You are here : Home > Research Entities > Medicines and healthcare techn ... > Molecular engineering of proteins unit

Laboratory | Molecular mechanisms


SIMOPRO

Molecular engineering of proteins unit

 

​​FRENCH

 

Published on 25 October 2018
The service objectives aim at the development of novel molecules, protein or pseudo-peptide nature, which may have applications in human health.
Head of unit
Denis Servent
denis.servent@cea.fr
33 1 69 08 52 02


 

Deputy
Bernard Maillere
bernard.maillere@cea.fr
33 1 69 08 94 47






Secretary
Alexandra Aleixo
33 1 69 08 71 95

 

The development of new chemical entities from "pseudo peptides to miniproteins" though multidisciplinary strategies with potential applications in diagnostic and therapeutic innovation is the specific contribution of SIMOPRO to health projects of the Life Science Division of CEA. The development of compounds of interest is based on the expertise of two additional laboratories and a number of teams dedicated to the analysis, protein engineering, radio-imaging or crystal growth.

SIMOPRO is part of several international research networks working on the molecular engineering of proteins, member of the Labex Lermit (Laboratory of Excellence in Research on Medication and Innovative Therapeutics) and participates to the Joint Ministerial Program of R&D against chemical, biological, radiological, nuclear and explosive (CBRNe) risks.

The Unit consists of two main laboratories and technical "platforms" specific to SIMOPRO:

Molecular toxinology and biotechnology laboratory
Chemistry for life sciences laboratory
Analyses facilities

 

  
THE CYCLIC IMINE PROROCENTROLIDE-A OBTAINED FROM CULTURED JAPANESE PROROCENTRUM LIMA DINOFLAGELLATES TARGET MUSCLE- AND NEURONAL-TYPE NICOTINIC ACETYLCHOLINE RECEPTORS
Amar M., Araoz R., Iorga BI., Yasumoto T., Servent D. and Molgo J.
Prorocentrolide-A from Cultured Prorocentrum lima Dinoflagellates Collected in Japan Blocks Sub-Types of Nicotinic Acetylcholine Receptors
Amar M., Araoz R., Iorga B. I., Yasumoto T., Servent D. and Molgo J.
Identification of T-cell epitopes from benzylpenicillin conjugated to human serum albumin and implication in penicillin allergy
Azoury M. E., Fili L., Bechara R., Scornet N., de Chaisemartin L., Weaver R. J., Claude N., Maillere B., Parronchi P., Joseph D. and Pallardy M.
Ribosome Inactivating Proteins: From Plant Defense to Treatments against Human Misuse or Diseases
Barbier J. and Gillet D.
MAMBALGINS, SNAKE PEPTIDES AGAINST INFLAMMATORY AND NEUROPATHIC PAIN THROUGH INHIBITION OF ASIC CHANNELS
Baron A., Diochot S., Salinas M., Alloui A., Douguet D., Mourier G., Kessler P., Stura EA., Besson T., Friend V., Servent D., Eschalier A. and Lingueglia E.
Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family
Bastard K., Isabet T., Stura E. A., Legrand P. and Zaparucha A.
"23(rd) and 24(th) Meetings of the French Society of Toxinology (SFET): Special Issue on ""Toxins: Immunity, Inflammation and Pain"""
Benoit E., Barbier J. and Molgo J.
ASSESSMENT OF SAXITOXIN SENSITIVITY OF NERVES ISOLATED FROM THE PACIFIC OYSTER, CRASSOSTREA GIGAS, EXPOSED TO ALEXANDRIUM MINUTUM
Boullot F., Fabioux C., Hegaret H., Soudant P., Boudry P. and Benoit E.
Incorporation of Non-canonical Amino Acids into 2,5-Diketopiperazines by Cyclodipeptide Synthases
Canu N., Belin P., Thai R., Correia I., Lequin O., Seguin J., Moutiez M. and Gondry M.
Copper mediated amyloid-beta binding to Transthyretin
Ciccone L., Fruchart-Gaillard C., Mourier G., Savko M., Nencetti S., Orlandini E., Servent D., Stura E. A. and Shepard W.
MUSCARINIC TOXIN 9: A NOVEL PEPTIDE FROM DENDROASPIS POLYLEPIS VENOM THAT SELECTIVELY TARGETS MUSCARINIC TYPE 2 RECEPTOR
Ciolek J., Carvalho CD., Quinton L., Mourier G., Servent D. and Gilles N.
Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo
Dai W., Wu Y., Bi J., Wang S., Li F., Kong W., Barbier J., Cintrat J. C., Gao F., Gillet D., Su W. and Jiang C.
Sydnone-coumarins as clickable turn-on fluorescent sensors for molecular imaging
Decuypere E., Riomet M., Sallustrau A., Bregant S., Thai R., Pieters G., Clavier G., Audisio D. and Taran F.
Late-stage isotopic carbon labeling of pharmaceutically relevant cyclic ureas directly from CO2
Del Vecchio A., Caille F., Chevalier A., Loreau O., Horkka K., Halldin C., Schou M., Camus N., Kessler P., Kuhnast B., Taran F. and Audisio D.
CRYSTAL STRUCTURE AND FUNCTIONAL DOMAINS OF THE MAMBAQUARETIN-1, A VASOPRESSIN TYPE 2 RECEPTOR PEPTIDE INHIBITOR FOR KIDNEY CYSTS TREATMENT
Droctove L., Ciolek J., Lancien M., Stura EA., Vera L., Floquet N., Witzgall R., Mouillac B., Mendre C., Mourier G., Servent D. and Gilles N.
FIRST INSIGHTS IN THE PHARMACODYNAMICS OF MAMBA TOXINS, PROMISING THERAPEUTIC CANDIDATES TO TREAT KIDNEY CYSTS BY INHIBITION OF VASOPRESSIN TYPE 2 RECEPTOR
Droctove L., Lancien M., Mourier G., Servent D. and Gilles N.
DEVELOPMENT OF NONHUMAN PRIMATES MODEL FOR RICIN EXPOSURE
Ducancel F., Delache B., Navarro F., Viargues P., Dano J., Contreras V., Gillet D., Barbier J. and Le Grand, R.
C-terminal truncation of IFN-gamma inhibits proinflammatory macrophage responses and is deficient in autoimmune disease
Dufour A., Bellac C. L., Eckhard U., Solis N., Klein T., Kappelhoff R., Fortelny N., Jobin P., Rozmus J., Mark J., Pavlidis P., Dive V., Barbour S. J. and Overall C. M.
Matrix metalloproteinase 12 promotes tumor propagation in the lung
Ella Ezra, Harel Yaniv, Abraham Michal, Wald Hanna, Benny Ofra, Karsch-Bluman Adi, Vincent Dive, Laurent Devel, Amir Gail, Izhar Uzi, Shapira Oz M, Yoon David, Lee Hyun-Sung, Sugarbaker David J, Burt Bryan, Peled Amnon and Wald Ori
D PEPTIDE, A PROMISING TOXIN AS POTENTIAL ANTINOCICEPTIVE AGENT TARGETING THE NAV1.7 SUBTYPE OF VOLTAGE-GATED SODIUM CHANNELS
Goncalves TC., Amar M., Boukaiba R., Partiseti M., Servent D. and Benoit E.
A MULTISCALE FUNCTIONAL APPROACH TO ASSESS PHARMACOLOGOCAL INTERACTIONS BETWEEN HUWENTOXIN-IV SPIDER PEPTIDE AND SODIUM CHANNEL SUBTYPES
Goncalves TC., Boukaiba R., Molgo J., Amar M., Partiseti M., Servent D. and Benoit E.
A NON-INVASIVE METHOD TO APPRAISE TIME-DEPENDENT EFFECTS OF VENOM TOXINS ON THE MOUSE NEUROMUSCULAR EXCITABILITY IN VIVO
Goncalves TC., Partiseti M., Servent D. and Benoit E.
Direct evidence for high affinity blockade of NaV1.6 channel subtype by huwentoxin-IV spider peptide, using multiscale functional approaches
Goncalves T. C., Boukaiba R., Molgo J., Amar M., Partiseti M., Servent D. and Benoit E.
A Comprehensive Overview of the Cyclodipeptide Synthase Family Enriched with the Characterization of 32 New Enzymes
Gondry M., Jacques I. B., Thai R., Babin M., Canu N., Seguin J., Belin P., Pernodet J. L. and Moutiez M.
Mutating the cholesterol binding site on amyloid precursor protein alters the processing and production of A beta-amyloid peptides
Hanbouch L., Marquer C., Boussicault L., Schaack B., Perronet K., Moreau J., Gilles N., Louis C., Millan MJ. and Potier MC.
alpha9-containing nicotinic acetylcholine receptors and the modulation of pain
Hone A. J., Servent D. and McIntosh J. M.
Secukinumab demonstrates significantly lower immunogenicity potential compared to ixekizumab and adalimumab and ustekinumab in human in vitro assays
Hutas G., Spindeldreher S., Maillere B., Correia E., Tenon M., Karle A., Jarvis P. and Kolbinger F.
AUSTRALASIAN JOURNAL OF DERMATOLOGY (), , 2018
Screening of drug library identifies inhibitors of cell intoxication by CNF1
Mahtal N., Brewee C., Pichard S., Visvikis O., Cintrat J. C., Barbier J., Lemichez E. and Gillet D.
HIGH-THROUGHPUT SCREENING OF RAC1 ENHANCERS AS STIMULATORS OF INNATE AND ACQUIRED IMMUNITY
Mahtal N., Visvikis O., Gillet D., Cintrat JC., Lemichez E. and Barbier J.
Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies
Nuti E., Cuffaro D., Bernardini E., Camodeca C., Panelli L., Chaves S., Ciccone L., Tepshi L., Vera L., Orlandini E., Nencetti S., Stura E. A., Santos M. A., Dive V. and Rossello A.
1 - 30Next