyrias. Diagnosis ; Mass spectrometry ; Biomarkers SPI Scientific result ; Article Fri, 23 Feb 2024 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Autophagy-involved-protecting-cells-against-ricin.aspx A team from SIMoS and SCBM, in collaboration with researchers from I2BC, has shown that autophagic degradation is at work when mammalian cells are poisoned by ricin. Stimulating this process could provide additional protection against this deadly toxin. CBRN-E threats ; Cellular mechanisms SCBM Scientific result ; Article Thu, 28 Sep 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2023/NRBC-CEA-Joliot-Jacob-RESILIENCE.aspx CBRN-E threats Joliot Academic partnerships bactéries;toxines;virus;CBRN;menaces radiologiques et nucléaires;santé pour la défense; Fri, 30 Jun 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Proteins-involved-pathogenesis-creatine-transporter-deficiency.aspx Researchers at SPI (DMTS) have identified by mass spectrometry and bioinformatics analysis several biomarkers linked to the creatine transporter deficiency disorder (CTD) using two original models : mice with the clinical characteristics of CTD subjects and brain organoids derived from CTD patient cells. Mass spectrometry ; Genetic diseases ; Biomarkers ; Proteomics SPI Scientific result Thu, 22 Jun 2023 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Link-intestinal-microbiota-Covid-19.aspx A team from SPI used mass spectrometry to analyze the degree of alteration of the intestinal microbiota of Covid-19 patients and to look for signatures of intestinal infection by the SARS-CoV-2 virus. The level of the observed gut dysbiosis would be an indicator of the stage and extent of the infection. Mass spectrometry ; Proteomics ; Biomarkers ; Infectious diseases SPI Scientific result ; Article Thu, 12 May 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/ProMetIS-open-database-multi-omics-phenotyping.aspx A consortium of researchers, led by SPI/DMTS, presents ProMetIS, a pilot study for the deep phenotyping of murine models by combining proteomic and metabolomic approaches. A significant advance for the functional characterization of genes and the development of bioinformatics integration approaches. Mass spectrometry ; Large-scale biology ; Bioinformatic SPI Scientific result Mon, 04 Apr 2022 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Diagnosis-MS-congenital-disorders-glycosylation.aspx A collaboration initiated in 2017 between AP-HP (Bichat Hospital), Paris-Saclay University (Inserm 1193) and the Laboratoire d’Études du Métabolisme des Médicaments (LEMM/SPI/DMTS), leading to 4 publications in 2021, is advancing knowledge on the origin of certain congenital disorders of glycosylation, through the identification of specific biochemical biomarkers. Mass spectrometry ; Biomarkers ; Genetic diseases SPI Scientific result Tue, 04 Jan 2022 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Metaproteomics-data-science-soil-microbiota.aspx Researchers from Li2D (SPI/DMTS, Marcoule) and LSCE have developed an innovative methodology for analyzing soil microbiota based on an optimal computational interpretation of metaproteomic databases, which should lead to a better understanding of the impact of pollutants on soil quality and to the prediction of their restoration potential. Environment ; Proteomics ; Mass spectrometry ; Bacteria Scientific result Thu, 07 Oct 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Pinnatoxin-crosses-physiological-barriers.aspx In a study published in Science of the Total Environment, researchers from SIMoS (DMTS/CEA-Joliot), in collaboration with the Faculty of Pharmacy of Paris and MIRCen (CEA-Jacob) have shown for the first time in an animal model the capacity of Pinnatoxin-G, a marine neurotoxin, to cross physiological barriers to reach its molecular targets. Toxicology ; Impacts on living (organisms) Scientific result Thu, 05 Aug 2021 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Food-poisoning-SE-targeted-mass-spectrometry.aspx SPI (DMTS), in collaboration with ANSES, has developed a test based on immuno-capture and targeted mass spectrometry for the quantitative and multiplex identification, in dairy products, of the eight main enterotoxins of Staphylococcus aureus, responsible for food poisoning epidemics. Mass spectrometry ; Toxicology ; CBRN-E threats Scientific result Thu, 18 Mar 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Vers-test-quantitatif-MS-diagnostic-specifique-COVID-19.aspx Le LEMM, en collaboration avec le LI2D et l’AP-HP, développe un test de diagnostic spécifique de la Covid-19 par spectrométrie de masse qui permettrait aussi la quantification de la charge virale du patient. Objectif à terme : adapter la méthode pour la rendre plus sensible et compatible avec les équipements d’analyse des hôpitaux. Diagnosis ; Mass spectrometry ; Virus Researchers SPI Scientific result SARS-CoV-2; Tue, 09 Mar 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/SPI-ATRACTion-consortium.aspx Coordinated by the Imagine Institute for Genetic Diseases, the ATRACTion program is based on a consortium of 11 academic and industrial partners, including SPI (DMTS), and aims to develop a precision medicine for patients with autoimmune and inflammatory diseases associated with primary immune deficiencies. Metabolomics ; Mass spectrometry ; Autoimmune diseases News Thu, 14 Jan 2021 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Variovorax-bacteria-living-heart-working-nuclear-reactor.aspx Researchers from I2BC and SPI (DMTS, Marcoule), in collaboration with CEA Grenoble and the Belgian nuclear research center, discovered, by using two meta-omic approaches, living bacteria in the core pool of the CEA Paris-Saclay research reactor, Osiris, in operation, thus opening up perspectives for the discovery of new radioresistant species. Bacteria ; Nuclear Toxicology Scientific result Thu, 17 Dec 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Retro1-new-molecule-against-intracellular-pathogens.aspx The SCBM and SIMoS collaborated to optimize the activity of Retro-1, a benzodiazepine compound, inhibitor of Shiga toxins and ricin, derived from high-throughput biological screening. They succeeded in obtaining an analog 70 times more protective against the cytotoxicity of Shiga toxins, Retro-1.1. Chemistry ; High-throughput screening ; CBRN-E threats Scientific result Mon, 14 Sep 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Methylglyoxal-detoxification-in-cyanobacteria.aspx A team from I2BC (SB2SM) used a combination of in vitro and in vivo approaches in the model cyanobacterium Synechocystis to establish a logical, but as yet never described, link between the detoxification of methylglyoxal, a toxic metabolite, and glutathione S-transferase, an enzyme of the xenobiotic metabolism, conserved during evolution. Photosynthesis ; Toxicology ; Microalgae News Fri, 04 Sep 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Composition-microbiota-animals-in-natura-mass-spectro.aspx A team from SPI in Marcoule, in collaboration with INRAE, characterized the intestinal microbiota of a small crustacean, Gammarus fossarum, used as a sentinel of water quality in France, by combining proteogenomics and metaproteomics approaches, thus opening up interesting perspectives for the analysis of host/microbiota interactions in other animal models. Mass spectrometry ; Bacteria ; Metagenomics ; Proteomics Scientific result Mon, 24 Aug 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/SARS-CoV-2-detection-mass-spectrometry-rapidity.aspx A team from SPI in Marcoule detected by mass spectrometry, in 3 minutes and without specific reagents, signature peptides of the SARS-CoV-2 virus in clinical samples (nasopharyngeal swabs). It thus provides a proof of concept of the use of this method as a possible alternative to PCR, currently the reference method. Mass spectrometry ; Virus ; Biodetection ; Diagnosis Scientific result Thu, 06 Aug 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/New-taxonomy-bacteria-archea.aspx The discovery of myriads of new species of bacteria and archaea, linked to the explosion of metagenomics, is leading microbiologists to consider rethinking how to map certain branches of life. Tools, such as the phylopeptidomics developed at Li2D, could help them do so. Mass spectrometry ; Bacteria ; Proteomics Researchers SPI Mon, 20 Jul 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Proteomic-analysis-SARS-CoV-2-infected-cells.aspx In order to optimize the amplification of quality inactivated virus, for the manufacture of a vaccine, a team from SPI (CEA Marcoule) used mass spectrometry to analyze the dynamics of the proteome of SARS-CoV-2 infected cells, at two multiplicities of infection. With more than 3,220 identified host proteins, researchers are also starting to decipher the processes and cellular networks impacted by this virus. Virus ; Mass spectrometry ; Proteomics News Mon, 06 Jul 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Succes-workshop-EuroBioTox.aspx ​​A training seminar "on biological toxins and on site detection" on in situ detection of biological toxins for first responders and validation of forensic procedures was held at CEA Paris-Saclay from 3 to 5 March 2020. Biodetection SPI Event ; Article Tue, 31 Mar 2020 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Characterization-predictive-survival-biomarker-septic-shock.aspx Two recent studies conducted by SPI researchers, in collaboration with Inserm and AP/HP teams, reveal the value of measuring plasma levels of calgranulins as biomarkers for the prediction of mortality risk of patients with septic shock, admitted in intensive care unit. Biomarkers ; Mass spectrometry ; Infectious diseases Scientific result Tue, 24 Mar 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Press/The-way-is-now-open-for-the-development-of-a-broad-spectrum-drug-candidate-for-several-pathogenic-viruses,-bacteria-and-tox.aspx Health ＆ life sciences ; Toxicology ; Virus News ; Press release Fri, 21 Feb 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Identification-target-mechanism-action-anti-infective-drug-candidate.aspx Researchers from SIMoS, SCBM and Institut Curie, in collaboration with Carnegie Mellon University (USA), have identified the intracellular target and the mechanism of action of Retro-2, a broad-spectrum inhibitor of intracellular toxins and pathogens. They are now working on the design of an effective drug in the event of a bioterrorist attack or a health crisis. Health ＆ life sciences ; CBRN-E threats Scientific result Wed, 19 Feb 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Magnetic-sensors-ultra-sensitive-biochips.aspx Researchers from IRAMIS collaborated with a team from SPI (LERI) for the development of a microfluidic biochip ("lab-on-chip") based on ultra-sensitive magnetic sensors with giant magnetoresistance (GMR sensors), capable of individually and effectively detect magnetically-labeled biological targets. Biotechnology ; Biodetection ; Physics Scientific result Wed, 08 Jan 2020 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Alzheimer-or-Lewy-bodies-dementia-MS-answer.aspx A team from SPI, in collaboration with the metabolic biochemistry service and the Institute of Memory and Alzheimer's Disease (IM²A) of the university hospitals Pitié-Salpêtrière, has developed a method for the simultaneous quantification of tau and α-synuclein proteins in human cerebrospinal fluid by high-resolution mass spectrometry. A promising new approach for the differential diagnosis of Lewy bodies dementia and Alzheimer's disease. Neurodegenerative diseases ; Mass spectrometry Scientific result Thu, 07 Nov 2019 11:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Corona-proteins-silica-nanoparticles-reveals-structure.aspx Researchers from I2BC@Saclay and Iramis, in collaboration with Léon Brillouin laboratory, analyzed the structure of the "corona" of two model proteins adsorbed on silica nanoparticles, by using the small-angle neutron scattering technique. They show that the structures formed are true nano-assemblies, in which the proteins retain their shape. Nanotoxicology Scientific result Wed, 18 Sep 2019 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/spectrometry-quality-control-vaccines.aspx ​A SPI Research Team (LI2D, Marcoule), in collaboration with CIRAD and AU-PANVAC, proposes a new quality control technique for veterinary vaccines, based on very high resolution mass spectrometry. This strategy, based on the use of an ad hoc database to measure the proportion of antigens and contaminants in the vaccine preparation, will improve the quality control of vaccines against contagious caprine pleuropneumonia. Mass spectrometry ; Vaccine Scientific result Thu, 05 Jul 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2018/SIMOPRO-project-supported-by-SATT-paris-saclay.aspx ​A SIMOPRO project supported by SATT Paris-Saclay: in vivo validation of the efficacy of the DTR8 molecule, developed and patented at SIMOPRO (Department of Medicines and Technologies for Health) in collaboration with Inserm, as a treatment for glomerulonephritis rapidly progressive. Institutional ; Toxicology ; Diagnosis and innovative treatment News Wed, 30 May 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2018/Toxins-vaccines-biobetters-butantan.aspx ​​Last April, a delegation of experts from the DRF visited colleagues at the Butantan Institute of São Paulo, a biomedical research center that has had close links with several researchers at the Joliot Institute since 2014. This mission is is concluded by the signing of a framework agreement between the two institutes in the field of therapeutic and vaccine innovation. Institutional ; Toxicology ; Vaccine News Fri, 25 May 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2018/metabolomic-analysis-facilitated-by-mass-spectrometry.aspx In a study published in Analytical Chemistry, the Mass Spectrometry Research Team of the Laboratory Drug Metabolism Research Laboratory (SPI) demonstrated the interest of Orbitrap Fusion, a state-of-the-art mass spectrometer for the identification of relevant metabolites based on their masses and isotopes measured with high accuracy. Chemistry ; Metabolomics ; Mass spectrometry Scientific result Wed, 25 Apr 2018 10:00:00 GMT https://www.cea.fr/drf/joliot/en/Pages/news/Science/2017/Silica_nanoparticles_trap_proteins_that_fix_RNA.aspx A collaboration between researchers at IBITECS and an IRAMIS Research Team shows that proteins that bind RNA strongly adsorb on silica nanoparticles. In particular, the proteins involved in the initiation of translation are easily trapped by these nanoparticles, inhibiting the synthesis of proteins. Nanotoxicology Scientific result Tue, 14 Feb 2017 11:00:00 GMT