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Service Hospitalier Frédéric Joliot

Published on 23 March 2015

The Service Hospitalier Frédéric Joliot (SHFJ), directed by Vincent Lebon, is a molecular and functional imaging center located on the Orsay hospital site. It ensures a public service mission and a research and development mission in biomedical imaging and in diagnostic and therapeutic innovation. The aim of this research is to create new imaging tools to improve diagnosis and evaluation of innovative therapeutics in three thematic areas :

  • oncological diseases,
  • neurodegenerative, neuro-inflammatory, psychiatric and addiction disorders,
  • cardiovascular, metabolic and systemic inflammatory diseases.

SHFJ is divided in 3 entities : the Nuclear Medicine Service, that ensures the public service mission of the SHFJ, the In Vivo Molecular Imaging Laboratory (IMIV), a Mixed Research Unit (UMR 1023) belonging to CEA, Inserm and Paris-Sud University and the Laboratory for Methodological Developments in PET (LDM/TEP), based in Caen. The SHFJ has also a branch of the pharmacy for internal use of the Orsay Hospital for 2 activities, namely the preparation of radiopharmaceuticals and the preparations for biomedical research including the experimental medicines one (Arrêté n° 08-065-91 du 23/05/2008).

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Moreover, the SHFJ is associated with three other Research Entities (Associated Units) : the Medical Magnetic Resonance Imaging and Multi-Modalities Unit (IR4M), the research team in clinical imaging of neurodegenerative diseases, and the Research Team "Child Epilepsy and Cerebral Plasticity".

To carry out their Research, SHFJ researchers have access to platforms, part of the National Infrastructures in Biology and Health France Life Imaging (FLI) et NeurATRIS financed by the Programme of Investments for the Future (PIA) :

  • PRIME (certified IBiSA) : Experimental Molecular Imaging Research Platform, a platform dedicated to preclinical and clinical molecular imaging,
  • IRM 1,5T : a clinical IRM.

 

  
Striatal and Extrastriatal Dopamine Transporter Availability in Schizophrenia and Its Clinical Correlates: A Voxel-Based and High-Resolution PET Study
Artiges E., Leroy C., Dubol M., Prat M., Pepin A., Mabondo A., De Beaurepaire R., Beaufils B., Korwin JP., Galinowski A., d'Albis MA., Santiago-Ribeiro MJ., Granger B., Tzavara ET., Martinot JL. and Trichard C.
Diphenhydramine as a selective probe to study H+-antiporter function at the blood-brain barrier: Application to [C-11]diphenhydramine positron emission tomography imaging
Auvity S., Chapy H., Goutal S., Caille F., Hosten B., Smirnova M., Decleves X., Tournier N. and Cisternino S.
Evaluation of TSPO PET imaging, a marker of glial activation, to study the neuroimmune footprints of morphine exposure and withdrawal
Auvity S., Goutal S., Theze B., Chaves C., Hosten B., Kuhnast B., Saba W., Boisgard R., Buvat I., Cisternino S. and Tournier N.
Susceptibility to morphine-induced glial activation assessed using TSPO PET imaging with F-18-DPA-714 in nonhuman primates
Auvity S., Saba W., Goutal S., Leroy C., Buvat I., Cayia J., Caille F., Bottlaender M., Cisternino S. and Tournier N.
JOURNAL OF NUCLEAR MEDICINE 58 (), -, 2017
Acute Morphine Exposure Increases the Brain Distribution of [F-18]DPA-714, a PET Biomarker of Glial Activation in Nonhuman Primates
Auvity S., Saba W., Goutal S., Leroy C., Buvat I., Cayla J., Caille F., Bottlaender M., Cisternino S. and Tournier N.
Shear Wave Elastography in Thyroid Nodules with Indeterminate Cytology: Results of a Prospective Bicentric Study
Bardet S., Ciappuccini R., Pellot-Barakat C., Monpeyssen H., Michels JJ., Tissier F., Blanchard D., Menegaux F., de Raucourt D., Lefort M., Reznik Y., Rouxel A., Heutte N., Brenac F., Leconte A., Buffet C., Clarisse B. and Leenhardt L.
Assessment of P-Glycoprotein Transport Activity at the Human Blood Retina Barrier with (R)-C-11-Verapamil PET
Bauer M., Karch R., Tournier N., Cisternino S., Wadsak W., Hacker M., Marhofer P., Zeitlinger M. and Langer O.
[18F]-FMISO PET study of hypoxia in gliomas before surgery: correlation with molecular markers of hypoxia and angiogenesis
Bekaert L., Valable S., Lechapt-Zalcman E., Ponte K., Collet S., Constans JM., Levallet G., Bordji K., Petit E., Branger P., Emery E., Manrique A., Barre L., Bernaudin M. and Guillamo JS.
Sonographic Dynamic Description of the Laryngeal Tract: Definition of Quantitative Measures to Characterize Vocal Fold Motion and Estimation of Their Normal Values
Bergeret-Cassagne H., Lazard DS., Lefort M., Hachi S., Leenhardt L., Menegaux F., Russ G., Tresallet C. and Frouin F.
Individual remyelination profiles in cortical grey matter and in white matter lesions in multiple sclerosis: a combined PET and MTR study
Bodini B., Poirion E., Battaglini M., Veronese M., Lubetzki C., Bottlaender M., De Stefano N., Turkheimer F. and Stankoff B.
EUROPEAN JOURNAL OF NEUROLOGY 24 (), 61-62, 2017
Heterogeneity in individual patterns of microglial activation in multiple sclerosis measured non-invasively with 18F-DPA-714 PET
Bodini B., Poirion E., Garcia-Lorenzo D., Battaglini M., Luapre C., Bera G., Maillart E., Papeix C., Bottlaender M. and Stankoff B.
EUROPEAN JOURNAL OF NEUROLOGY 24 (), 654-654, 2017
Physiological variations of SUV and textural indices in normal breast tissue as a function of age and body mass index in FDG-PET.
Boughdad S., Nioche C., Orlhac F., Champion L. and Buvat I.
JOURNAL OF NUCLEAR MEDICINE 58 (), -, 2017
Variations in SUV and textural indices in breast tissue satellite to breast cancer compared to normal breast tissue in FDG-PET.
Boughdad S., Nioche C., Orlhag F., Champion L. and Buvat I.
JOURNAL OF NUCLEAR MEDICINE 58 (), -, 2017
Synthesis and in vitro characterization of novel fluorinated derivatives of the translocator protein 18 kDa ligand CfO-DPA-714
Cacheux F., Medran-Navarrete V., Dolle F., Marguet F., Puech F. and Damont A.
Biodistribution of [F-18]FC0324, a new PET tracer targeting CB2 receptors
Caillac F., Cacheux F., Peyronneau MA., Jego B., Jaumain E., Pottier G., Ullmer C., Grether U., Dolle F., Damont A. and Kuhnast B.
JOURNAL OF NUCLEAR MEDICINE 58 (), -, 2017
From Structure-Activity Relationships on Thiazole Derivatives to the In Vivo Evaluation of a New Radiotracer for Cannabinoid Subtype 2 PET Imaging
Caille F., Cacheux F., Peyronneau MA., Jego B., Jaumain E., Pottier G., Ullmer C., Grether U., Winkeler A., Dolle F., Damont A. and Kuhnast B.
QUANTIFICATION OF DOPAMINE D2 RECEPTOR DENSITY AND APPARENT AFFINITY CAN BE USED TO LONGITUDINALLY ASSESS TRANSIENT STRIATAL VARIATIONS DURING ADOLESCENCE USING [11C]RACLOPRIDE PET IMAGING
Callaghan P., Sobbi PF., Safavi-Naeini M., Wimberley C., Davis E., Zahra D., Arthur A., Rahardjo G., Perkins G., Pascali G., Reilhac-Laborde A. and Gregoire MC.
INTERNAL MEDICINE JOURNAL 47 (), 19-19, 2017
FMISO-PET-derived brain oxygen tension maps: application to glioblastoma and less aggressive gliomas
Chakhoyan A., Guillamo JS., Collet S., Kauffmann F., Delcroix N., Lechapt-Zalcman E., Constans JM., Petit E., MacKenzie ET., Barre L., Bernaudin M., Touzani O. and Valable S.
Issues in quantification of registered respiratory gated PET/CT in the lung
Cuplov V., Holman BF., McClelland J., Modat M., Hutton BF. and Thielemans K.
Avidin/Biotin Bioinspired Platform for Dual In Vivo F-18-PET/NIRF Molecular Imaging
Damont A., Boisgard R., Dolle F., Hollocou M. and Kuhnast B.
Comparison of four dynamic filtering techniques in the reconstruction of 4D PET data
Delaplace R., Jullian Y., Laporte P., Stute S. and Tauber C.
JOURNAL OF NUCLEAR MEDICINE 58 (), -, 2017
Post-injection syndrome and olanzapine pamoate: A severe case report
Descusse A., Chebili S. and Artiges E.
Impact of respiratory motion compensation in patients with solid tumors undergoing integrated Time of Flight PET/MR
Djelbani S., Fernandez B., Comtat C., Buvat I. and Soussan M.
JOURNAL OF NUCLEAR MEDICINE 58 (), -, 2017
Dopamine Transporter and Reward Anticipation in Psychiatric Patients: A Positron Emission Tomography and Functional Magnetic Resonance Imaging Study
Dubol M., Trichard C., Sandu AL., Leroy C., Rahim M., Martinot JL. and Artiges E.
BIOLOGICAL PSYCHIATRY 81 (10), S117-S118, 2017
GABRB1 Single Nucleotide Polymorphism Associated with Altered Brain Responses (but not Performance) during Measures of Impulsivity and Reward Sensitivity in Human Adolescents
Duka T., Nikolaou K., King SL., Banaschewski T., Bokde ALW., Buchel C., Carvalho FM., Conrod PJ., Flor H., Gallinat J., Garavan H., Heinz A., Jia TY., Gowland P., Martinot JL., Paus T., Rietschel M., Robbins TW., Smolka M., Schumann G. and Stephensfor DN.
Preclinical in vivo and in vitro comparison of the translocator protein PET ligands [F-18]PBR102 and [F-18]PBR111
Eberl S., Katsifis A., Peyronneau MA., Wen L., Henderson D., Loc'h C., Greguric I., Verschuer J., Pham T., Lam P., Mattner F., Mohamed A. and Fulham MJ.
Pubertal Changes Affect Intrinsic Functional Brain Connectivity of mPFC and PCC Differently in Boys and Girls: A Potential Contributor to Vulnerability to Mood Disorders
Ernst M., Benson B., Lemaitre H., Gorka A., Lago T., Artiges E., Martinot MLP. and Martinot JL.
BIOLOGICAL PSYCHIATRY 81 (10), S47-S47, 2017
Integrated Time of Flight PET-MR for lung cancer staging: comparison with conventional procedures
Faouzi I., Negroni J., Assouline P., Kettaneh L., Decoux L., Oliviero G., Buvat I. and Soussan M.
JOURNAL OF NUCLEAR MEDICINE 58 (), -, 2017
An improved FSL-FIRST pipeline for subcortical gray matter segmentation to study abnormal brain anatomy using quantitative susceptibility mapping (QSM)
Feng X., Deistung A., Dwyer MG., Hagemeier J., Polak P., Lebenberg J., Frouin F., Zivadinov R., Reichenbach JR. and Schweser F.
A Focus on Young Researchers and an Outstanding Career in the Spotlight: The Success of the RITS Conference
Frouin F., Gehin C., Massot B., Lafon C. and Peyrin F.
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