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Laboratory | Chemistry | High-throughput screening


14C-labeling laboratory



Published on 20 August 2022
The focus of our research is the discovery of high throughput reactions, the development of new tools for bio-orthogonal and click chemistry and the investigation of reliable methodologies for carbon-14 labeling of biologically active small molecules and nanoparticles.

We are recepient of the ERC Consolidator Grant FASTLabEx (awarded to D. Audisio). Our laboratory is member of the ISOTOPICS (ITN) and FLIX (Fet Open) ISOBIOTICS (ITN) European consortia.

Team Leader
01 69 08 38 25

Isotope labeling, Click Chemistry, reaction screening (Research Interests)

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LMC 2022 © C. Creminon

​Group Members

Davide Audisio, Team Leader
Frédéric Taran, Group Leader

Dominique Georgin, Researcher
Olivier Loreau, Researcher
Antoine Sallustrau
, Researcher
Maylis Nörloff, PhD Student
Quentin Lemesre, PhD Student
Lea Madegard, PhD student 
Apolline Mahmoudi Dominic, PhD student
Manon Louis, PhD student
Sébastien Bruyere, PhD student
Alexandre Labiche, PhD student 

Sarah Ungeheuer, PhD student
Clara Zavarise, PhD Student
Maxime Molins, PhD Student
Augustin Malandain, PhD student
Emma Bourgeat, L3 student
Louise Fogel, M2 student
Geoffrey Stosse, M2 student
Emilie Lesur, post-doc
Benoit Guichard, post-doc
Amit Kumar, post-doc
Enzo Nobile, post-doc
Guillaume Force, post-doc
Minghao Feng, post-doc
Bouchaib Mouhsine, post-doc

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      TEAM LMC

​​             GROUP photos 


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- May 2023: Two PhD positions available! Within EU funded project Isobiotics
If you are interested, please send CV with a list of current publications, a cover letter motivating the interest in the position and the names and addresses of two referees. See details below:

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- April 2023 : Our milestone review on Carbon Isotope Exchange is out in Angewandte Chemie ! Congrats to Alexandre, Augustin and Maxime! 

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- 19 February 2021: Our photocatalytic labeling procedure with CO2 is out in ACS Catalysis! Congratulations to Victor, Alex, Alexandre, Gianluca, Antonio and all co-workers! Well done !!!

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ACS Catalysis suppementary cover: Nice Artwork @Antoine!

- 25 November 2020: Our review on "Click and Bio-Orthogonal Reactions with Mesoionic Compounds" is accepted in Chem. Rev.! Congratulations to Karine, Margaux and Carlotta!

- 29 April 2020: Excellent news, our latest work on the development of a transition-metal free carbon isotope exchenge is out in Angewandte! Congratulations to Gianluca and all co-authors for this excellent work! 

- 10 December 2019: We are very happy to share that Davide is recepient of a 2019 ERC Consolidator grant! Congratulations for this great news! For informations see here: ERC-CEA, ERC-JOLIOT, Italian newspapers 1 2 3

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Fast Radio-Labeling and Isotope Exchange​
Proposal Acronym: FASTLabEx​​​

The impact of synthetic organic molecules on health, life quality and lifestyle is beyond doubt. It is therefore of fundamental importance to detect and quantify the fate of organic compounds and provide a precise risk/benefit assessment, before they reach the market and large public exposure. The traceless incorporation of carbon-14 allows tracking organic molecules and provides vital knowledge on their fate. This information is critical for pharmaceutical development, crop science and human food safety evaluation. Surprisingly, carbon radiolabeling still represents a bottleneck and an unsolved fundamental problem. In fact, current synthetic strategies are marred by several major drawbacks, including the generation of radioactive waste, being multi-step time-consuming and high resource-demanding. To circumvent such disadvantages, I present FASTLabEx, a novel approach for the straightforward preparation of carbon-labeled complex organic molecules that introduces the radioactive tag at the ultimate-stage of the synthesis. Inspired by efficient metal-catalyzed transformations, FASTLabEx makes use of a novel paradigm of “carbon isotope exchange", defined as the selective replacement of molecular moieties into organic molecules, by reversible molecular deconstruction/reconstruction in presence of an appropriate radiolabeled moiety. FASTLabEx will explore this concept onto a large variety of functional groups and structural diversity, far beyond the case of carboxylic acids. This approach has the potential to streamline the radio-synthesis of pharmaceuticals and agrochemicals. Outcomes from FASTLabEx will have a tangible societal impact not only for the radiochemical community, but also for pharmaceutical and agrochemical industries and in fine the consumers and patients. In order to mitigate the risks inherent to the project, preliminary results demonstrate its feasibility.

Scientific outcome from FASTLabEx: 

J. Am. Chem. Soc. 2021, 143, 5659–5665; ACS Catal. 2021, 11, 2968−2976; JACS Au, 2022, 2, 1234–1251; SynLett 2022, 33, 171-176; Eur. J. Org. Chem. 2022, ejoc.202200133; Chem. Commun. 2022, 58, 12831–12834; Angew. Chem. Int. Ed. 2023, e20​2303535; Asian J. Org. Chem. 2023, 12, e202200640

- 6 March 2018: Davide Audisio received the “Young Researcher in Medicinal Chemistry Award” provided by the French Medicinal Chemistry Society (SCT) and sponsored by Servier, during the "25th Young Research Fellows Meeting" in Orléans. Congratulations!!!

“Young Researcher in Medicinal Chemistry Award 2018” © S. Papot