To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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BRAINOMICS team, directed by Vincent Frouin, develops innovative analysis methods to integrate brain imaging with genomics data, often combined to clinical or environmental data to determine how brain phenotypes variability originates in genetic and environmental variabilities.
My research, situated in imaging-genomics field, aims to integrate brain imaging with genomics data often combined to clinical or environmental data. It provides novel biomarkers and helps to determine how brain phenotypes variability originates in genetic and environmental variabilities. Applications include fundamental or clinical neuroscience, to shed lights on normal and pathological development of the brain in both early and aged life. Brain imaging genomics requires expertise and ethics in data engineering to handle the population cohorts that support these researches. Finally, it requires the development of original methods of machine and deep learning to integrate multi-sources data and learn interpretable models.
Imaging-genetics is an emerging field at the crossroad where neuroinformatics, bioinformatics, and machine learning meet. Neuroimaging is used as a proxy to assess the impacts of environment and genetics on neurological syndromes or diseases. My research projects aim at searching image-derived endophenotypes associated with complex traits in general population cohorts like UKBiobank or in cohorts dedicated to clinical research. These endophenotypes will then be tested for association with biological mechanisms and genetic architecture to disentangle genetic factors from environmental ones, leveraging various methodologies from univariate to multivariate approaches
Involvement of the Institute of life sciences Frédéric Joliot in EU programmes.
The group is interested in molecular mechanisms of eukaryotic transcriptional regulation in vivo on the genomic scale. The Mediator complex, essential for regulation of transcription by RNA polymerase II, is central for our projects. We use the budding yeast Saccharomyces cerevisiae and human cells as our biological models and apply integrative approaches to understand how the transcriptional regulation works and how transcription is coordinated with others nuclear processes like DNA repair.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.