To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Davide AUDISIO holds a PhD degree in medicinal chemistry from the University Paris Sud (France) under the supervision of Dr. M. Alami and Dr. S. Messaoudi. After a postdoctoral experience at the Max-Planck-Institut für Kohlenforschung (Germany) with Prof. N. Maulide working on asymmetric catalysis, in 2012 he joined the chemistry department of Eli Lilly & Co (UK). In 2014, he joined the group of Dr. Frédéric Taran at CEA, the Alternative Energies and Atomic Energy Commission (France) and since 2016, he is the head of the Laboratory of Carbon-14 Labeling. His research interests span diverse areas within organic chemistry, including carbon radiolabeling methodologies, the development of new tools for bio-orthogonal chemistry and the investigation of alternatives synthetic access to poly-aromatic compounds.
Frédéric TARAN is
in charge of the department of organic chemistry (50 persons) at the French Alternative Energies and Atomic Energy
Commission (CEA) located at Saclay. Dr. Taran secured a PhD in chemistry at the Paris
XI University under the supervision of Dr. Charles Mioskowski. In 1996, he
moved to a post-doctoral position with Prof. Sir Derek Barton (Nobel Prize
1969) at Texas A&M University (USA) and then came back to CEA in 1998 as
permanent researcher. His research aims at developing new reagents for bioorthogonal
chemistry to address important problems in the fields of bioconjugation,
labeling, imaging and drug delivery.
Antoine SALLUSTRAU received his PhD degree in Organic Chemistry at the University of Birmingham (UK) under the supervision of Prof. J.H.R. Tucker in 2013. In 2014, he joined CEA-Saclay (French Atomic Energy Commission) as post-doctorant under the supervision of Dr. Frédéric Taran. In 2017, he joined the Department of Bioorganic Chemistry and Isotope Labeling in CEA as research-engineer and work now with carbon isotopes for the labeling of small organic molecules and carbon-based nanoparticles together with Dr. Frédéric Taran and Dr. Davide Audisio.
Sébastien BRUYÈRE graduated in 2019 in Chemistry from the University Clermont-Auvergne. In 2022, he obtained a Master's degree in Organic Synthesis and Chemistry of Bioactive Molecules at the University Claude BERNARD Lyon 1. He is now working towards a Ph.D degree in Chemistry focusing on the development of a new method for the identification of biological targets based on autoradiography at CEA Paris-Saclay and University Paris-Saclay. His scientific interests are based on radioisotope labelling of molecules of interest such as fluorophores or drugs, particularly in the case of glioblastoma to understand the mechanisms of action and biological targets of its treatments.
Alexandre Labiche received a master degree specialized in "Biomolecules and Organic Synthesis" in 2020 at the University of Rouen-Normandie (France). Since, he started a PhD position at the University Paris-Saclay and the CEA of Paris-Saclay (France) directed by Dr. Davide Audisio in the "Molecular Labeling and Bio-Organic Chemistry" laboratory, led by Dr. Frederic Taran. His research topic is the development of new methodologies giving access to radiolabeled organic compounds, using carbon isotopes.
Augustin Malandain obtained his M. Sc. in chemistry in 2021 at the national
graduate school of chemistry of Montpellier (France). In the same time, he
obtained a double master degree in “Biomolecules chemistry: research and
innovation”. Thereafter he started his PhD in organic
chemistry/radiolabeling at Atomic Energy Commission CEA (France) under the
supervision of Dr. Davide Audisio. His scientific interests focus on the
development of new late-stage carbon labeling methodologies.
After a gap year working at Abbvie (Ludwigshafen) in the medchem team, Quentin Lemesre obtained his M. Sc. Chemistry degree specialized in organic chemistry in 2022 at the national graduate school of chemistry of Montpellier. Since, he’s working towards a Ph. D. degree at the University of Paris-Saclay and the CEA Paris-Saclay under the supervision of Dr. Davide Audisio. His research interests focus on the development of new late-stage carbon isotope labeling methodologies.
Maxime Molins received his M. Sc in chemistry and life sciences in 2021 at the PSL university (Paris, France). Since, he has been a PhD student in Dr. Davide Audisio’s group, at Atomic Energy Commission CEA (France). His research focus on the development of new carbon isotope exchange methodologies for Carbon 14 radiolabeling.
Rémi BLIECK received his PhD degree in Organic Chemistry in 2017 from the national graduate school of chemistry of Montpellier, working under the supervision of Prof. Florian Monnier and Dr. Marc Taillefer on copper-catalyzed hydrofunctionalizations of allenes. He then joined the team of Dr. Besset in Rouen for a first post-doctoral position, focusing on remote C-H activation. In 2019, he joined the team of Prof. Echavarren in Tarragona, working on hydroacenes synthesis. In 2021, he moved to Orsay to work with Dr. de la Torre in the field of total synthesis of natural products. Since September 2022, he's working in the Molecular Labeling and Bio-organic Chemistry Unit of the Atomic Energy Commission (CEA), working on the development of new late-stage carbon labeling strategies.
Manon Louis obtained her master degree in organic chemistry in 2020 at the University of Caen. Since 2020, she is working as a PhD student at Atomic Energy Commission CEA under the supervision of Dr. Frédéric Taran and Dr. Antoine Sallustrau. Her research focuses on click and bioothogonal chemistry.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.