To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Laboratory | Cell and molecular imaging
Molecular Imaging and Delivery of Active Substances
These projects consist in developing new tools based on transcranial ultrasound to deliver drugs to the brain and to non-invasively stimulate neural circuits.
Coordinator: B. Larrat (UNIRS)
These projects consist in developing new tools based on transcranial ultrasound to deliver drugs to the brain and to non-invasively stimulate neural circuits. These new devices are dedicated to theranostic applications in rodent and non-human primate models of neurodegenerative diseases.
Our research program is divided as follows:
Develop a motorized focused ultrasound equipment working under MRI guidance (7 T) and adapted to the geometry of rodent head, validate this system for image-guided temporary permeabilization of the BBB and neurostimulation (MRgFUS project)2012-2015, collaboration with Image Guided Therapy (Pessac)
Develop and validate a transcranial focused ultrasound system working under MRI guidance (7 T) and adapted to the geometry of the macaque brain (MACAKUS project)2014-2016, collaboration with CEA-MIRCen (Fontenay-aux-Roses)
Develop and validate a benchtop transcranial focused ultrasound device adapted to the geometry of mouse and rat brains for drug delivery to cerebral tissue (3BOPUS project)Since 2014, collaboration with CEA-Clinatec (Grenoble)
Combine Fluorine MRI (19F) and ultrasound induced release of fluorinated nanoparticles encapsulating drugs (FLUORIMUS project)Since 2014, collaboration with Galien Paris-Sud Institute (Châtenay-Malabry)
Evaluate the potential of ultrasound induced transient BBB permeabilization in Alzheimer’s disease, as new diagnostic tool, new assessment tool of therapeutic efficacy and new therapeutic tool per se (FUSETAD project)2015-2018, collaboration with Lumière Matière Institute (Villeurbanne)
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.