To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Europe | European ＆ international partnerships | Chemistry
Isotope Labeling for Drug Innovation
The main objective of the ISOTOPICS project will be to train 15 Early Stage Researchers (ESRs) during 3-year PhD fellowships to meet the need of industry by providing new researchers specialized in labeling chemistry with a dual academic/industrial culture.
Excessive attrition rates during clinical trials dramatically impact on Drug Discovery and Development (DDD). Absorption, Distribution, Metabolism and Excretion studies carried out on larger series of drug candidates at an earlier stage of the DDD timeline and evaluation of drug efficacy through better assessment of pharmacokinetic/pharmacodynamic relationships, target engagement and receptor occupancy are critically important approaches for de-risking drug innovation since they facilitate early identification of the candidates that display the best in vivo profile.
When successfully implemented, this strategy can accelerate the discovery of new therapeutic solutions to existing and emerging diseases, and enhance European pharmaceutical innovation. For implementation, large sets of isotopically-labeled molecules are required and consequently, a huge revival of labeling techniques is urgently needed. Another crucial issue is the scarcity of expert radiochemists in Europe and the lack of first class training programs in this inter-disciplinary field merging chemistry, radiochemistry and medicinal chemistry.
The aims of ISOTOPICS are:
Joliot Institute Contact: Christophe Dugave (email@example.com)
The Innovative Training Networks (ITN) aim to train a new generation of creative, entrepreneurial and innovative early-stage researchers, able to face current and future challenges and to convert knowledge and ideas into products and services for economic and social benefit. Partnerships take the form of collaborative:
European Training Networks(ETN),
European Industrial Doctorates (EID),
European Joint Doctorates(EJD)
The beneficiary organizations are located in a Member State of the European Union or an associated country and recruit young researchers. Partner organizations can be located in any country and participate in the training of young researchers.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.