To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
Laboratory | Chemistry | High-throughput screening
The focus of our research is the discovery of high throughput reactions, the development of new tools for bio-orthogonal and click chemistry and the investigation of reliable methodologies for carbon-14 labeling of biologically active small molecules and nanoparticles.We are recepient of the ERC Consolidator Grant FASTLabEx (awarded to D. Audisio). Our laboratory is member of the
ISOTOPICS (ITN) and
FLIX (Fet Open) ISOBIOTICS (ITN) European consortia.
Team LeaderDavide AUDISIO01 69 08 38 firstname.lastname@example.org
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- May 2023: Two PhD positions available! Within EU funded project Isobiotics. If you are interested, please send CV with a list of current publications, a cover letter motivating the interest in the position and the names and addresses of two referees. See details below:
- April 2023 : Our milestone review on Carbon Isotope Exchange is out in Angewandte Chemie ! Congrats to Alexandre, Augustin and Maxime!
- 19 February 2021: Our photocatalytic labeling procedure with CO2 is out in ACS Catalysis! Congratulations to Victor, Alex, Alexandre, Gianluca, Antonio and all co-workers! Well done !!!
ACS Catalysis suppementary cover: Nice Artwork @Antoine!
- 25 November 2020: Our review on "Click and Bio-Orthogonal Reactions with Mesoionic Compounds" is accepted in Chem. Rev.! Congratulations to Karine, Margaux and Carlotta!
- 29 April 2020: Excellent news, our latest work on the development of a transition-metal free carbon isotope exchenge is out in Angewandte! Congratulations to Gianluca and all co-authors for this excellent work!
- 10 December 2019: We are very happy to share that Davide is recepient of a 2019 ERC Consolidator grant! Congratulations for this great news! For informations see here: ERC-CEA, ERC-JOLIOT, Italian newspapers 1 2 3
The impact of synthetic organic molecules
on health, life quality and lifestyle is beyond doubt. It is therefore of
fundamental importance to detect and quantify the fate of organic compounds and
provide a precise risk/benefit assessment, before they reach the market and
large public exposure. The traceless incorporation of carbon-14 allows tracking
organic molecules and provides vital knowledge on their fate. This information
is critical for pharmaceutical development, crop science and human food safety
evaluation. Surprisingly, carbon radiolabeling still represents a bottleneck
and an unsolved fundamental problem. In fact, current synthetic strategies are
marred by several major drawbacks, including the generation of radioactive
waste, being multi-step time-consuming and high resource-demanding. To
circumvent such disadvantages, I present FASTLabEx, a novel approach for the
straightforward preparation of carbon-labeled complex organic molecules that
introduces the radioactive tag at the ultimate-stage of the synthesis. Inspired
by efficient metal-catalyzed transformations, FASTLabEx makes use of a novel
paradigm of “carbon isotope exchange", defined as the selective
replacement of molecular moieties into organic molecules, by reversible
molecular deconstruction/reconstruction in presence of an appropriate
radiolabeled moiety. FASTLabEx will explore this concept onto a large variety
of functional groups and structural diversity, far beyond the case of
carboxylic acids. This approach has the potential to streamline the
radio-synthesis of pharmaceuticals and agrochemicals. Outcomes from FASTLabEx
will have a tangible societal impact not only for the radiochemical community,
but also for pharmaceutical and agrochemical industries and in fine the
consumers and patients. In order to mitigate the risks inherent to the project,
preliminary results demonstrate its feasibility.
J. Am. Chem. Soc. 2021, 143, 5659–5665; ACS Catal. 2021, 11, 2968−2976; JACS Au, 2022, 2, 1234–1251; SynLett 2022, 33, 171-176; Eur. J. Org. Chem. 2022, ejoc.202200133; Chem. Commun. 2022, 58, 12831–12834; Angew. Chem. Int. Ed. 2023, e202303535; Asian J. Org. Chem. 2023, 12, e202200640
- 6 March 2018: Davide Audisio received the
“Young Researcher in Medicinal Chemistry Award” provided by the French Medicinal Chemistry Society (SCT) and sponsored by Servier, during the "25th Young Research Fellows Meeting" in Orléans. Congratulations!!!
“Young Researcher in Medicinal Chemistry Award 2018” © S. Papot
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.