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IMAGING OF NEURODEVELOPMENTAL PHENOTYPES

InDEv team

Published on 20 June 2021


Team leaders : Dr Lucie Hertz-Pannier (DR CEA) and Jessica Dubois (CR Inserm)

​Presentation OF the team

The InDEV Neuropediatrics team was created on January 1, 2019 at NeuroSpin, as a team of UNIACT (Unité de Recherche en Neuroimagerie Applicative Clinique et Translationnelle).

The InDEV team is co-supervised by the CEA and the UMR1141 "NeuroDiderot" unit, directed by Professor Pierre Gressens (Inserm, University of Paris, CNRS, CEA).

THEMATICS :


InDEV topics concern the study of brain development in typical children or children with early brain pathologies (epilepsy, microencephaly, brain tumors, neonatal stroke...) using structural and functional MRI. In sick children, we are particularly interested in the cerebral plasticity of the immature brain, which allows learning and a surprising functional efficiency considering the cerebral lesions.

Our multidisciplinary team (neuropediatricians, neuroscientists, neuropsychologists, engineers) shows the interest of an interface between basic and clinical research.

 
Diffusion MRI in babies
© UNIACT CEA NeuroSpin


These pediatric studies, in collaboration with other groups at NeuroSpin or in the Ile de France region, focus on :

 1- On the anatomical side : the changes that occur during development in relation to gyrification, the development of the medial temporal lobe by measuring regions of interest such as the hippocampus, amygdala, parahippocampal gyrus, the study of the white matter by means of diffusion MRI which provides information on myelination, anatomical connectivity...

 2- On the functional side : the setting up and organization of neural networks that underlie the development of sensorimotor and cognitive functions, more specifically language and memory, as well as the plasticity of these networks in a healthy and pathological brain. To address these objectives, functional MRI (fMRI) paradigms are adapted for different developmental ages (infant to adolescent), controls and patients. We study the concomitant brain activities of the tasks. We are also interested in the functional activity at rest (functional connectivity) to better understand the development of neural networks.

TEAM MEMBERS

InDEV is a multidisciplinary team. It is composed of neuropediatricians, neuroscientists, neuropsychologists and engineers.

STATUTORY MEMBERS


 
Dr Lucie Hertz-Pannier
Neuroradiologist Pediatrician
MD, PhD, HDR


 
Jessica Dubois
CRCN Inserm
PhD, HDR


Marion Noulhiane
MCU Neuroscience
Paris-Descartes
PhD, HDR


Dr David Germanaud
Neuropediatrician
MD, PhD, Robert-Debré hospital

 

Dr Catherine Chiron

DR Emeritus Inserm
MD, PhD, HDR


Yann Leprince
Research Engineer
CEA UNIACT
PhD

OTHER TEAM MEMBERS



Parvaneh Adibpour
Post-doctoral fellow
PhD

Dorothée Arzounian
Post-doctoral fellow
PhD

         Dr Sara Neumane
Post-doctoral fellow
MD, PhD

Antoine Bouyeure
PhD student
MSc

Laurie Devisscher
PhD student
MSc

       Dr Justine Fraize
PhD student
MD, MSc

Andrea Gondova
PhD student
MSc

Clément Poiret
PhD student
MSc


Gabrielle Convert
Research Engineer
MSc


Eliot Kerdreux
Research Assistant
MSc


Sandesh Patil
Design engineer
MSc




VIEW ALL MEMBERS OF INDEV / UNIACT

VIEW ALL INDEV / NEURODIDEROT MEMBERS

project tsaf-r (Transversal scientific actions in FASD-related research)



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