To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
A study led by Oxford University researchers and involving researchers from the Institut Joliot (I2BC) and the University of Århus reveals the crucial role of the E340 residue in the inter-domain communication of the calcium transporter SERCA.
Researchers from I2BC and SPI (DMTS, Marcoule), in collaboration with CEA Grenoble and the Belgian nuclear research center, discovered, by using two meta-omic approaches, living bacteria in the core pool of the CEA Paris-Saclay research reactor, Osiris, in operation, thus opening up perspectives for the discovery of new radioresistant species.
A study led by the Institut Pasteur and involving CEA-Joliot has shown, in a mouse model, that a modification of the intestinal microbiota caused by chronic stress is accompanied by modifications of the metabolome which induce a defect in the signaling pathway for endogenous cannabinoids in the hippocampus, which may explain the mood disorders observed.
A European study involving CEA-Joliot provides the first overview of the amino acids circulating in the blood of patients with decompensated cirrhosis and concludes that there is a strong redistribution of their metabolism in order to provide the fuel necessary for the intense inflammatory response.
In the field of artificial intelligence, international competition is tough. So when researchers from CEA-Joliot and Irfu challenge start-ups and other companies specializing in AI, we cheer them on. Here’s a success story from the field of MRI reconstruction.
Researchers from the Neurofunctional Imaging Group (GIN, NeuroSpin, Bordeaux) studied by functional MRI, the organization of the brain network of sentence processing in individuals "atypical" for language, i.e. with a major role of the right hemisphere.
A collaborative study by NeuroSpin suggests that psychosis and impaired conscious access may be closely related phenomena.
Chemists of CEA-Joliot have synthesized the two enantiomers of a molecule containing a deuterated chiral ethyl group and characterized their chiral properties using advanced spectroscopic tools. These two compounds will be useful for probing the reaction mechanism of enzymes, as alkyl transferases.
The recent publication, in the journal Diagnostics, of a collaborative study associating AP-HP, NG-Biotech and a team from the Institute, is an opportunity to recall the Institute's commitment to the development of means of detecting antimicrobial resistance, a global phenomenon in the WHO's sights, as recalled by the World Antimicrobial Awareness Week.
Researchers at NeuroSpin are proposing a new magnetic resonance thermometry method to increase the accuracy in the measurement of small temperature variations induced by MRI.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.