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Molecular labeling and bio-organic chemistry unit




Published on 27 June 2018
​The molecular labeling and bio-organic chemistry unit (SCBM) brings together about fifty people including around twenty doctoral and post-doctoral students. The research focuses on the following themes: isotopic labeling, bioactive molecules, new tools for biology, nanosciences.

Head of Unit
Frédéric Taran
01 69 08 26 85

​Deputy Manager
Christophe Créminon
01 69 08 13 20
Chantal Faux
01 69 08 52 55

All these research uses unique expertise common to all researchers of the service: organic chemistry. This research requires, in most cases, a multidisciplinary approach carried out in close collaboration with academic and industrial partners.

The service is organized in three laboratories and one group, which each develop original and innovative approaches:

14C - labeling Laboratory
Tritium - labeling Laboratory
Bio-organic Chemistry Laboratory
Analysis Group
The molecular labeling and bio-organic chemistry unit is affiliated with two Laboratories of Excellence in the Campus Paris-Saclay IDEX: 


The Laboratory of Excellence in Research on ​Medication and Innovative Therapeutics (LERMIT).

The Laboratory of Excellence in Chemistry of Multifunctional Molecular Architectures and of Materials 

It is also, since January 2016, coordinator of a European program, ISOTOPICS
Contact: Christophe Dugave​​, project co​ordinator



Discover the video presentation of SCBM
 F.Rhod​​​es © CEA - 2013

Functionalization of Bambusurils by a Thiol-Ene Click Reaction and a Facile Method for the Preparation of Anion-Free Bambus[6]urils
Azazna D., Lafosse M., Rivollier J., Wang J., Cheikh I. B., Meyer M., Thuery P., Dognon J. P., Huber G. and Heck M. P.
Mode of PEG Coverage on Carbon Nanotubes Affects Binding of Innate Immune Protein C1q
Belime A., Gravel E., Brenet S., Ancelet S., Caneiro C., Hou Y., Thielens N., Doris E. and Ling W. L.
Recognition protein C1q of innate immunity agglutinates nanodiamonds without activating complement
Belime A., Thielens N. M., Gravel E., Frachet P., Ancelet S., Tacnet P., Caneiro C., Chuprin J., Gaboriaud C., Schoehn G., Doris E. and Ling W. L.
A Practical Synthesis of Valuable Strained Eight-Membered-Ring Derivatives for Click Chemistry
Bernard S., Kumar R. A., Porte K., Thuery P., Taran F. and Audisio D.
Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo
Dai W., Wu Y., Bi J., Wang S., Li F., Kong W., Barbier J., Cintrat J. C., Gao F., Gillet D., Su W. and Jiang C.
Combination of Aryl Diselenides/Hydrogen Peroxide and Carbon-Nanotube/Rhodium Nanohybrids for Naphthol Oxidation: An Efficient Route towards Trypanocidal Quinones
de Carvalho R. L., Jardim G. A. M., Santos A. C. C., Araujo M. H., Oliveira W. X. C., Bombaca A. C. S., Menna-Barreto R. F. S., Gopi E., Gravel E., Doris E. and da Silva Junior E. N.
Copper-Catalyzed Aza-Iminosydnone-Alkyne Cycloaddition Reaction Discovered by Screening
Decuypere Elodie, Bernard Sabrina, Feng Minghao, Porte Karine, Riomet Margaux, Thuéry Pierre, Audisio Davide and Taran Frédéric
Sydnone-coumarins as clickable turn-on fluorescent sensors for molecular imaging
Decuypere E., Riomet M., Sallustrau A., Bregant S., Thai R., Pieters G., Clavier G., Audisio D. and Taran F.
Late-stage isotopic carbon labeling of pharmaceutically relevant cyclic ureas directly from CO2
Del Vecchio A., Caille F., Chevalier A., Loreau O., Horkka K., Halldin C., Schou M., Camus N., Kessler P., Kuhnast B., Taran F. and Audisio D.
Recent Developments in Heterocycles Labeling with Carbon Isotopes
Del Vecchio A., Destro G., Taran F. and Audisio D.
Biotin-functionalized targeted polydiacetylene micelles
Doerflinger A., Quang N. N., Gravel E., Pinna G., Vandamme M., Duconge F. and Doris E.
Palladium-Mediated Site-Selective C-H Radio-iodination
Dubost E., Babin V., Benoist F., Hebert A., Barbey P., Chollet C., Bouillon J. P., Manrique A., Pieters G., Fabis F. and Cailly T.
Ruthenium-catalyzed hydrogen isotope exchange of C(sp(3))-H bonds directed by a sulfur atom
Gao L., Perato S., Garcia-Argote S., Taglang C., Martinez-Prieto L. M., Chollet C., Buisson D. A., Dauvois V., Lesot P., Chaudret B., Rousseau B., Feuillastre S. and Pieters G.
Where do nanometric micelles stand for biomedical applications?
Gravel E. and Doris E.
"Tungsten (VI) based ""molecular puzzle"" photoluminescent nanoparticles easily covered with biocompatible natural polysaccharides via direct chelation"
Lobaz V., Hladik M., Steinhart M., Paruzel A., Cernoch P., Panek J., Vetrik M., Jirak D., Jiratova M., Pop-Georgievski O., Slouf M., Garcia-Argote S., Pieters G., Doris E. and Hruby M.
Screening of drug library identifies inhibitors of cell intoxication by CNF1
Mahtal N., Brewee C., Pichard S., Visvikis O., Cintrat J. C., Barbier J., Lemichez E. and Gillet D.
Mahtal N., Visvikis O., Gillet D., Cintrat JC., Lemichez E. and Barbier J.
Visible?Light?Driven Reduction of CO2 to CO and Its Subsequent Valorization in Carbonylation Chemistry and 13C Isotope Labeling
Philipp Gotico, Antonio Del?Vecchio, Davide Audisio, Annamaria Quaranta, Zakaria Halime, Winfried Leibl and Ally Aukauloo
Carbon nanotube-copper ferrite-catalyzed aqueous 1,3-dipolar cycloaddition of in situ-generated organic azides with alkynes
Prakash P., Kumar R. A., Miserque F., Geertsen V., Gravel E. and Doris E.
Design and Synthesis of Iminosydnones for Fast Click and Release Reactions with Cycloalkynes
Riomet M., Decuypere E., Porte K., Bernard S., Plougastel L., Kolodych S., Audisio D. and Taran F.
Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection
Shtanko O., Sakurai Y., Reyes A. N., Noel R., Cintrat J. C., Gillet D., Barbier J. and Davey R. A.
Synthesis of bis(amidoxime)s and evaluation of their properties as uranyl-complexing agents
Stemper Jérémy, Tuo Wei, Mazarío Eva, Helal Ahmed S., Djurovic Alexandre, Lion Claude, El Hage Chahine Jean-Michel, Maurel François, Hémadi Miryana and Le Gall Thierry
Tepshi L., Gupta N., Noel R., Goudet A., Hinsinger K., Michau A., Pons V., Abdelkafi H., Secher T., Shima A., Shtanko O., Sakurai Y., Cojean S., Pomel S., Moal VLL., Leignel V., Herweg JA., Fischer A., Johannes L., Harrison K., Beard PM., Rudel T., Vacus J., Loiseau PM., Davey RA., Oswald E., Cintrat JC., Barbier J. and Gillet D.
Impact of the surface charge of polydiacetylene micelles on their interaction with human innate immune protein C1q and the complement system
Thielens N. M., Belime A., Gravel E., Ancelet S., Caneiro C., Doris E. and Ling W. L.
Tungsten as a plasma-facing material in fusion devices: impact of helium high-temperature irradiation on hydrogen retention and damages in the material
Bernard E., Sakamoto R., Kreter A., Barthe MF., Autissier E., Desgardin P., Yamada H., Garcia-Argote S., Pieters G., Chene J., Rousseau B. and Grisolia C.
Bioorthogonal Click and Release Reaction of Iminosydnones with Cycloalkynes
Bernard S., Audisio D., Riomet M., Bregant S., Sallustrau A., Plougastel L., Decuypere E., Gabillet S., Kumar RA., Elyian J., Trinh MN., Koniev O., Wagner A., Kolodych S. and Taran F.
A Synthetic Alternative to Canonical One-Carbon Metabolism
Bouzon M., Perret A., Loreau O., Delmas V., Perchat N., Weissenbach J., Taran F. and Marliere P.
Aqueous 1,3-dipolar cycloadditions promoted by copper nanoparticles in polydiacetylene micelles
Clarisse D., Prakash P., Geertsen V., Miserque F., Gravel E. and Doris E.
Antiviral effects of Retro-2(cycl) and Retro-2.1 against Enterovirus 71 in vitro and in vivo
Dai W. W., Wu Y., Bi J. P., Lu X. T., Hou A., Zhou Y., Sun B., Kong W., Barbier J., Cintrat J. C., Gao F., Gillet D., Su W. H. and Jiang C. L.
Sydnone-alkyne cycloaddition: applications in synthesis and bioconjugation
Decuypere E., Plougastel L., Audisio D. and Taran F.
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