To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Institute | Structural biology
The Institute for Integrative Biology of the Cell (I2BC) UMR 9198 is a “Unité Mixte de Recherche” (joint research unit ; UMR ) supported by both Université Paris-Sud, the CNRS and the CEA. The Institute regroup 80 teams of scientists, 15 technological facilities from 8 research units (CGM, IBBMC, IGM, ISV, LEBS, VMS, SB2SM, SBiGeM)The Institute is in 3 research campus (Orsay Campus of the Université Paris Sud, Gif Sur Yvette Campus of CNRS, and Saclay Campus of CEA) with 14 buildings. All the I2BC activities will be join on the Gif Sur Yvette Campus in 2018.
Adress: Avenue de la Terrasse, Bâtiment 21,91190 Gif-sur-Yvette Cedex
I2BC@Saclay Department of the Frédéric Joliot Institute for Life Sciences permanently receives and prepares approximately 120 doctoral students., directed by Thierry Meinnel, carries out research in
Integrative Biology of the Cell around four thematic axes :
Thanks to recent developments in cryo-electron microscopy, a study led by a team from the I2BC reveals, at the atomic scale, the unsuspected structural complexity of lanreotide nanotubes, a drug used in the treatment of acromegaly and some neuro-endocrine cancers.
A project at the interface between quantum chemistry and molecular dynamics for the study of complex molecular assemblies, led by Michel Masella (Joliot) and Luigi Genovese (IRIG), makes it possible, for applications in biology/health, to take full advantage of the new supercomputers of the Public Procurement of Innovations for High-Performance Computing (PPI4HPC, H2020) project hosted at the Très Grand Centre de Calcul (TGCC) of the CEA-Bruyères-le-Châtel.
I2BC researchers, in collaboration with the European Institute of Chemistry and Biology (University of Bordeaux, CNRS), have developed a chimeric peptide/foldamer molecule that is resistant to proteolysis and inhibits ASF1, a potential target for anticancer treatment. The resolution of the structure of this chimera in interaction with its target, the first of its kind, reveals an unsuspected plasticity of the urea-based backbone that hugs the surface of ASF1.
In a study conducted by a team from the Institut Curie, researchers from the CEA-Joliot (B3S/I2BC department) have modeled in silico protein-protein interactions and thus contributed to establish at the molecular level the mechanisms that coordinate the pairing and recombination of homologous chromosomes during meiosis.
I2BC researchers, in collaboration with the Autonomous University of Barcelona, have provided the first studies of the function and structural organization of a flippase encoded by a parasite responsible for malaria, a first step towards understanding the essential physiological function of this transporter and its potential use as an antimalarial target.
The French National Infrastructure of Integrated Structural Biology (FRISBI) is now integratinf Genopole's structural biology platform into its Paris-Sud node.
Paris-Saclay University is pleased to present the MOOC "Journey to the heart of life with X-rays: crystallography", result of a close collaboration between the Department I2BC @ Saclay (pedagogical director: Marie-Hélène Le Du ), the Sun Synchrotron, the Ecole Polytechnique, the CNRS, and the University Paris Sud.
Its Research Teams are all members of the
Institute of Integrative Biology of the Cell (I2BC), a Joint research unit (UMR 9198), whose tutors are CEA, CNRS and Paris Sud University. Currently located on the site of Saclay, they will join all the staff of the I2BC in 2019 in a new building, on the CNRS campus of Gif-sur-Yvette.
To carry out their activities, researchers of I2BC@Saclay Department have access to research platforms certified
IBiSA within the
Frédéric Joliot Institute for Life Sciences:
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.