Frédéric Joliot Institute for Life Sciences - On the same theme https://joliot.cea.fr/drf/joliot/en/Pages/news/Science/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx Website of the Frédéric-Joliot Institute of Life Sciences which includes 4 departments: I2BC, DMTS, NeuroSpin and Service hospitalier Frédéric Joliot (SHFJ). The teams are mainly located at the CEA Paris-Saclay center and at the Orsay hospital. en-US https://www.cea.frhttps://www-cea-fr.admsite.extra.cea.fr/Style%20Library/Themes/drf/instituts/images/logo-cea-joliot.png Frédéric Joliot Institute for Life Sciences - On the same theme https://joliot.cea.fr/drf/joliot/en Towards a neurodevelopmental model for the prediction of psychotic transition https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Neurodevelopmental-model-prediction-psychotic-transition.aspx A NeuroSpin team has built a predictive model for the onset of psychosis using a combination of supervised learning analyses and a model of neuroanatomical age, based on neuroimaging data from healthy subjects and those at risk of psychotic transition. MRI ; Diseases ; Artificial intelligence ; Brain Neurospin Scientific result Thu, 21 Mar 2024 11:00:00 GMT What do cognitive neurosciences have to say about our perception of time? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Cognitive-neurosciences-perception-of-time.aspx A team from NeuroSpin has recently published 3 papers that address the question of how we perceive time from a cognitive neuroscience perspective, using real-life temporal experiments, laboratory experiments and MEG brainwave measurements indicative of the passage of time, and that shed light on how the brain constructs our experience of lived time. Brain ; Cognition Neurospin Scientific result Tue, 27 Feb 2024 11:00:00 GMT Improved diagnosis of acute hepatic porphyrias using mass spectrometry https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Diagnosis-acute-hepatic-porphyrias-mass-spectrometry.aspx A collaborative study between SPI and a team from Hôpital Louis Mourier demonstrates the contribution of liquid chromatography coupled with mass spectrometry to the day-to-day analytical needs of a clinical laboratory. Application to the rapid quantification of biomarkers in acute hepatic porphyrias. Diagnosis ; Mass spectrometry ; Biomarkers SPI Scientific result ; Article Fri, 23 Feb 2024 11:00:00 GMT Innovative methodological developments for the emergence of ultra-high field MRI in clinical research https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Methodological-developments-emergence-ultra-high-field-MRI.aspx Researchers at NeuroSpin have recently published 3 articles in Magnetic Resonance in Medicine on their technological and methodological developments that will help meet the challenges of ultra-high field MRI for tomorrow's medical brain imaging. MRI ; Technologies Neurospin Scientific result Mon, 19 Feb 2024 11:00:00 GMT First complete atlas of chimpanzee brain connectivity https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/First-complete-atlas-chimpanzee-brain-connectivity.aspx NeuroSpin researchers map chimpanzee brain structural connectivity for the first time using diffusion MRI data. New image processing enabled them to create two atlases of deep and superficial white matter connectivity. A step towards a better understanding of the evolution of the hominid brain. Brain ; MRI ; Computing Neurospin Scientific result préclinique; Mon, 12 Feb 2024 11:00:00 GMT Where and how is the representation of quantities generated in the brain? Study using ultra-high field functional MRI https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Quantities-representation-brain-fMRI-UHF.aspx In a study published in Nature Communications, researchers from UNICOG and BAOBAB use high-field functional MRI to reveal the brain areas where the representations of quantities generated by a mental arithmetic operation are encoded. Cognition Researchers Neurospin Scientific result Wed, 31 Jan 2024 11:00:00 GMT Dyslexie : certains des dispositifs vendus pour faciliter la lecture ne sont pas efficaces https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/Dyslexie-dispositifs-vendus-inefficaces.aspx Les dispositifs tels que les lampes et les lunettes stroboscopiques censés faciliter la lecture des personnes dyslexiques n’auarient en fait aucun impact. C’est ce que révèle une étude menée par une équipe d’UNICOG (NeuroSpin) et publiée dans la revue Proceedings Royal Society. Cognition Scientific result ; Article Sun, 28 Jan 2024 11:00:00 GMT Validation of a new elasticity biomarker for biological tissue diagnosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2024/elasticity-biomarker-biological-tissue-diagnostics.aspx SHFJ researchers have validated the use of a new biomarker, the nonlinear shear modulus, to measure the elasticity of biological tissues, by comparing results obtained using echography with those obtained using MRI imaging and digital simulation. This biomarker is of particular interest for the diagnosis of certain breast cancers. Medical imaging ; MRI ; Diagnosis SHFJ Scientific result Wed, 24 Jan 2024 11:00:00 GMT 38 millions d’euros sécurisés pour EBRAINS https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2024/38-millions-euros-EBRAINS.aspx Brain Europe ; Infrastructures ; Article Human Brain Project;HBP; Thu, 11 Jan 2024 11:00:00 GMT Neural representation of uncertainty: towards a consensus? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Neural-representation-uncertainty-consensus.aspx In a review article published in Nature Neuroscience, researchers, including Florent Meyniel from UNICOG (NeuroSpin), show that the two dominant approaches to the neural representation of uncertainty are complementary and would benefit from being used synergistically. Cognition Scientific result ; Article Fri, 17 Nov 2023 11:00:00 GMT Characterization of low-frequency neuronal oscillations in human magnetoencephalography https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Low-frequency-neuronal-oscillations-MEG.aspx NeuroSpin researchers show that spontaneous neuronal oscillations in the 'delta' frequency band (0.5-3 Hz), the wave of unconscious states, can be observed in awake human volunteers using MEG. A step towards characterizing underlying physiological signals? Brain ; Cognition Neurospin Scientific result ; Article Wed, 18 Oct 2023 10:00:00 GMT IRM : effets transitoires des ultra hauts champs sur le système vestibulaire https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/IRM-effets-transitoires-UHF-systeme-vestibulaire.aspx Des chercheurs de NeuroSpin, en collaboration avec NeuroPSI montrent que l’effet des ultra hauts champs magnétiques sur l’appareil vestibulaire de souris est transitoire. MRI Researchers Neurospin Scientific result ; Article cochlée; Fri, 06 Oct 2023 10:00:00 GMT Understanding the relationship between cerebellar structure and social abilities in young subjects with autism-related symptoms https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Relationship-cerebellar-structure-social-abilities-young-autistic.aspx A collaborative study by NeuroSpin researchers, using anatomical MRI data and a dimensional approach in 850 subjects from the Healthy Brain Network cohort, shows how the social skills of these children and adolescents are linked to the structure of their cerebellum Brain ; Cognition ; MRI Neurospin Scientific result Tue, 12 Sep 2023 10:00:00 GMT Rentrée « en mode kick-off » pour l’équipe MIND https://www.cea.fr/drf/joliot/en/Pages/news/Events/2023/Kick-off-meeting-MIND.aspx ​​​Le 07 septembre, l'équipe MIND organisait son kick-off meeting, symbolisant la volonté commune de sestutell es, CEA et Inria, de consolider et de créer des synergies en intelligence artificielle et machine learning pour les neurosciences. MRI ; Artificial intelligence ; Brain Researchers ; Institutions Neurospin Inauguration ; Colloquium deep learning;Deep Neural Network;réseaux de neurones; Mon, 11 Sep 2023 10:00:00 GMT kick-off meeting for the MIND team https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2023/Kick-off-meeting-MIND.aspx On 07 September, the young MIND team organised its kick-off meeting, symbolising the shared desire of its two supervisory administrations, the CEA and Inria, to consolidate and create synergies in artificial intelligence and machine learning for neuroscience. MRI ; Artificial intelligence ; Brain Researchers ; Institutions Neurospin Inauguration ; Colloquium deep learning;Deep Neural Network; Mon, 11 Sep 2023 10:00:00 GMT Un composé radiosensible pour combiner radiothérapie et chimiothérapie ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Composé-radiosensible-combiner-radiotherapie-et-chimiotherapie.aspx Des chercheurs du SCBM et de l’Iramis publient une étude preuve-de-concept d’un composé radiosensible qui pourrait servir à « libérer » in vivo des médicaments anti-tumoraux, et ainsi de combiner les effets d’une radiothérapie et d’une chimiothérapie. Chemistry ; Radiotherapy Researchers SCBM Scientific result ; Article Tue, 05 Sep 2023 10:00:00 GMT L’IA pour l’IRM à haut champ : les multiples pistes développées par l’équipe MIND pour ne plus choisir entre temps et qualité de l’image https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/IA-IRM-haut-champ-multiples-pistes-equipe-MIND.aspx Brain ; MRI ; Artificial intelligence Researchers Neurospin Scientific result ; Patent Wed, 30 Aug 2023 10:00:00 GMT Identification of metabolomic signatures of high-grade breast tumors https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Metabolomic-signatures-high-grade-breast-tumors.aspx The TIRO laboratory of the SHFJ (Nice) identifies for the first time discriminating biomarkers of high-grade invasive breast tumors, using a non-targeted metabolomics approach performed on surgical specimens and cytoponctions from patients at different stages of malignancy. Metabolomics ; Cancer ; Biomarkers SHFJ Scientific result Fri, 04 Aug 2023 10:00:00 GMT Longitudinal monitoring of tauopathy in PET imaging to better understand the various modalities of clinical evolution of Alzheimer's disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Longitudinal-monitoring-tauopathy-PET-imaging.aspx A joint team from GHU Paris and BioMaps (SHFJ) conducted a 2-year longitudinal study of 27 people with Alzheimer's disease, tracking the progression of tau pathology measured by PET imaging, of cortical atrophy using MRI, and their links with cognitive decline. Alzheimer's disease ; Medical imaging ; MRI ; Positron Emission Tomography SHFJ Scientific result ; Article Wed, 02 Aug 2023 10:00:00 GMT Comment le cerveau intègre-t-il efficacement les informations visuelles et auditives de la parole ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Parole-integrations-informations-visuelles-et-auditives.aspx Une étude dirigée par une équipe d’UNICOG montre que le cerveau humain optimise l’intégration des informations auditives et visuelles de la parole à différentes échelles anatomiques et fonctionnelles, grâce à un ensemble de réseaux neuronaux hiérarchiquement imbriqués et synchronisés. Brain ; Cognition Scientific result Tue, 25 Jul 2023 10:00:00 GMT Agir sur les protéines pour limiter la dispersion des microplastiques dans l’eau ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/proteines-dispersion-microplastiques-dans-eau.aspx Des chercheurs de l’I2BC ont contribué à une étude menée par l’Iramis qui dévoile le rôle des protéines dans la dispersion des microplastiques dans l’eau. Leurs résultats permettent d’imaginer de nouvelles stratégies low tech pour débarrasser l’eau de cette pollution. Impacts on living (organisms) ; Molecular mechanisms ; Remediation Researchers SB2SM Scientific result surfactant;polypropylène;polyéthylène; Wed, 12 Jul 2023 10:00:00 GMT Creatine transporter deficiency: use of two original models to characterize this rare genetic disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Proteins-involved-pathogenesis-creatine-transporter-deficiency.aspx Researchers at SPI (DMTS) have identified by mass spectrometry and bioinformatics analysis several biomarkers linked to the creatine transporter deficiency disorder (CTD) using two original models : mice with the clinical characteristics of CTD subjects and brain organoids derived from CTD patient cells. Mass spectrometry ; Genetic diseases ; Biomarkers ; Proteomics SPI Scientific result Thu, 22 Jun 2023 10:00:00 GMT The "rabbit motif" in 18F-DOPA PET imaging for a simplified diagnostic evaluation of parkinsonian syndromes https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/rabbit-motif-PET-imaging-diagnostic-evaluation-parkinsonian-syndromes.aspx BioMaps researchers compared the diagnostic performance of the rabbit visual pattern observed in 18F-DOPA PET imaging with the standard procedure approved by the international nuclear imaging societies for the diagnosis of parkinsonian syndromes in PET/MRI and obtained encouraging results, which may validate the clinical utility of such a model Positron Emission Tomography ; Medical imaging ; Parkinson's disease ; Brain SHFJ Scientific result Tue, 23 May 2023 10:00:00 GMT Characterization of the neural representation of confidence during probabilistic learning https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Neural-representation-confidence-probabilistic-learning.aspx Using a dynamic probability learning task and high-field (7T) fMRI, a NeuroSpin team identifies regions in parietal and frontal cortex involved in the neural representation of prediction confidence during human learning Brain ; Cognition Neurospin Scientific result Wed, 10 May 2023 10:00:00 GMT Mise en exploitation de l’IRM 11.7 T Iseult : revue de détails https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Mise-en-exploitation-IRM-11-7-T-Iseult.aspx La mise en exploitation de l’IRM 11.7 T Iseult en 2021 a couronné près de 20 ans de recherche et développement du CEA. Dans un article publié dans le journal Magnetic Resonance Materials in Physics, Biology and Medecine, Nicolas Boulant et Lionel Quettier, chefs du projet Iseult pour les instituts Joliot et Irfu du CEA, passent en revue les détails de cette mise en service. MRI ; Brain Article Fri, 28 Apr 2023 10:00:00 GMT Combining neuroanatomical markers to strengthen the diagnosis of fetal alcohol spectrum disorder https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Structuring-neuroanatomical-criteria-fetal-alcohol-spectrum-disorder.aspx By analyzing brain imaging data, researchers from InDEV (NeuroSpin / UMR NeuroDiderot) have identified recurrent abnormalities in subjects with fetal alcohol syndrome, the combination of which could have a particularly interesting diagnostic value for non-syndromic forms of fetal alcohol spectrum disorders. MRI ; Diagnosis and innovative treatment Researchers Scientific result Mon, 13 Mar 2023 11:00:00 GMT Genetic variations in evolutionarily acquired DNA regulatory regions affect the morphology of certain sulci in the human cerebral cortex https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Genetic-variations-regulatory-regions-morphology-brain-sulci.aspx Using UK Biobank imaging-genetics data, a collaborative study led by NeuroSpin found that variation in genomic regions, known as enhancers, could affect the morphology of cortical sulci and be associated with the evolution of locomotion in primates and bipedalism in our hominin ancestors. MRI ; Genomics ; Brain Neurospin Scientific result Mon, 27 Feb 2023 11:00:00 GMT Anatomical atypia in autistic people ? Fine morphological analyses contradict the results of the last decade https://www.cea.fr/drf/joliot/en/Pages/news/Science/2023/Anatomical-atypia-cerebellum-autistic-people.aspx By studying the morphology of the cerebellar gray matter, an international consortium coordinated by NeuroSpin researchers concludes that there are no anatomical atypia in the cerebellum of people with autism. Diseases ; Brain ; Medical imaging Researchers Saclay Scientific result IRM 3T;TDAH; Mon, 06 Feb 2023 11:00:00 GMT ERC Starting Grant for Timo van Kerkoerle at NeuroSpin! https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2022/ERC-Starting-Grant-Timo-van-Kerkoerle-NeuroSpin.aspx Timo van Kerkoerle, researcher at NeuroSpin, is one of the 408 winners of the prestigious ERC Starting Grant 2022 call of the European Research Council. Another European success for the Institute. Cognition Neurospin Success ; Europe Tue, 22 Nov 2022 11:00:00 GMT MRI: signal-to-noise ratio at high field strengh, when experiment validates theory https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/SNR-high-field-MRI.aspx ​A collaboration led by a METRIC team (BAOBAB/NeuroSpin) has undertaken to measure the signal-to-noise ratio (SNR) in MRI at the centre of a spherical phantom at different magnetic field strengths (B0). Their data confirm the theories that SNR increases with approximately the square of B0. MRI Researchers Neurospin Scientific result ; Article Thu, 17 Nov 2022 11:00:00 GMT Studying low-concentration metabolites in the brain with CEST-linescan https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/CEST-linescan-Etudier-des-metabolites-peu-concentres-dans-cerveau.aspx NeuroSpin researchers, in collaboration with Iramis and the Università Statale di Milano, have developed a CEST magnetic resonance spectroscopy sequence that allows them to detect and confirm the presence of three dipeptides in the brain and skeletal muscle of adult rats and thus to consider future studies of their physiological role. MRI ; Cell and molecular imaging Researchers Neurospin Scientific result Tue, 15 Nov 2022 11:00:00 GMT First results of the "Confined time" study released in Blursday, a resource to understand our perception of time during lockdown https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Blursday-resource-to-understand-our-time-perception-during-lockdown.aspx The participative study on our time perception during the confinement, led by Virginie van Wassenhove (NeuroSpin), provides the first open database, Blursday, which analyzes the nature of the alterations in our relationship to time during physical and social distancing, as we experienced during the Covid-19 pandemic. Brain ; Cognition Neurospin Scientific result Mon, 19 Sep 2022 10:00:00 GMT Specificity of reading and face recognition cerebral circuits during reading acquisition https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Specificity-of-reading-and-face-recognition-cerebral-circuits.aspx By measuring fMRI responses to written words, faces, houses and checkerboards in three groups of children, pre-readers and beginning readers aged 6 and advanced readers aged 9, a team from UNICOG (NeuroSpin) shows that reading acquisition recycles and specializes a pre-existing but plastic visual circuit connected to language areas. Brain ; MRI ; Learning Neurospin Scientific result Mon, 12 Sep 2022 10:00:00 GMT Predicting all cognitive activities from images of the functionning brain, it's possible https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Predicting-cognitives-activities-fMRI-maps.aspx A NeuroSpin team succeeded in decoding a large set of human mental processes by training neural networks to predict cognitive labels from a cognitive atlas and by leveraging the data set of NeuroVault, a web-based database for collecting and sharing statistical maps of the human brain. Brain ; Cognition ; MRI ; Artificial intelligence Neurospin Scientific result Thu, 30 Jun 2022 10:00:00 GMT New generation of dielectric pads for ultra high field MRI imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Pads-dielectriques-IRM-tres-haut-champ.aspx To address the problem of ultre high field MRI signal loss in certain regions of the human body, a collaboration involving the CEA-Joliot, the CEA-Iramis, the Fresnel Institute and Multiwave Imaging has led to the development of a new generation of simple and inexpensive silicon carbide-based pads. The new composition makes the pads invisible to MRI and prolongs their performance when compared to existing solutions. MRI Researchers ; Partners Iramis Scientific result ; Article specific absorption rate;radiofrequency passive shimming;shims; Tue, 07 Jun 2022 10:00:00 GMT First atlas of anatomical brain connectivities in quail! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/First-atlas-anatomical-brain-connectivities-quail.aspx The expertise of NeuroSpin in diffusion MRI has allowed to establish the first atlas of the anatomical connectivities of the Japanese quail brain at a resolution of 150 m in three dimensions. MRI ; Brain Researchers Neurospin Scientific result ; Article Tue, 31 May 2022 10:00:00 GMT What if the shape of the early brain sulci could predict certain pathologies? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Shape-early-brain-sulcus-predict-pathologies.aspx Neurospin researchers conducted a longitudinal brain imaging study in very premature infants to analyze the variability of the shape of the central sulcus early in its development and its functional implications. Brain ; MRI Researchers Neurospin Scientific result brain fold;gyrification;prematurity;hemispheric asymmetry; Fri, 20 May 2022 10:00:00 GMT Multisensory integration may be a matter of temporal coincidences https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Integration-multisensory-temporal-coincidences.aspx A team at NeuroSpin, in collaboration with the University of Ulm (Germany), published a study in Nature Communications that suggests the existence of multisensory correlation detectors in the human brain. Brain ; Cognition Researchers Neurospin Scientific result Wed, 18 May 2022 10:00:00 GMT A possible link between changes in gut microbiota and fecal SARS-CoV-2 load ? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Link-intestinal-microbiota-Covid-19.aspx A team from SPI used mass spectrometry to analyze the degree of alteration of the intestinal microbiota of Covid-19 patients and to look for signatures of intestinal infection by the SARS-CoV-2 virus. The level of the observed gut dysbiosis would be an indicator of the stage and extent of the infection. Mass spectrometry ; Proteomics ; Biomarkers ; Infectious diseases SPI Scientific result ; Article Thu, 12 May 2022 10:00:00 GMT Object detection facilitates segmentation of rare brain tumors in MR imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Segmentation-rare-brain-tumors.aspx A study led by NeuroSpin researchers proposes an optimized delineation of rare brain tumors, based on a combined approach of object detection and deep learning segmentation in tumor images, a key step in the characterization of cancers. Brain ; Medical imaging ; MRI Neurospin Scientific result ; Article Thu, 05 May 2022 10:00:00 GMT MRI: the SPARKLING algorithm, even more sparkling! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/MRI-3D-sparkling.aspx NeuroSpin researchers propose a new version of their compressed MRI acquisition algorithm, SPARKLING, extended to 3D imaging. Their method reduces acquisition time by a factor of 20 for T2*-weighted scans without compromising image quality. Simulation & modelling ; MRI Researchers Neurospin Scientific result ; Europe Thu, 28 Apr 2022 10:00:00 GMT ptairMS software: real-time study of biomarkers in exhaled breath https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/ptairMS-COVs-biomarkers.aspx The ptairMS software, developed in the framework of a collaboration led by the CEA-Joliot, allows the processing and analysis of proton transfer mass spectrometry data, an ideal method for the real-time study of volatile organic compounds (VOCs) present in exhaled breath. Bioinformatic ; Biomarkers Researchers List Scientific result Tue, 26 Apr 2022 10:00:00 GMT Hybrid PET/MRI imaging, a unique examination to improve the detection of epileptogenic lesions https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/PET-MRI-imaging-epilepsy-detection.aspx A team from BioMaps (SHFJ), in collaboration with several hospital groups, shows that hybrid PET/MRI imaging significantly improves the detection of epileptogenic foci and, consequently, the outcome of surgical treatment of epilepsy. Medical imaging ; Positron Emission Tomography ; MRI SHFJ Scientific result Tue, 05 Apr 2022 10:00:00 GMT The New York Times is interested in the studies on the sensitivity to geometry conducted at NeuroSpin https://www.cea.fr/drf/joliot/en/Pages/news/Press/2022/The-New-York-Times-geometrie-NeuroSpin.aspx In an article in the New York Times, Stanislas Dehaene (NeuroSpin director) and Mathias Sablé-Meyer (PhD student) discuss recent results obtained in collaboration with the Collège de France, the CNRS and the University of Paris 8 that show that humans have a universal capacity to understand abstract geometric concepts. Cognition ; Artificial intelligence Researchers ; general public Neurospin réseaux neuronaux;modélisation;psychologie exoérimentale;réseaux convolutionnels;cognition comparée; Thu, 31 Mar 2022 10:00:00 GMT Deep brain stimulation of the thalamus restores signatures of consciousness https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/thalamus-DBS-signatures-conscience.aspx Using fMRI and EEG, NeuroSpin and ICM researchers show that deep brain stimulation of the central part of the thalamus restores the richness of brain activity specific to consciousness, which is "switched off" in an anesthetized non-human primate. This work paves the way for clinical studies in patients with consciousness disorders. Cognition ; MRI Researchers Neurospin Scientific result Sat, 26 Mar 2022 11:00:00 GMT 7T Sodium MRI confirms early metabolic damage in Alzheimer's disease https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/7T-sodium-MRI-Alzheimer.aspx ​7T Sodium MRI may well prove increasingly useful in the study of physiological processes in inflammatory and neurodegenerative diseases and brain tumors. An example is a study on Alzheimer's disease, led by a NeuroSpin team. Brain ; Alzheimer's disease Researchers SHFJ Scientific result Mon, 07 Mar 2022 11:00:00 GMT Brain aging: European funding to evaluate an early biomarker https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2022/QSM4SENIOR.aspx The QSM4SENIOR project, led by NeuroSpin and the company VENTIO, aims at developing an original early biomarker of aging by using data from the SENIOR study of NeuroSpin. QSM4SENIOR has just been funded by the EOSC-Life. Brain ; MRI Researchers ; Institutions Neurospin Europe ; Industrial partnerships Wed, 02 Mar 2022 11:00:00 GMT AI: predicting simply and efficiently like the brain https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/IA-predict-like-brain-gated-recurrence.aspx Two researchers of UNICOG/NeuroSpin show that a gated recurrence model of neural networks would allow to make efficient and simple predictions, like our brain, in different environments. In addition to being biologically plausible, this model would be generalizable. Brain ; Artificial intelligence ; Cognition Researchers Neurospin Scientific result sciences cognitives;Bayes; Thu, 17 Feb 2022 11:00:00 GMT The genetic architecture of language functional connectivity revealed https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Genetic-architecture-language-functional-connectivity.aspx Using data from the UK Biobank, the world's largest general population imaging-genetics cohort, a collaboration led by a team at BAOBAB (NeuroSpin) has identified genes involved in the genetic architecture of language functional connectivity. These genes could be a priority for studying natural language. Brain ; MRI ; Cognition ; Genomics Neurospin Scientific result Mon, 14 Feb 2022 11:00:00 GMT Signal optimization in very high field functional MRI: a matter of compromise? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/tSNR-optimization-functional-MRI.aspx A NeuroSpin team (BAOBAB) has tested a signal denoising method dedicated to very high field (7T) functional MRI. It is based on the weighted combination of images from each reception channel of the radio frequency coil, a combination that optimizes the stability of the signal over time. MRI ; Physics Neurospin Scientific result ; Article Thu, 27 Jan 2022 11:00:00 GMT Brain development and mental health in adolescents and young adults https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Brain-development-mental-health.aspx A NeuroSpin team has exploited data on mental health and brain developmental disorders of subjects in the Healthy Brain Network cohort. It established a link between certain symptoms, precursors of possible mood disorders, and structural changes in the developing brain in more than 650 young people. Brain ; Diseases Neurospin Scientific result Tue, 25 Jan 2022 11:00:00 GMT Biochemical analysis and mass spectrometry for the diagnosis of congenital disorders of glycosylation https://www.cea.fr/drf/joliot/en/Pages/news/Science/2022/Diagnosis-MS-congenital-disorders-glycosylation.aspx A collaboration initiated in 2017 between AP-HP (Bichat Hospital), Paris-Saclay University (Inserm 1193) and the Laboratoire d’Études du Métabolisme des Médicaments (LEMM/SPI/DMTS), leading to 4 publications in 2021, is advancing knowledge on the origin of certain congenital disorders of glycosylation, through the identification of specific biochemical biomarkers. Mass spectrometry ; Biomarkers ; Genetic diseases SPI Scientific result Tue, 04 Jan 2022 11:00:00 GMT Lipid biomarkers to identify the different stages of liver cirrhosis https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/biomarkers-lipids-cirrhosis.aspx European research teams, including one from the CEA's Joliot Institute, have analyzed the blood lipidome of patients with cirrhosis. They highlight specific biomarkers of the different stages of the disease. Methodologies for life sciences ; Biomarkers ; Diseases Researchers SPI Scientific result Mon, 06 Dec 2021 11:00:00 GMT Minimal computational models accounting for emergence of a specific region underlying orthographic coding https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/CNN-accounting-for-emergence-of-specific-region-underlying-orthographic-coding.aspx ​Researchers from NeuroSpin designed, trained and tested biologically plausible artificial deep neural networks to identify pictures and written words. They show that these may suffice to account for emergence during reading acquisition of the visual word form area, a specific region underlying orthographic coding. Cognition ; Artificial intelligence Researchers Neurospin Scientific result Tue, 30 Nov 2021 11:00:00 GMT Multiparametric PET-MRI imaging: toward a biological characterization of tumors at the supervoxel level https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PET-MRI-imaging-tumors-supervoxel-level.aspx A collaborative study led by BioMaps researchers (SHFJ) demonstrates that fully integrated quantitative multiparametric analysis of non-small cell lung cancer in hybrid 18F-FDG PET/MRI 3T imaging is clinically feasible and could enable biological characterization of tumors at the supervoxel scale. Medical imaging ; Positron Emission Tomography ; MRI ; Cancer Scientific result Wed, 10 Nov 2021 11:00:00 GMT The most powerful MRI scanner in the world delivers its first images! https://www.cea.fr/drf/joliot/en/Pages/news/Press/premieres-images-irm-iseult-2021.aspx September 2021, the 11.7 Tesla MRI of the Iseult project, the most powerful in the world for human imaging, has just unveiled its first images. Health & life sciences ; Brain ; Physics Journalists ; general public ; Researchers ; Partners Neurospin News ; Press release ; Découvertes et avancées Brain;MRI;neuroanatomy;Iseult;supra; Thu, 07 Oct 2021 05:00:00 GMT A combinatorial neural code for speech is present in the infant https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Combinatorial-neural-code-speech-infant.aspx Researchers at UNICOG (NeuroSpin) show, using a high-resolution electroencephalographic system, that speech, an extremely complex and variable acoustic signal, is perceived by infants as a sequence of stable and invariant segments through an encoding based on distinctive and orthogonal phonetic features, such as manner and place of articulation, which are secondarily combined into phonemes, such as ″b″ or ″m″. Brain ; Cognition Scientific result Tue, 14 Sep 2021 10:00:00 GMT Disentangle the neuronal and vascular components of the BOLD signal for an improved visualization of brain activity https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Disentangle-neuro-vasc-BOLD.aspx Researchers at NeuroSpin have developed a deconvolution method to estimate from BOLD fMRI data the coupling between neuronal activity and blood flow, the characteristic signals of neuronal activity and the associated brain areas. The work was published in NeuroImage. MRI ; Simulation & modelling Researchers SHFJ Scientific result BOLD signal;multivariate modeling;sparsity;dictionary learning; Tue, 14 Sep 2021 10:00:00 GMT Automatic recognition of brain "lines" https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Automatic-recognition-brain-lines.aspx Researchers at NeuroSpin (CEA-Joliot) propose to automate the classification and recognition of folding patterns on the surface of the cortex that may be related to the occurrence of psychiatric diseases or cognitive disorders using artificial intelligence algorithms. A path towards deciphering the "lines" of the brain. Brain ; Artificial intelligence Scientific result Mon, 23 Aug 2021 10:00:00 GMT A marine neurotoxin, seafood contaminant, is able to cross physiological barriers https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Pinnatoxin-crosses-physiological-barriers.aspx In a study published in Science of the Total Environment, researchers from SIMoS (DMTS/CEA-Joliot), in collaboration with the Faculty of Pharmacy of Paris and MIRCen (CEA-Jacob) have shown for the first time in an animal model the capacity of Pinnatoxin-G, a marine neurotoxin, to cross physiological barriers to reach its molecular targets. Toxicology ; Impacts on living (organisms) Scientific result Thu, 05 Aug 2021 10:00:00 GMT Diffusion MRI characterizes radiation-induced neurological impairments https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress. Brain ; Impacts on living (organisms) ; MRI ; Biomarkers ; Radiobiology Researchers ; Journalists ; general public DRF Scientific result ; Highlight ionizing radiations;Brain;neurodevelopmental disorder;neurogenesis;MRI;structural MRI;diffusion MRI; Thu, 24 Jun 2021 10:00:00 GMT Characteristics of the initial symptoms of Alzheimer's disease in young patients https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Initial-symptoms-Alzheimer-disease-in-young.aspx Researchers from BioMaps (SHFJ) and the Department of Memory and Language Neurology (Ste Anne's Hospital) studied the early clinical signs of Alzheimer's disease (AD) reported by young patients (< 62 years old) compared to those reported in classic AD of the elderly (> 65 years old). They show that these signs are misleading and often appear in the professional context. Alzheimer's disease ; Diagnosis ; Brain Scientific result Thu, 10 Jun 2021 10:00:00 GMT PET imaging reveals the neuropharmacology of buprenorphine https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/PETimaging-neuropharmacology-buprenorphine.aspx Researchers at BioMaps (SHFJ) have succeeded in determining the interaction dynamics of buprenorphine, an opioid drug with a particularly complex pharmacology, with its brain receptors in vivo. To do so, they developed an original PET imaging approach based on the use of the radiolabeled molecule (11C-buprenorphine). Brain ; Positron Emission Tomography ; Pharmacology Scientific result Wed, 05 May 2021 10:00:00 GMT WIKIBrainStem: a new ex vivo anatomical atlas of the human brainstem from ultra-high field MRI (11.7 T) https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/WIKIBrainStem.aspx The Ginkgo team (BAOBAB / NeuroSpin), in collaboration with the Inserm iBRAIN U1253 unit (Tours), published in NeuroImage the first anatomical atlas of the human brainstem with at mesoscopic scaleresolution from extreme ultra-high field MRI. Freely available as a wiki, this atlas will be used in particular by neuroanatomists and neurosurgeons. MRI Researchers Neurospin Scientific result ; Europe brainstem;Anatomy; Wed, 28 Apr 2021 10:00:00 GMT Humans Share an Exceptional Sense of Geometry https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Humains-geometrie.aspx Research from CEA, Collège de France, CNRS and Université Paris 8 shows that humans share a universal ability to understand abstract geometric concepts. This human ability does not depend on age, culture or education, but does not exist in the non-human primates tested. PNAS has just published their results. Cognition Researchers Neurospin Scientific result réseaux neuronaux;modélisation;cognition comparée;psychologie expérimentale; Fri, 23 Apr 2021 10:00:00 GMT Brain sulci imaging and genetics: the UK Biobank cohort has spoken. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Brain-sulci-imaging-and-genetics.aspx Researchers from NeuroSpin and CNRGH (Jacob Institute) have studied, on a genome-wide scale, the potential associations of haplotypes (set of variants located side by side on a chromosome) with the opening value of imaged brain sulci, indicator of brain aging, from the UK Biobank neuroimaging-genetics cohort. MRI ; Genomics ; Brain Scientific result Mon, 19 Apr 2021 10:00:00 GMT Aloïse Mabondzo receives exceptional funding from NIH ! https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/A-Mabondzo-funding-from-NIH.aspx Aloïse Mabondzo, research director, head of the Neurovascular Pharmacology Group of the SPI (DMTS), co-founder and scientific director (CSO) of CERES BRAIN THERAPEUTICS, has just obtained funding of nearly one million US dollars from the prestigious National Institute of Health for his project « Neuroprotective Strategy: Novel Purine Derivatives for Neonatal Hypoxia-ischemia ». Brain ; Diseases News ; Article Mon, 29 Mar 2021 10:00:00 GMT Food poisoning? Targeted mass spectrometry brings an answer https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Food-poisoning-SE-targeted-mass-spectrometry.aspx SPI (DMTS), in collaboration with ANSES, has developed a test based on immuno-capture and targeted mass spectrometry for the quantitative and multiplex identification, in dairy products, of the eight main enterotoxins of Staphylococcus aureus, responsible for food poisoning epidemics. Mass spectrometry ; Toxicology ; CBRN-E threats Scientific result Thu, 18 Mar 2021 11:00:00 GMT A micellar probe for fluorine magnetic resonance tumor imaging https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Micellar-probe-fluorine-MRI-tumor.aspx A SCBM (DMTS) team, in collaboration with researchers at NeuroSpin and I2BC, is describing micellar nanometric vectors targeting tumors that have been imaged by fluorine magnetic resonance imaging (MRI). The observed 19F signal made it possible to precisely delimit the volume of the tumor zone in a mouse model and to quantify the probe accumulated in the target tissue. Chemistry ; Nanomedicine ; Cancer ; MRI Scientific result Thu, 04 Mar 2021 11:00:00 GMT Carbon labeling with light https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Carbon-labeling_light.aspx Researchers from the LMC (DMTS), in collaboration with a team from AstraZeneca, have developed a labeling method, based on the exchange of carbon dioxide, simply using visible blue light and a photocatalyst. Chemistry ; Biomarkers ; Diagnosis and innovative treatment Researchers SCBM Scientific result ; Europe radiolabeling; Wed, 24 Feb 2021 11:00:00 GMT Metabolomics for the clinician and the development of a neuroprotective strategy in acute stroke https://www.cea.fr/drf/joliot/en/Pages/news/Science/2021/Metabolomics-clinician-neuroprotective-strategy-stroke.aspx The TIRO team (SHFJ), in collaboration with the neurovascular clinicians of the Nice and Marseille University Hospitals, carried out analyses of the metabolome of cerebral clots at the origin of the occlusion of a cerebral artery responsible for a cerebral vascular accident (stroke). A pilot study that improved the understanding of the complex relationship between blood glucose levels and patients' functional prognosis. Metabolomics ; Brain ; Diseases Scientific result Thu, 04 Feb 2021 11:00:00 GMT Towards a transcranial echography https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/Towards-transcranial-echography.aspx Jean-Luc Gennisson (BioMaps/SHFJ) coordinated, in partnership with the CEA-List (Sylvain Chatillon), the EchoBrain project (ATTRACT/H2020) aimed at adapting the digital tools developed by the List (CIVA platform) to significantly increase the quality of brain echography images, simple alternative compared to the methods (MRI, X-ray scanner) currently used for the diagnosis of strokes. Brain ; Medical imaging ; Simulation & modelling News ; Article Tue, 19 Jan 2021 11:00:00 GMT Launch of AROMA, a european project to exploit the full potential of NeuroSpin's future 11.7 T scanner. https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2021/Launch-of-AROMA.aspx AROMA, a FET-Open H2020 project, aims to develop the methodology necessary for the optimal operation of the future 11.7 T MRI being installed at NeuroSpin. This 5-year project, coordinated by Nicolas Boulant (NeuroSpin), with an overall budget of 3.6 million euros, involving six partners from five countries representing academia and industry, started on January 1, 2021. Methodologies for life sciences ; Brain ; MRI News Wed, 06 Jan 2021 11:00:00 GMT Amazing discovery: Variovorax, a bacterium that lives in the heart of a working nuclear reactor! https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Variovorax-bacteria-living-heart-working-nuclear-reactor.aspx Researchers from I2BC and SPI (DMTS, Marcoule), in collaboration with CEA Grenoble and the Belgian nuclear research center, discovered, by using two meta-omic approaches, living bacteria in the core pool of the CEA Paris-Saclay research reactor, Osiris, in operation, thus opening up perspectives for the discovery of new radioresistant species. Bacteria ; Nuclear Toxicology Scientific result Thu, 17 Dec 2020 11:00:00 GMT Facebook challenge in AI: CEA researchers ranked 2nd https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Facebook-challenge-IA-CEA-researchers-2d.aspx In the field of artificial intelligence, international competition is tough. So when researchers from CEA-Joliot and Irfu challenge start-ups and other companies specializing in AI, we cheer them on. Here’s a success story from the field of MRI reconstruction. MRI ; Artificial intelligence Researchers Neurospin Success Fri, 11 Dec 2020 11:00:00 GMT An atypical cerebral organization for language https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Atypical-cerebral-organization-for-language.aspx Researchers from the Neurofunctional Imaging Group (GIN, NeuroSpin, Bordeaux) studied by functional MRI, the organization of the brain network of sentence processing in individuals "atypical" for language, i.e. with a major role of the right hemisphere. Brain ; MRI Scientific result Wed, 09 Dec 2020 11:00:00 GMT CEA carries for France the EBRAINS infrastructure inscription on the ESFRI roadmap https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/CEA-carries-EBRAINS-inscription-for-ESFRI.aspx EBRAINS (European Brain ReseArch INfrastructureS) is a european research infrastructure designed by the scientific community which, based on a set of state-of-the-art digital platforms, aims to answer the analysis and processing needs of large brain data sets. CEA carries for France EBRAINS inscription on the European Strategy Forum on Research Infrastructures roadmap, which was submitted in early September 2020. Brain ; Simulation & modelling News ; Article ; Europe Wed, 09 Dec 2020 11:00:00 GMT Psychotic symptoms are linked with poor diffusion of information in the brain https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Psychotic-symptoms-poor-information-diffusion-in-brain.aspx A collaborative study by NeuroSpin suggests that psychosis and impaired conscious access may be closely related phenomena. MRI Researchers Neurospin psychiatry;diffusion MRI;dMRI; Tue, 08 Dec 2020 11:00:00 GMT Towards greater accuracy in the measurement of temperature variations induced by MRI examinations https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/thermometry-MRI.aspx Researchers at NeuroSpin are proposing a new magnetic resonance thermometry method to increase the accuracy in the measurement of small temperature variations induced by MRI. MRI ; Methodologies for life sciences Researchers Neurospin Scientific result MR thermometry;ultra high field; Wed, 18 Nov 2020 11:00:00 GMT BRICON, a project of the Human Brain Project for NeuroSpin (UNICOG) https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/BRICON-project-Human-Brain-Project-NeuroSpin.aspx Theofanis Panagiotaropoulos (NeuroSpin) obtains funding from the Human Brain Project for BRICON (Brain Inspired Consciousness), a project of HBP's neuroscience activities. Brain ; Cognition News ; Article Thu, 29 Oct 2020 11:00:00 GMT A double ceramic probe to optimize magnetic resonance microscopy. https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Double-ceramic-probe-magnetic-resonance-microscopy.aspx Researchers from the M-CUBE european consortium, together with a team from NeuroSpin, are demonstrating the possibility of imaging two samples by 17.2 T magnetic resonance microscopy (NeuroSpin imager), at a single acquisition time, using two coupled ceramic resonators (probes) that lead to a better signal-to-noise ratio compared to reference MRI probes. MRI ; Physics Scientific result ; Article Mon, 26 Oct 2020 11:00:00 GMT Analysis of multitask functional MRI data for the establishment of a neurocognitive atlas of the human brain https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Analysis-multitask-functional-MRI-data-IBC.aspx In this study, NeuroSpin researchers leveraged the Individual Brain Charting (IBC) dataset, acquired by high-resolution functional MRI during the performance of behavioural tasks, to investigate the feasibility of individual mapping of the cognitive components underlying the tasks. They thus individualized six regions of interest in the language network and established their cognitive profile. MRI ; Cognition Scientific result Thu, 08 Oct 2020 10:00:00 GMT Functional neuroanatomy of number processing at high-resolution https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Functional-neuroanatomy-number-processing.aspx NeuroSpin researchers used ultra-high field (7 Tesla) functional magnetic resonance imaging (fMRI) to better localize the processing and manipulation of numbers in the human brain. The results, which enrich our understanding of the functional organization of the intra-parietal sulcus, the cerebral center of digitization, are published in NeuroImage. Brain ; MRI ; Cognition ; Mathematics Scientific result Wed, 23 Sep 2020 10:00:00 GMT Towards a new generation of antennas for ultra-high field imaging of the brain https://www.cea.fr/drf/joliot/en/Pages/news/Press/mri-antenna-brain.aspx The European Commission once more places its trust on Multiwave company and its partners, Aix-Marseille Université , CEA and Université Catholique de Louvain to revolutionize ultra-high field magnetic resonance imaging of the brain. Health & life sciences ; Brain ; Methodologies for life sciences ; Medical imaging ; MRI Journalists ; Institutions ; Companies Neurospin News ; Focus NeuroSpin;DRF;Europe;MRI;Brain;project;Joliot;antenna;imagery; Tue, 22 Sep 2020 08:06:13 GMT Predicting brain age using a computer model https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Predicting-brain-age-computer-model.aspx Researchers from the PARIETAL team (Inria/CEA) at NeuroSpin and the University of Zurich have developed a computer model capable of accurately determining brain age. This model could be used to combine different types of brain function tests to predict, for example, cognitive decline or depression. Computing ; Brain Neurospin Scientific result algorithm; Mon, 14 Sep 2020 10:00:00 GMT Methylglyoxal detoxification revisited in cyanobacteria https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Methylglyoxal-detoxification-in-cyanobacteria.aspx A team from I2BC (SB2SM) used a combination of in vitro and in vivo approaches in the model cyanobacterium Synechocystis to establish a logical, but as yet never described, link between the detoxification of methylglyoxal, a toxic metabolite, and glutathione S-transferase, an enzyme of the xenobiotic metabolism, conserved during evolution. Photosynthesis ; Toxicology ; Microalgae News Fri, 04 Sep 2020 10:00:00 GMT Florent Meyniel, laureate of the prestigious "ERC Starting grant" call https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Florent-Meyniel-ERC-SG.aspx On September 3, the European Research Council announced the names of the 436 winners of the ERC Starting Grant 2020 call. Florent Meyniel, CEA researcher at the NeuroSpin department of the Joliot Institute, is among them. MRI Neurospin Prizes and awards ; Europe ; Article H2020;Bayes; Thu, 03 Sep 2020 10:05:00 GMT Mapping of normal brain aging: unprecedented results from the SENIOR cohort https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/SENIOR-cohort-cerebral-aging.aspx The SENIOR study, conducted by several NeuroSpin teams, consists in monitoring, since March 2012, a cohort of 100 subjects aged 50 to 70 years by annual MRI imaging over a period of 10 years, to establish a normal aging brain imaging biomarkers mapping. This publication in Alzheimer's Research & Therapy describes the baseline experimental protocol and presents first promising results. Neurodegenerative diseases ; Brain ; MRI ; Positron Emission Tomography Scientific result Tue, 04 Aug 2020 10:00:00 GMT Numerical simulation for treatment planning in hadrontherapy https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/numerical-simulation-hadrontherapy.aspx ​The international OpenGATE collaboration, involving the BioMaps laboratory[1](SHFJ), has demonstrated the value of the GATE numerical simulation platform in clinical use for cancer treatment planning using hadrontherapy. Radiotherapy SHFJ Scientific result Mon, 27 Jul 2020 10:00:00 GMT Diffusion MRI to monitor astrocyte activity? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/diffusionMRI-astrocyte-activity.aspx In two articles published in PLoS ONE, researchers at NeuroSpin show that diffusion MRI can monitor astrocyte activity in the brain in a non-invasive way, allowing a better understanding of its involvement in the glymphatic system and in functional MRI. MRI ; Brain Neurospin Scientific result BOLD MRI;functional MRI;aquaporins;diffusion MRI; Thu, 11 Jun 2020 10:00:00 GMT Deep learning in MRI: A standard for comparing the performance of artificial neural networks https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Deep-learning-MRI-Standard-networks-comparison.aspx Using public MRI data sets from the knee and brain, researchers from NeuroSpin and Cosmostat (CEA-Irfu) have written a consistent benchmark of several deep neural networks used for image reconstruction with significantly reduced acquisition time. Artificial intelligence ; MRI ; Brain Neurospin Scientific result Deep Neural Network;fastMRI;3D reconstruction;compressed-sensing MRI; Thu, 04 Jun 2020 10:00:00 GMT Do social and physical distancing change the way we relate to time?…. https://www.cea.fr/drf/joliot/en/Pages/news/Institute/2020/Confined-time-study.aspx In order to answer this question, a vast study of experimental psychology and chronobiology, directed by Virginie Van Wassenhove (NeuroSpin) was launched in collaboration with Inserm and the University of Paris-Saclay. Brain News ; Article Thu, 30 Apr 2020 10:00:00 GMT Ultra high-field Lithium-7 imaging reveals its accumulation in the hippocampus of patients with bipolar disorder https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Ultra-high-field-7Li-imaging-accumulation-hippocampus-BD-patients.aspx A study conducted by a multidisciplinary team from NeuroSpin, in collaboration with researchers from the AP-HP (Hôpitaux Universitaires St Louis-Lariboisière-F Widal), reveals for the first time, by 7Tesla MRI of Lithium-7, an accumulation of Lithium in the left hippocampus of patients with bipolar disorder and treated with Lithium. These results should help to better understand the therapeutic response to this drug. MRI ; Medical imaging Scientific result Tue, 31 Mar 2020 10:00:00 GMT Characterization of a predictive survival biomarker in the event of septic shock https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Characterization-predictive-survival-biomarker-septic-shock.aspx Two recent studies conducted by SPI researchers, in collaboration with Inserm and AP/HP teams, reveal the value of measuring plasma levels of calgranulins as biomarkers for the prediction of mortality risk of patients with septic shock, admitted in intensive care unit. Biomarkers ; Mass spectrometry ; Infectious diseases Scientific result Tue, 24 Mar 2020 11:00:00 GMT The way is now open for the development of a broad-spectrum drug candidate for several pathogenic viruses, bacteria and toxins https://www.cea.fr/drf/joliot/en/Pages/news/Press/The-way-is-now-open-for-the-development-of-a-broad-spectrum-drug-candidate-for-several-pathogenic-viruses,-bacteria-and-tox.aspx Health & life sciences ; Toxicology ; Virus News ; Press release Fri, 21 Feb 2020 11:00:00 GMT An atlas of the rat brain to better understand the human brain https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Atlas-rat-brain-SIGMA.aspx A team from NeuroSpin, in collaboration with researchers from the Sainte-Anne Hospital and from the University of Minho, has developed, using magnetic resonance imaging, a unique set of resources for the analysis and visualization of preclinical data in the rat brain. Brain ; Computing Researchers Neurospin Scientific result functional MRI;high field MRI; Mon, 27 Jan 2020 11:00:00 GMT Pypreclin: a new tool for fMRI preprocessing to facilitate interpretation https://www.cea.fr/drf/joliot/en/Pages/news/Science/2020/Pypreclin.aspx NeuroSpin researchers have developed a software for preprocessing non-human primate brain raw images obtained by functional magnetic resonance imaging. The aim is to help harmonize methods, improve procedures, facilitate comparison and interpretation of the acquired images and to minimize the number of animals to be used in research. Brain ; Computing Scientific result functional MRI;MR imaging;Neuroimaging; Tue, 21 Jan 2020 11:00:00 GMT Alzheimer's: a more effective method to diagnose the disease? https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Sulcal-morphology-to-diagnose-Alzheimer.aspx A study conducted by Maxime Bertoux (Unit 1171 Inserm / Lille University / CHU Lille) in collaboration with researchers from the Centre Hospitalier Saint Anne, the SHFJ (CEA-Joliot), NeuroSpin (CEA-Joliot) and the ICM shows that the morphological analysis of the cortical sulci would make it possible to recognize Alzheimer's disease in 91% of the cases, against 80% now by anatomical analysis of the cortex. Alzheimer's disease ; MRI Researchers SHFJ Scientific result Fri, 20 Sep 2019 10:00:00 GMT The corona of proteins adsorbed on silica nanoparticles reveals its structure https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/Corona-proteins-silica-nanoparticles-reveals-structure.aspx Researchers from I2BC@Saclay and Iramis, in collaboration with Léon Brillouin laboratory, analyzed the structure of the "corona" of two model proteins adsorbed on silica nanoparticles, by using the small-angle neutron scattering technique. They show that the structures formed are true nano-assemblies, in which the proteins retain their shape. Nanotoxicology Scientific result Wed, 18 Sep 2019 10:00:00 GMT NeuroSpin and ENIGMA identify a potential biomarker of bipolar disorder https://www.cea.fr/drf/joliot/en/Pages/news/Science/2019/NeuroSpin-ENIGMA-potential-biomarker-bipolar-disorder.aspx NeuroSpin's psychiatric researchers and the Inserm U955 unit (CHU Mondor) coordinated, in collaboration with the ENIGMA consortium (an international group of researchers sharing brain imaging data), the first mega-analysis of diffusion MRI data including 3033 subjects with or without bipolar disorders. They identified extensive abnormalities in the cerebral white matter microstructure in sick people. Abnormalities that could represent a robust biomarker of bipolar disorder. Brain ; MRI ; Diseases Scientific result Tue, 10 Sep 2019 10:00:00 GMT