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Pharmacology | Biodetection | Mass spectrometry


Pharmacology and Immunoanalysis unit

Published on 2 September 2022
For 30 years, the Pharmacology and Immunoanalysis (SPI) unit has been demonstrating its expertise in the development of immunoanalytical methods, physicochemical analyzes (especially LC-MS) and cell culture enabling it to address multiple issues concerning detection, quantification and future development of molecules of various and varied kinds.
Head​ Stéphanie Simon​+33 1 69 08 77 04
​DEPUTY HEADin the process of appointment
​ +33 1 69 08 45 83
administrative/HR ASSISTANT
Sandrine Leblois​+ 33 1 69 08 72 99
​Purchasing ASSISTANT Laurie MENEZ +33 1 69 08 51 39 
Stéphane NANO​+ 33 1 69 08 45 83 

The research carried out in SPI always connects with the fundamental aspects of the methodological and analytical developments and always integrates the "Therapeutic Innovation and Diagnostic" line of the CEA's Fundamental Research Division. Research is usually carried out in collaboration with academic partners or contract with industry or government partners. 
The themes developed by the laboratory are based on an important park of mass spectrometers and are articulated around :
  • the development of new methods for the detection, identification and quantification of drugs and their metabolites by mass spectrometry as well as recombinant proteins or pathogens (within the framework of the CBRN-E program of the CEA),
  • the development of metabolomic, lipidomic and glycomic approaches for the search of biomarkers for diagnosis or monitoring of pathologies
The subjects of the laboratory all involve the "antibody molecule" through the means of production of polyclonal and monoclonal antibodies at its disposal to develop:
  • diagnostic methods (ELISA and immuno-chromatographic tests) for various types of targets: xenobiotics, proteins and especially pathogens handled in the laboratory L3 available at LERI,
  • new technological developments around the "fast" dosages like immunochromatography, 
  • immunotherapeutic or vaccine approaches

- The mission of the laboratory, based on the CEA site of Marcoule, is to develop methodologies and technologies for the detection of pathogens or toxic substances found in the environment or in biological samples / tissues and the discovery and validation of biomarkers for diagnosis. 
- The research carried out at Li2D is based on his expert knowledge in microbiological, immunological, genetic, genomic, proteomic, bioinformatics and high-resolution mass spectrometry techniques.

The work done at the Food Immuno-Allergy Unit aims to develop tools and knowledge to assess, manage and if possible prevent food-related allergic risk. Indeed, food allergies are a major public health problem because of the increase in prevalence, but also the number of affected food and the severity of clinical symptoms they cause. Therefore, it is a challenge and a concern for the Food Industry and the Public Authorities in charge of the health of consumers to have means to assess, manage and if possible prevent the allergic risks of food.

The LENIT conducts research activities in the fields of :
  • pharmacology and experimental modeling of the human blood-brain barrier for the screening and selection of therapeutic molecules
  • precision medicine through the modeling of pathological brain organoids for the search of molecular signatures
  • translational research on metabolic and tumoral brain pathologies
Finally, since its inception, the SPI has developed commercialization projects that proved particularly successful (Prion or bioterrorism agents dosage, for example), by the realization of numerous contractual studies or collaborative research with industrial partners in pharmaceuticals and diagnostics for over twenty years ("spin-off" from our developments).The existence of a strong quality policy also contributes to the identity of our service: the presence of two full-time quality professionals, accreditation of Good Laboratory Practices (ANSM) of LEMM and iso9001 certification of SPI obtained on December 2014 (LI2D in 2003).