To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Scientific result | Article | MRI
To address the problem of ultre high field MRI signal loss in certain regions of the human body, a collaboration involving BAOBAB (NeuroSpin), the CEA's Iramis Institute, the Fresnel Institute and Multiwave Imaging has led to the development of a new generation of simple and inexpensive silicon carbide-based pads. The new composition makes the pads invisible to MRI and prolongs their performance when compared to existing solutions.
The arrival of MRI scanners with ultra-high magnetic fields (≥ 7 Tesla) is expected to provide a huge leap forward in the early diagnosis of certain diseases, especially brain diseases. At these ultra-high fields, the images enjoy excellent spatial and/or temporal resolutions. However, at this field strength, the physics of MRI leads to signal losses in certain regions (typically in the temporal lobe and cerebellum) and prevents the expansion of their use in hospitals.
Several solutions are under development. One of them, simple to implement, consists in inserting in the radiofrequency antenna, which surrounds the head of the subject, "pads" containing a material with a high dielectric constant. This material, by its nature, creates currents which will modify the global distribution of the radiofrequencies coming from the transmission coil and generate a secondary radiofrequency field which corrects the problem significantly.
Itroduced in the early 1990's, this solution has since been improved in its design with new material compositions that still had some imperfections.
Researchers from the METRIC team (BAOBAB, NeuroSpin department), the Magnetic Resonance Structure and Dynamics Laboratory (UMR NIMBE, Iramis Institute of the CEA), the Fresnel Institute (Aix-Marseille University), and Multiwave Imaging have developed an alternative. Their new "recipe", made of silicon carbide, makes the pads invisible to magnetic resonance and considerably prolongs their performance, two points that were limiting for the previous generations.
Zo Raolison, Marc Dubois, Michel
Luong, Ana Luisa Neves, Franck Mauconduit,
Stefan Enoch, Nicolas Mallejac, Pierre Sabouroux, Fawzi Boumezbeur, Patrick Berthault, Mikhail Zubkov, Anne-Lise
Adenot-Engelvin, Lucie Hertz-Pannier,
Georget Elodie, Redha Abdeddaim, Alexandre
Vignaud. Evaluation of new MR invisible silicon carbide
based dielectric pads for 7 T MRI. | Magnetic Resonance Imaging,
2022, 90 (37-43).
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.