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French Infrastructure for Integrated Structural Biology


FRISBI (French Infrastructure for Integrated Structural Biology) is a National Infrastructure in Biology and Health, which provides the academic and industrial community with access to technologies and know-how dedicated to integrative structural biology.

Published on 28 November 2017

Its missions

Integrative structural biology uses a combination of different approaches to obtain structural and dynamic information at different spatial and temporal scales on macromolecules and biological complexes. FRISBI:

  • provides the academic and industrial community with access to a set of technologies and know-how in integrated structural biology,
  • offers courses in structural biology integrated with post-master researchers.


Coordinated by Bruno Klaholz (IGBMC, Strasbourg), FRISBI is divided in 5 regional nodes: Strasbourg, Grenoble, Montpellier, Marseille et Paris-Sud. Research Team of the Frédéric Joliot Institute for Life Sciences font take part in Paris-Sud node.

The Frédéric Joliot Institute for Life Sciences and FRISBI

Research Team of the SB2SM (I2BC@Saclay) contribute to the Paris-Sud node of FRISBI. They hold several equipments and know-how, shared within FRISBI:

  • Preparation of samples (expression in yeast and in insect cells),
  •  Biophysical characterization (study of interactions)
  • Structural analysis (biophysics platform)
    • FTIR (Fourier Transform InfraRed) spectroscopy
    • Electronic Spectroscopy
    • Electronic Paramagnetic Resonance (EPR)
    • Solution NMR
    • Super-resolution Optical Spectroscopy
    • Raman Resonance Spectroscopy

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