To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
Scientific result | Brain | MRI
Funded by the Human Brain Project*, Individual Brain Charting, involving NeuroSpin, acquires a set of high-resolution functional MRI maps of the brain during a wide range of behavioral tasks. The data, in open access, will be used to develop a macroscopic functional atlas including a cognitive mapping.This is the first version of the IBC project dataset.
Despite an abundant literature on the neurocognitive mechanisms underlying specific tasks, little is known about the links between cognition and the overall functional organization of the brain. Neuroimaging techniques like functional magnetic resonance imaging (fMRI) have been used by labs all over the world to characterize the relationships between regional brain activity and cognition in thousands of individual studies. However, to date, no study has systematically addressed functional mapping at a fine spatial scale of cognitive processes over a wide range of tasks. The objective of the Individual Brain Charting project (IBC) within the HBP is to establish a high-resolution (1.5 mm) multi-task fMRI data set, which will be used to develop a complete functional atlas of the human brain. The data were acquired at NeuroSpin Paris, which is part of the HBP partner institution CEA, under the responsibility of Lucie Hertz-Pannier, principal investigator of the project and under the scientific responsibility of Bertrand Thirion. A cohort of twelve participants performed several cognitive tasks: low-level tasks, such as looking at an image or typing three times with a finger; high-level tasks like mental calculation, reading sentences or interpreting a story involving someone's beliefs. Obtaining a wide range of fMRI data from the same subjects and at the same site helps to minimize the problem of inter-subject and inter-site variability.In their recently published article, researchers present the first version of the IBC data set, which includes a dozen tasks. The raw data are public and available on the OpenNeuro website (ds000244) and the post-processed data on NeuroVault (id2138). Also included are estimates of data quality and a statistical assessment of cognitive networks. Future developments will include data for new tasks and the development of a neurocognitive atlas derived from the data set. The datasets are also being integrated into the HBP Knowlegde Graph where they will be available shortly.
These first results have already been the subject of several articles, among which a DRF scientific article (08/06/2018) and an Inria-Saclay article. *: Human Brain Project (H2020) is an international collaboration dedicated to the modeling of the human brain, particularly through high performance computing, in which NeuroSpin is involved.
Read the French version.
Pinho AL, Amadon A, Ruest T, Fabre M, Dohmatob E, Denghien I, Ginisty C, Becuwe-Desmidt S, Roger S, Laurier L, Joly-Testault V, Médiouni-Cloarec G, Doublé C, Martins B, Pinel P, Eger E, Varoquaux G, Pallier C, Dehaene S, Hertz-Pannier L, Thirion B. Individual Brain Charting, a high-resolution fMRI dataset for cognitive mapping.(2018) Scientific Data, 5, 180105. http://dx.doi.org/10.1038/sdata.2018.105
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.