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SB2SM - UMR 9198

Bioenergetics, Structural Biology and Mechanisms Unit

 

​​FRENCH

 

Published on 27 June 2018
Research carried out in the Unit of Bioenergetics, Structural Biology and Mechanisms aims at understanding how the different levels of organisation of biological macromolecules define their function. Principal studies concern soluble and membrane protein architectures, involved in the biological processes of bioenergetics, oxidative stress, and genome control and repair.

Head of Unity
Bruno Robert
bruno.robert@cea.fr

Deputy
Francis Haraux
francis.haraux@cea.fr

 

 


This unit is part of the Institute of Integrative Biology of the Cell (I2BC), established on 1 January 2015 (mixed research unit (UMR) 9198, CEA/CNRS/Paris Sud university).   

Extensive use is made of approaches combining biochemistry, molecular biology and genetics, together with structural and spectroscopic methods. This combination of techniques can provide information on a wide range of different scales.
 - At the atomic scale, EPR, Raman and infrared absorption spectroscopy yield information on the detailed structure of protein active sites, and how this structure is related to protein function. Time-resolved techniques may be used for determining the reaction pathways in these active sites.
- At a molecular scale, the structure of the protein and of the interaction surfaces necessary for the formation of active complexes may be obtained from NMR spectroscopy and crystallography.
- At a multi-molecular or cellular scale, studying the composition, the structure and the dynamics of multi-subunit protein assemblies yields information on the regulation of complex processes in vivo.

SB²SM is composed of six laboratories

Biology and biotechnology of cyanobacteria
Laboratory of Fundamental Mechanisms in Bioenergetics
Laboratory of bioenergetics, metalloproteins and stress
Structural biology and radiobiology laboratory
Laboratory of membrane proteins and membrane sytems
Oxidative stress and detoxification laboratory

  
Meet-U: Educating through research immersion
Abdollahi N., Albani A., Anthony E., Baud A., Cardon M., Clerc R., Czernecki D., Conte R., David L., Delaune A., Djerroud S., Fourgoux P., Guiglielmoni N., Laurentie J., Lehmann N., Lochard C., Montagne R., Myrodia V., Opuu V., Parey E., Polit L., Prive S., Quignot C., Ruiz-Cuevas M., Sissoko M., Sompairac N., Vallerix A., Verrecchia V., Delarue M., Guerois R., Ponty Y., Sacquin-Mora S., Carbone A., Froidevaux C., Le Crom S., Lespinet O., Weigt M., Abboud S., Bernardes J., Bouvier G., Dequeker C., Ferre A., Fuchs P., Lelandais G., Poulain P., Richard H., Schweke H., Laine E. and Lopes A.
Energy transfer and trapping in Synechococcus WH 7803
Acuna A. M., Lemaire C., van Grondelle R., Robert B. and van Stokkum I. H. M.
The PHD finger protein Spp1 has distinct functions in the Set1 and the meiotic DSB formation complexes
Adam C., Guerois R., Citarella A., Verardi L., Adolphe F., Beneut C., Sommermeyer V., Ramus C., Govin J., Coute Y. and Borde V.
A charge polarization model for the metal-specific activity of superoxide dismutases
Barwinska-Sendra A., Basle A., Waldron K. J. and Un S.
Disentangling the molecular determinants for Cenp-F localization to nuclear pores and kinetochores
Berto A., Yu J., Morchoisne-Bolhy S., Bertipaglia C., Vallee R., Dumont J., Ochsenbein F., Guerois R. and Doye V.
The low spin - high spin equilibrium in the S2-state of the water oxidizing enzyme
Boussac A., Ugur I., Marion A., Sugiura M., Kaila V. R. I. and Rutherford A. W.
A long-lived Triplet State is the Entrance Gateway to Oxidative Photochemistry in Green Fluorescent Proteins
Byrdin M., Duan C., Bourgeois D. and Brettel K.
(1)H, (13)C and (15)N backbone resonance assignment of the lamin C-terminal region specific to prelamin A
Celli F., Petitalot A., Samson C., Theillet F. X. and Zinn-Justin S.
Water Molecules Gating a Photoinduced One-Electron Two-Protons Transfer in a Tyrosine/Histidine (Tyr/His) Model of PhotosystemII
Chararalambidis G., Das S., Trapali A., Quaranta A., Orio M., Halime Z., Fertey P., Guillot R., Coutsolelos A., Leibl W., Aukauloo A. and Sircoglou M.
Properties and structure of a low-potential, penta-heme cytochrome c 552 from a thermophilic purple sulfur photosynthetic bacterium Thermochromatium tepidum
Chen J. H., Yu L. J., Boussac A., Wang-Otomo Z. Y., Kuang T. and Shen J. R.
Nonequilibrium self-assembly dynamics of icosahedral viral capsids packaging genome or polyelectrolyte
Chevreuil M., Law-Hine D., Chen J., Bressanelli S., Combet S., Constantin D., Degrouard J., Moller J., Zeghal M. and Tresset G.
State transitions in the cyanobacterium Synechococcus elongatus 7942 involve reversible quenching of the photosystem II core
Choubeh R. R., Wientjes E., Struik P. C., Kirilovsky D. and van Amerongen H.
A Scalable and Efficient Approach to Polarizable Force Fields in Molecular Dynamics Simulations
Coles JP. and Masella M.
BIOPHYSICAL JOURNAL (), , 2018
Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13
David M., Lebrun C., Duguet T., Talmont F., Beech R., Orlowski S., Andre F., Prichard R. K. and Lespine A.
A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation
De Muyt A., Pyatnitskaya A., Andreani J., Ranjha L., Ramus C., Laureau R., Fernandez-Vega A., Holoch D., Girard E., Govin J., Margueron R., Coute Y., Cejka P., Guerois R. and Borde V.
A tribute to Ulrich Heber (1930-2016) for his contribution to photosynthesis research: understanding the interplay between photosynthetic primary reactions, metabolism and the environment
Dietz K. J., Krause G. H., Siebke K. and Krieger-Liszkay A.
FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination
Fernandes J. B., Duhamel M., Seguela-Arnaud M., Froger N., Girard C., Choinard S., Solier V., De Winne N., De Jaeger G., Gevaert K., Andrey P., Grelon M., Guerois R., Kumar R. and Mercier R.
Structural rearrangements in the C-terminal domain homolog of Orange Carotenoid Protein are crucial for carotenoid transfer
Harris D., Wilson A., Muzzopappa F., Sluchanko N. N., Friedrich T., Maksimov E. G., Kirilovsky D. and Adir N.
Photoinduced electron transfer in a molecular dyad by nanosecond pump-pump-probe spectroscopy
Ha-Thi M. H., Pham V. T., Pino T., Maslova V., Quaranta A., Lefumeux C., Leibl W. and Aukauloo A.
Sak4 of Phage HK620 Is a RecA Remote Homolog With Single-Strand Annealing Activity Stimulated by Its Cognate SSB Protein
Hutinet G., Besle A., Son O., McGovern S., Guerois R., Petit M. A., Ochsenbein F. and Lecointe F.
Apoprotein heterogeneity increases spectral disorder and a step-wise modification of the B850 fluorescence peak position
Ilioaia C., Kruger T. P. J., Ilioaia O., Robert B., van Grondelle R. and Gall A.
Ectopic Neo-Formed Intracellular Membranes in Escherichia coli: A Response to Membrane Protein-Induced Stress Involving Membrane Curvature and Domains
Jamin N., Garrigos M., Jaxel C., Frelet-Barrand A. and Orlowski S.
A mechanism for CO regulation of ion channels
Kapetanaki S. M., Burton M. J., Basran J., Uragami C., Moody P. C. E., Mitcheson J. S., Schmid R., Davies N. W., Dorlet P., Vos M. H., Storey N. M. and Raven E.
Author Correction: A mechanism for CO regulation of ion channels
Kapetanaki S. M., Burton M. J., Basran J., Uragami C., Moody P. C. E., Mitcheson J. S., Schmid R., Davies N. W., Dorlet P., Vos M. H., Storey N. M. and Raven E.
Local ionic liquid environment at a modified iron porphyrin catalyst enhances the electrocatalytic performance of CO2 to CO reduction in water
Khadhraoui A., Gotico P., Boitrel B., Leibl W., Halime Z. and Aukauloo A.
Interorganelle Communication: Peroxisomal MALATE DEHYDROGENASE 2 Connects Lipid Catabolism to Photosynthesis through Redox Coupling in Chlamydomonas
Kong F., Burlacot A., Liang Y., Legeret B., Alseekh S., Brotman Y., Fernie A. R., Krieger-Liszkay A., Beisson F., Peltier G. and Li-Beisson Y.
Importing manganese into the chloroplast: many membranes to cross
Krieger-Liszkay A. and Thomine S.
X-ray structure of an asymmetrical trimeric ferredoxin-photosystem I complex
Kubota-Kawai H., Mutoh R., Shinmura K., Setif P., Nowaczyk M. M., Rogner M., Ikegami T., Tanaka H. and Kurisu G.
Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2
Lafite P., Andre F., Graves J. P., Zeldin D. C., Dansette P. M. and Mansuy D.
Involvement of the FOXO6 transcriptional factor in breast carcinogenesis
Lallemand F., Petitalot A., Vacher S., de Koning L., Taouis K., Lopez B. S., Zinn-Justin S., Dalla-Venezia N., Chemlali W., Schnitzler A., Lidereau R., Bieche I. and Caputo S. M.
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