To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Platforms ＆ installations | Brain | Cell and molecular imaging
The Cell culture laboratory aims at preparing in vitro models used to test interactions of cell lines with innovative drugs or contrast agents, but also at developing in vivo animal models for MRI studies. The lab also offers histology and fluorescence microscopy capabilities to image immunostained organs, allowing validating and complementing MRI acquisitions.
Frozen cell lines are stored to prepare
in vitro/in vivo models of cancer (glioblastoma, epidermoid carcinoma, cervical or breast cancer), and to generate 2D cell cultures or even more innovative 3D cell cultures, in order to study interactions of drugs or contrast agents with cells of interest, before moving to animal models.
Histological studies performed after MRI acquisitions are a classical way to confirm MRI data and to give more information about organ features (structure, active cells or dying cells, interactions between contrast agent and target, vasculature…) at a higher resolution than MRI. Immunostaining is usually performed on tissue slice of organ, especially brain, providing informations about the microenvironment (inflammation, apoptosis, generation of new cells…). Finally, new techniques are currently under development to perform tissue clearing, enabling for example deep imaging of the whole mouse brain (500-1000 μm).
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.